ライフサイエンスコーパス: AS

1 AS 129 mice performed poorly on wire hang and contextual

2 AS C57BL/6J mice displayed robust behavioral impairments

3 AS F1 hybrid mice (C57BL/6J x 129) showed milder behavio

4 AS of the anti-apoptotic and proliferation-associated su

5 AS represents a strategy to mitigate overtreatment in yo

6 AS-1, the TIR/BB loop mimetic, plays a protective role i

7 AS-48 is a bacteriocin with potential application as foo

8 AS-derived neurons showed impaired maturation of resting

9 AS-OCT is valuable in identifying EOM insertions in prim

10 AS-OCT measurements were within 1 mm of intraoperative m

11 AS-PCR assays were used to screen patients with and with

12 ERAP1 haplotypes were constructed for 213 AS cases and 46 rheumatoid arthritis controls using fami

13 the anteroseptal wall in 135 patients (36%; AS [anteroseptal] group), and other segments in 59 patie

14 or CAC: 0, 1-99 Agatston score [AS], 100-400 AS, and >400 AS, respectively; for FT: normal, mild=late

15 99 Agatston score [AS], 100-400 AS, and >400 AS, respectively; for FT: normal, mild=late positive tre

16 were retrospectively recruited: AR (n = 7), AS (n = 10) and control subjects (n = 10).

17 score (GS) of 6 or less to 7 or more across AS studies after accounting for differences in surveilla

18 Regarding adsorbed AS-48, the in vitro digestion profile shows that the con

19 y such ion-releasing resins before and after AS immersion.

20 Although AS variation has been observed among single cells, littl

21 African Americans (AA), and Asian Americans (AS).

22 Finally, in multivariable analysis, AS LGE was the best independent CMR predictor of the com

23 ed substantial differences among CA, AA, and AS populations in the expression of DXME genes and in ac

24 AP and AS binding to immobilized BSA at different concentration

25 BSA upon increasing concentration of AP and AS have been shown.

26 all, the attained results showed that AP and AS molecules can bind to BSA.

27 The KD value for binding of AP and AS to BSA were 4.09x10(-5) and 1.89x10(-5), at 25 degree

28 nit (KD) showed high affinity of both AP and AS to BSA.

29 distinguish AS vs control, AR vs control and AS vs AR groups, respectively.

30 c mutations, copy number alterations, DE and AS, indicating their propensity for multidimensional reg

31 d I483R conferred resistance to both FIP and AS-48 without compromising membrane fusion.

32 oof-of-concept data in models of AD-like and AS hippocampus oxidative stress that also exhibit impair

33 nsion, renal disease, diabetes mellitus, and AS severity.

34 ies of the interactions between proteins and AS as well as nonionic surfactants (NIS) are of both bas

35 NA-seq) can deliver both transcriptional and AS information, but accurate methods to analyse the adde

36 assessed whole exome-based transcriptome and AS profiles of 43 pancreas tissues using Affymetrix exon

37 0 patients with moderate-severe asymptomatic AS (aortic valve area, 0.5+/-0.1 cm(2)/m(2); peak gradie

38 ve replacement in patients with asymptomatic AS.

39 mprove outcome in patients with asymptomatic AS.

40 eighboring cells and exhibited asynchronous (AS) Ca transients.

41 and 4-nitro-2-phenylacetyl amino-benzamide (AS-48) have similar efficacies in blocking membrane fusi

42 NQE," "MKDRQ," "MRDRE," and "MKDRE") in both AS cases and controls apart from two rare (<0.5%) previo

43 Data for patients with RT-associated breast AS evaluated at our institution from 1993 to 2015 who un

44 For patients with RT-associated breast AS, radical resection was associated with reduced recurr

45 hemodynamic and metabolic burden imposed by AS.

46 ction against H/R-induced myocytes injury by AS-1.

47 that the conformational change undergone by AS-48 upon adsorption affects its digestibility.

48 r Nacc1, which regulate neural and stem cell AS programs, respectively, reveal roles in controlling t

49 t in both normal and in NMD-deficient cells, AS rates strongly decrease with increasing expression le

50 ia in mice infected with Plasmodium chabaudi AS.

