ライフサイエンスコーパス: APC

1 APC and TC from the blood and BAL were purified based on

2 APC biallelic loss-of-function mutations are the most pr

3 APC deletion deregulates beta-catenin, leads to high Wnt

4 APC expression and activation of PDGFRbeta promotes the

5 APC were stratified by time periods and pooled using ran

6 APC-dependent RNAs become enriched in high-contractility

7 APCs from patients with metachromatic leukodystrophy, wh

8 24 years old, dropping from 1027.7 to 627.1 (APC, -6.3; 95% CI, -10.9 to -1.4; P = .02).

9 d different patterns of migration on ICAM-1, APC interactions, and tissue retention, as well as alter

10 isk gene mutations (19 monoallelic MUTYH, 17 APC*I1307K, two CHEK2).

11 appendectomy steadily decreased since 1990 (APC after 1989=-1.54; 95% CI: -2.22, -0.86), whereas the

12 ided in nonexpansion states (14.7% to 13.3%; APC, -1.4%; 95% CI, -2.0% to -0.7%), with an adjusted di

13 endocarditis decreased (from 17.7% to 15.3%; APC, -1.0%; 95% CI, -1.4% to -0.7%; P < .001).

14 endocarditis decreased (from 74.5% to 68.4%; APC, -0.7%; 95% CI, -0.9% to -0.5%; P < .001).

15 tient was found to carry a mosaic c.4666dupA APC variant in only 10 of 16 adenomas, indicating the im

16 o resided in expansion states (9.6% to 3.6%; APC, -6.0%; 95% CI, -6.5% to -5.5%) versus their counter

17 endocarditis increased (from 32.1% to 35.9%; APC, 0.8%; 95% CI, 0.5% to 1.1%; P < .001).

18 nd shRNA in iDR-NCs synergistically activate APCs for sustained antigen presentation.

19 Strikingly, introducing just the activated APC into aged mice significantly enhances otherwise comp

20 ependent on IL-6 production by the activated APC.

21 %; 95% CI, -0.8% to 0.6%; P = .77; adjusted: APC, -1.3%; 95% CI, -1.8% to -0.7%; P < .001).

22 d beta-catenin levels could be modeled in an APC-mutated human colon cancer cell line.

23 cumulates in the brain of AD patients, is an APC/C(Cdh1) substrate in vivo and that Rock2 protein and

24 AS (13%), SNX31 (9%), NF1 (9%), KIT (7%) and APC (7%).

25 lar sprouting, APC vessel niche affinity and APC vessel occupancy.

26 Wild-type APC and APC (m4) localized to focal adhesions (FAs), and APC (m4

27 operative activity of the APC/C(CCS52A1) and APC/C(CCS52A2) complexes during root and trichome develo

28 ative contribution of the APC/C(CCS52A1) and APC/C(CCS52A2) complexes to different developmental proc

29 ion of the immune complex between T cell and APC starts with formation of the transmembrane complexes

30 al model for the interaction of a T cell and APC.

31 dback loop between antigen-specific CTLs and APC to amplify adaptive immunity.

32 (m4) localized to focal adhesions (FAs), and APC (m4) was defective in promoting actin assembly at FA

33 govern adipose vascular niche formation and APC niche interaction are unknown.

34 of myeloid-derived suppressor cell-like and APC-like myeloid phenotypes and differentiated NK cells.

35 play reduced association between the MCC and APC/C, are defective in poly-ubiquitination of Cdc20, an

36 nto the diverse functions of neutrophils and APC in disease states including sepsis.

37 Overall microbiota between rinsate and APC plate microbial populations revealed generally simil

38 luding BRAF, NRAS, NF1, EGFR, ALK, TERT, and APC.

39 ased allergen uptake by epithelial cells and APCs in the lungs of C57BL/6 mice but not CD36(-/-) or P

40 ls (DCs), the essential immunoregulatory and APCs, are major producers of the central mediator of inf

41 -0.25, 2.17) and nonperforated appendicitis (APC=0.44; 95% CI: -0.84, 1.73).

42 The tumor suppressors ID3, ARID1A, APC, and CDKN2A are frequently impaired also on the prot

43 this study, using a novel CD1c(+) artificial APC (aAPC)-based system, we isolated human CD1c-restrict

44 rechallenged with peptide-loaded artificial APCs in the presence of anti-TIM-3 Ab.

45 xpanded from healthy donors using artificial APCs.

