ライフサイエンスコーパス: ATP analog

1 f ATP as well as AMP-PCP (a non-hydrolyzable ATP analog).

2 tubule-attached, dimeric kinesin bound to an ATP analog.

3 analyzed to find an efficient unhydrolyzable ATP analog.

4 number in the presence of a nonhydrolyzable ATP analog.

5 benzoyladenosine, an irreversible inhibitory ATP analog.

6 trand with duplex DNA in the presence of the ATP analog.

7 lication of ATP but not by a nonhydrolyzable ATP analog.

8 nts containing AMPPNP, a slowly hydrolyzible ATP analog.

9 at the engineered v-Src uniquely accepted an ATP analog.

10 triphosphate, gamma-S-ATP, a nonhydrolyzable ATP analog.

11 ompassing all six subunits, upon binding the ATP analog.

12 receptor with AMPPNP, a hydrolysis-resistant ATP analog.

13 by another kinase that could not utilize the ATP analog.

14 and ssDNA in the presence and absence of an ATP analog.

15 as well as that bound to a non-hydrolyzable ATP analog.

16 ed by binding of a specific non-hydrolyzable ATP analog.

17 odulated by the polynucleotide substrate and ATP analog.

18 e obtained with either peptide inhibitors or ATP analogs.

19 ion showed intermediate sensitivity to these ATP analogs.

20 g studies using fluorescent and spin-labeled ATP analogs.

21 eriments and inhibition with nonhydrolyzable ATP analogs.

22 s in the presence of ATP and nonhydrolyzable ATP analogs.

23 th neutral-backbone DNA and non-hydrolyzable ATP analogs.

24 ressed in the form of reductions in kcat for ATP analogs.

25 combination of peptide and non-hydrolysable ATP analogs.

26 changes in ternary complexes with different ATP analogs.

27 of the Pat1 kinase (pat1-as2) by adding the ATP analog 1-NM-PP1 in G1-arrested cells allows the indu

28 e required to activate the receptor, and the ATP analog 2',3'-O-(4-benzoyl-benzoyl)ATP (BzATP) is bot

29 Finally, we demonstrate that the fluorescent ATP analog 2'/3'-O-(N'-methylanthraniloyl)-ATP (mantATP)

30 The C-2-modified ATP analogs 2-amino-ATP and 2-chloro (Cl)-ATP were excel

31 ers in rigor were labeled with a fluorescent ATP analog, 3'-DEAC-propylenediamine (pda)-ATP (3'-O-{N-

32 GRK5 in complex with the ATP analog 5'-adenylyl beta,gamma-imidodiphosphate or th

33 nosine triphosphate, and the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidodiphosphate (AMP-

34 presence and absence of the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidodiphosphate (AMPP

35 Moreover, Top2 bound to the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidodiphosphate exhib

36 ctivity in the presence of the non-substrate ATP analog 5'-adenylyl-beta,gamma-imidodiphosphate verif

37 Similarly, Cak1p is insensitive to the ATP analog 5'-fluorosulfonylbenzoyladenosine, which inhi

38 iminated by substituting the nonhydrolyzable ATP analog 5-adenylyl-imidodiphosphate or UTP for ATP in

39 hydrolyze ATP, or to bind a nonhydrolysable ATP analog, 5'-adenylyl-beta,gamma-imidodiphosphate (ADP

40 Chemical modification with the ATP analog, 5'-p-fluorosulfonylbenzoyladenosine, showed

41 We show that JFC1 specifically binds to the ATP analog 8-azido-[alpha-(32)P]ATP.

42 enol ATP, as well as with a photoactivatable ATP analog, 8-azido-ATP (N(3)-ATP).

43 mass spectrometry using a novel fluorescent ATP analog, 8-azido-ATP-[gamma]-1-naphthalenesulfonic ac

44 Upon binding to the ATP analog, a 100-fold reduction in affinity for ssDNA w

45 in ternary complex with the nonhydrolyzable ATP analog adenosine 5'-(beta,gamma-imido)-triphosphate

46 oli PhoQ complexed with the non-hydrolyzable ATP analog adenosine 5'-(beta,gamma-imino)triphosphate a

47 The enzyme co-crystallized with the ATP analog adenosine 5'-[gamma-thio]triphosphate contain

48 ctivity is inhibited by the non-hydrolysable ATP analog (adenosine 5'-O-(thiotriphosphate)), T4 singl