51 Here we characterize AS in the polyploid species cotton.

52 Targeted deep-sequencing confirmed AS-PCR findings, and identified an additional BTK(Cys481

53 layers that positively or negatively control AS events linked to cell fate.

54 peutics are often ineffective in controlling AS-associated seizures.

55 er gap junction coupling in HF-AS versus CTL-AS myocytes.

56 eatures and their dominant roles in decoding AS patterns, highlighting the necessity of including the

57 ips Healthcare with iDose(4)); - Definitions AS+ (Siemens Medical Solutions with SAFIRE system).The m

58 iRNA and phasiRNA in litchi, and demonstrate AS/APA as a new layer of regulation in small RNA-mediate

59 splice graph transversal algorithm to detect AS; anchor, a Bayesian approach to assign modalities; an

60 A sibling history of clinically diagnosed AS was associated with increased risk of AS.

61 n for evaluating therapeutics with different AS-like phenotypes.

62 0.69 and 0.69; all P > 0.05) to distinguish AS vs control, AR vs control and AS vs AR groups, respec

63 chamber imaging using a Visante time-domain AS-OCT according to an IRB-approved protocol.

64 of biopsy-based Gleason score upgrade during AS but not with risk of definitive treatment in the inte

65 of biopsy-based Gleason score upgrade during AS.

66 ase (80% vs 56%, P = 0.04), chemotherapy for AS (58% vs 22%, P < 0.01), margin-negative resection (10

67 is that caveolae and Cav-3 are essential for AS-1-induced cardioprotection against myocardial I/R inj

68 We then develop a new target function for AS prediction in exon skipping events and show it signif

69 peripheral mechanism, with implications for AS.

70 enges: Can we improve on previous models for AS outcome prediction and can we integrate additional so

71 This relationship is observed for AS events that are detectable by NMD as well as for thos

72 l sources of data to improve predictions for AS regulatory factors.

73 al, and previously underrecognized, role for AS in the pathogenesis of autoimmune disorders and parti

74 Depleting ALKBH5 and FOXM1-AS disrupted GSC tumorigenesis through the FOXM1 axis.

75 ong non-coding RNA antisense to FOXM1 (FOXM1-AS) promotes the interaction of ALKBH5 with FOXM1 nascen

76 d pluripotent stem cell-derived neurons from AS patients and unaffected controls.

77 ient (>/=40 mm Hg; normal-flow high-gradient AS) or low mean gradient (normal-flow low-gradient [NFLG

78 larly to an increase in the MKDRQ haplotype (AS 35% vs. control 25%, P = 0.01).

79 6 and integrin alpha5beta1, while hemoglobin AS did not modify IE adhesion to any receptors.

80 Here, AS was globally analyzed in the wild strawberry Fragaria

81 uggesting weaker gap junction coupling in HF-AS versus CTL-AS myocytes.

82 In HF-AS, enhancing gap junction conductance (with rotigaptide

83 faster calcein diffusion than in HF, with HF-AS myocyte being slowest.

84 Astragaloside II (AS II) extracted from Astragalus membranaceus has been r

85 ether nociceptive responses were affected in AS model mice (global deletion of maternal Ube3a allele;

86 eline in donor and to lower than baseline in AS and DCM.

87 Further browning in AS and methylammonium sulfate seeds was triggered by clo

88 h could contribute to behavioral deficits in AS, including motor dysfunction.

89 Fpassive-cardiomyocytes was higher in AS and DCM at shorter muscle lengths, whereas Fpassive-c

90 ths, whereas Fpassive-collagen was higher in AS at longer muscle lengths and in DCM at shorter and lo

91 SR and SR-like proteins possibly involved in AS.

92 variety of biological contexts involving in AS, such as development and diseases.

93 by elucidating the basis of microcephaly in AS, a highly penetrant syndromic feature with early post

94 s that SMRT sequencing is highly powerful in AS discovery and provides a rich data resource for later

95 matter (WM) is disproportionately reduced in AS mice, indicating that deficits in WM development are

96 ent risk factor for higher fibrosis score in AS valves (P=0.003).

97 3.48%), illustrating the efficacy of SMRT in AS identification.

98 P < 0.001) but less eroded than specimens in AS and DW.

99 lation further upward in donor and upward in AS and DCM.

