ライフサイエンスコーパス: ARC

1 ARC after 6 months was 95% in the control group and 91%

2 ARC glial activation non-specifically depolarizes both A

3 ARC interacts with DAXX in a CARD-dependent manner to bl

4 ARC possesses the unusual property of antagonizing both

5 ARC TH cells project to the hypothalamic paraventricular

6 ARC's caspase recruitment domain (CARD) directly interac

7 ent manner by arachidonate-regulated Ca(2+) (ARC) channels.

8 re-independent arachidonate-regulated Ca(2+)(ARC) channels are regulated by STIM1.

9 tore-independent, arachidonic acid-activated ARC channels.

10 The chemical phenotype of activated ARC neurons was assessed by monitoring agonist-induced c

11 number, but not the magnitude, of activated ARC POMC neurons and is of therapeutic relevance to obes

12 In total, 290 adult ARC patients (148 females; 142 males) with established H

13 uide strands was observed within 5 min after ARC-520 injection, and was detected for at least 4 weeks

14 CR simulation in the case of partial agonist ARC binding to the M2 receptor.

15 X binding to block ASK1-JNK activation as an ARC-specific endogenous mechanism that interferes with n

16 t 5 years, ARC-like definite GO (n = 32) and ARC-like definite/probable GO (n = 53) were associated w

17 At 5 years, ARC definite ST (n = 48) and ARC definite/probable ST (n = 75) were associated with 1

18 t presentation, ARC definite ST (n = 48) and ARC-like definite GO (n = 32) were adjudicated to be lin

19 he kisspeptin enriched hypothalamic AVPV and ARC respectively, which are essential for progesterone r

20 ional states are identified for the IXO- and ARC-bound M2 receptor.

21 JNK, suggesting interaction between JNK and ARC decreases amyloid-induced JNK phosphorylation and do

22 flux ratio of 12 from the mantle at MOR and ARC is comparable to the C/S ratio in the surface invent

23 deficiency in Vps33b(fl/fl)-ER(T2) mouse and ARC patients.

24 mouse hypothalamic cell line mHypoE-N41 and ARC neuron primary cultures, 2) likewise blocked by a pe

25 ting that the combined disruption of SCN and ARC function impairs the expression of behavioral URs.

26 The incidence of 5-year ARC definite ST and ARC-like definite GO did not significantly differ (7% [n

27 ::Cre leads to a severe loss of both VMH and ARC cellular phenotypes, demonstrating a role for Rax in

28 demonstrating a role for Rax in both VMH and ARC fate specification.

29 functions of endogenously expressed TPCs and ARCs in the context of the global calcium signals at fer

30 We apply ARC-seq to directly assess transcriptome-wide epimutatio

31 i-related protein (AgRP) neurons in the ARC (ARC(AgRP) neurons) are stimulated by fasting and, once a

32 oventral periventricular (AVPV) and arcuate (ARC) nuclei, while the region-specific role of progester

33 to investigate whether hypothalamic arcuate (ARC) dopamine/tyrosine hydroxylase (TH) neurons interact

34 mediobasal hypothalamus, namely the arcuate (ARC) and ventromedial (VMH), tasked with proper signal i

35 peroxo (IXO), the partial agonist arecoline (ARC), and the inverse agonist 3-quinuclidinyl-benzilate

36 these protein-coding partner genes, such as ARC, include long-term potentiation, synaptic activity,

37 demonstrate that the neural circuits between ARC kisspeptin and GnRH neurons are fully established an

38 ional linchpins employs initial through-bond ARC by an SN 2' reaction, followed by through-space ARC

39 Activity Recording Capillary Feeder or CAFE (ARC), a machine-vision (automated image tracking)-based

40 uction of the apoptosis repressor with CARD (ARC) in in vitro and in vivo models of cerebral ischemia

41 describe that apoptosis repressor with CARD (ARC) interacts and inhibits DAXX and proximal signals of

42 Apoptosis Repressor with CARD (ARC) is a cell death inhibitor that antagonizes multiple

43 therapy (BBT) and assisted referral to care (ARC) studied 185 youths (aged 8.0-16.9 years) from 9 ped

44 e been associated with age-related cataract (ARC).

