ライフサイエンスコーパス: ARIC

1 ARIC participants were enrolled from four communities ac

2 ARIC participants with elevated hs-CRP and low LDL-C had

3 ARIC-based limits for diastolic function improved risk d

4 ARIC-based reference limits for TDI e' (4.6 and 5.2 cm/s

5 Among 15,140 ARIC participants followed from 1987-1989 (baseline) to

6 KD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants

7 We followed up 12 230 ARIC participants free of prior HF at baseline (visit 2,

8 or missing data and prevalent cancer, 13 253 ARIC participants were included for analysis.

9 120 of 804 CHS participants and 181 of 3517 ARIC participants developed incident AF.

10 a median follow-up of 7.3 and 13.1 years, 44 ARIC study participants and 275 CHS participants had SCD

11 From 14,709 ARIC (Atherosclerosis Risk in Communities) study partici

12 d by genotyping an independent sample of 718 ARIC African Americans (minor allele frequency=1%; P=1.2

13 ing serum creatinine were measured among 807 ARIC participants with CKD (estimated GFR between 15 and

14 of black participants within CHS (n = 811), ARIC (n = 3112), and Health ABC (n = 1015).

15 cantly associated with CKD progression among ARIC participants overall and among those without baseli

16 3, 8.5, and 14.4 per 1000 person-years among ARIC participants with an estimated GFR of >/=90, 60 to

17 By reanalyzing data from an ARIC study of coronary heart disease and simulations bas

18 pants in CHS (11.4%; 95% CI, 2.9%-29.9%) and ARIC (31.7%; 95% CI, 16.0%-53.0%).

19 ted Framingham, recalibrated Health ABC, and ARIC risk scores by 18%, 12%, and 13%, respectively.

20 correlates of circulating LCMUFAs in CHS and ARIC and US dietary sources of LCMUFAs in the 2003-2010

21 re related to circulating LCMUFAs in CHS and ARIC, consistent with food sources of LCMUFAs in NHANES,

22 ent congestive heart failure in both CHS and ARIC; hazard ratios were 1.34 (95% confidence interval,

23 correlation was 0.80 when comparing EHR and ARIC type 2 diabetes mellitus phenotypes.

24 r allele frequency 4.45 and 3.96% in FHS and ARIC, respectively) was associated with higher CKD preva

25 After adjustment for age, race, gender, and ARIC field center, among those with CKD, the relative ri

26 activity, lipid levels, blood pressure, and ARIC Study center, compared with adults who never smoked

27 dney function, the age-, gender-, race-, and ARIC field center-adjusted RR for PAD was 1.04 (95% conf

28 ecalibrated, Health ABC HF recalibrated, and ARIC risk scores were 0.610, 0.762, 0.783, and 0.797, re

29 tudied 9240 individuals without HF or CVD at ARIC visit 4 and followed them for a mean of 10.5 years.

30 ses were ascertained by electrocardiogram at ARIC follow-up visits, hospital discharge diagnosis, or

31 Vascular risk factors at ARIC baseline (age 45-64 years; risk factors included bo

32 Cp was measured at ARIC visit 4 (1996-1998).

33 nical stroke who underwent a cerebral MRI at ARIC visit 3 (n = 1622) and a second cerebral MRI approx

34 cestry individuals from the population-based ARIC (Atherosclerosis Risk In Communities) Study cohort

35 had DBP between 80 to 89 mm Hg at baseline (ARIC visit 2), the adjusted odds ratio of having hs-cTnT

36 al CHD incidence was assessed from baseline (ARIC=1987-1989, CHS=1989-1990, REGARDS=2003-2007) throug

37 l change in hs-cTnT over the 6 years between ARIC visits 2 and 4.

38 rson-years in African-American and Caucasian ARIC participants, respectively.

39 osclerosis Risk in Communities study cohort (ARIC) and the Framingham Heart Study cohort (FHS)].

40 osclerosis Risk in Communities study cohort (ARIC).

41 rticipants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and te

42 3), the Atherosclerosis Risk in Communities (ARIC) (n = 12341) study, and the Health, Aging, and Body

43 in the Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis cohorts.

