ライフサイエンスコーパス: ATM protein

1 d by western blot for abnormal expression of ATM protein.

2 acid changes or premature truncation of the ATM protein.

3 All four cases lacked ATM protein.

4 ing to generate mice that do not express the Atm protein.

5 era raised against the approximately 350 kDa ATM protein.

6 ompanied by a change in the abundance of the ATM protein.

7 of p53 or the ataxia telangiectasia mutated (ATM) protein.

8 ated with the ataxia telangiectasia mutated (ATM) protein.

9 The ATM protein, a member of the phosphatidylinositol 3-kina

10 is the human Ataxia Telangiectasia Mutated (ATM) protein, a wortmannin-sensitive protein kinase that

11 The ATM protein acts as a sensor of radiation-induced cellul

12 in A-T cells; AMOs restored up to 20% of the ATM protein and corrected the A-T cellular phenotype.

13 ex of approximately 500 kDa containing the X-ATM protein and other, as yet unidentified component(s).

14 ecombinant X-ATM are highly specific for the ATM protein and recognize a single polypeptide of 370-kD

15 Ataxia telangiectasia mutated (ATM) protein and AT- and Rad9-related protein kinases, b

16 ctors such as ataxia telangiectasia mutated (ATM) protein and combined deficiencies in classical non-

17 Inhibition of ataxia telangiectasia mutated (ATM) protein and DNA-PK could not suppress the induction

18 reatment-induced apoptosis by activating the ATM protein, and that the presence of the XPC protein is

19 The ATM protein appears to be a regulator of ABL activity in

20 pattern and the nuclear localization of the ATM protein are consistent with the proposed function of

21 nd immunoblot analysis, we show that Atr and Atm proteins are approximately 300 and 350 kD relative m

22 ntly reduced episome levels, suggesting that ATM proteins are playing an important role in HPV episom

23 Kinase-dead ATM protein (Atm-KD), but not loss of ATM (Atm-null), pr

24 We have observed purified human ATM protein, ATM-DNA and ATM-DNA-avidin bound complexes

25 ases of B-CLL were studied for expression of ATM protein by Western blot analysis and RIA.

26 nase' subclass of kinases which includes the ATM protein defective in ataxia telangiectasia patients.

27 de a progressive neurodegeneration caused by ATM protein deficiency.

28 The level of X-ATM protein did not change throughout the meiotic divisi

29 now show that ATM kinase inhibition, but not ATM protein disruption, also inhibits DNA synthesis.

30 reported that ATM kinase inhibition, but not ATM protein disruption, blocks sister chromatid exchange

31 Furthermore, we demonstrate that the Atm protein exists as two discrete molecular species, an

32 es with LOH at the ATM gene were studied for ATM protein expression by Western blot analysis.

33 In addition, we analyse ATM protein expression in a variety of A-T patients.

34 When ATM protein expression was suppressed by short hairpin R

35 y, monoubiquitination of Fanconi protein D2, ATM protein expression, and non-homologous DNA end joini

36 rve any change in the level or mobility of X-ATM protein following gamma-irradiation of embryos.

37 o the translation of full-length, functional ATM protein for at least 84 h in the three cell lines ex

38 (A-T) is a syndrome associated with loss of ATM protein function.

39 Pharmacological inhibition of ATM proteins had no effect on episome levels, but ATM kn

40 We find that in neurons, ATM protein has a substantial cytoplasmic distribution.

41 The ATM protein has been implicated in pathways controlling

42 Since the ATM protein has been implicated in telomere metabolism o

43 The ATM protein has roles in DNA repair and in the regulatio

44 y at 11q22-23 and, more recently, absence of ATM protein, have been associated with poor prognosis in

45 ng compounds consistently induced functional ATM protein in ATM-deficient cells containing disease-ca

46 important function of catalytically inactive ATM protein in DNA repair.

