ライフサイエンスコーパス: APC3

コーパス検索結果 (１語後でソート)

通し番号をクリックするとPubMedの該当ページを表示します

1 of the TPR subunits Cdc16, Cdc23 and Cdc27 (Apc3).

2 sm that is reset after inactivation of bimA1(APC3).

3 bunit (Cks) to a hyperphosphorylated loop of Apc3.

4 to coimmunoprecipitate with Cdc20 and Cdc27/APC3.

5 bias for transition mutations to occur at 5'ApC3'/3'TpG5' sites (where bases 5'A and 3'T are mutated

6 de movements, whereas APC2 (aa 1034-2130) or APC3 (aa 2130-2844) reduced both anterograde and retrogr

7 renamed bimA10) and two other ts lethal bimA(APC3) alleles, bimA1 and bimA9.

8 Human APC3 also binds APC16 and APC7 and contains a >200-resid

9 ough highly temperature-sensitive, the bimA1(APC3) anaphase-promoting complex/cyclosome (APC/C) mutat

10 through coordinated phosphorylation between Apc3 and Apc1.

11 tratricopeptide repeat (TPR) proteins (APC7, APC3, APC6, and APC8) that homodimerize and stack with q

12 Here, we map the basis for human APC3 assembly with APC16 and APC7, report crystal struct

13 tein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).

14 repeat (TPR) proteins that form homo-dimers (Apc3/Cdc27, Apc6/Cdc16, Apc7 and Apc8/Cdc23).

15 APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior dat

16 require active NIMA, because a nimA5 + bimA1(APC3) double mutant arrests in a mitotic state with very

17 These bimA1(APC3)-induced cell cycle oscillations require active NIM

18 lated during mitosis, although the basis for APC3 interactions and whether loop phosphorylation is re

19 Instead, rapid inactivation of bimA1(APC3) is shown to promote repeating oscillations of chro

20 rylation of APC/C subunits, notably Apc1 and Apc3, is required for Cdc20 to activate the APC/C, where

21 r results demonstrate that mutations in bimA(APC3) lead to errors in DNA metabolism that indirectly b

22 The bimA1(APC3) mutation may also make the APC/C resistant to acti

23 The bimA1(APC3) mutation therefore first inactivates the APC/C but

24 in how APC16 recruits APC7 to APC3, show how APC3's C-terminal domain is rearranged in the full APC/C

25 -terminal domain of APC16, and test roles of APC3's loop and IR tail binding surfaces in APC/C-cataly

26 APC3's TPR motifs recruit substrate-binding coactivators

27 Within the APC/C complex, APC3 serves as center for regulation.

28 ior data, explain how APC16 recruits APC7 to APC3, show how APC3's C-terminal domain is rearranged in

29 checkpoint inhibits septation in these bimA(APC3) strains.

30 C/EBPdelta induces expression of the Cdc27 (APC3) subunit of the anaphase promoting complex/cyclosom

31 1 mutation represents a novel allele of bimA(APC3), which encodes a conserved component of the anapha

WebLSDに未収録の専門用語（用法）は "新規対訳" から投稿できます。