ライフサイエンスコーパス: AT2 receptor

1 mouse fetal VSMCs, which express endogenous AT2 receptor.

2 effects are partly due to activation of the AT2 receptor.

3 ugh stimulation by Ang II at the angiotensin AT2 receptor.

4 apoptosis and abolished the up-regulation of AT2 receptor.

5 lpha2 and Gialpha3, also co-immunoselect the AT2 receptor.

6 f sodium restriction occur via ANG II at the AT2 receptor.

7 acid (AA) release from cultured neurons via AT2 receptors.

8 olved in this process other than the RAS and AT2 receptors.

9 ptor and activate the angiotensin II type 2 (AT2) receptor.

10 cells induced by the angiotensin II type 2 (AT2) receptor.

11 ossess abundant LOX-1 as well as Ang II (AT1>AT2) receptors, (2) Ang II upregulates LOX-1 receptor an

12 The relative importance of AT1 and AT2 receptor actions depends on the levels of AT1 and AT

13 AT2 receptor activated serine palmitoyltransferase with

14 AT2 receptor activation also inhibited the tyrosine phos

15 osphorylation was stimulated by NGF, whereas AT2 receptor activation blocked this NGF effect.

16 AT2 receptor activation did affect intracellular Bcl-2 p

17 The selective AT2 receptor agonist CGP 42112 (100 nmol/L) produced sim

18 Furthermore, the AT2 receptor agonist N-alpha-nicotinoyl-Tyr-Lys-(N-alpha

19 he target organ, exogenous administration of AT2 receptor agonists or angiotensin 1-7 analogs may sim

20 In contrast, the AT2 receptor analogues PD-123319 and CGP-42112 at concen

21 sibility that selective interactions between AT2 receptor and different G proteins may result in spec

22 he AT1-ant is triggered by activation of the AT2 receptor and is also mediated in part by kinins.

23 the dephosphorylation of MAP kinases by the AT2 receptor and restored the apoptotic changes.

24 In young rats, AT2 receptors and AT2 receptor mRNA are discretely local

25 r olive reduced [125I]Sar1-Ang II binding to AT2 receptors and AT2 receptor mRNA levels in this area

26 the role of Ang II type 1 (AT1) and type 2 (AT2) receptors, and MAPK p42/44 in this process.

27 contain many angiotensin II (Ang II) type 2 (AT2) receptors, and we previously determined that activa

28 ctivation was also inhibited by PD123319, an AT2 receptor antagonist but not by losartan, an AT1 rece

29 ibited Ang II binding, whereas PD 123319, an AT2 receptor antagonist did not.

30 The selective AT2 receptor antagonist PD 123319 (1 mumol/L) but not th

31 P in response to intravenous infusion of the AT2 receptor antagonist PD 123319 (PD), the AT1 receptor

32 The AT2 receptor antagonist PD 123319 had no effect on incre

33 The putative AT2 receptor antagonist PD 123319 inhibited 30 to 40% of

34 The AT2 receptor antagonist PD123319 (3 mg/kg/day) and AngII

35 Conversely, the AT2 receptor antagonist PD123319 had no effect on Ang II

36 II-induced endoglin expression, whereas the AT2 receptor antagonist PD123319 had no effect.

37 lthough a pharmacological approach using the AT2 receptor antagonist PD123319 has implicated a role.

38 ethylester (L-NAME), but not by the specific AT2 receptor antagonist, PD-123319 (PD).

39 response, the effects of the central AT1 and AT2 receptor antagonists losartan and PD123319 were inve

40 CCDs with losartan but not PD123319 AT1 and AT2 receptor antagonists, respectively, blocked the resp

41 Some studies suggest that AT2 receptors are also functional, but the cell type car

42 ese corresponding domains in the AT1 and the AT2 receptors are crucial to the activation mechanism, d

43 To determine whether AT2 receptors are expressed in climbing fiber terminals

44 first use RT-PCR to show that AT1A, AT1B and AT2 receptors are expressed in thoracic spinal cord of t

45 ceptor blocker PD123319, indicating that the AT2 receptors are functional and exert an antigrowth eff

46 Our results support the hypothesis that AT2 receptors are produced by inferior olivary neurons a

47 ) receptor, and the functions of the type-2 (AT2) receptor are largely unknown.

48 etic intracellular third loop peptide of the AT2 receptor (AT2-3LP, 22 amino acids) and control pepti

49 Mice lacking the AT2 receptor (AT2-null mice) had slightly elevated systo

50 is a highly selective nonpeptide angiotensin AT2 receptor (AT2R) agonist.