44 in the Atherosclerosis Risk in Communities (ARIC) cohort (3679 African-Americans and 10 427 Whites)

45 rom the Atherosclerosis Risk in Communities (ARIC) cohort (n = 14,222, 27% African Americans).

46 rom the Atherosclerosis Risk in Communities (ARIC) cohort study who underwent 3-dimensional intracran

47 in the Atherosclerosis Risk in Communities (ARIC) cohort study.

48 The Atherosclerosis Risk in Communities (ARIC) cohort was followed for a median of 13 years for C

49 rom the Atherosclerosis Risk in Communities (ARIC) cohort, we tested the hypotheses that the incidenc

50 rom the Atherosclerosis Risk in Communities (ARIC) cohort, which sampled middle-aged adults and their

51 n-based Atherosclerosis Risk in Communities (ARIC) cohort.

52 in the Atherosclerosis Risk in Communities (ARIC) cohort.

53 examine Atherosclerosis Risk in Communities (ARIC) participants in midlife and to explore association

54 in the Atherosclerosis Risk in Communities (ARIC) Study (1987-1998).

55 rom the Atherosclerosis Risk in Communities (ARIC) Study (1987-1998).

56 in the Atherosclerosis Risk in Communities (ARIC) Study (1987-1999).

57 of the Atherosclerosis Risk in Communities (ARIC) study (76+/-5 years and 60% women) who underwent t

58 in the Atherosclerosis Risk in Communities (ARIC) Study (mean age-62 years, moderate CP-43% and seve

59 rom the Atherosclerosis Risk in Communities (ARIC) study (n = 1,741).

60 in the Atherosclerosis Risk in Communities (ARIC) Study (n = 42).

61 in the Atherosclerosis Risk in Communities (ARIC) Study (n=3517).

62 89, the Atherosclerosis Risk in Communities (ARIC) Study analyzed plasma fatty acids in cholesteryl e

63 of the Atherosclerosis Risk in Communities (ARIC) study and 4559 participants of the Cardiovascular

64 in the Atherosclerosis Risk in Communities (ARIC) Study and compared it with these other schemes.

65 in the Atherosclerosis Risk in Communities (ARIC) study and focusing on loss-of-function (LoF) varia

66 rom the Atherosclerosis Risk in Communities (ARIC) study and included 7,260 nondiabetic Caucasian ind

67 of the Atherosclerosis Risk in Communities (ARIC) Study and interrogated the regions of the nine pub

68 rom the Atherosclerosis Risk in Communities (ARIC) Study and quantified the independent association b

69 in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up.

70 le-aged Atherosclerosis Risk in Communities (ARIC) Study cohort members.

71 iethnic Atherosclerosis Risk in Communities (ARIC) Study cohort.

72 blished Atherosclerosis Risk in Communities (ARIC) Study criteria with the presence or absence of an

73 in the Atherosclerosis Risk in Communities (ARIC) study for the association between baseline urine a

74 rom the Atherosclerosis Risk in Communities (ARIC) Study in 1987-1989.

75 y-based Atherosclerosis Risk in Communities (ARIC) Study in 1990 to 1992 (baseline).

76 of the Atherosclerosis Risk in Communities (ARIC) study in 1990-92 (baseline).

77 rom the Atherosclerosis Risk in Communities (ARIC) Study in 1996 to 1998.

78 The Atherosclerosis Risk in Communities (ARIC) study investigators, for example, typically report

79 The Atherosclerosis Risk in Communities (ARIC) study is a large, predominantly biracial, National

80 The Atherosclerosis Risk in Communities (ARIC) Study is a prospective, observational cohort.

81 rom the Atherosclerosis Risk in Communities (ARIC) study matched for age, gender, and, for the majori

82 in the Atherosclerosis Risk In Communities (ARIC) study over 17 to 19 years of follow-up.