45 Annualised rates of change (ARC) for incidence, prevalence, and death became negativ

46 linchpins for type II anion relay chemistry (ARC) has been achieved.

47 multicomponent Type I Anion Relay Chemistry (ARC) tactic, and a dithiane-epoxide union in conjunction

48 tions include Type II Anion Relay Chemistry (ARC) to construct the polyol chain, a Ti-catalyzed asymm

49 Anion relay chemistry (ARC), an effective, multicomponent union tactic, was suc

50 itial nucleophile for anion relay chemistry (ARC).

51 synthetic utility of anion relay chemistry (ARC).

52 ryposis, renal dysfunction, and cholestasis (ARC) syndrome is caused by deficiencies in the trafficki

53 rthrogryposis-renal dysfunction-cholestasis (ARC) syndrome-associated mutations in VPS33B selectively

54 25 patients with alcohol-related cirrhosis (ARC; 12 were actively drinking or abstinent for <6 month

55 nerates monomeric antibody-siRNA conjugates (ARCs) that retain antibody and siRNA activities.

56 , defining an Area of Required Connectivity (ARC).

57 ommittee using Academic Research Consortium (ARC) criteria.

58 the Universal/Academic Research Consortium (ARC) definition (CKMB or troponin >3x normal).

59 evidence), the Academic Research Consortium (ARC) definition for ST, and the newly devised "ARC-like"

60 n-immunoreactive boutons appeared to contact ARC TH neurons.

61 Compared to controls, ARC-deficient RCCs exhibited decreased colony formation

62 tecture of the left auditory-related cortex (ARC), this specific trait possibly enabling an optimized

63 Percentages of average recession coverage (ARC) and complete recession coverage (CRC) were evaluate

64 ocellular enzymes, the ADP-ribosyl cyclases (ARCs), has emerged as being able to change their enzymat

65 ith monosodium glutamate (MSG) that destroys ARC neurons were subjected in adulthood to a circadian d

66 C) definition for ST, and the newly devised "ARC-like" definition of GO (i.e., definite, probable, or

67 The dexamethasone-ARC-induced inhibition of hepatic insulin sensitivity wa

68 s repressor with caspase recruitment domain (ARC) binds and inactivates components of the intrinsic a

69 s repressor with caspase recruitment domain (ARC) is an inhibitor of apoptosis that is expressed in c

70 eurons that synthesize TH in the dorsomedial ARC also contain immunoreactive dopamine, and show eithe

71 roperties were identified in the dorsomedial ARC where 94% of TH neurons contained immunoreactive dop

72 ein we assessed the importance of endogenous ARC in maintaining islet structure and function in vivo.

73 t focal cerebral ischemia reduced endogenous ARC protein in neurons in the ischemic striatum at early

74 (Rax) gene plays a key role in establishing ARC and VMH nuclei in mice.

75 This excitatory ARC-->PVH satiety circuit, and its modulation by alpha-M

76 cate that the GLP-1R on POMC/CART-expressing ARC neurons likely mediates liraglutide-induced weight l

77 Two different binding poses are revealed for ARC in the orthosteric pocket.

78 The C-G-T haplotype increased the risk for ARC overall (P = 0.005, OR = 1.8), and both alleles and

79 indeed displayed an overexpression of FosB, ARC, Zif268 and FRA2 only in dyskinetic rats.

80 ich displayed an overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats exper

81 We found ARC knockdown enhances JNK pathway activation, whereas A

82 t time substantial synaptic projections from ARC TH cells to other ARC neurons.