100 n lighting led to significant variability in AS-OCT parameters.

101 ppear to be significant diurnal variation in AS-OCT parameters in normal individuals, but lighting co

102 and dose-response associations with incident AS in an unselected population of older individuals, and

103 ing method for single-cell studies including AS variants quantification and rare miRNA detection in s

104 Specifically inhibiting AS activity in these mice is a promising therapy for red

105 ilar to those of another chemical inhibitor, AS-48, which appears to interfere with the conformationa

106 food formulations; assuring that some intact AS-48 resists digestion guarantees its antibacterial act

107 t of DW on the incorporation of added-N into AS.

108 movement of the lamina (LD-BM increase or LD-AS increase) occurred with the same frequencies as thinn

109 rease) compared with the anterior sclera (LD-AS decrease) reference plane (hazard ratio, 3.23; P < 0.

110 fidence interval, 1.07-1.21) than was the LD-AS (0.15 mum/mum; 95% confidence interval, 0.08-0.22).

111 , reference plane (LD-BM decrease without LD-AS decrease).

112 Lipase AS catalyzes the selective hydrolysis of the rear foot o

113 g that the enhanced arginine uptake mediates AS II-induced wound healing.

114 controls 27%, P = 1.2 x 10(-24)) and MKDRE (AS 8% vs. controls 7%, P = 0.004).

115 a for the two K528-bearing haplotypes MKDRQ (AS 33% vs. controls 27%, P = 1.2 x 10(-24)) and MKDRE (A

116 Moderate AS was defined as aortic valve area between 1.0 and 1.5

117 Patients with concomitant moderate AS and LV systolic dysfunction are at high risk for clin

118 utcome of patients with concomitant moderate AS and LV systolic dysfunction.

119 plit into 2 groups (severe and mild/moderate AS) according to their echocardiographic mean pressure g

120 and clinical data of patients with moderate AS and LV systolic dysfunction between 2010 and 2015 fro

121 mechanisms that regulate survivin DEx3 mRNA AS is clearly important.

122 The response of total (15)N-AS to DW varied depending on drying intensities.

123 ine on proteome and lysine acetylome in SK-N-AS cells and expands our understanding of the mechanisms

124 acetylome after perifosine treatment in SK-N-AS neuroblastoma cells using SILAC labeling, affinity en

125 In 3 human neuroblastoma cell lines (SK-N-AS, SK-N-BE2, and SH-SY5Y), soluble HBEGF is sufficient

126 an gradient (normal-flow low-gradient [NFLG] AS).

127 O-AS supplementation in artificial diets and germination m

128 KDE1B) in the trichomes reduced total leaf O-AS by 20% to 30% and increased susceptibility to Fusariu

129 -fold quantitative variation in total leaf O-AS was found among the natural accessions.

130 O-Acyl sugars (O-AS) are abundant trichome-specific metabolites that func

131 We conclude that O-AS function as direct defenses to protect plants from at

132 fferentiation, we discover that up to 20% of AS exons exhibit bimodality.

133 05") previously reported by others in 53% of AS cases.

134 A total of 4.8% of AS cases had a sibling history of AS.

135 The extent and complexity of AS has been revealed in model plants using high-throughp

136 were treated with multiple concentrations of AS II to assess cell proliferation, scratch wound closur

137 Moreover, after 30 d of AS storage, BAG-F showed the greatest remineralizing eff

138 actors contribute less to the development of AS than genetic factors.

139 of which 13 442 had a clinical diagnosis of AS, was collected from the nationwide Swedish Multi-Gene

140 However, the effect of AS II on inflammatory bowel disease is unknown.

141 s imputed from the International Genetics of AS Consortium (IGAS) Immunochip study were also studied.

142 of 4.8% of AS cases had a sibling history of AS.

143 ight into the haemodynamic cardiac impact of AS and AR.

144 h between the haemodynamic cardiac impact of AS and AR.

145 dently associated with a higher incidence of AS.

146 We investigated the effects and mechanism of AS II on intestinal wound healing in both in vitro and i

147 in a maternal Ube3a knock-out mouse model of AS.

148 We investigated different modes of AS in the context of fruit development; the percentage o

149 ngth FLNC reads, including a large number of AS events associated with rhizome systems.