83 Atherosclerosis Risk in Communities (ARIC) study participants (n = 1980) underwent brain MR i

84 14 569 Atherosclerosis Risk in Communities (ARIC) study participants aged 45 to 64 years with mean f

85 in the Atherosclerosis Risk in Communities (ARIC) study participants at 5 examination visits between

86 ed 6516 Atherosclerosis Risk in Communities (ARIC) Study participants who were free of prevalent hype

87 14,590 Atherosclerosis Risk In Communities (ARIC) study participants with lipid measurements in 1987

88 iologic Atherosclerosis Risk in Communities (ARIC) study reported that plasma protein C may be protec

89 ased on Atherosclerosis Risk in Communities (ARIC) Study surveillance adjudicating 12,450 eligible ho

90 hin the Atherosclerosis Risk in Communities (ARIC) Study to determine the association between plasma

91 in the Atherosclerosis Risk in Communities (ARIC) Study visit 4 (1996-1998).

92 of the Atherosclerosis Risk in Communities (ARIC) Study was conducted from 1987-1989 through 2011-20

93 rom the Atherosclerosis Risk in Communities (ARIC) study were enrolled in the ARIC Carotid MRI Study.

94 rom the Atherosclerosis Risk in Communities (ARIC) study were followed from 1987 to 1998.

95 in the Atherosclerosis Risk in Communities (ARIC) Study who attended visit 4 (1996-1998) were analyz

96 rom the Atherosclerosis Risk in Communities (ARIC) Study who were aged 45-64 years at baseline (1987-

97 in the Atherosclerosis Risk in Communities (ARIC) Study who were aged 47-68 years, had normal kidney

98 rom the Atherosclerosis Risk in Communities (ARIC) study who were free of cardiovascular disease at b

99 rom the Atherosclerosis Risk in Communities (ARIC) study who were free of coronary heart disease at b

100 of the Atherosclerosis Risk in Communities (ARIC) study who were free of prevalent HF at baseline we

101 in the Atherosclerosis Risk in Communities (ARIC) study who were in sinus rhythm, free of valvular d

102 in the Atherosclerosis Risk in Communities (ARIC) Study with acute incident MI, there was a decline

103 in the Atherosclerosis Risk in Communities (ARIC) study without cardiovascular disease at baseline (

104 of the Atherosclerosis Risk in Communities (ARIC) Study without heart failure or diabetes at baselin

105 rom the Atherosclerosis Risk in Communities (ARIC) Study, 14,280 middle-aged adults were categorized

106 in the Atherosclerosis Risk in Communities (ARIC) study, 21,222 in the Women's Genome Health Study (

107 in the Atherosclerosis Risk in Communities (ARIC) Study, a community-based prospective cohort of whi

108 rom the Atherosclerosis Risk in Communities (ARIC) Study, a large multicenter cohort study that enrol

109 of the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cohort of adults in 4 US

110 in the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort study of subjects aged

111 S), the Atherosclerosis Risk in Communities (ARIC) Study, and the Cardiovascular Health Study (CHS).

112 rom the Atherosclerosis Risk in Communities (ARIC) study, and the GWAS for PT was conducted in 2,583

113 dy, the Atherosclerosis Risk in Communities (ARIC) Study, and the San Antonio Heart Study.

114 rom the Atherosclerosis Risk in Communities (ARIC) study, Cardiovascular Health Study (CHS), and Fram

115 in the Atherosclerosis Risk in Communities (ARIC) Study, comprising 6,429 men in four US communities

116 n-based Atherosclerosis Risk in Communities (ARIC) study, including associations with eGFR decline, v

117 ongoing Atherosclerosis Risk in Communities (ARIC) Study, the authors assessed the relation of tradit

118 of the Atherosclerosis Risk in Communities (ARIC) study, the Illumina Infinium HumanMethylation450 (

119 in the Atherosclerosis Risk in Communities (ARIC) Study, was used to assess LV dimensions in 1572 bl

120 dy, the Atherosclerosis Risk in Communities (ARIC) Study, we measured change in performance on 3 cogn

121 in the Atherosclerosis Risk in Communities (ARIC) Study, who received a complete periodontal examina

122 rom the Atherosclerosis Risk in Communities (ARIC) study.