51 d 21 (C-21) is a highly selective nonpeptide AT2 receptor (AT2R) agonist.

52 In the vasculature, the angiotensin type 2 (AT2) receptor (AT2R) exerts antiproliferative, antifibro

53 cytes is precluded by blocking either AT1 or AT2 receptors (ATRs).

54 AT2 receptor binding and AT2 receptor mRNA levels in the

55 s after serum removal; instead, it increased AT2 receptor binding and enhanced angiotensin II-mediate

56 Consistent with in vivo data, AT2 receptor binding in cultured Agtr2(+) VSMC increased

57 a by 50%, and produced a similar decrease in AT2 receptor binding in the molecular layer of the cereb

58 In addition, a low amount of AT2 receptor binding was detected in the paraventricular

59 AT1 and AT2 receptor binding were determined with the AT1 recept

60 We previously detected AT2 receptor binding, but not AT2 receptor mRNA, in the

61 , functioning via the angiotensin II type 2 (AT2) receptor, blocked both the nicotine-induced activat

62 eceptor antagonist (losartan), but not by an AT2 receptor blocker (PD123319).

63 olished all responses to Ang II, whereas the AT2 receptor blocker PD123,319 had no effect.

64 Ang II (100 nmol/L), in the presence of the AT2 receptor blocker PD123,319, elicited an inhibition o

65 VSMC (embryonic day 20) was increased by the AT2 receptor blocker PD123319, indicating that the AT2 r

66 with the AT1 receptor blocker, Losartan, the AT2 receptor blocker, PD 123319 (PD), or angiotensin II,

67 The effects of the AT1 and AT2 receptor blockers candesartan and PD123319 on hemody

68 cts were inhibited by selective AT1 (but not AT2) receptor blockers.

69 ytoma cell line) cells that express abundant AT2 receptor but not Ang II type 1 receptor.

70 PC12W cells express abundant AT2 receptor but not angiotensin II type 1 receptor and

71 ibroblast cell line), which express abundant AT2 receptor but not AT1 receptor.

72 Taken together, our results suggest that AT2 receptor can crosstalk negatively with multiple fami

73 port that the stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth

74 n the other hand, the angiotensin II type 2 (AT2) receptor counteracts the AT1 receptor-mediated tyro

75 The finding that AT2 receptor couples to both Gialpha2 and Gialpha3 raise

76 While AngII infusion induced AAAs, AT2 receptor deficiency did not significantly affect eit

77 AT2 receptor deficiency does not affect AngII-induced AA

78 altered in AT1A receptor-deficient mice, and AT2 receptor deficiency had no effect on lesion area or

79 AT2 receptor deficiency had no significant effect on sys

80 Neither AT2 receptor deficiency nor PD123319 had any significant

81 stolic blood pressure in either wild type or AT2 receptor deficient mice.

82 by the activation of AT1 receptors, and that AT2 receptors do not appear to modulate hemodynamic resp

83 mouse are mediated by AT1 receptors and that AT2 receptors do not modulate the pressor response to An

84 n Agtr1a-/-; Agtr1b-/- mice, indicating that AT2 receptor does not exert acute depressor effects in t

85 Angiotensin II type 2 (AT2) receptor exerts an inhibitory action on cell growth

86 is and that increased IRF-1 up-regulates the AT2 receptor expression after serum starvation, resultin

87 These results suggest that the AT2 receptor expression during the fetal vasculogenesis

88 To examine directly the influence of AT2 receptor expression in the developmental biology of

89 g were harvested to measure cortical AT1 and AT2 receptor expression, 125I-Ang II glomerular binding,

90 rent arterioles, while there was very little AT2 receptor expression.

91 Ang II AT1 receptor expression and decreases AT2 receptor expression.

92 than in Agtr2(+), inversely correlating with AT2 receptor expression.

93 tor actions depends on the levels of AT1 and AT2 receptor expression.

94 The AT2 receptor function in lung stromal fibroblasts may be

95 tory factor (IRF) binding motif in the mouse AT2 receptor gene promoter region.

96 NG II) in mice with targeted deletion of the AT2 receptor gene.

97 effect of PD123319 occurred irrespective of AT2 receptor genotype.

98 tibodies were both able to co-immunoselected AT2 receptor-Gialpha complexes, but consistent with the

99 Recently growth-inhibitory effects of the AT2 receptor have been reported to be mediated by the ac

100 AT2 receptors have an unclear function on development of

101 This indicates that AT1 and AT2 receptors have opposite actions on Erk1 and Erk2 act

102 mouse strain mutant for angiotensin type 2 (AT2) receptors have given new insight into this mystery.