46 ans, B lymphocytes play an important role as APC-expanding autoreactive T cell responses ultimately c

47 in tumors with common CRC mutations such as APC, beta-catenin, or RNF43.

48 matopoietic stem cell precursors, as well as APC, under appropriate culture conditions.

49 ate that neutrophils can adapt a function as APCs and, in combination with their abundance in the imm

50 of the adenoma-carcinoma sequence (such as, APC).

51 ndotoxin, whereas sTM did not, and augmented APC production by thrombin approximately 50-fold more th

52 bin complexes; nor did antibodies that block APC anticoagulant activity suppress the prophylactic ant

53 3), and macrophage-1 antigen (Mac-1) blocked APC inhibition of NETosis.

54 Both APC/C activation and inhibition depend on Cdc20 fluxing

55 Of interest, both APC and GSK-3beta interact with microtubules and cellula

56 a central role for the production of IL-6 by APC during initial cognate interactions in the generatio

57 genitors in vivo MCPH1 itself is degraded by APC/C(C)(dh1), but not APC/C(C)(dc20), in late mitosis a

58 ewborn mice to hyperoxia for 24 hours, or by APC specific deficiency in hypoxia inducible factor (HIF

59 id carries sulfatide that can be captured by APCs and presented by CD1d to iNKT cells.

60 ecreted l-phenylalanine oxidase expressed by APCs, has been detected in B cells, yet its immunoregula

61 L-27, a multifunctional cytokine produced by APCs, antagonizes inflammation by affecting conventional

62 Activated protein C (APC) breaks down the complex that produces thrombin by p

63 wnward arrow results in activated protein C (APC; residues 222-461).

64 ver, the role of gp96 in regulating CD11c(+) APCs in the gut immunity and tolerance is unknown.

65 ing complex/cyclosome associated with Cdc20 (APC/C(Cdc20)) activates separase and thereby destroys co

66 of T cells with two antigen-presenting cell (APC) populations, B cells and dendritic cells (DCs), in

67 of BMDCs, increases antigen presenting cell (APC) trafficking to draining lymph nodes, and enhances a

68 o identify the lung antigen-presenting cell (APC) types that sustain the self-renewal of TH17 cells.

69 interface with the antigen presenting cell (APC).

70 ton, controls Notch activation at the T cell:APC interface thereby linking T cell receptor and Notch

71 tigens to CD11c(+) antigen-presenting cells (APC).

72 an act in vitro as antigen-presenting cells (APCs) and induce alphabeta T-cell activation.

73 ecific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of alphaPD-

74 n of the skin with antigen presenting cells (APCs) and T cells.

75 Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell

76 Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes, an

77 Antigen-presenting cells (APCs) occupy diverse anatomical tissues, but their tissu

78 Antigen-presenting cells (APCs) play an important role in transplant rejection and

79 ls can function as antigen-presenting cells (APCs) to memory CD4(+) T cells.

80 on the surface of antigen presenting cells (APCs) via MHC class II (MHC-II) molecules.

81 lecules (pMHCs) on antigen-presenting cells (APCs).

82 ple mechanisms via antigen-presenting cells (APCs).

83 geal space for autoantigen-presenting cells (APCs).

84 (PMVDS) to target antigen-presenting-cells (APCs) such as dendritic cells.

85 Adipose progenitor cells (APCs) reside in a vascular niche, located within the per

86 t analyses quantified annual percent change (APC) and evaluated whether decreases in CVD mortality ac

87 ssion and reported as annual percent change (APC) with 95% confidence intervals (CI).

88 port changes as an annual percentage change (APC) with 95% CI.

89 er 100000 persons (annual percentage change [APC], -0.06%; 95% CI, -0.3% to 0.2%; P = .59).

90 o 1590.6 for CIN1 (annual percentage change [APC], -9.0; 95% CI, -12.0 to -5.8; P < .001), from 896.4

91 .8; P < .001), from 896.4 to 414.9 for CIN2 (APC, -10.5; 95% CI, -18.8 to -1.2; P = .03), and from 24

92 1.2; P = .03), and from 240.2 to 0 for CIN3 (APC, -41.3; 95% CI, -65.7 to 0.3; P = .05).