150 Of note, the highest numbers of AS probe-sets were found in collagen genes, which encode

151 impaired axon growth in the pathogenesis of AS and identify noninvasive structural neuroimaging as a

152 During the last century, the pathogenesis of AS has undergone transitions in developed countries, fro

153 findings suggest that the pathophysiology of AS and thus potential targets for drug development may b

154 we find that axons within the WM pathways of AS model mice are abnormally small in caliber.

155 sights into the complexity and regulation of AS, and will enhance our understanding of AS in polyploi

156 The population-attributable risk of AS associated with 3 cardiac risk factors was 34.4% (95%

157 duration of cardiac risk factors and risk of AS.

158 sed AS was associated with increased risk of AS.

159 This role of AS, combined with the relation of aberrant splicing to m

160 We also collate a set of AS and DE genes encoding cell surface proteins, which pr

161 e browning processes in aqueous solutions of AS and 4-oxopentanal (4-OPA), which has a 1,4-dicarbonyl

162 will be a useful reference for the study of AS in other species.

163 Vmax >/=5 m/s at the time of AS diagnosis identifies patients with very severe AS at

164 The most prevalent type of AS event (40%) was retention of introns, most of which w

165 single cells redefines our understanding of AS complexity in cell biology.

166 of AS, and will enhance our understanding of AS in polyploid species.

167 ese results are important towards the use of AS-48 in food formulations; assuring that some intact AS

168 Here, we analyzed the physical AS process and found that it can be modeled by a stochas

169 Agreement between preoperative AS-OCT and intraoperative measurements.

170 g-wetting (DW) on dynamics of newly-produced AS is critical because this represents microbial-driven

171 C-terminal telopeptide (CTX) after prolonged AS storage.

172 NA-binding specificity variant of Rap1 (Rap1(AS)).

173 The Rap1(AS) variant will likely also be useful for studies of th

174 We used Rap1(AS) to map and characterize a 41-amino acid activation d

175 d allele-specific polymerase chain reaction (AS-PCR) assays that we developed for Bruton tyrosine kin

176 ption factors, some of which dually regulate AS through direct and indirect mechanisms.

177 s indicate a central role of ESRP1-regulated AS for intestinal barrier integrity.

178 we identified a putative H3K36me3-regulated AS event leading to a nonsense-mediated mRNA decay of BA

179 d metabolism in the development of resistant-AS in broilers.

180 or BAG-F) and immersed in artificial saliva (AS) up to 30 d.

181 inerals with no proteins [artificial saliva (AS)] and neither proteins nor ions [deionised water (DW)

182 ve calcification loads than men for the same AS hemodynamic severity.

183 y abnormal (for CAC: 0, 1-99 Agatston score [AS], 100-400 AS, and >400 AS, respectively; for FT: norm

184 ce tomography (OCT) of the anterior segment (AS) to measure anterior chamber (AC) inflammation (both

185 f 13 years, 20,995 subjects developed severe AS.

186 ted with increased risk of developing severe AS (all p < 0.001).

187 diovascular risk factors and incident severe AS in a large, unselected elderly population.

188 diabetes, dyslipidemia, and incident severe AS requiring hospitalization or surgical or intervention

189 Patients with NFLG had less severe AS and LV remodeling than patients with normal-flow high

190 ed by similar symptom burden but less severe AS measured by aortic valve area index (0.50+/-0.09 vers

191 imately one-third of the incidence of severe AS.

192 ly formally indicated for symptomatic severe AS.

193 d in 1,038 patients with symptomatic, severe AS at 53 centers on 4 continents.

194 agnosis identifies patients with very severe AS at high risk of death.

195 (AS); however, the definition of very severe AS based on peak aortic jet velocity (Vmax) remains uncl

196 ine the best threshold to define very severe AS.

197 ODS AND A total of 1140 patients with severe AS (aortic valve area </=1 cm(2), Vmax >/=4 m/s) and pre

198 se approximately 20% of patients with severe AS and preserved left ventricular ejection fraction have

199 n Vmax and mortality in patients with severe AS and preserved left ventricular ejection fraction irre

200 tive for treating older patients with severe AS at increased operative risk.

201 among intermediate-risk patients with severe AS treated with either TAVR or SAVR.