123 y-based Atherosclerosis Risk in Communities (ARIC) study.

124 in the Atherosclerosis Risk in Communities (ARIC) study.

125 in the Atherosclerosis Risk in Communities (ARIC) study.

126 of the Atherosclerosis Risk in Communities (ARIC) Study.

127 rom the Atherosclerosis Risk in Communities (ARIC) study.

128 pective Atherosclerosis Risk in Communities (ARIC) study.

129 in the Atherosclerosis Risk in Communities (ARIC) study.

130 of the Atherosclerosis Risk in Communities (ARIC) study.

131 in the Atherosclerosis Risk in Communities (ARIC) study.

132 in the Atherosclerosis Risk in Communities (ARIC) study.

133 in the Atherosclerosis Risk in Communities (ARIC) study.

134 in the Atherosclerosis Risk in Communities (ARIC) Study.

135 HS) and Atherosclerosis Risk in Communities (ARIC) Study.

136 in the Atherosclerosis Risk in Communities (ARIC) study.

137 y-based Atherosclerosis Risk in Communities (ARIC) Study.

138 in the Atherosclerosis Risk in Communities (ARIC) Study.

139 rom the Atherosclerosis Risk in Communities (ARIC) Study.

140 in the Atherosclerosis Risk in Communities (ARIC) Study.

141 of the Atherosclerosis Risk in Communities (ARIC) study.

142 in the Atherosclerosis Risk in Communities (ARIC) Study.

143 in the Atherosclerosis Risk in Communities (ARIC) Study.

144 of the Atherosclerosis Risk in Communities (ARIC) Study.

145 iethnic Atherosclerosis Risk in Communities (ARIC) Study.

146 in the Atherosclerosis Risk in Communities (ARIC) study.

147 in the Atherosclerosis Risk in Communities (ARIC) Study.

148 in the Atherosclerosis Risk in Communities (ARIC) Study.

149 rom the Atherosclerosis Risk in Communities (ARIC) study.

150 n-based Atherosclerosis Risk in Communities (ARIC) Study.

151 S-based Atherosclerosis Risk in Communities (ARIC) Study.

152 in the Atherosclerosis Risk in Communities (ARIC) Study.

153 at the Atherosclerosis Risk in Communities (ARIC) visit 4 using both tooth loss and clinical signs o

154 The Atherosclerosis Risk in Communities (ARIC)-PET Amyloid Imaging Study, a prospective cohort st

155 S), and Atherosclerosis Risk in Communities (ARIC).

156 tates (Atherosclerosis Risks in Communities [ARIC] and Cardiovascular Health Study [CHS]) to assess t

157 study (Atherosclerosis Risk in Communities [ARIC] study).

158 es in the Atherosclerosis Risk in Community (ARIC) HF prediction model.

159 d the Atherosclerosis Risk In the Community (ARIC) visit 5 examination (2011-2013) and underwent tran

160 plored as a secondary analysis of the Dental ARIC (Atherosclerosis Risk in Communities) study using s

161 an American adult participants of the Dental ARIC study.

162 centile values for the hs-cTnT assay in DHS, ARIC, and CHS were 18, 22, and 36 ng/l (subcohort 1) and

163 We included 1,887 eligible ARIC African Americans, and 671 deaths occurred during a

164 tudy (HAPI; n = 861) were genotyped at five (ARIC) and two (FHS) common TCF7L2 variants.

165 core variables had a C statistic of 0.61 for ARIC study and 0.67 for CHS; the full multivariable mode

166 phic variables had a C statistic of 0.76 for ARIC study and 0.74 for CHS.

167 Results for ARIC demonstrated similar lifetime risks for HF in black

168 t brain MR imaging from 2011 to 2013 at four ARIC sites.

169 events involving hospitalization in the four ARIC communities had ICD-9-CM codes screened for AMI.

170 The Framingham, ARIC, and San Antonio models maintained high discriminat

171 ere 0.78, 0.84, and 0.83 for the Framingham, ARIC, and San Antonio risk prediction models, respective

172 The EHR IHD risk profile differed from ARIC and indicates that treatment and prevention efforts

173 Evidence from ARIC community surveillance suggests that the severity o

174 The study included 11153 participants from ARIC, 4830 from CHS, and 5887 from MESA.

175 -cause deaths were ascertained starting from ARIC visit 4 until 2010.