93 ulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of human breast cancer

94 ting mutation of adenomatous polyposis coli (APC) gene reduces intestinal adenomatous polyposis via A

95 mutations of the adenomatous polyposis coli (APC) gene, whose product is an important component of th

96 Adenomatous polyposis coli (APC) regulates the activity of beta-catenin, an integral

97 r cell migration.Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellula

98 ctivation of the adenomatous polyposis coli (APC) tumor suppressor is frequently found in colorectal

99 ppressor protein adenomatous polyposis coli (APC), which is a known MT-associated protein, directly n

100 at Schwann cells are potentially conditional APCs, but the functional relevance of MHC-II expression

101 However, the importance of these conditional APCs is unknown.

102 ned full-length antibody-polymer conjugates (APCs).

103 rcial anti-EpCAM red fluorophore conjugates, APC and AlexaFluor(R)647.

104 Consequently, APC niche communication and retention are boosted by VEG

105 de that interdependency of CCS52A-controlled APC/C activity is controlled in a tissue-specific manner

106 pal neurons in the anterior piriform cortex (APC) can be divided into 2 subtypes: semilunar (SL) and

107 ere applied to estimate aerobic plate count (APC) and Campylobacter as well as Salmonella prevalence.

108 Kinetic studies indicate cultured APCs release high amounts of immunoreactive LEP followin

109 se and anaphase-promoting complex/cyclosome (APC/C) activity, which also triggers the acquisition of

110 of the anaphase-promoting complex/cyclosome (APC/C) bound to its coactivator, Cdc20.

111 dopsis anaphase-promoting complex/cyclosome (APC/C) coactivator genes CDC20 and CCS52B (CDH1 ortholog

112 of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase in neurons [Cdh1 conditional kno

113 ts the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase.

114 of the Anaphase Promoting Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase targeting cel

115 ligase anaphase promoting complex/cyclosome (APC/C), whose action is necessary for anaphase initiatio

116 ts the anaphase-promoting complex/cyclosome (APC/C).

117 of the anaphase-promoting complex/cyclosome (APC/C).

118 the anaphase-promoting complex or cyclosome (APC/C [2]).

119 the anaphase-promoting complex or cyclosome (APC/C), in the regulation of cell fate through modulatio

120 which can phosphorylate Dsh and is a direct APC/C(Fzr/Cdh1) substrate.

121 rmacologically, targeting PDGFRbeta disrupts APC niche contact thus blocking adipose tissue expansion

122 NT-signaling-pathway-regulator gene encoding APC, and we generated COs that exhibit enhanced WNT acti

123 Here we demonstrate that two non-essential APC/C subunits (Apc14 and Apc15) regulate association of

124 issive milieu to transplanted LEP-expressing APCs.

125 ith mutations in high-penetrance genes (five APC, three biallelic MUTYH, 11 BRCA1/2, two PALB2, one C

126 diator of colorectal tumorigenesis following APC loss.

127 esults provide the first direct evidence for APC-mediated actin assembly in vivo and establish a role

128 ts highlight a new mechanism responsible for APC adaptation to hypoxia and instrumental to vascular r

129 in assembly in vivo and establish a role for APC in coordinating MTs and actin at FAs to direct cell

130 exhibit poor reactivity and selectivity for APC.

131 Furthermore, we found APC/C(CCS52A1) activity to control CCS52A2 expression.

132 Furthermore, APC promotes the directional assembly of viral component

133 0 directly targets the tumor suppressor gene APC (adenomatous polyposis coli), thereby affecting Wnt

134 e at which Cdk1 is activated following GVBD, APC/C(Cdh1) creates conditions necessary for the removal

135 kine leptin (LEP) in the regulation of human APC biological functions.

136 Enhanced interactions between Il27ra (-/-) APC and CD4(+) T cells in the aortic wall contribute to

137 t bed is inflamed and vascularized, immature APCs in the donor corneal stroma quickly mature and migr

138 in or inhibition of beta-catenin activity in APC-null progenitors rescues the APC-null phenotype.

139 lumes reduced by 86% and observed changes in APC activity consistent with increased SAC control.

140 PrxII as a targetable antioxidant enzyme in APC-mutation-positive colorectal cancer.2-Cys peroxiredo

141 The marked increase in APC function for allergen-specific TC proliferation duri

142 tient, we found no evidence for mosaicism in APC in non-neoplastic intestinal mucosa.

143 itor clones with the "first hit" mutation in APC that subsequently gave rise to both the primary and

144 otyped for somatic and germline mutations in APC and CTNNB1.

145 Mutations in APC likely impair the ability to respond appropriately t

146 ts accrued to the study, 15 had mutations in APC or CTNNB1 genes.