49 ATP analogs (adenosine 5'-(alpha, beta-methylene)triphos

50 The ATP analogs (adenosine 5'-O-(3-thiotriphosphate) or 5'-a

51 structure, in complex with a nonhydrolyzable ATP analog, adenosine 5'-adenylyl-beta,gamma-imidodiphos

52 nding in the presence of the nonhydrolyzable ATP analog, adenosine 5'-O-(3-thio)triphosphate (ATPgamm

53 Using either ATP or the non-hydrolyzable ATP analog, adenosine 5'-O-(3-thiophosphate), events in

54 ants, L273A and L108A, and a nonhydrolyzable ATP analog, adenosine 5'-O-(3-thiotriphosphate) (ATPgamm

55 RepA in the presence of a poorly hydrolyzed ATP analog, adenosine 5'-O-(thiotriphosphate), and to re

56 zation was abrogated in vitro by ATP and the ATP analog adenyl-5'-yl imidodiphosphate.

57 nced upon the addition of a non-hydrolyzable ATP analog (adenylyl-imidophosphate), whereas ADP had no

58 The ATP analog, adenylyl methylenediphosphonate (AMP-PCP), a

59 presence and absence of the non-hydrolyzable ATP analog ADP(BeF3).

60 Pase domain, bound with the non-hydrolyzable ATP analog ADP-beryllium fluoride, we studied the NtrC1-

61 teins in the presence of the nonhydrolyzable ATP analog ADP-beryllium fluoride.

62 ADP.Pi analogs ADP.AlF4 and ADP.Vi, and the ATP analogs ADP.BeFx, AMPPNP and ATPgammaNH2, all induce

63 only in the presence of the non-hydrolyzable ATP analog, ADP(BeF3).

64 nucleoside triphosphates, a nonhydrolyzable ATP analog, ADP, or AMP had no effect.

65 Another ATP analog, ADP-aluminum fluoride, does not promote unwi

66 hile in the presence of the non-hydrolyzable ATP analog, ADP-beryllium fluoride, we observe additiona

67 A nonhydrolyzable ATP analog, ADPCP (beta,gamma-methylene adenosine 5'-tri

68 rate that the presence of a non-hydrolyzable ATP analog allows Mtr4p to discriminate between partial

69 mammalian cartilage and bone, the effects of ATP analogs, ALP substrates, and specific inhibitors on

70 trate (2S,5S)-5-carboxymethylproline (CMPr), ATP analog alpha,beta-methyleneadenosine 5'-triphosphate

71 A single binding site for the ATP analog, alpha,beta-methylene ATP (Ap(CH2)pp), was al

72 ose homo-oligomers that are sensitive to the ATP analog alphabeta-methylene ATP(alphabetameATP) (P2X(

73 ATP and a nonhydrolyzable ATP analog also influence the stability of the DNA-PKcs*

74 p did not catalyze the hydrolysis of ATP and ATP analogs, although fluorescence measurements indicate

75 e investigated whether interactions with the ATP analog AMP-PNP and ADP can shift the conformational

76 The nonmetabolizable ATP analog AMP-PNP cannot be substituted for ATP in this

77 cellular perfusion with the non-hydrolyzable ATP analog AMP-PNP dramatically reduce the amplitude of

78 hondrial ATP, and cocrystallization with the ATP analog AMP-PNP suggests that binding of nucleotides

79 data establish that, in the presence of the ATP analog AMP-PNP, or ADP, a maximum of six DnaC monome

80 f the receptor with the hydrolysis-resistant ATP analog AMP-PNP.

81 6p complexed with an RNA oligonucleotide and ATP analogs AMP-PNP, ADP-BeF(3)(-), or ADP-AlF(4)(-).

82 te (Vi), acetate, ATP, or a non-hydrolyzable ATP analog (AMP-PNP), with differential effects on matri

83 The inability of the nonhydrolyzable ATP analog, AMP-PNP, to cause a similar effect is explai

84 the presence or absence of a nonhydrolyzable ATP analog, AMP-PnP.

85 of the open state bound to a nonhydrolyzable ATP analog (AMPPCP) and 1,6-anhydroMurNAc provide detail

86 The ATP analog, AMPPNP, protects probes in the active site a

87 pon exchange of ATP with the nonhydrolyzable ATP analog and ATP hydrolysis.