83 ections synaptically converge with GABAergic ARC(AgRP) projections on melanocortin-4 receptor (MC4R)-

84 These glutamatergic ARC projections synaptically converge with GABAergic ARC

85 of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by caloric depletion and c

86 of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric ins

87 in the arcuate nucleus of the hypothalamus (ARC)-are both necessary and sufficient for driving feedi

88 via a highly efficient four-component type I ARC union.

89 We identify ARCs that induce targeted silencing in vitro and extend

90 hemisphere was constructed via a new type II ARC/CuCN cross-coupling tactic, while the southern hemis

91 lergen peptide 8x6Q2W significantly improved ARC symptoms after rye grass allergen challenge in an EE

92 This suggests that Th 1 responses to ADH in ARC are induced by alcohol consumption.

93 First, we show that Rax is expressed in ARC and VMH progenitors throughout development, consiste

94 ombinase-dependent ChIEF-AAV-DJ expressed in ARC TH neurons evoked postsynaptic GABA currents in the

95 ased c-fos expression and spike frequency in ARC TH neurons.

96 -E2F1 is an obesity suppression mechanism in ARC POMC neurons and HFD-AMPK inhibits this mechanism by

97 ment with the platelet phenotype observed in ARC patients.

98 le disruption of Ca(2+) signaling pathway in ARC glia reduces food intake.

99 ylation and E2F target gene de-repression in ARC neurons.

100 ur study illustrates that Rax is required in ARC/VMH progenitors to specify neuronal phenotypes withi

101 When AgRP/NPY neurons are inactivated, ARC glial activation fails to evoke any significant chan

102 k analyses indicated significantly increased ARC definite ST within 30 days (3% [n = 19] vs. 1% [n =

103 dent CRAC channels and the store-independent ARC channels are regulated by the protein STIM1, CRAC ch

104 nges in islet amyloid deposition, indicating ARC acts downstream of amyloid formation.

105 otentiate the firing frequency of individual ARC POMC-EGFP cells compared with agonists alone.

106 rgoid SCIT dose finding study in HDM-induced ARC, concentrations of >/=20 000 AUeq/ml showed both imm

107 igated for treatment of grass pollen-induced ARC.

108 mptoms in patients with grass pollen-induced ARC.

109 at the expression of the apoptosis inhibitor ARC (apoptosis repressor with a CARD domain) was induced

110 ial functional connectivity between the left ARC and DLPFC in a sample of musicians with and without

111 availability of food to dynamically modulate ARC(AgRP) neuron activity and feeding behavior.

112 Optogenetic stimulation of mouse ARC TH neurons increased food intake; attenuating transm

113 nscription) of key plasticity related mRNAs (ARC and BDNF).

114 s and animal NLRs (and, by extension, all NB-ARC and NACHT domains) possessed a domain structure that

115 For the F-box and NB-ARC gene families, the genes conserved in all species we

116 genomes for the super-families F-box and NB-ARC, and five additional families: the Aspartic protease

117 In F-box, NB-ARC, and BTB, the expanded groups were enriched in genes

118 In addition, we show that the CC-NB-ARC can operate independently of the recognition specifi

119 The genetic fusion of the CC-NB-ARC of Gpa2 with the LRR of Rx1 (Gpa2CN/Rx1L) results in

120 r prediction software, the highly complex NB-ARC domain is described in detail using several individu

121 which a nucleotide-binding switch domain, NB-ARC, is tethered to a LRR sensor domain.

122 Rs, and their homologs that represent the NB-ARC (nucleotide-binding adaptor shared by APAF-1, certai

123 Here we show that the NB-ARC (nucleotide-binding, Apaf-1, R-proteins, and CED-4)

124 The NB-ARC and LRR domains dissociate upon effector-dependent a

125 nts governing the interaction between the NB-ARC and LRR in the highly homologous plant immune recept

126 In addition, the output of the NB-ARC domain sequence can directly be used for phylogeneti

127 However, unlike ARC(AgRP) neurons, ARC(POMC) neurons are extremely slow in affecting hunger

128 In a manner reciprocal to ARC(AgRP) neurons, ARC-projecting leptin receptor-expressing GABAergic vDMH

129 bers of the NMDAR complex (P=0.0015) but not ARC (P=0.14).