147 Mutations in APC that disrupt the regulation of beta-catenin by GSK-3

148 We identified mosaic variants in APC in adenomas from 9 of the 18 patients with 21 to app

149 feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1beta

150 ating that Mer immunoregulatory signaling in APCs regulates B cell selection and autoimmunity.

151 roinflammatory disease and that sulfatide in APCs may contribute to the endogenous pathway of iNKT ce

152 antigen cross-presentation and the increased APC recruitment to secondary lymphoid tissues expand the

153 Most of the intralesional APCs expressed the CD86 maturation marker and co-localiz

154 flammatory cytotoxic killers to myeloid-like APC in response to infectious stimuli.

155 e, BAL mononuclear cells demonstrated little APC function.

156 ay in cyclin A2 degradation is caused by low APC/C activity.

157 TH17 cells were also cocultured with lung APC subsets to determine which of these could revive the

158 nstitution studies have shown that human MCC-APC/C can contain two molecules of Cdc20 [5-7].

159 human cells by independent mediators of MCC-APC/C binding.

160 Mechanistically, APC loss leads to overexpression of c-MYC, RPL11 and RPL

161 n-based approach to specifically mislocalize APC-dependent RNAs suggests that localization of the APC

162 at Myd88 and FcRgamma, presumably on myeloid APCs, were required to downregulate T cell help for the

163 itself is degraded by APC/C(C)(dh1), but not APC/C(C)(dc20), in late mitosis and G1 phase.

164 Of note, APC proteolytic activity was required for inhibiting NET

165 s enables the timely and rapid activation of APC/C, while the nuclear sequestration of these transcri

166 ants; we performed deep sequence analysis of APC in at least 2 adenomas or carcinomas per patient.

167 Conversely, the depletion of APC leads to a significant decrease in membrane targetin

168 These tumors lack deregulation of APC/beta-catenin signaling components, which are crucial

169 The effect of APC/C on Dsh is mediated by Nek2 kinase, which can phosp

170 ine the prognostic impact of co-existence of APC and PIK3CA mutations in patients undergoing preopera

171 nd targeting PrxII inhibits the expansion of APC-mutant colorectal cancer cells in vitro and in vivo

172 Ectopic expression of APC, but not its familial adenomatous polyposis-related

173 ls presented increased surface expression of APC-associated markers HLA-DR and CD86.

174 This study examined the function of APC and TC accumulating at sites of inflammation after s

175 ggest that the anti-inflammatory function of APC at therapeutic concentrations may include the inhibi

176 Selective inhibition of APC might therefore be effective for the treatment of he

177 lizing carotid plaques through inhibition of APC, ensuring smooth muscle cell survival.

178 The endogenous inhibitors of APC are members of the serpin family: protein C inhibito

179 n) is blocked by tumor-promoting isoforms of APC that reduce an interaction between wild-type APC and

180 hich in turn is required for localization of APC-dependent RNAs.

181 Loss of APC function results in deregulation of the Wnt/beta-cat

182 Loss of APC/C function leads to reduced levels of Dishevelled (D

183 Double mutation of APC and PIK3CA predicts inferior response to preoperativ

184 heat-killed B. pertussis in the presence of APC.

185 may influence the reparative proficiency of APC therapy.

186 Recruitment of APC and TC to the lung during allergic responses has bee

187 These findings reveal an unexpected role of APC in the directional spread of HIV-1.

188 ational regulatory proteins, and subunits of APC/C that validate the accuracy of our measurements.

189 assay reveals that the carboxyl terminus of APC interacts with the matrix region of Gag.

190 previously demonstrated as a primary type of APC in patients infected with L (V) panamensis and thus

191 , and belatacept, depending on which type of APC was used, with MEDI5265 consistently being the most

192 Mosaic variants of APC were variably detected in leukocyte DNA and/or non-n

193 R therefore mediates metabolic adaptation of APCs in distinct tissues, influencing the immunological

194 Transcriptomic analysis of APCs showed components of the LEP signalling pathway are

195 mma9/Vdelta2 T cells with characteristics of APCs were generated from human blood and intestinal orga

196 voring exogenous Ag access to the cytosol of APCs.

197 ta promotes the recruitment and retention of APCs to the niche.

198 In addition, increased numbers of Olig2(+)APC(+) oligodendrocytes were detected.

199 are additionally differentially dependent on APC.

