ライフサイエンスコーパス: ASGPR

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1 ASGPR is composed of two highly homologous subunits, ter

2 dified siRNA has enabled asialoglycoprotein (ASGPR)-mediated targeted delivery of therapeutically act

3 rf1) of HuH-7 alters the asialoglycoprotein (ASGPR) and transferrin receptor subcellular distribution

4 rst X-ray crystal structures of ligand-bound ASGPR.

5 uman primates with antigens fused to anti-DC-ASGPR monoclonal antibody generates antigen-specific CD4

6 DC-asialoglycoprotein receptor (DC-ASGPR), a lectinlike receptor, is a known scavenger rece

7 that targeting antigens to human DCs via DC-ASGPR, but not lectin-like oxidized-LDL receptor, Dectin

8 rgeting whole protein antigens to DCs via DC-ASGPR.

9 on experiments suggest that other endogenous ASGPR ligands, the nature of which remain to be determin

10 new ligands were obtained with affinity for ASGPR as good as or better than that of the parent N-ace

11 This molecule also exhibited increased ASGPR-directed hepatocellular uptake and prolonged reten

12 njugated ASOs showed high affinity for mouse ASGPR, which results in enhanced ASO delivery to hepatoc

13 s to biosynthesis and functional activity of ASGPR in vivo has remained controversial.

14 to make potent di- and trivalent binders of ASGPR.

15 ference in the kinetics of ER degradation of ASGPR H2a in susceptible as compared with protected host

16 hepatocytes or Hepa1 cell line), but not of ASGPR-negative 293 cells.

17 dase gene (LacZ) resulted in transduction of ASGPR-positive cells (rat hepatocytes or Hepa1 cell line

18 to express an unassembled membrane protein, ASGPR H2a.

19 the function of these compounds showed rapid ASGPR-dependent cellular uptake in vitro and high levels

20 subunit of the asialoglycoprotein receptor (ASGPR H2a) were expressed in skin fibroblast cell lines

21 content of the asialoglycoprotein receptor (ASGPR) and three trafficking proteins, Rab3D, Rab7and Ra

22 The asialoglycoprotein receptor (ASGPR) is a high-capacity galactose-binding receptor exp

23 The mammalian asialoglycoprotein receptor (ASGPR) is located on the sinusoidal membrane of hepatocy

24 Likewise, asialoglycoprotein receptor (ASGPR) was up-regulated in UCMSCs upon differentiation.

25 tocyte-specific asialoglycoprotein receptor (ASGPR), enhances the potency of second-generation gapmer

26 apical membrane asialoglycoprotein receptor (ASGPR), which is related to the ASGPR of liver cells.

27 Asialoglycoprotein receptor (ASGPR)-mediated endocytosis has been used to target gene

28 ligand for the asialoglycoprotein receptor (ASGPR).

29 ocyte-specific asialoglycoprotein receptors (ASGPR) to enhance uptake to hepatocytes and to increase

30 to disrupt the heterocomplex reduced surface ASGPR binding activity by 65 +/- 5.7%.

31 dependent sorting proteins from cytosol, the ASGPR cytoplasmic domain was expressed as a GST fusion p

32 provide a hitherto unsuspected role for the ASGPR in transcriptional signaling, aside from its role

33 ng low-micromolar or better affinity for the ASGPR.

34 provide evidence that phosphorylation of the ASGPR cytoplasmic domain is required for the binding of

35 in receptor (ASGPR), which is related to the ASGPR of liver cells.

36 the absence of a change in TG binding to the ASGPR.

37 ting glycoproteins are not elevated in these ASGPR-deficient mice.

38 After the FPL binds to ASGPR on the hepatocyte surface, fusogenic activity of t

39 of HBV binding and uptake was observed when ASGPR was saturated with known specific ligands.

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