103 ent study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult

104 ave failed to show G protein coupling of the AT2 receptor in the fetus.

105 We investigated the role of the AT2 receptor in the vascular and renal responses to phys

106 e present study was to determine the role of AT2 receptors in AngII-induced AAAs using a combination

107 We also defined effects of AT2 receptors in AngII-induced atherosclerosis and thora

108 in-converting enzyme, and the Ang II AT1 and AT2 receptors in embryonic day 10.25 Sprague-Dawley rats

109 Purkinje cell connectivity suggest a role of AT2 receptors in the development of this pathway.

110 The high expression of AT2 receptors in the inferior olivary-cerebellar pathway

111 AT1 receptors were more abundant than AT2 receptors in the retina.

112 To determine the roles of brain AT1 and AT2 receptors in this response, the effects of the centr

113 In contrast, the function of renal AT2 receptors in unknown.

114 usly shown that angiotensin II (Ang II), via AT2 receptors, increases whole-cell K+ current in cultur

115 23319 augments AngII-induced AAAs through an AT2 receptor-independent mechanism.

116 The AT2 receptor-induced accumulation of ceramide was blocke

117 -42) in PC12 cells are blocked by Ang II via AT2 receptor-induced activation of SHP-1.

118 of this pathway, possibly ceramide, mediates AT2 receptor-induced apoptosis.

119 AT2 receptor-induced ceramide accumulation did not resul

120 AT2 receptor-induced ceramide accumulation preceded the

121 re, the potential biological significance of AT2 receptor-induced effects on both the nicotine-induce

122 mechanism of angiotensin II (Ang II) type 2 (AT2) receptor-induced apoptosis in PC12W (rat pheochromo

123 16-residue segment (Cys101-Val116) from the AT2 receptor induces constitutive activity, although Asn

124 trate that in PC12W cells the stimulation of AT2 receptor induces the activation of de novo pathway,

125 Moreover, AT2 receptor inhibited serine phosphorylation of STAT1al

126 Stimulation of AT2 receptor inhibited the binding of STATs with sis-ind

127 AT1 and AT2 receptor inhibition had no affect on AngII-mediated

128 The AT2 receptor inhibits MAP kinase activation, resulting i

129 We studied the mechanism of NGF and AT2 receptor interaction on apoptosis by examining their

130 t the intracellular third loop domain of the AT2 receptor is closely linked with the cellular signali

131 In contrast, the AT2 receptor is expressed at low levels in the adult but

132 We now provide evidence that the AT2 receptor is G protein-coupled.

133 AT2 receptor is highly expressed in the fetal kidney and

134 These results demonstrate that the AT2 receptor is necessary for normal physiological respo

135 Angiotensin II type 2 (AT2) receptor is abundantly expressed in vascular smooth

136 The expression of the angiotensin II type 2 (AT2) receptor is developmentally and growth regulated.

137 third loop domain of angiotensin II type-2 (AT2) receptor is essential for the subsequent intracellu

138 ng MAP kinase phosphatase 1 activated by the AT2 receptor, is involved in apoptosis.

139 Absence of the AT2 receptor leads to vascular and renal hypersensitivit

140 ccessible sites reduced AT1 (by 65%) but not AT2 receptor levels.

141 losartan (Ki = 1.4 X 10(-7)) but also by the AT2 receptor ligand PD 123319 (Ki = 5.0 X 10(-7)).

142 doses of the angiotensin II receptor type 2 (AT2) receptor ligand CGP-42112 had only a weak inhibitor

143 othesize that this apoptotic function of the AT2 receptor may play an important role in developmental

144 Nevertheless, AT2 receptors may mediate vasodilation under certain con

145 AT1 but not AT2 receptors mediate Ang II actions on ENaC.

146 MAP kinase dephosphorylation and blocked the AT2 receptor-mediated apoptosis.

147 ta-chloro-L-alanine completely abrogated the AT2 receptor-mediated apoptosis.

148 Pertussis toxin and orthovanadate blocked AT2 receptor-mediated ceramide production.

149 We have now investigated the AT2 receptor-mediated effects of Ang II on the activity

150 de to MAP kinase phosphatase 1 inhibited the AT2 receptor-mediated MAP kinase dephosphorylation and b

151 igated the involvement of PLA2 and AA in the AT2 receptor-mediated stimulation of IK by Ang II.