200 We show that the removal of USP1 depends on APC(Cdh1) and requires Chk1 activation known to be catal

201 elta-like ligand 4 (Dll4) was upregulated on APC after respiratory syncytial virus (RSV) infection, a

202 y, activated Toll-Like Receptor-4 (TLR-4) on APCs to release chemokine's/cytokines as an immune-adjuv

203 TCR stimulation by peptide-MHC complexes on APCs requires precise reorganization of molecules into t

204 The transmembrane protein CD83, expressed on APCs, B cells, and T cells, can be expressed as a solubl

205 cells, and its ligand, CD70, is expressed on APCs.

206 loping Drosophila eye, we found that partial APC/C inactivation severely inhibits retinal differentia

207 6; 95% CI: -0.97, 0.26) for both perforated (APC=0.95; 95% CI: -0.25, 2.17) and nonperforated appendi

208 Transplantation of adventitial pericytes (APCs) improves recovery from tissue ischemia in preclini

209 Six subsets of phagocytic APC (HLA-DR(+)) were consistently observed.

210 of colon cancer, the adenomatous polyposis (APC) mutant (Apc (716/+)) model.

211 Preactivating APC overcomes this deficiency.

212 TRIP13 and p31(comet) prevent APC/C inhibition by MCC components, but cannot reactivat

213 ritic cells (DCs), which act as professional APC to control cutaneous immunity.

214 Dendritic cells (DCs) are professional APCs that traffic to the draining lymph nodes where they

215 o reconstitution, we show that Mps1 promotes APC/C inhibition by MCC components through phosphorylati

216 age, APC/C associated with the Cdh1 protein (APC/C(Cdh1)) delays the increase in Cdk1 activity, leadi

217 ppressor adenomatous polyposis coli protein (APC) directs the localization and assembly of human immu

218 ous polyposis coli tumor suppressor protein (APC), and glycogen synthase kinase-3beta (GSK-3beta), wh

219 ate five tumor suppressor genes (TP53, PTEN, APC, BRCA1, and BRCA2) and activate one oncogene (KRAS),

220 ion by MCC components, but cannot reactivate APC/C already bound to MCC.

221 Recombinant APC and soluble fragments of TM (sTM) have been tested i

222 the Gla and protease domains of recombinant APC caused a loss of NETosis.

223 Interactions between recruited APC and TC may occur as an early event promoting allergi

224 anscripts for beta-catenin and its regulator APC associate with a subset of forebrain FXGs.

225 he phenotype and function of tissue-residing APCs.

226 t maternal ageing compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimat

227 LPs are efficiently co-delivered to the same APCs in lymph nodes.

228 they were taken up and processed by the same APCs, namely dendritic cells and macrophages.

229 livery of antigens and adjuvants to the same APCs.

230 Skin APCs are a highly heterogeneous population with function

231 Skin APCs are endowed with antigen-sensing, -processing, and

232 d Ag targeting system that uptake by splenic APC subsets is severely hampered in mice lacking complem

233 r hierarchy that induces vascular sprouting, APC vessel niche affinity and APC vessel occupancy.

234 as the incidence of appendicitis stabilized (APC=-0.36; 95% CI: -0.97, 0.26) for both perforated (APC

235 d Cdc25B at the germinal vesicle (GV) stage, APC/C associated with the Cdh1 protein (APC/C(Cdh1)) del

236 t melanocyte-derived CXCL12 and CCL5 support APC and T-cell recruitment, antigen acquisition, and T-c

237 Targeting of gammadelta T-APC functions may lead to the development of novel gut-d

238 potency of blood and intestinal gammadelta T-APCs was compared with that of monocytes and dendritic c

239 The power of targeting APC was further demonstrated by the complete normalizati

240 DNA or myeloperoxidase, we demonstrate that APC binds human leukocytes and prevents activated platel

241 Here we provide evidence demonstrating that APC(Cdh1) plays a critical role in choosing the repair p

242 These results reveal that APC-regulated beta-catenin activity in cortical progenit

243 Here the authors show that APC-dependent RNAs are enriched in contractile protrusio

244 Our data indicate that APCs direct adipose tissue niche expansion via a PPARgam

245 The APC model revealed that the increase of ALS incidence is

246 The APC/C controls both cell-cycle progression and postmitot

247 The APC/C degrades dNek2 upon synchronous G1 arrest prior to

248 The APC/C is inhibited by the spindle checkpoint in the pres

249 hatase 1, which allows Cdc20 to activate the APC/C.