130 in-producing neurons in the arcuate nucleus (ARC) already communicate with a specific subset of GnRH

131 de bound neurons within the arcuate nucleus (ARC) and other discrete sites in the hypothalamus.

132 ons within the hypothalamic arcuate nucleus (ARC) are important regulators of energy balance.

133 )-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the

134 ithin the hypothalamus, the arcuate nucleus (ARC) functions as a gateway for hormonal signals of ener

135 The Arcuate nucleus (ARC) in hypothalamus contains antagonizing POMC and AGRP

136 Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate

137 ority of mouse hypothalamic arcuate nucleus (ARC) neurons that synthesize TH in the dorsomedial ARC a

138 othesis that destruction of arcuate nucleus (ARC) neurons, in concert with dampening of suprachiasmat

139 gen species (ROS) levels in arcuate nucleus (ARC) neurons.

140 The arcuate nucleus (ARC) of the hypothalamus comprises neurons regulating fo

141 number of microglia in the arcuate nucleus (ARC) of the hypothalamus.

142 activation of hypothalamic arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons, which are also

143 vation of glia in the mouse arcuate nucleus (ARC) reversibly induces increased food intake while disr

144 t only the SCN but also the arcuate nucleus (ARC), are involved in the Tb setting through afferents t

145 In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-de

146 roxylase (TH) neuron of the arcuate nucleus (ARC), that we show makes an orexigenic contribution.

147 found that the hypothalamic arcuate nucleus (ARC), ventromedial nucleus (VMN), and lateral hypothalam

148 eptors, in the hypothalamic arcuate nucleus (ARC).

149 neurons in the hypothalamic arcuate nucleus (ARC).

150 omelanocortin (POMC) in the arcuate nucleus (ARC).

151 through its actions in the arcuate nucleus (ARC).

152 ntricular nucleus (PVN) and arcuate nucleus (ARC).

153 l hypothalamic area and the arcuate nucleus (ARC)/medial basal hypothalamus, where the expression of

154 Deletion of CHOP in ob/ob; ARC -/- mice led to reversal of beta-cell death and abno

155 Mechanistically, the absence of ARC increased levels of C/EBP homologous protein (CHOP)

156 The specific activation of ARC glia enhances the activity of agouti-related protein

157 Various aspects of ARC neurons are affected in high-fat diet (HFD)-induced

158 to revealing new insight into the biology of ARC channels in neuroblastoma cells, these findings prov

159 Depletion of ARC in isolated islets augments palmitate-induced apopto

160 tify these cells as a functional exponent of ARC(AgRP) neuron-driven hunger.

161 Thus, HIF-mediated increased expression of ARC in RCC can explain how loss of VHL can promote survi

162 Finally, firing of ARC neurons was also rapidly modulated within seconds of

163 data indicate a functional heterogeneity of ARC POMC neurons by revealing distinct subpopulations of

164 Immunoprecipitation of ARC from mouse islet lysates showed ARC binds JNK, sugge

165 ther establishing that, even at the level of ARC(AgRP) neurons, choices are remarkably flexible compu

166 suppression of CHOP by endogenous levels of ARC is critical for beta-cell viability and maintenance

167 While generalized loss of ARC did not result in detectable abnormalities, its abse

168 In addition, loss of ARC resulted in a dramatic reduction of RCC tumor growth

169 tribute to the preconsummatory modulation of ARC(AgRP) neurons.