176 In ARIC, of 680 pneumonia cases, 112 had CVD over 10 years

177 1.89 (95% confidence interval, 1.42-2.51) in ARIC, 1.25 (95% confidence interval, 0.81-1.92) in REGAR

178 Cohort risk equations (c-statistic 0.808 in ARIC and 0.743 in CHS).

179 imination for SCD risk (c-statistic 0.820 in ARIC and 0.745 in CHS).

180 Participants 45 to 64 years of age in ARIC (men=6479, women=8488) and REGARDS (men=5296, women

181 ck versus white men 45 to 64 years of age in ARIC and REGARDS were 2.09 (95% confidence interval, 1.4

182 Among women 45 to 64 years of age in ARIC and REGARDS, age-adjusted hazard ratios comparing b

183 s from a genome-wide Affymetrix 6.0 array in ARIC African Americans yielded similar results.

184 ociated with higher hazard ratios for CHD in ARIC.

185 igher low-density lipoprotein cholesterol in ARIC but not in REGARDS or KPSC.

186 s is the first study to characterize CNPs in ARIC and the first genome-wide analysis of CNPs and uric

187 variance in serum magnesium concentration in ARIC African-American participants.

188 variance in serum magnesium concentration in ARIC African-American participants.

189 nd TRPM6 on serum magnesium concentration in ARIC European-American participants.

190 CP, no other loci were associated with CP in ARIC or aggressive periodontitis in the German sample.

191 de significant interactions were detected in ARIC for systolic blood pressure between PLEKHA7 (a know

192 ARDS, 6547 events in KPSC, and 583 events in ARIC.

193 aluate their association with incident HF in ARIC participants.

194 hazards ratio estimates for incident IHD in ARIC (Pearson correlation [r]=0.62), indicating that the

195 ated with increased risk of CVD incidence in ARIC cigarette nonsmokers.

196 the test of gene-environment interaction in ARIC EA participants, the index variant at MUC1 had 2.5

197 enome-wide significant local interactions in ARIC in the 4p16.1 region located mostly in an intergeni

198 ps), finding association with LDL-C level in ARIC Caucasians (P = 0.0064).

199 festyle to 5.1% for a favorable lifestyle in ARIC, from 4.6% to 2.0% in WGHS, and from 8.2% to 5.3% i

200 nal effects and three epistatic SNP pairs in ARIC-three marginal SNPs were located within SLC2A9 and

201 An analysis of metabolic phenotypes in ARIC also showed that the P wave was genetically correla

202 r multivariable adjustment, hazard ratios in ARIC and REGARDS were 0.67 (95% confidence interval, 0.3

203 ardiovascular risk factors, hazard ratios in ARIC and REGARDS were 1.19 (95% confidence interval, 0.7

204 bes passed the threshold for significance in ARIC (P < 1 x 10(-7); Bonferroni), including probes in t

205 nteraction P = 2.9 x 10(-9)) with smoking in ARIC was not replicated in Health ABC, although estimate

206 ing glucose genome-wide association study in ARIC.

207 ents occurred during 39 238 person-years; in ARIC, 330 events congestive heart failure events occurre

208 Association Detection Project in Industry), ARIC (Atherosclerosis Risk in Communities), and CHS (Car

209 validate these findings for CP in the larger ARIC cohort (n = 821 participants with severe CP, 2031-m

210 Fifty-nine percent of cases met ARIC criteria for ADHF and 13.9% and 27.1% were classifi

211 In NHANES (ARIC/CHS), the cut-point of 5 or more points selected 35

212 95% confidence interval, 1.20-2.73) but not ARIC (hazard ratio, 1.21; 95% confidence interval, 0.96-

213 innesota and North Carolina field centers of ARIC who were free of clinically recognized CHD.

214 ith inflection points for risk supportive of ARIC-based limits.