88 e in a quaternary complex with tRNA(Gln), an ATP analog and glutamate reveals that the non-cognate am

89 f activated NTPDase3 with a non-hydrolyzable ATP analog and the cofactor Mg(2+) to a resolution of 2.

90 ed here, of bovine F1-ATPase inhibited by an ATP analog and the phosphate analog, thiophosphate, repr

91 or its nucleotide substrate was tested using ATP analogs and alternative nucleotide donors.

92 ith ligand-gated P2X1 receptors activated by ATP analogs and high levels of ATP.

93 rystal structures of Mss116p in complex with ATP analogs and single-stranded RNA show that the helica

94 domains of AC in complex with two different ATP analogs and various divalent metal ions.

95 as mimicked by several sterically restricted ATP analogs and was blocked by suramin.

96 AMP-PNP (gamma-imino ATP, a nonhydrolyzable ATP analog) and Mg(2+)/ADP.

97 microM in the presence of a nonhydrolyzable ATP analog, and 45 microM in the presence of ADP or no n

98 -adenylylimidodiphosphate, a nonhydrolyzable ATP analog, and was blocked in the presence of H7 or the

99 plants display protein kinase activity, bind ATP analogs, and possess C-terminal domains similar to b

100 ment formed on DNA in the presence of ATP or ATP analogs, and this has been studied at low-resolution

101 Modified ATP analogs are described that do not activate either co

102 p specifically requires ATP; nonhydrolyzable ATP analogs are ineffective.

103 e intrinsic affinities of all of the studied ATP analogs are lower than the intrinsic affinities of t

104 , the detection of which can be modulated by ATP analogs as well as DNA sequence flanking the TATA se

105 AMP-PNP, a nonhydrolyzable ATP analog, at a concentration of 1 or 3 mM was unable t

106 e interrupted by adding the non-hydrolyzable ATP analog ATP-gamma-S.

107 In contrast, the poorly hydrolyzed ATP analog ATP-gammaS only partially stabilizes the nucl

108 ional changes in the loop that surrounds the ATP analog (ATP-lid) and has implications for interactio

109 We demonstrate that the nonhydrolyzable ATP analog, ATP gamma S, supports the formation of an is

110 he E. coli clamp-loader complex bound to the ATP analog ATPgammaS (at a resolution of 3.5 A) and ADP

111 The ATP analog ATPgammaS is a competitive inhibitor of the r

112 addition of an excess of the unhydrolyzable ATP analog ATPgammaS, supplementation with exogenous ATP

113 Using the ATP analog ATPgammaS, we showed that ATP hydrolysis is r

114 esolution structure of the core bound to the ATP analog ATPgammaS.

115 rlc) binding to actin in the presence of the ATP analog ATPgammaS.

116 his complex reveal that the non-hydrolyzable ATP analog, ATPgammaS, induces a high-affinity binding m

117 nucleotide, or in the presence of ADP or the ATP analog, ATPgammaS, there was no helical ordering.

118 unctional cycle by use of a non-hydrolyzable ATP analog, ATPgammaS, to mimic the ATP-bound GroEL stat

119 ures of Pho85-Pcl10 and its complex with the ATP analog, ATPgammaS.

120 IC50 of inhibitors using the nonhydrolyzable ATP analog, beta, gamma-methyleneadenosine 5'-triphospha

121 ATP analogs bind MRP1 with reduced apparent affinity, in

122 ATP analog binding to either site diminishes the intrins

123 e have previously shown that nonhydrolyzable ATP analogs block the lytic activity of NK cells and CD8

124 that binds ADP in bovine F(1) ATPase has an ATP analog bound and therefore this structure does not r

125 .ATP, and we observe a single molecule of an ATP analog bound in the aforementioned surface cavity, n

126 e the effect of force on the lifetime of the ATP analog bound to the actomyosin complex.

127 plex, deiNOS quenches the fluorescence of an ATP analog bound to TrpRS II, and increases its affinity

128 ences compared to AMPPNP (a non-hydrolyzable ATP analog) bound to PhoQcat and radicicol bound to Hsp9

129 ene)triphosphate (AMP-PCP) (non-hydrolyzable ATP analog) bound were also solved at 1.9-A resolution.