170 Furthermore, real-time monitoring of ARC(AgRP) activity revealed time-locked responses to con

171 The rate of ARC definite ST in stable patients, the majority of whom

172 y, these results reveal an important role of ARC glia in the regulation of energy homeostasis through

173 tricular nucleus; optogenetic stimulation of ARC TH axons inhibited paraventricular nucleus neurons b

174 Optogenetic stimulation of ARC TH cells inhibited pro-opiomelanocortin (POMC) neuro

175 The stringency of ARC-seq can be scaled to accommodate the quality of inpu

176 ts could therefore contribute to symptoms of ARC syndrome, a disease linked to loss of Vps33B.

177 otherapy liquid extract for the treatment of ARC.

178 nditions and only observed using a subset of ARCs.

179 ith or without asthma were selected based on ARC symptom severity and erythema skin prick reaction to

180 vation of the CRAC channels has no effect on ARC channel activity.

181 Three TPCs and one ARC were found in the sea star (Patiria miniata) that we

182 Pro-opiomelanocortin (ARC(POMC)) neurons are viewed as the counterpoint to ARC

183 aptic projections from ARC TH cells to other ARC neurons.

184 hydroxylase (TH) neurons interact with other ARC neurons, how they respond to hypothalamic neuropepti

185 NMDAR postsynaptic signalling and, possibly, ARC complexes, which are known to be important in synapt

186 At presentation, ARC definite ST (n = 48) and ARC-like definite GO (n = 3

187 binoid degradation in mHypoE-N41 and primary ARC neuronal cultures from MAGL(-/-) mice, respectively,

188 y-regulated cytoskeleton-associated protein (ARC) (P=3.78 x 10(-)(8)) postsynaptic signalling complex

189 y-regulated cytoskeleton-associated protein (ARC) and N-methyl-d-aspartate receptor (NMDAR) complexes

190 y-regulated cytoskeleton-associated protein (ARC), and the neuregulin 1 receptor ERBB4.

191 ed cytoskeleton-associated scaffold protein (ARC) of the postsynaptic density, sets previously implic

192 ndrite spine morphology regulatory proteins (ARC, NMDAR1 and GRM1) was confirmed in both clade B and

193 Thus, a temporally analogous, rapid ARC satiety pathway does not exist or is presently unide

194 m secondary prevention significantly reduced ARC definite ST, including very late ST.

195 Vorapaxar reduced ARC definite ST (1.1% vs. 1.4%, hazard ratio [HR]: 0.71,

196 store-independent arachidonic acid-regulated ARC channels.

197 inor pool of plasma membrane STIM1 regulates ARC channel activity.

198 Here we show that glutamate-releasing ARC neurons expressing oxytocin receptor, unlike ARC(POM

199 interact with plasma membrane (PM)-resident ARC forming subunits in the neuroblastoma cell line SH-S

200 proportion of allergic rhinoconjunctivitis (ARC) patients experience recurrent symptoms after succes

201 (HDM)-induced allergic rhinoconjunctivitis (ARC) using a titrated nasal provocation test (TNPT).

202 e treatment of allergic rhinoconjunctivitis (ARC), but a lack of robust evidence has deterred its use

203 erapy to treat allergic rhinoconjunctivitis (ARC).

204 with tunnel technique leads to satisfactory ARC and increase in KTW similar to CTG, but yields lower

205 Accurate RNA consensus sequencing (ARC-seq) uniquely combines RNA barcoding and generation

206 ic mouse model of islet amyloidosis, we show ARC knockdown increases amyloid-induced beta-cell apopto

207 Importantly, the synthesis of 1 showcases ARC as a rapid, scalable coupling strategy for the union

208 ation of ARC from mouse islet lysates showed ARC binds JNK, suggesting interaction between JNK and AR

209 ide linchpins for through-bond/through-space ARC are now reported.

210 an SN 2' reaction, followed by through-space ARC exploiting a 1,4-Brook rearrangement.