215 Results from previous ARIC (Atherosclerosis Risk In Communities) analyses indi

216 In the prospective ARIC Study, the outcome of AF on the rates of stroke, he

217 e Atherosclerosis Risk in Communities Study (ARIC) population.

218 , Atherosclerosis Risk in Communities Study (ARIC), and Multiethnic Study of Atherosclerosis (MESA).

219 e Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health Study (CHS), and the Re

220 e Atherosclerosis Risk in Communities study (ARIC), the Cardiovascular Health Study (CHS), and the Re

221 e Atherosclerosis Risk in Communities study (ARIC, n = 15,792; enrollment age, 45-64 years; enrollmen

222 e Atherosclerosis Risk in Communities Study (ARIC; n = 11,061 self-identified white and n = 4014 blac

223 2013, through the ARIC Neurocognitive Study (ARIC-NCS), participants underwent a detailed neurocognit

224 (Atherosclerosis Risk in Communities Study [ARIC]).

225 a large population-based prospective study, ARIC (Atherosclerosis Risk in Communities), and in the p

226 k in Communities Study, Minnesota subcohort (ARIC; 1987-2008).

227 The ARIC HF risk score is more parsimonious yet performs sli

228 From 1987 through 1989, the ARIC Study enrolled 15792 men and women and conducted 4

229 isk SNPs among participants from CHS and the ARIC study.

230 nterview, for participants not attending the ARIC-NCS visit, or by an International Classification of

231 irwise genetic correlations (rG) between the ARIC and EHR phenotypes using linear mixed models.

232 he genetic correlation estimates between the ARIC risk factors and the EHR IHD were modestly linearly

233 48 (68%; n=9276 weighted) such events by the ARIC reviewer panel.

234 coronary disease age 45 to 74 years from the ARIC (Atherosclerosis Risk In Communities) and CHS (Card

235 The authors studied 11,565 adults from the ARIC (Atherosclerosis Risk In Communities) cohort, analy

236 METHODS AND We analyzed data from the ARIC (Atherosclerosis Risk in Communities) Study Heart F

237 Using data from the ARIC (Atherosclerosis Risk in Communities) study, we cat

238 African Americans (27%) and whites from the ARIC cohort [aged 45-64 y at baseline (1987-1989)] were

239 ncident CHD cases and 726 non-cases from the ARIC participants.

240 +/-5.7 years; 26% black; 55% women) from the ARIC study (Atherosclerosis Risk in Communities).

241 ed on 2383 participants (1993-1995) from the ARIC study (Atherosclerosis Risk in Communities; 100% bl

242 ETHODS AND We used ECG measurements from the ARIC study (Atherosclerosis Risk in Communities; n=6731

243 an independent subsample (N = 1088) from the ARIC study, suggests that the ABO blood group may influe

244 80 African Americans) were selected from the ARIC Study--a prospective investigation of atheroscleros

245 nts (AA) free of diagnosed diabetes from the ARIC Study.

246 otal of 16,169 European individuals from the ARIC, GHS, MARTHA and PROCARDIS studies, were meta-analy

247 dy included 11,715 middle-aged adults in the ARIC (Atherosclerosis Risk In Communities) cohort with h

248 mean baseline age 59 years, 43% male) in the ARIC (Atherosclerosis Risk In Communities) study and the

249 up.Among 14,082 participants enrolled in the ARIC (Atherosclerosis Risk in Communities) Study initial

250 d with acute or chronic heart failure in the ARIC (Atherosclerosis Risk In Communities) study surveil

251 f European descent (aged 45-64 years) in the ARIC (Atherosclerosis Risk in Communities) study were fo

252 In the ARIC (Atherosclerosis Risk In Communities) study, we use

253 cipants free of CHD and heart failure in the ARIC (Atherosclerosis Risk in Communities) study.

254 ipoprotein cholesterol (LDL-C) strata in the ARIC (Atherosclerosis Risk in Communities) study.

