ライフサイエンスコーパス: ATP synthase

1 bly of the Atp6p and Atp8p products into the ATP synthase.

2 elease requires H135 in the ATP5O subunit of ATP synthase.

3 g protein subunits of the mitochondrial F1FO ATP synthase.

4 s dissociation from the beta subunit of F1Fo-ATP synthase.

5 ryo-EM) analysis of the bovine mitochondrial ATP synthase.

6 d of PS II, the cytochrome b6/f complex, and ATP synthase.

7 Ca(2+) stimulates the citric acid cycle and ATP synthase.

8 tion pore (mPTP) within the c-subunit of the ATP synthase.

9 f the ion-driven membrane rotor of an F-type ATP synthase.

10 version in the coupled rotary motors of FoF1-ATP synthase.

11 modes of bending and twisting in the intact ATP synthase.

12 omplex, it might not function as a bona fide ATP synthase.

13 aryotic cells primarily by the mitochondrial ATP synthase.

14 eparation from both the proton pumps and the ATP synthase.

15 eral assembly modules of yeast mitochondrial ATP synthase.

16 x II/III of the electron transport chain and ATP synthase.

17 of the Atp9p ring with other modules of the ATP synthase.

18 rane because of the loss of stability of the ATP synthase.

19 rane space to promote ATP production through ATP synthase.

20 eractions induced by dephosphorylation of an ATP synthase.

21 rotary motion of the subunit c ring in F1Fo ATP synthase.

22 ich also binds the lateral stalk of the FOF1 ATP synthase.

23 dicate that the PTP forms from dimers of the ATP synthase.

24 e MgtC protein acts on Salmonella's own F1Fo ATP synthase.

25 he single b subunit present in mitochondrial ATP synthase.

26 substep in the synthetic cycle of mammalian ATP synthase.

27 e encodes the alpha subunit of mitochondrial ATP synthase.

28 ggested a different binding site for SQAs on ATP synthase.

29 the encoded Atp6p and Atp8p subunits of the ATP synthase.

30 diolipin is an essential component of active ATP synthases.

31 for proton-translocation-driven rotation in ATP synthases.

32 al and universal life process carried out by ATP synthases.

33 is the catalytic complex of rotary nanomotor ATP synthases.

34 -chain complexes and adenosine triphosphate (ATP) synthase.

35 drogenase 1, 3, and 6 (ND-1, ND-3, ND-6) and ATP synthase 6 (ATP-6) genes was significantly down-regu

36 nt pathway that involved reduced activity of ATP synthase (80% inhibition in pancreatic mitochondria

37 F1-ATPase (F1) is the catalytic portion of ATP synthase, a rotary motor protein that couples proton

38 on in MgtC that prevents binding to the F1Fo ATP synthase abolishes control of ATP levels and attenua

39 ies indicate that the leash is important for ATP synthase activity and support a mechanism in which r

40 The subsequent inhibition of ATP synthase activity causes complex I oxidative damage,

41 1 inhibits ATP synthase activity from isolated mitochondria and tri

42 ts indicate that Abeta-mediated reduction of ATP synthase activity in AD pathology results from direc

43 The low light-specific decrease in ATP synthase activity in ntrc resulted in a buildup of t

44 on, mothra retained wild-type fine-tuning of ATP synthase activity in response to changes in ambient

45 trol mechanism of the nanomotor to favor the ATP synthase activity over the ATPase turnover in the al

46 which was likely caused by the 33-51% lower ATP synthase activity present in both vehicle- and rapam

47 clein concentrations is able to increase the ATP synthase activity that rescues the mitochondrial phe

48 and matrix, [MgADP]-dependent mitochondrial ATP synthase activity, and cytosolic free ADP homeostasi

49 eta-adrenergic responsiveness, mitochondrial ATP synthase activity, cell survival signaling, and othe

50 that ATP5G1 is a rate-limiting component for ATP synthase activity, knockdown of ZC3H14 decreases cel

51 rate, mitochondrial membrane potential, F1F0-ATP synthase activity, or gross mitochondrial morphology

52 phosphate was reduced to levels that limited ATP synthase activity.

53 We used a mutant gamma ATP synthase allele (MGA) to circumvent the normal essen

54 the F1-gamma-subunit of the two-sector F1Fo-ATP synthase allow for Fo-independent generation of a mi

55 obacterial C-terminal domain to a standard F-ATP synthase alpha subunit suppresses ATPase activity.