130 Non-hydrolyzable ATP analogs (but not ATP or ADP) release P1 from the pro

131 nzyl)-ATP and N(6)(phenethyl)-ATP over other ATP analogs, but still retained a 30 microm K(m) for ATP

132 In the presence of ADP or ATP analogs, calcium increased the asymmetry of the HMM

133 n allostery not catalysis, and the classical ATP-analog class of tyrosine kinase inhibitors fail to i

134 clamps in the presence of a non-hydrolyzable ATP analog compared with the wild type enzyme.

135 e of magnesium and ATP (or a nonhydrolyzable ATP analog), contains maximal DNA helicase in the presen

136 with the models based on the nonhydrolyzable ATP analog data.

137 (fluorosulfonyl)benzoyl]adenosine (FSBA), an ATP analog, demonstrate that both inhibitors bind to the

138 Non-hydrolyzable ATP analogs did not substitute for ATP in the RNA-unwind

139 Nonhydrolyzable ATP analogs did not substitute for ATP to promote recove

140 ATP-gamma-S, a poorly hydrolyzable ATP analog, did not support endocytosis but instead prod

141 wever, in the presence of a non-hydrolyzable ATP analog, DNA binding was only slightly compromised.

142 rom Dictyostelium in the presence of various ATP analogs do not show changes at the reactive thiol re

143 midodiphosphate (AMP-PNP), a nonhydrolyzable ATP analog, each kinesin-1 dimer binds two tubulin heter

144 The accessibility of the fluorescent ATP analog, epsilon ADP, to acrylamide quenching was als

145 pecific interactions with the adenine of the ATP analog, establishing the molecular basis of ATP reco

146 Substitution of nonhydrolyzable ATP analogs for ATP slowed or prevented recovery.

147 in, solved to 2.4 A both with and without an ATP analog, form isologous, but asymmetric homodimers.

148 Two ATP analogs, FSBA and ATP gamma S, used in this study, w

149 olyzable (AMP-PNP, AMP-PCP) nor hydrolyzable ATP analogs (GTP, CTP, UTP, and ITP) activated hIK1.

150 The addition of a nonhydrolyzable ATP analog had no effect at early time periods (measured

151 e in complex with a peptide substrate and an ATP analog has been determined at 1.9 A resolution.

152 structure of this mutant in complex with an ATP analog has been determined at 2.4-A resolution.

153 kinase domain and its binary complex with an ATP analog has revealed an identical open kinase conform

154 o]triphosphate (AMP-PNP), a non-hydrolyzable ATP analog, has no effect on MGAD activity.

155 iphosphate (AMP-PNP), a hydrolysis-resistant ATP analog; however, this study mainly used AMP-PNP to f

156 -type Cdk7 with a version sensitive to bulky ATP analogs in human cancer cells.

157 Inclusion of ATP analogs in the binding assay with Ca2+ and Mg2+ to s

158 ormation when complexed with nonhydrolysable ATP analogs, in contrast to other transporter structures

159 A series of ATP analogs, in which moieties of various sizes have bee

160 presence of either ADP or a non-hydrolyzable ATP analog induces conversion to a monomeric form.

161 Nonhydrolyzable or poorly hydrolyzable ATP analogs inhibited MgATP-supported binding.

162 e specifically sensitive to a cell-permeable ATP analog inhibitor, allowing us to perform high-resolu

163 transduction networks has relied heavily on ATP analog inhibitors.

164 difications that confer sensitivity to novel ATP analog inhibitors.

165 tibility of another protein kinase, PDK1, to ATP analog inhibitors.

166 Specifically, ATPgammaS (a nonhydrolyzable ATP analog) inhibits secretion of interferon gamma by NK

167 dominantly the P2X7 receptor (P2X7R), via an ATP analog initiate innate proinflammatory inflammation,

168 Binding of a nonhydrolyzable ATP analog inverts the transporter to an outward-facing

169 synchronous meiosis at 25 degrees C when an ATP analog is added to the culture.