255 T to TRF improves CHD risk prediction in the ARIC (Atherosclerosis Risk In Communities) study.

256 models discriminated reasonably well in the ARIC and Multi-Ethnic Study of Atherosclerosis data (C s

257 ommunities (ARIC) study were enrolled in the ARIC Carotid MRI Study.

258 ntified in MESA, were also replicated in the ARIC cohort (Atherosclerosis Risk in Communities).

259 factors for SCD were first identified in the ARIC cohort to derive a 10-year risk model of SCD.

260 No identified variant in the ARIC or FHS cohorts was associated with albuminuria.

261 with incident HF, mortality, and CVD in the ARIC population.

262 ardiographic measures in participants in the ARIC study (Atherosclerosis Risk in Communities) (n=13 6

263 cular disease events or heart failure in the ARIC Study (Atherosclerosis Risk in Communities) underwe

264 VRF and incidence of AF over 25 years in the ARIC study (Atherosclerosis Risk in Communities).

265 Among 5801 elderly participants in the ARIC study (Atherosclerosis Risk in Communities; age ran

266 We used 37 phenotypes measured in the ARIC study (Atherosclerosis Risk in Communities; n=7716,

267 , and the 12 independent risk factors in the ARIC study included age, male sex, black race, current s

268 sms nominally predicting incident CHD in the ARIC study were included in the GRS.

269 spective cohort study of participants in the ARIC study who did not have diagnosed diabetes and who a

270 (P = 0.16 in North Carolina; P = 0.97 in the ARIC study) and did not segregate with type 2 diabetes i

271 y investigated in the female subgroup in the ARIC study, and the CARE and WOSCOPS trials included onl

272 his lack of association was confirmed in the ARIC study, even after the analysis was restricted to le

273 In the ARIC study, there was no trend of VTE hazard ratios acro

274 s and 1635 participants with diabetes in the ARIC study, who did not have cardiovascular disease, wer

275 an improve prediction of incident CHD in the ARIC study.

276 sk factor for ASCVD and de novo ASCVD in the ARIC study.

277 dontitis or edentulism and Stroke/TIA in the ARIC Study.

278 s) (n = 2029, p value = 6.7 x 10(-3)) of the ARIC and was confirmed by replication in both EAs and AA

279 trics for echocardiography in visit 5 of the ARIC cohort.

280 food groups used in previous studies of the ARIC cohort.

281 e optimism-corrected area under curve of the ARIC HF risk score increased from 0.773 (95% CI, 0.753-0

282 ighest category (>/=0.014 mug/L; 7.4% of the ARIC population) had significantly increased risk for CH

283 valvular disease from the fifth visit of the ARIC study (Atherosclerosis Risk in Communities) who und

284 We studied 4343 participants of the ARIC study (Atherosclerosis Risk in Communities) who wer

285 art failure, who attended the visit 5 of the ARIC study (Atherosclerosis Risk in Communities).

286 The community surveillance component of the ARIC Study consisted of tracking residents 35 to 74 year

287 n A-I (apoA-I) in 14 488 participants of the ARIC study.

288 Pooling the ARIC and replication data yielded two additional loci in

289 Most recently, in 2011-2013, through the ARIC Neurocognitive Study (ARIC-NCS), participants under

290 Addition of PASP to the ARIC model resulted in a significant improvement in mode

291 s to derive a SCD prediction model using the ARIC cohort and validate it in CHS.

292 were also genetically correlated with these ARIC risk factors.

293 estimated from 4,089 women is comparable to ARIC in direction and magnitude (1.414.707.88, p=5.46x10

294 documented MI (CMI) after the baseline until ARIC visit 4 (1996-1998).

295 as ADHF, chronic stable HF, or no HF, using ARIC classification guidelines.

296 The setting was ARIC field centers (Washington County, Maryland; Forsyth

297 ncreased risk of dementia in black and white ARIC Study participants.

298 specificity of the automated algorithm with ARIC reviewer panel as the referent standard were 0.68 (

299 phenotype was most strongly correlated with ARIC metabolic phenotypes, including total:high-density

300 0 participants, the mean age was 62.4 years (ARIC, 57.9 years; MESA, 62.4 years; and CHS, 72.5 years)