56 The ATP synthase, also known as complex V of the mitochondri

57 these differences may lie in the chloroplast ATP synthase amount, which declined dramatically in the

58 rgetics through its ability to interact with ATP synthase and increase its efficiency.

59 ts show that the yeast PTP originates from F-ATP synthase and indicate that dimerization is required

60 esults from direct binding between Abeta and ATP synthase and inhibition of O-GlcNAcylation of Thr432

61 eaum equitans, lacks several subunits of the ATP synthase and is suspected to be energetically depend

62 ndosymbionts: the alpha and beta subunits of ATP synthase and its relatives, and the elongation facto

63 proteins, including increases in plastidial ATP synthase and some CBC enzymes, relieved potential bo

64 eral of these protein complexes, such as the ATP synthase and the ATP/ADP carriers, show an increase

65 Here we show that ectopic ATP synthase and the electron transfer chain exist on th

66 that the pore is associated with the dimeric ATP synthase and the oligomycin sensitivity conferral pr

67 onferring protein (OSCP) subunit of the F1FO-ATP synthase and the physical interaction of OSCP with a

68 Dimerization of the F1FO-ATP synthase and the presence of the MICOS complex are n

69 We show that alpha-KG inhibits ATP synthase and, similar to ATP synthase knockdown, inh

70 rast, transcripts of adenosine triphosphate (ATP) synthase and ribosomal protein genes were depleted

71 ) synthesis, combining Escherichia coli F1Fo ATP-synthase and the primary proton pump bo3-oxidase, in

72 rotations of the Fo and F1 rotary motors in ATP synthase, and explain the need for the finer steppin

73 force: the bacterial flagellar motor, the Fo ATP synthase, and the gliding motor.

74 electron transport chain membrane complexes, ATP synthase, and the mitochondrial contact site and cri

75 We found that UCP4, F0F1-ATP synthase, and the mitochondrial marker voltage-depen

76 A3B3DF, from the Methanosarcina mazei Go1 A-ATP synthase, and the thermophilic motor alpha3beta3gamm

77 ng the unique features of the P. tetraurelia ATP synthase are directly responsible for generating the

78 is that uncoupling protein 4 (UCP4) and F0F1-ATP synthase are spatially separated to eliminate compet

79 P synthases are well characterized, archaeal ATP synthases are relatively poorly understood.

80 F-type ATP synthases are rotary nanomotor enzymes involved in c

81 FOF1 ATP synthases are rotary nanomotors that couple proton t

82 F1Fo-ATP synthases are universal energy-converting membrane p

83 Whereas eukaryotic and prokaryotic ATP synthases are well characterized, archaeal ATP synth

84 rmophilus (formerly known as Bacillus PS3) F-ATP synthase, are resolved at 5 mus resolution for the f

85 of resistant mutants implicates the vacuolar ATP synthase as a genetic determinant of resistance to T

86 ments can be corrected using theory, with F1-ATP synthase as an example.

87 ant mutants of SQAs unambiguously identified ATP synthase as its molecular target.

88 ulosis has validated adenosine triphosphate (ATP) synthase as an attractive target to kill Mycobacter

89 Cox6p involvement in ATP synthase assembly is also supported by studies showi

90 Minor deficits in respiration and ATP synthase assembly were noted in individual mutants.

91 cI) proteins that are thought to function in ATP synthase assembly.

92 membrane rotor of the Acetobacterium woodii ATP synthase, at 2.1 A resolution.

93 The chloroplast CF0-CF1-ATP synthase (ATP synthase) is activated in the light an

94 these genes, which include three subunits of ATP synthase, atp1, atp8 and atp9 and two cytochrome gen

95 The alpha- and beta-subunits of ATP synthase, AtpA and AtpD, are translated from the sam

96 F1F0 ATP synthase (ATPase) either facilitates the synthesis o

97 The chloroplast F1Fo-ATP synthase/ATPase (cpATPase) couples ATP synthesis to

98 ATP synthases (ATPases) are enzymes that produce ATP and

99 We knocked out the mitochondrial ATP synthase beta subunit gene in the rodent malaria par

100 We crossed the self-infertile ATP synthase beta subunit knockout parasites with a male

101 ce knockout of hpRNA1 derepresses its target ATP synthase-beta in testes and compromises spermatogene