211 P = .0403) in patients with more symptomatic ARC.

212 survival of mice was even preserved when TAT-ARC therapy was initiated in a delayed manner after stim

213 Treatment with TAT-ARC protein completely abrogated otherwise lethal liver

214 TAT.ARC protein delivery led to a dose-dependent better surv

215 TAT.ARC-treated mice showed better performance in the pole t

216 territory of the middle cerebral artery, TAT.ARC salvages brain tissue when given during occlusion or

217 Functionally, TAT.ARC treatment inhibited DAXX-ASK1-JNK signaling in the i

218 ; p = 0.005; T2-weighted MRI) smaller in TAT.ARC-treated mice (1 mug intraventricularly during MCAo)

219 Delayed delivery of TAT.ARC may present a promising target for stroke therapy.

220 tially stronger response to BBT (76.5%) than ARC (7.1%) (chi21 = 14.90; P < .001; number needed to tr

221 tions in the protein-coupling interface than ARC, especially in the receptor transmembrane helix 5 (T

222 nction approaches, our data demonstrate that ARC inhibits beta-cell apoptosis elicited by multiple in

223 These data demonstrate that ARC is a previously unrecognized inhibitor of apoptosis

224 These data indicate that ARC overexpression diminishes amyloid-induced JNK pathwa

225 odistribution studies in mice indicated that ARC-520 guide strands predominantly accumulated in liver

226 Here we report that ARC protein is abundant in cells of the endocrine pancre

227 We previously reported that ARC is abundant in pancreatic beta-cells and modulates s

228 Accordingly, our results show that ARC is not expressed in normal renal tissue but is highl

229 We show that ARC kisspeptin neurons are upstream of GnRH neurons, and

230 Together these data support the view that ARC TH cells play an unrecognized and influential positi

231 The ARC families received personalized referrals to mental h

232 The ARC is efficiently assembled with minimal training, and

233 Transmission across the ARC(Glutamatergic)-->PVH(MC4R) synapse is potentiated by

234 ble targeting of the MnPO by the SCN and the ARC in male Wistar rats.

235 eprivation increased Deptor mRNA in both the ARC and VMH of obese rats.

236 c)-->PVH(MC4R) synapse is potentiated by the ARC(POMC) neuron-derived MC4R agonist, alpha-melanocyte

237 Agouti-related protein (AgRP) neurons in the ARC (ARC(AgRP) neurons) are stimulated by fasting and, o

238 preserves the carbonyl functionality in the ARC adducts, thus permitting access to functionally comp

239 pulsatile secretion via its receptor in the ARC and/or AVPV nuclei.

240 T5-labeled cells were widely observed in the ARC but absent from the rPOA and PVN.

241 T group (n = 95), compared with those in the ARC group (n = 90), had significantly higher rates of cl

242 ent studies suggest that neurogenesis in the ARC is an important regulator of body mass in response t

243 ies indicated negligible neurogenesis in the ARC of sedentary or exercise-trained mice.

244 In the ARC, liraglutide was internalized in neurons expressing

245 owering glucose sensing, specifically in the ARC, resulted in glucose intolerance due to deficient in

246 ease in number of activated microglia in the ARC, the expression of the proinflammatory cytokine tumo

247 tors of leptin-mediated ROS formation in the ARC.

248 calized with leptin receptors (LEPRs) in the ARC.

249 athway in vitro and its application into the ARC of the Dicer-deficient mice both reverses upregulati

250 ialysis of dexamethasone for 90 min into the ARC or the PVN did not have significant effects on basal

251 rone blockade LH surge, while RU486 into the ARC shortened LH pulse interval in the progesterone trea

252 channels actually prevent activation of the ARC channels by arachidonic acid.

253 We now demonstrate that activation of the ARC channels, but not CRAC channels, is uniquely depende

254 is necessary for effective activation of the ARC channels, whilst phosphorylation of the same residue

255 channels are also key for activation of the ARC channels.

256 rane that is essential for activation of the ARC channels.