152 d LO metabolite intracellular pathway in the AT2 receptor-mediated stimulation of neuronal IK by Ang

153 rvations provide a novel mechanism for AngII-AT2 receptor-mediated transport modulation.

154 s AT1 receptor-mediated vasoconstriction and AT2 receptor-mediated vasodilation of coronary arteriole

155 tensin II (Ang II) elicits an Ang II type 2 (AT2) receptor-mediated increase in delayed-rectifier K+

156 The angiotensin AT2 receptor modulates renal production of cyclic guanos

157 These results suggest that activation of AT2 receptors modulates rat hypothalamus and brain stern

158 In young rats, AT2 receptors and AT2 receptor mRNA are discretely localized in neurons of

159 Aortic AT2 receptor mRNA expression was not altered in AT1A rec

160 AT2 receptor binding and AT2 receptor mRNA levels in the deep cerebellar nuclei w

161 25I]Sar1-Ang II binding to AT2 receptors and AT2 receptor mRNA levels in this area by 50%, and produc

162 ously detected AT2 receptor binding, but not AT2 receptor mRNA, in the molecular layer of the cerebel

163 AT1- and AT2-receptor mRNA could be detected in all samples.

164 There was no significant difference in AT2-receptor mRNA expression in failing and nonfailing h

165 These results imply that the AT2 receptor negatively regulates the level of active TG

166 fetal and postnatal wild-type (Agtr2(+)) and AT2 receptor null (Agtr2(-)) mice.

167 ion but attenuated the inhibitory effects of AT2 receptor on MAP kinase, Bcl-2 phosphorylation, and a

168 These results strongly suggest that the AT2 receptor plays a counterregulatory protective role m

169 eath and that angiotensin acting through the AT2 receptor protects dopamine neurons from rotenone tox

170 e recently discovered angiotensin II type 2 (AT2) receptor remains elusive.

171 contribution of its type 1 (AT1) and type 2 (AT2) receptors remains unknown.

172 erved in the AT2 receptor; the corresponding AT2 receptor residues are, in fact, disruptive of AngII-

173 an and PD123,319 to block the Ang II AT1 and AT2 receptors resulted in reduced ventricular developmen

174 est that this is a result of interruption of AT2-receptor signaling.

175 ein tyrosine phosphatases (PTPases) and that AT2 receptor stimulation is associated with a rapid acti

176 n kinase activity, simulating the effects of AT2 receptor stimulation.

177 l mechanisms by which angiotensin subtype-2 (AT2) receptor stimulation induces net fluid absorption a

178 , Marion et al. provide a new chapter to the AT2 receptor story.

179 The selective AT2 receptor subtype antagonist PD 123319 (10 microM) wa

180 mediates its effects through a novel non-AT1/AT2 receptor subtype.

181 ACE, Ang II, and AT1 as well as AT2 receptor subtypes are present in the mouse hypothala

182 ins II or III, as documented for the AT1 and AT2 receptor subtypes, and is heavily distributed in the

183 II has a second receptor, the Ang II type 2 (AT2) receptor, the function of which, even after over 20

184 y of these residues are not conserved in the AT2 receptor; the corresponding AT2 receptor residues ar

185 ARB may exert antifibrotic actions via the AT2 receptor, through increased levels of angiotensin II

186 zed that angiotensin II (Ang II) acts at the AT2 receptor to stimulate renal production of nitric oxi

187 as used to inhibit 125I-SI Ang II binding to AT2 receptors to determine AT1 receptor density in brain

188 est that ANG II acts at the serosal side via AT2 receptors to stimulate cGMP production via soluble g

189 removal mediated apoptosis and up-regulated AT2 receptor, we transfected antisense oligonucleotides

190 Similar effects of AT2 receptor were observed in R3T3 fibroblast and mouse

191 eventh transmembrane-spanning domains of the AT2 receptor were substituted into the AT1 receptor were

192 ptapeptide metabolite Ang-(1-7), and AT1 and AT2 receptors were localized by immunohistochemistry and

193 AT2 receptors were localized throughout the Muller cells

194 rly, levels of the AT1 receptor, but not the AT2 receptor, were significantly lower in mesangial cell

195 giotensins; these angiotensins stimulate the AT2 receptor, which in turn may play an important role i

196 Surprisingly, the chimeric AT1/AT2 receptors--which also lack these crucial AT1 residue

197 Male AT2 receptor wild type (AT2 +/y) and deficient (AT2 -/y)

198 k2 activities was potentiated by blockade of AT2 receptors with (S)-1-[4-(dimethylamino)-3-methylphen