102 he C2H2-inhibition, while genes encoding for ATP synthase, biosynthesis, and Hym hydrogenase were dow

103 photosystems, cytochrome b(6)f complex, and ATP synthase but 30% more light-harvesting complex II th

104 healthy mitochondria, a pool of SIRT3 binds ATP synthase, but upon matrix pH reduction with concomit

105 ect connection between the precisely adapted ATP synthase c-ring stoichiometry and its ion-to-ATP rat

106 The recent demonstration that the F-ATP synthase can reversibly undergo a Ca(2+)-dependent t

107 Bacterial ATP synthases can be autoinhibited by the C-terminal dom

108 Mitochondrial ATP synthase catalyzes the coupling of oxidative phospho

109 H(+)-transporting F1F0 ATP synthase catalyzes the synthesis of ATP via coupled

110 cation and extent of PTMs in the chloroplast ATP synthase (cATPase) purified from spinach leaves.

111 Fo-dependent rotation of the c10 ring in the ATP synthase (clockwise) direction against the countercl

112 Perturbation of ATP synthase completely blocks transmission to the mosqu

113 suggest that the pore is associated with the ATP synthase complex and specifically with the ring of c

114 to generate a proton-motive force using the ATP synthase complex during fermentation.

115 protein C7orf55 (FMC1) and the mitochondrial ATP synthase complex that we have experimentally validat

116 o be associated with the dimeric form of the ATP synthase complex, therefore we propose that the inte

117 ing, but instead in the stabilization of the ATP synthase complex.

118 e we show that proper expression of the F1FO ATP synthase (complex V) depends on a cytosolic complex

119 Furthermore, the F1Fo ATP synthase (complex V) is unique, with the highly cons

120 ochondrial vesicles (SMVs) enriched for F1FO ATP synthase (complex V).

121 din A, selective inhibitors of the mammalian ATP synthase (complex V).

122 The c-rings of ATP synthases consist of individual c-subunits, all of w

123 is possible to generate a functional E. coli ATP synthase containing a b/delta fusion protein.

124 Thus, although N. equitans possesses an ATP synthase core A3B3 hexameric complex, it might not f

125 We conclude that ectopic ATP synthase could be an accessible molecular target for

126 Notably, blockade of the F1F0 ATP synthase-CypD interaction by CypD ablation protected

127 evation of CypD triggers enhancement of F1F0 ATP synthase-CypD interaction, which in turn leads to mP

128 um albumin, apolipoprotein B, HSP27, H-FABP, ATP synthase, cytochrome bc-1 subunit 1 and alpha-ETF.

129 h yeast and patient-derived cells exhibiting ATP synthase deficiency.

130 Leigh syndrome (MILS) patient iPS cells with ATP synthase deficiency.

131 in intact membrane-embedded mycobacterial F-ATP synthases deletion of the C-terminal domain enabled

132 ndent regulation of oxidative metabolism and ATP synthase-dependent respiration in beta cell mitochon

133 We observe that ATP synthase-dependent respiration is markedly increased

134 t dimers results in the formation of helical ATP synthase dimer arrays, which differ from the loose d

135 ned the structure of an intact mitochondrial ATP synthase dimer by electron cryo-microscopy at near-a

136 Dissociation of the ATP synthase dimer may involve the peptidyl prolyl isome

137 ucture and organization of the mitochondrial ATP synthase dimer of the ciliate Paramecium tetraurelia

138 iates and other eukaryotes, the formation of ATP synthase dimer rows is a universal feature of mitoch

139 Conversely, deleting F1Fo-ATP synthase dimerization factors generates concentric r

140 Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated crist

141 ATP synthase dimers determine sharp cristae edges, where

142 mine the in situ structures of mitochondrial ATP synthase dimers from two organisms belonging to the

143 despite major structural differences between ATP synthase dimers of ciliates and other eukaryotes, th

144 Purified F-ATP synthase dimers of yeast mitochondria display Ca(2+)

145 The ATP synthase dimers that form rows at the cristae tips d

146 ATP synthase dimers vs monomers and state-3/state-4 resp

147 er-membrane vesiculation and dissociation of ATP synthase dimers would impair the ability of mitochon

148 rmancy in glycolytic cells via disruption of ATP synthase dimers.