257 ver, differences in the accessibility of the ARC to prolactin in blood may influence the responsivene

258 in detail the structure and function of the ARC-PVH circuit in mediating leptin signaling and in reg

259 ctions at leptin-sensitive AgRP cells of the ARC.

260 We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioa

261 ) and reporter assays also indicate that the ARC gene is regulated by direct binding of HIF1 to a hyp

262 It is also well established that the ARC is a primary residence for hypothalamic melanocortin

263 of AT1A and LEPR was almost exclusive to the ARC and occurred primarily within neurons expressing ago

264 ng was found in the fibers projecting to the ARC of obese mice (ob/ob and high-fat diet fed) concurre

265 ulates store-independent Ca(2+)entry via the ARC channels.

266 ars to be constitutively associated with the ARC channels.

267 appeared to release synaptic GABA within the ARC onto dopamine neurons and unidentified neurons, sugg

268 Within the ARC, we find that only the junction nucleotides between

269 municate extensively with neurons within the ARC.

270 he RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection co

271 y, the broader elimination of Rax throughout ARC/VMH progenitors using Six3::Cre leads to a severe lo

272 Our work identifies for the first time ARC-DAXX binding to block ASK1-JNK activation as an ARC-

273 eurons, and that GnRH neuron connectivity to ARC kisspeptin neurons does not depend on their spatial

274 )) neurons are viewed as the counterpoint to ARC(AgRP) neurons.

275 Trafficking studies point to ARC entrapment in endocytic compartments as a limiting f

276 In a manner reciprocal to ARC(AgRP) neurons, ARC-projecting leptin receptor-expres

277 Unexpectedly, ARC diminishes the ER stress response, acting distal to

278 antial differences in frequency of universal/ARC MI if only CKMB (5.4%) or troponin (18.7%) data were

279 MI rates according to protocol or universal/ARC MI definitions.

280 However, unlike ARC(AgRP) neurons, ARC(POMC) neurons are extremely slow

281 neurons expressing oxytocin receptor, unlike ARC(POMC) neurons, rapidly cause satiety when chemo- or

282 Utilizing ARC(AgRP) neurons as an entry point, we analyzed the hie

283 Most ventrolateral ARC TH cells did not contain dopamine and did not show b

284 bursty translation for Venus-FMRP and Venus-ARC RNAs.

285 i by Ca(2+) ionophore or by Ca(2+) entry via ARC channels in native cells, although ERK1/2 phosphoryl

286 ood intake and significantly greater in vivo ARC neuron activation in mice.

287 sulphur flux of 720 Gmol/y at arc volcanoes (ARC) with a contribution from the mantle of 2.9%, which

288 own enhances JNK pathway activation, whereas ARC overexpression reduces JNK, c-Jun phosphorylation, a

289 pathway activation, we investigated whether ARC affects JNK signaling in amyloid-forming islets.

290 -induced beta-cell apoptosis and loss, while ARC overexpression decreases amyloid-induced apoptosis,

291 y STIM1 in the endoplasmic reticulum, whilst ARC channels are regulated by the STIM1 constitutively r

292 468 in the CRYAA promoter is associated with ARC through increasing binding of KLF-10 and thus decrea

293 Three SNPs nominally associated with ARC were identified in the promoter region of CRYAA: rs3

294 e CRYAA promoter region for association with ARC and elucidates the mechanisms of this association.

295 region due to stronger binding compared with ARC.

296 zes T-cell responses in active drinkers with ARC, whereas IL-4 production prevails in abstinents.

297 nonuclear cells (HMCs) from 14 patients with ARC who were undergoing transplantation, we investigated

298 The incidence of 5-year ARC definite ST and ARC-like definite GO did not signifi

299 At 5 years, ARC definite ST (n = 48) and ARC definite/probable ST (n

300 At 5 years, ARC-like definite GO (n = 32) and ARC-like definite/prob