170 tegy, a neo-substrate approach involving the ATP analog kinetin triphosphate (KTP), can be used to in

171 Binding of a nonhydrolyzable ATP analog locks pNS3h in a conformation that is more co

172 The fluorescent ATP analog, mantATP (2'(3')-O-(N-methylanthraniloyl)ATP)

173 Base-modified ATP analogs may exert their biological effects through p

174 The MDE structure with an ATP analog (MgADP x BeFx) was also determined to 3.6 A r

175 Previously we found that the ATP analog N(6)-(2-phenylethyl)-ATP (P-ATP) potentiates

176 PKG Ialpha (M438G) that efficiently used the ATP analog N(6)-benzyl-ATP.

177 nase displayed catalytic efficiency with the ATP analog, N(6)-(cyclopentyl) ATP, which is similar to

178 Interestingly, we found that the ATP analog N6-(2-phenylethyl)-ATP (P-ATP) increases G551

179 The effects of modified ATP analogs on ATP-dependent poly(A) tail synthesis by y

180 finity for ATP, to probe the action of these ATP analogs on conformational switching.

181 Effects of two nonhydrolyzable ATP analogs on helicase denaturation were measured as co

182 the effects of ATP, ADP, and nonhydrolyzable ATP analogs on the lifetime of protein.DNA complexes.

183 In the presence of an ATP analog only one conformation is observed, indicating

184 ocked by the use of either a nonhydrolyzable ATP analog or a single-ring GroEL mutant, substrates com

185 ection from inhibition by a non-hydrolyzable ATP analog or acetylphosphate, in conjunction with the s

186 mplex with either APS and a non-hydrolyzable ATP analog or APS and sulfate revealed the overall struc

187 e enzyme is titrated with a non-hydrolyzable ATP analog or the enzyme is mutated such that it is able

188 n the presence of AMP-PNP (an unhydrolyzable ATP analog) or the autophosphorylation-site mutant, T267

189 ciated with ATPgammaS, a poorly hydrolyzable ATP analog, or ADP plus AlF(4), which mimics the transit

190 S, a nonphysiological and slowly hydrolyzed ATP analog, or by inactivating one of the two nucleotide

191 er with ATP-gamma-s, the slowly hydrolyzable ATP analog, or with ATP in the presence of alpha, beta-m

192 as observed with MgADP, with nonhydrolyzable ATP analogs, or with MgATP by catalytically inactive eny

193 diphosphate (AMPPNP), a hydrolysis-resistant ATP analog, prior to treatment with FSBMantAdo resulted

194 imidodiphosphate (AMPPNP), a nonhydrolyzable ATP analog, promotes stable complex formation between Re

195 bound to labeled RNA and a non-hydrolyzable ATP analog provide a direct view of how large domain mov

196 treatment with ATPgammaS, a nonhydrolyzable ATP analog, recapitulated early signaling events associa

197 tified using a combination of more selective ATP analogs, receptor expression studies, and study of d

198 The three complexes of ABCB10/ATP analogs reported here showed varying degrees of open

199 ty (5-8-fold) and binding of the 14C-labeled ATP analog rho-fluorosulfonylbenzoyl 5'-adenosine (FSBA)

200 The Prp43*ATP-analog*RNA complex shows the localization of the RNA

201 not ATP hydrolysis, because nonhydrolyzable ATP analogs satisfy the nucleotide requirement.

202 horylation in receptor activation, and 4) an ATP analog selectively inhibits the GC-B mutants, indica

203 Inhibition of an ATP analog-sensitive allele of Cdk1 completely blocked t

204 To explore Ypk1/2 function, we constructed ATP analog-sensitive alleles of both kinases and monitor

205 Using ATP analog-sensitive alleles of PKA and Sch9, we find th

206 nhibition of PKA catalytic subunits that are ATP analog-sensitive causes increased Bcy1 phosphorylati

207 Here we use an ATP analog-sensitive form of ATM to determine that ATP b

208 Chemical inactivation of an ATP analog-sensitive form of the Pat1 kinase (pat1-as2)

209 Moreover, using an ATP analog-sensitive PKCdelta mutant in mouse L(tk(-)) f

210 Here we developed an ATP analog-sensitive PKCepsilon mutant to selectively in

211 3.8 A resolution) for this S1 complexed with ATP analogs, some of which are cross-linked by para-phen

212 Using the engineered kinases and an ATP analog, specific kinase substrates within the PIC we

213 normal function and disease, we developed an ATP analog-specific (AS) PKCdelta that is sensitive to s

214 -(benzyl) ATP to a cell lysate containing an ATP analog-specific kinase allele (as1 allele) results i

215 Finally, a photoactivable ATP analog specifically labeled presenilin 1-C-terminal

216 ret disjunctional protein) motors in ATP and ATP-analog states.