149 Indeed, Abeta bound to ATP synthase directly and reduced the O-GlcNAcylation of

150 protein sorting as an intervention point for ATP synthase disorders, and because of the central role

151 roves an array of phenotypes associated with ATP synthase disorders, including biogenesis and activit

152 Using yeast models of mitochondrial ATP synthase disorders, we screened a drug repurposing l

153 zes at atomic resolution the N-terminal HerA-ATP synthase domain and a conserved C-terminal extension

154 , the molecular mechanisms that connect F1FO-ATP synthase dysfunction and AD remain unclear.

155 Therefore, mitochondrial F1FO-ATP synthase dysfunction associated with AD progression

156 P carrier, whereas MgADP is the substrate of ATP synthase (EC 3.6.3.14), the cytosolic and mitochondr

157 ore, synuclein deficiency results in reduced ATP synthase efficiency and lower ATP levels.

158 lein in its unfolded monomeric form improves ATP synthase efficiency and mitochondrial function.

159 lity of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions m

160 onfirmed by RNAi repression of the F(0)/F(1)-ATP synthase F(1)beta subunit, which is lethal when perf

161 The ATP synthase (F(O)F1) of Escherichia coli couples the tr

162 Similarly, the ATP synthase F0 subunit 6 from normal human mitochondria

163 get mRNAs, we selected the gene encoding the ATP synthase F0 subunit C (ATP5G1) transcript.

164 stress responses, whereas the mitochondrial ATP synthase F0 subunit component is a vasoactive peptid

165 philin D/cyclosporine A binding sites in the ATP synthase F1, providing a mechanism for mPTP opening.

166 The proton-driven ATP synthase (FOF1) is comprised of two rotary, stepping

167 tem II (PSII), cytochrome b6f (cyt b6f), and ATP synthase (FOF1).

168 tituted c-subunit ring of the FO of the F1FO ATP synthase forms a voltage-sensitive channel, the pers

169 The ATP synthase forms U-shaped dimers with parallel monomer

170 In mitochondria of yeast and mammals, the ATP synthase forms V-shaped dimers, which assemble into

171 tial role in determining the transition of F-ATP synthase from and energy-conserving into an energy-d

172 eotide-bound A3B3 structure of the related A-ATP synthase from Enterococcus hirae, the arrangements o

173 The ATP synthase from Gram-positive and -negative model bact

174 We applied this strategy to the F-type ATP synthase from spinach chloroplasts (cATPase) providi

175 The structure of the intact ATP synthase from the alpha-proteobacterium Paracoccus d

176 The structure of the intact monomeric ATP synthase from the fungus, Pichia angusta, has been s

177 ed the structure of a complete, dimeric F1Fo-ATP synthase from yeast Yarrowia lipolytica mitochondria

178 energy coupling are essentially the same in ATP synthases from all forms of life, yet the protein co

179 re identified that prevent epsilon-deficient ATP synthases from dissipating the electrochemical poten

180 olecular mechanism whereby vacuolar (V-type) ATP synthase fulfills its biological function remains la

181 connecting link between diabetic insult and ATP synthase function.

182 th ATP synthase subunit alpha, and modulates ATP synthase function.

183 Two host proteins in enriched fractions, ATP-synthase gamma-subunit (AtpC) and Rubisco activase (

184 rasites lacking the beta subunit gene of the ATP synthase generated viable gametes that fuse and form

185 Several holoparasites retain ATP synthase genes with intact open reading frames, sugg

186 anscription and mitochondrial translation of ATP synthase genes.

187 rotein 1), SCMAS (subunit c of mitochondrial ATP synthase), glypican 5, beta-amyloid, P-tau] were red

188 nes such as THPO (thrombopoietin) and ATP5B (ATP synthase, H+ transporting, mitochondrial F1 complex,

189 ation with AD in the adenosine triphosphate (ATP) synthase, H+ transporting, mitochondrial F0 (ATP5H)

190 kinetes lacking the beta subunit gene of the ATP synthase had normal motility but were not viable in

191 disulfide/sulfhydryl couple in the modified ATP synthase has a more reducing redox potential and thu

192 tional information obtained on the E. coli F-ATP synthase has been generated using cryo-electron micr

193 diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputu

194 gtC interacts with the a subunit of the F1Fo ATP synthase, hindering ATP-driven proton translocation

195 Under pathological conditions, ATP synthase hydrolyzes ATP to replenish protons from th

196 isplay storage of subunit c of mitochondrial ATP-synthase, hypertrophic lysosomes as well as localize

197 that probably do not involve the chloroplast ATP synthase, implicating this system in multiple photos

198 ment, we have functionally reconstituted the ATP synthase in giant unilamellar vesicles and tracked t

199 The hydrolysis of ATP by the ATP synthase in mitochondria is inhibited by a protein c

200 ndamental role for sequestration of SIRT3 by ATP synthase in mitochondrial homeostasis.