202 2032 intermediate-risk patients with severe AS were randomized to TAVR with the Sapien XT valve or S

203 Among intermediate-risk patients with severe AS, health status improved significantly with both TAVR

204 Further, shifting AS modes may contribute to rapid changes of gene express

205 ata led us to identify 15 102 fibre-specific AS events and estimate that c. 51.4% of homoeologous gen

206 We observe that mammalian-specific AS events are enriched in transcript sequences encoding

207 , in the proximity of alternatively spliced (AS) exons and poly(A) sites.

208 to monitor individual alternatively spliced (AS) variants and miRNA copies within single cells.

209 ation, a comprehensive alternative splicing (AS) analysis of pancreatic ductal adenocarcinoma (PDAC)

210 d identify genome-wide alternative splicing (AS) and alternative polyadenylation (APA) in the rhizome

211 ction was coupled with alternative splicing (AS) and alternative polyadenylation (APA).

212 hat most genes undergo alternative splicing (AS) and that these patterns are tightly regulated.

213 etworks of coordinated alternative splicing (AS) events play critical roles in development and diseas

214 of gene expression and alternative splicing (AS) in autoimmunity.

215 ighlighted the role of alternative splicing (AS) in increasing transcriptome complexity.

216 od model to understand alternative splicing (AS) in plants from an evolutionary perspective as it div

217 Alternative splicing (AS) is a crucial regulatory mechanism in eukaryotes, whi

218 Alternative splicing (AS) is a key post-transcriptional regulatory mechanism,

219 Alternative splicing (AS) patterns have diverged rapidly during vertebrate evo

220 Messenger RNA alternative splicing (AS) regulates the expression of a variety of genes invol

221 Alternative splicing (AS) that occurs at the final coding exon (exon 47) of th

222 both transcription and alternative splicing (AS).

223 Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders.

224 ed the proposal that ankylosing spondylitis (AS) is associated with unusual ERAP1 genotypes.

225 d arthritis (RA) and ankylosing spondylitis (AS).

226 th AS compared with subjects without spousal AS (hazard ratio 1.16 for husbands and 1.18 for wives).

227 corbyl palmitate (AP) and ascorbyl stearate (AS) are examples of food additives, which have extensive

228 ic dysfunction and moderate aortic stenosis (AS) are more frequent with advancing age and often coexi

229 In patients with severe aortic stenosis (AS) at intermediate surgical risk, treatment with transc

230 nts with severe symptomatic aortic stenosis (AS) in routine clinical practice.

231 RATIONALE: Calcific aortic stenosis (AS) is characterized by calcium deposition in valve leaf

232 Severe aortic stenosis (AS) most often presents with reduced aortic valve area (

233 it occurs, for instance, in aortic stenosis (AS).

234 factors and development of aortic stenosis (AS).

235 c patients with very severe aortic stenosis (AS); however, the definition of very severe AS based on

236 s procured in patients with aortic stenosis (AS, n=9) and dilated cardiomyopathy (DCM, n=6).

237 rdiac consequences of aortic valve stenosis (AS) and aortic valve regurgitation (AR).

238 Aortic valvular stenosis (AS) is the most common cause of cardiac valvular replace

239 isted upon restriction to men meeting strict AS inclusion criteria.

240 For in vitro studies, AS-1 treatment prevented Cav-3 re-distribution induced b

241 types were increased in the AS family study (AS 43% vs. control 35%), due particularly to an increase

242 f extraneous nitrogen (N) into amino sugars (AS) could reflect the contribution of microbial residues

243 ancer (PCa) for initial active surveillance (AS) has been questioned on the basis of eventual treatme

244 Active surveillance (AS) is increasingly accepted for managing low-risk prost

245 Angelman syndrome (AS) is a genetic neurodevelopmental disorder, most commo

246 AS.SIGNIFICANCE STATEMENT Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss or m

247 Angelman syndrome (AS) is a neurogenetic disorder caused by deletion of the

248 Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mu

249 of the UBE3A gene develop Angelman syndrome (AS), a severe neurodevelopmental disorder.

250 Aldosterone synthase (AS, cytochrome P450 11B2, cyp11B2) is the sole enzyme re

251 Systematic AS characterization in single cells redefines our unders

252 oss but greater SMH change (P < 0.0001) than AS and DW groups.