47 findings are consistent with a role for the ATM protein in ensuring the fidelity of DNA repair and c

48 of human A-T and found evidence for residual ATM protein in seven of them.

49 cent study suggests the presence of residual ATM protein in the brain of one such model.

50 telangiectasia based on their effect on the ATM protein, including five that caused a protein trunca

51 ion experiment further demonstrated that the ATM protein interacted with the TFIIH basal transcriptio

52 Abnormal expression of ATM protein is a frequent finding in B-CLL.

53 The ATM protein is a member of the PI 3-kinase-like superfam

54 The ATM protein is a single, high-molecular weight protein p

55 A fraction of ATM protein is localized in mitochondria, and it is rapi

56 ATM protein is normally present at high levels primarily

57 as been previously proposed and that loss of ATM protein is not sufficient to induce cerebellar degen

58 In addition, we found that the ATM protein is predominantly cytoplasmic in Purkinje cel

59 The ATM protein is therefore critical both for cellular resp

60 show that the ataxia-telangiectasia mutated (ATM) protein is activated and forms telomeric foci in re

61 The ataxia-telangiectasia mutated (ATM) protein is an apical kinase that orchestrates the m

62 astogens, the ataxia telangiectasia mutated (ATM) protein is rapidly activated, which in turn initiat

63 The ataxia telangiectasia mutated (ATM) protein is the principal activator of the p53 prote

64 emonstrate that DNA-PKcs, unlike the related ATM protein, is not essential for the activation of p53

65 In response to DNA damage, the ATM protein kinase activates signal transduction pathway

66 The Atm protein kinase and Mre11-Rad50-nibrin (MRN) complex

67 patients are deficient in activation of the Atm protein kinase and phosphorylation of downstream Atm

68 l function in facilitating activation of the ATM protein kinase at sites of DNA double-strand breaks

69 Here we show that the ATM protein kinase directly phosphorylates T68 within th

70 cell cycle checkpoint protein related to the ATM protein kinase family.

71 tasia, a disorder caused by mutations in the Atm protein kinase gene.

72 double-strand break (DSB) activates ATR and ATM protein kinase homologs Mec1 and Tel1, which then ac

73 a consensus site for phosphorylation by the ATM protein kinase in cells; and TAO and p38 activation

74 The ATM protein kinase is a critical intermediate in a numbe

75 ATM protein kinase is activated by DNA damage and respon

76 The ATM protein kinase is activated by intermolecular autoph

77 The Atm protein kinase is central to the DNA double-strand b

78 The ATM protein kinase is essential for cells to repair and

79 The ATM protein kinase is mutated in ataxia telangiectasia,

80 The gene that encodes the ATM protein kinase is mutated in ataxia-telangiectasia (

81 The ATM protein kinase regulates the cell's response to DNA

82 The ATM protein kinase regulates the DNA damage response by

83 The ATM protein kinase regulates the response of the cell to

84 The ATM protein kinase, mutations of which are associated wi

85 The ATM protein kinase, the product of the gene mutated in A

86 nzymes, end tethering, and activation of the ATM protein kinase.

87 tasia (A-T) results from inactivation of the ATM protein kinase.

88 licit a rapid signaling response through the ATM protein kinase.

89 e chief mobilizer of the DSB response is the ATM protein kinase.

90 , in response to IR also is dependent on the ATM protein kinase.

91 trated by the ataxia-telangiectasia mutated (ATM) protein kinase and involves interruption of Hdm2-me

92 The ataxia-telangiectasia mutated (ATM) protein kinase blocks cell cycle progression in res

93 The ataxia telangiectasia mutated (ATM) protein kinase is a critical component of a DNA-dam

94 The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA dam

95 The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand br

96 The ataxia-telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activate

97 The Ataxia Telangiectasia-Mutated (ATM) protein kinase is recruited to sites of double-stra

98 The Ataxia Telangietasia mutated (ATM) protein kinase promotes DNA repair and activates ch

99 The ataxia telangiectasia mutant (ATM) protein kinase regulates the cell's response to DNA

100 The ataxia telangiectasia mutated (ATM) protein kinase regulates the cellular response to d

101 Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (D

102 gest that the ataxia-telangiectasia-mutated (ATM) protein kinase signal-transduction pathway is prima

103 on activation of the ataxia-telangiectasia (ATM) protein kinase, which phosphorylates cell-cycle eff

104 ogated by caffeine and requires ATR, but not ATM, protein kinase.