201 emergence of collective effects of rotating ATP synthases in lipid membranes.

202 otal respiration under resting conditions is ATP synthase-independent.

203 functionally tagged PSI, PSII, Cyt b6f, and ATP synthase individually with fluorescent proteins, and

204 Channel openings were inhibited by the ATP synthase inhibitor AMP-PNP (gamma-imino ATP, a nonhy

205 ubunit of the enzyme at the same site as the ATP synthase inhibitor benzodiazepine 423 (Bz-423), that

206 and carboxyatractyloside (CAT), and the F1FO-ATP synthase inhibitor, oligomycin (OLIG), inhibited ure

207 arations were treated with the mitochondrial ATP synthase inhibitors oligomycin or dicyclohexylcarbod

208 hepatocyte surface expression of beta-chain ATP synthase, inhibits the removal of HDL-apolipoprotein

209 ibitory factor 1 (IF1) is a nuclear-encoded, ATP synthase-interacting protein that selectively inhibi

210 Thus, blockade of ATP synthase interaction with CypD provides a promising

211 vesicles, and the membrane curvature at the ATP synthase inverts.

212 ixfold ring arrangement typical of all other ATP synthases investigated so far.

213 ATP synthase is a rotating membrane protein that synthes

214 The activity of the ATP synthase is also fine-tuned during steady-state phot

215 The central stalk of the ATP synthase is an elongated hetero-oligomeric structure

216 F1FO-ATP synthase is critical for mitochondrial functions.

217 Mitochondrial ATP synthase is driven by chemiosmotic oxidation of pyru

218 The proton-driven ATP synthase is embedded in a proton tight-coupling memb

219 oites, which demonstrates that mitochondrial ATP synthase is essential for ongoing viability through

220 The "stator stalk" of F1Fo-ATP synthase is essential for rotational catalysis as it

221 F(o)F(1) ATP synthase is interesting as a model system: a delicat

222 The chloroplast ATP synthase is known to be regulated by redox modulatio

223 ATP synthase is likewise a key enzyme of cell respiratio

224 at the inner boundary membrane, whereas F0F1-ATP synthase is more centrally located at the cristae me

225 h begs the question of whether mitochondrial ATP synthase is necessary during the blood stage of the

226 ATP synthase is organized into supramolecular units call

227 Rotary catalysis in F1F0 ATP synthase is powered by proton translocation through

228 e efficiency of ATP production, while within ATP synthase is the cyclophilin D (CypD) regulated mitoc

229 ATP synthase is the most prominent bioenergetic macromol

230 Mitochondrial adenosine 5'-triphosphate (ATP) synthase is a multiprotein complex that synthesizes

231 The F1F0 -ATP (F-ATP) synthase is essential for growth of Mycobacterium t

232 The chloroplast CF0-CF1-ATP synthase (ATP synthase) is activated in the light and inactivated

233 F1-ATPase, the catalytic complex of the ATP synthase, is a molecular motor that can consume ATP

234 ), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobact

235 pha-KG inhibits ATP synthase and, similar to ATP synthase knockdown, inhibition by alpha-KG leads to

236 ss and its interplay with Abeta disrupt F1FO-ATP synthase, leading to reduced ATP production, elevate

237 ns down a large electrochemical gradient via ATP synthase located on the folded inner membrane, known

238 ns down a large electrochemical gradient via ATP synthase located on the folded inner membrane, known

239 s signal recognition particle components and ATP synthase machinery.

240 Inhibition of mitochondrial ATP synthase markedly reduces macrophage cholesterol eff

241 g enhanced interaction of cyclophilin D with ATP synthase mediates L-arginine-induced pancreatitis, a

242 This suggests that this ATP synthase might be a rudimentary machine.

243 itol polyphosphate 5-phosphatase J (Inpp5j), ATP synthase mitochondrial F1 complex O subunit (Atp5o),

244 tp5o), phytanol-CoA-2hydroxylase (Phyh), and ATP synthase mitrochondrial F1 complex alpha subunit 1 (

245 We then generated a heterologous F-ATP synthase model system, which demonstrated that trans

246 of PD-1 decreased the efficacy of later F1F0-ATP synthase modulation.