217 el is partly based on the reduced ability of ATP analogs such as adenosine 5'-(beta,gamma-imino)triph

218 ATP analogs such as ADP and AMP exerted marked inhibitor

219 Finally, experiments with non-hydrolyzable ATP analogs suggest that SpoIIIE can operate with non-co

220 netic and binding studies with a fluorescent ATP analog suggested that ATP induces a conformational c

221 inhibited by the addition of nonhydrolyzable ATP analogs, suggesting that ATP hydrolysis and not just

222 Finally, sensitivity to various ATP analogs suggests that all editing-like activities re

223 magnitude weaker than in the presence of the ATP analog (tense state).

224 Cdk1 was engineered to accept an ATP analog that allows it to uniquely label its substrat

225 Slippage is not reduced by an ATP analog that blocks promoter escape, but it is inhibi

226 nalysis the protective effect of AMP-PCP, an ATP analog that is not utilized for enzyme phosphorylati

227 s to be uniquely sensitive to inhibitors and ATP analogs that are not recognized by wild-type kinases

228 Searching for ATP analogs that strongly bound to Thermus aquaticus (Ta

229 ns (unlike with assays utilizing radioactive ATP analogs), the assay described can be used to disting

230 ly, whereas with AMP-PNP, a non-hydrolyzable ATP analog, the affinity was 11 nM.

231 Upon binding the ATP analog, the DnaB hexamer transforms into a "tense" s

232 In the presence of a nonhydrolyzable ATP analog, the enzyme is known to promote a single turn

233 In the absence of the ATP analog, the hexamer exists in a "closed" conformatio

234 In the presence of ATP or a nonhydrolyzable ATP analog, the initial step is the self-assembly of Clp

235 Despite being in complex with an ATP analog, the kinase domain of GRK6 remains in an open

236 For several ATP analogs, the concentration required to inhibit P2X3

237 crystal structures in complexes with RNA and ATP analogs, Thomsen and Berger now elucidate the molecu

238 troms resolution and in complex with with an ATP analog to 2.3 angstrosms A resolution.

239 but not the wild type (WT) kinase, used the ATP analog to phosphorylate both a model peptide substra

240 Second, the binding of a nonhydrolyzable ATP analog to the yeast enzyme appears to affect citraco

241 igases and also point to strategies that use ATP analogs to improve specificity.

242 tic resonance spectroscopy with spin-labeled ATP analogs to probe the structure of the ATP active sit

243 e kinetics of binding mantATP (a fluorescent ATP analog) to the microtubule K341 complex, the dissoci

244 The finding that slowly hydrolyzable ATP analogs trigger slower nucleotide release than ATP s

245 pool also can be filled with the fluorescent ATP analog trinitrophenol ATP, as well as with a photoac

246 The 6-histidine loop bound the fluorescent ATP analog trinitrophenyl-ATP with high affinity, as det

247 bstrate, as well as spectroscopically active ATP analogs (trinitrophenyl-ATP and ATP gamma S-acetamid

248 circle in the presence of a nonhydrolyzable ATP analog under the same conditions that the wild type

249 bstrate on which RecA is polymerized and the ATP analog used.

250 engineered to accept bulky N(6)-substituted ATP analogs, using a chemical genetics approach initiall

251 A non-hydrolyzable ATP analog was a competitive inhibitor.

252 ase kinase/phosphatase in the presence of an ATP analog was attempted.

253 However, the N(6)-(cyclopentyl) ATP analog was not accepted by the wild-type kinase.

254 (yPAP) toward various C-2- and C-8-modified ATP analogs was examined.

255 -actin with bound AMPPNP, a non-hydrolyzable ATP analog, was determined to 1.85-A resolution.

256 Upon removal of an ATP analog, we show that the nucleotide-binding pocket i

257 l-regulated kinase 2 (ERK2) that can utilize ATP analogs, we have identified the alternative mRNA spl

258 ix/chemical quench experiments using various ATP analogs were performed.

259 tructures of yeast dynein bound to different ATP analogs, which collectively provide insight into the

260 g by BLM in the presence of non-hydrolysable ATP analogs, which has implications for the underlying m

261 ased on their ability to bind a spin-labeled ATP analog with stoichiometries and equilibrium binding

262 erently in the presence of a nonhydrolyzable ATP analog, with subconductance openings significantly s