253 Together, our results demonstrate that AS control of IDR-mediated interactions between hnRNPs r

254 We demonstrate that AS-1 administration significantly decreased infarct size

255 Our findings indicate that AS II can contribute to epithelial barrier repair follow

256 We reveal that AS allows differential regulation of the same gene by mi

257 uman transcriptomes and we further show that AS rates correlate with the fitness cost of splicing err

258 The AS analysis of PDAC indicated on average two AS probe-se

259 The AS group had a greater extent of LGE and a higher LV end

260 The AS landscape was characterized and compared between the

261 The AS sodium dodecyl sulfate (SDS) denatures and unfolds gl

262 528-bearing haplotypes were increased in the AS family study (AS 43% vs. control 35%), due particular

263 In the AS model, abnormally high free radical levels were obser

264 significant correlation was observed in the AS patient group.

265 gain insight into the functional role of the AS in vivo and whether modulating the splice patterns at

266 served LVEF, LGE in the midwall layer of the AS myocardial segment is associated with a worse prognos

267 Here, we reveal a critical role of the AS regulator epithelial splicing regulator protein 1 (ES

268 plan-Meier curve analysis indicated that the AS group had a worse prognosis than the other groups (p

269 telescoped synthesis of measles therapeutic, AS-136A, in a total residence time of 31.7 min (1.76 g h

270 These AS myocytes were much more frequent in HF (10.8% of myoc

271 re much more common in HF myocytes and these AS myocytes are also poorly coupled, enabling local Ca-i

272 ise to four main transcript isoforms through AS/APA, and diverse phasiRNAs generated from these isofo

273 e loss of maternal UBE3A might contribute to AS phenotypes.

274 terior segment optical coherence tomography (AS-OCT) in measuring the distance of extraocular muscle

275 anterior segment optic coherence tomography (AS-OCT) was conducted at the Wilmer Eye Institute at Joh

276 terior segment optical coherence tomography (AS-OCT).

277 AS analysis of PDAC indicated on average two AS probe-sets (ranging from 1-28) in 1,354 significantly

278 of genes ( 20% of multi-exon genes) undergo AS than previously reported (3-5%).

279 tected multiexon genes in strawberry undergo AS, some of which lead to a gain or loss of conserved do

280 g depth, it identifies more genes undergoing AS (57.67% of detected multiexon genes) when it is compa

281 vestigating pathogenic mechanisms underlying AS and identifying novel therapeutic strategies.

282 yer confirms also the presence of undigested AS-48.

283 cisco (UCSF); and University of Toronto (UT) AS studies.

284 sing deficits are frequently associated with AS, it is currently unknown whether Ube3a is expressed i

285 sensory processing deficits associated with AS.SIGNIFICANCE STATEMENT Angelman syndrome (AS) is a ne

286 The ERAP1 association with AS is therefore predominantly attributable to common ERA

287 ly slightly more likely to be diagnosed with AS compared with subjects without spousal AS (hazard rat

288 ce interval, 2.23-5.21) to be diagnosed with AS in an adjusted model.

289 limbus-anterior chamber angle distance with AS-OCT and the axial length with IOLMaster.

290 s and Methods We identified men managed with AS at our institution with a minimum follow-up of 6 mont

291 rmation of BrC in the reaction of 4-OPA with AS and ammonium nitrate was greatly accelerated by evapo

292 Aqueous reactions of 4-OPA with AS were found to produce 2-methyl pyrrole (2-MP), which

293 METHODS AND Fifty-one patients with AS (67+/-15 years, 20 female) and 10 healthy age-matched

294 Spouses of patients with AS only had a modest risk increase, suggesting that shar

295 Individuals with >1 sibling with AS had an exceptionally high risk (hazard ratio, 32.84)

296 Having at least 1 sibling with AS was associated with a hazard ratio of 3.41 (95% confi

297 In contrast, spouses of subjects with AS were only slightly more likely to be diagnosed with A

298 was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy

299 ficant correlation between VAS-work and WPAI:AS (Rho=0.53, P<0.0001).

300 irment Allergic Specific Questionnaire (WPAI:AS) in six EU countries.