105 The ATR and ATM protein kinases are known to be involved in a wide v

106 ATM protein levels and localization remain constant thro

107 ATM protein levels remained constant throughout the cell

108 We revealed that total ATM protein levels were high in some human melanoma line

109 e reduced in ataxia telangiectasia cells and ATM protein levels were low in primary murine fibroblast

110 Cellular Atm protein levels were lower in AS-IGF1R-transfected ce

111 metic drug neocarzinostatin had no effect on ATM protein levels, in contrast to a noted rise in p53 l

112 d by DNA damage, indicating that the Nbs and Atm proteins may participate in common pathways.

113 ypothesized that the absence of a functional ATM protein might involve perturbations to the ubiquitin

114 , in contrast to the nuclear localization of ATM protein observed in cultured cells.

115 The ataxia telangiectasia mutated (ATM) protein plays a central role in early stages of DNA

116 homolog of the human ataxia telangiectasia (ATM) protein, prevents these translocations, whereas the

117 e the acetyltransferase Tip60 must acetylate ATM proteins prior to their full activation by autophosp

118 lines lacking ataxia telangiectasia mutated (ATM) protein produced wild-type levels of infectious vir

119 ns, as demonstrated by direct measurement of ATM protein, restored ATM kinase activity, and colony su

120 A-T patients with 5-20% of normal levels of ATM protein show slower neurological progression, A-T ma

121 anslated and produces a catalytically active ATM protein that responds to DNA damage by phosphorylati

122 The ATM protein that the gene encodes is involved in DNA dou

123 The central region of the ATM protein therefore contains multiple sequences which

124 In brain, although Bal/Bal mice have no ATM protein, they have nearly normal amounts of Atm mRNA

125 62ins137) that express a low level of normal ATM protein to evaluate the impact of residual Nbs1 func

126 tein was required for the association of the ATM protein to genomic DNA.

127 ino acids 1-150 of ATM were required for the ATM protein to regulate cellular radiosensitivity.

128 XPC protein is essential for recruiting the ATM protein to the DNA template.

129 -T patients and mouse models that express no ATM protein undergo normal embryonic development but exh

130 Steady-state levels of ATM protein varied from undetectable in most AT cell lin

131 The restored ATM protein was close to normal levels in cells with hom

132 No ATM protein was detected by western blotting in any AT c

133 ne ATM mutation, and a variable reduction in ATM protein was detected in all 4 patients examined.

134 In adult mice, ATM protein was detected in all tissues examined and was

135 that the aminoglycoside-induced full-length ATM protein was functional and corrected, to various ext

136 Expression of the ATM protein was impaired in eight (40%) of the 20 tumour

137 Truncated ATM protein was not detected in lymphoblasts from ataxia

138 Functional ATM protein was required for HuCds1 modification after i

139 A significant amount of the ATM protein was still detected 21 days after a single 5

140 help clarify the physiological roles of the ATM protein, we disrupted the ATM gene in mice through h

141 Here, we show that the expression levels of Atm protein were gradually increased during liver regene

142 the status of ataxia-telangiectasia mutated (ATM) protein, which activates p53 in response to DNA dam

143 Pre-incubation of ATM protein with active DNA-PKcs also significantly redu

144 stration of a nuclear association of Atr and Atm proteins with meiotic chromosomes and suggests a dir

145 Xenopus ATM protein (X-ATM) is 85% identical to human ATM within