250 ed for ubiquitylation and degradation by the APC/C(Cdh1) ubiquitin ligase.

251 The analysis of deviance for the APC regression models indicated that the drift variable

252 indicate a post-mitotic requirement for the APC/C(Fzr/Cdh1) in epithelial cell patterning and planar

253 LA4 depletes CD80 and CD86 proteins from the APC membrane, rendering the APC incapable of activating

254 MUTYH; 2, MSH6; 5, PMS2); 1 patient had the APC c.3920T>A, p.I1307K mutation and a PMS2 variant; 9 p

255 he presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated

256 superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of

257 a Cdc20-containing complex that inhibits the APC/C.

258 dial progenitor-specific inactivation of the APC-beta-catenin pathway indicates that the maintenance

259 ndent RNAs suggests that localization of the APC-dependent RNA subgroup is functionally important for

260 Strikingly, deletion of the APC/C subunit Apc15 mimics mutations in this motif, reve

261 his Cdc20 molecule; and (3) occupancy of the APC/C with full MCC, where Mad3 and Apc15 are involved.

262 data illustrate cooperative activity of the APC/C(CCS52A1) and APC/C(CCS52A2) complexes during root

263 Here, the relative contribution of the APC/C(CCS52A1) and APC/C(CCS52A2) complexes to different

264 sent rate-limiting activator subunits of the APC/C.

265 roteins from the APC membrane, rendering the APC incapable of activating T cells.

266 activity in APC-null progenitors rescues the APC-null phenotype.

267 We had shown that the APC (adenomatous polyposis coli) protein controls locali

268 e sites along chromosome arms, such that the APC is fully inhibited within 30 min.

269 terior piriform cortex (PPC) showed that the APC projects to these brain regions mainly through layer

270 onclusion was supported by the fact that the APC-specific activity in the medium of COS-1 cells is ex

271 nally required for binding of the MCC to the APC/C and for MCC disassembly.

272 ng meiotic G2/M transition by acting via the APC/C(Cdh1)-cyclin B1 pathway.

273 s display increased MCC association with the APC/C and are unable to silence the checkpoint efficient

274 e mitotic checkpoint complex (MCC), with the APC/C. apc14Delta mutants display increased MCC associat

275 naling may posttranslationally regulate this APC/C function.

276 Thus, APC/C(Cdh1)-mediated degradation of Rock2 maintains the

277 insulin epitope B:9-23 (InsB9-23) by thymic APCs is insufficient to induce deletion of high- or low-

278 ated with insufficiency of the endogenous TM/APC pathway, such as sepsis.

279 that specifically activate and provide Ag to APC could potentially enhance Ab-mediated protection in

280 ditions, insulin decreases dynein binding to APC to stimulate minus end-directed transport, which cou

281 murine double minute 2 (MDM2)-p53 pathway to APC loss-induced tumorigenesis, we crossed mice bearing

282 improved and persistent antigen delivery to APCs as an efficient vaccine delivery system, and simult

283 d T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is n

284 vestigated whether enrichment of tolerogenic APCs (tolAPCs) in donor corneas can enhance graft surviv

285 Wild-type APC and APC (m4) localized to focal adhesions (FAs), and

286 that reduce an interaction between wild-type APC and dynein.

287 l endocarditis did not increase (unadjusted: APC, -0.1%; 95% CI, -0.8% to 0.6%; P = .77; adjusted: AP

288 EBV infection upregulated APC-related markers on B cells and activated the cross-p

289 We find that using APC pretreated ex vivo with TLR agonists, polyinosinic-p

290 the lower tract (vagina and cervix), whereas APCs and innate lymphoid cells were mainly located in th

291 us uncovered a pathway of regulation whereby APC/C(Fzr/Cdh1) negatively regulates Nek2, which negativ

292 Thus, we studied whether APC is capable of directly inhibiting NETosis via recept

293 ikely uncouple chromosome biorientation with APC activity.

294 authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its

295 In human colorectal cancer cells with APC mutations, PrxII depletion consistently reduces the

296 n of intracellular LFA-1 at the contact with APC was maintained during cell division and led to an un

297 erestingly, pretreatment of neutrophils with APC prior to induction of NETosis inhibited platelet adh

298 che is controlled by PPARgamma acting within APCs.

299 Without APC activation, aging CD4 T cell responses shift toward

300 ic1 at the G1/S checkpoint in budding yeast, APC:Cdc20 and its inhibitor MCC at the mitotic checkpoin