247 evidence that before its assembly with other ATP synthase modules, most of Atp9p is present in at lea

248 on may be sufficient to produce the level of ATP synthase needed for maintaining a membrane potential

249 The ATP synthases of these organisms present a unique model

250 Disruption of the beta subunit gene of the ATP synthase only marginally reduced asexual blood-stage

251 ATP synthases operate by a rotary catalytic mechanism wh

252 In the case of the ATP synthase pgr5 double mutant, a decrease in photosens

253 n addition to their synthase function most F-ATP synthases possess an ATP-hydrolase activity, which i

254 ATP synthases produce ATP by rotary catalysis, powered b

255 portion is distantly related to prokaryotic ATP SYNTHASE PROTEIN1 (Atp1/UncI) proteins that are thou

256 ese results, we reassess previous models for ATP synthase regulation and propose that NTRC is most li

257 tly related a subunit from the bovine F-type ATP synthase revealed a conserved pattern of residues, s

258 increased levels of ATPIF1, an inhibitor of ATP synthase reversal-dependent mitochondrial repolariza

259 We find that ATP synthase rotates at a frequency of about 20 Hz, prom

260 P production by increasing the expression of ATP synthase's catalytic domain, cytochrome c oxidase an

261 es, including the subunit c of mitochondrial ATP synthase (SCMAS).

262 s, in particular the transcript encoding the ATP synthase subunit 6 (A6).

263 e oxidase 1 (COX1) by 4-fold, P < 0.001; and ATP synthase subunit 6 (ATP6) by 6.5-fold, P < 0.005); b

264 rome oxidase subunit 1, Apocytochrome b, and ATP synthase subunit 6 in the cytoplasm of HeLa cells co

265 Here, we found that ATP synthase subunit alpha (ATP5A) was O-GlcNAcylated at

266 glyceraldehyde-3-phosphate dehydrogenase and ATP synthase subunit alpha in Escherichia coli BL21 impr

267 nd localizes to mitochondria, interacts with ATP synthase subunit alpha, and modulates ATP synthase f

268 els of carbamyl-palmitoyl transferase 1a and ATP synthase subunit ATP5G1 were reduced in livers of AL

269 t the lifespan increase by alpha-KG requires ATP synthase subunit beta and is dependent on target of

270 ATP synthase subunit beta is identified as a novel bindi

271 atient isolates had nonsynonymous changes in ATP synthase subunit c (atpE), the primary target of BDQ

272 The lysosomes contain mitochondrial F0-ATP synthase subunit c along with undigested membranes,

273 r assays, and western blot also verified the ATP synthase subunit genes ATP5G1 and ATPIF1 as bone fid

274 cYEG determinant for the endogenous proteins ATP synthase subunits a and b and the TatC subunit of th

275 orophyll-binding proteins in chloroplasts to ATP synthase subunits in bacteria.

276 ontrol mechanism that links the synthesis of ATP synthase subunits in Chlamydomonas reinhardtii does

277 aTIM11 and DeltaATP20 (lacking the e and g F-ATP synthase subunits, respectively, which are necessary

278 leotide-binding subunit alpha (Mtalpha) of F-ATP synthase suppresses its ATPase activity and determin

279 F1-ATPase, the catalytic domain of ATP synthase, synthesizes most of the ATP in living orga

280 refore, none of the membrane subunits of the ATP synthase that are involved directly in transmembrane

281 ation in the PTP; thus, the only subunits of ATP synthase that could participate in pore formation ar

282 and a reassessment of the modifications of F-ATP synthase that take place in the heart under patholog

283 pparatus, resulting in a loss of chloroplast ATP synthase that then limits photosynthetic capacity.

284 The functional Na(+) specificity of this ATP synthase thus results from two opposing factors, nam

285 cteriorhodopsin (BR) proteins cooperate with ATP synthase to convert captured solar energy into a bio

286 Living organisms rely on the FoF1 ATP synthase to maintain the non-equilibrium chemical gr

287 electrochemical gradient that is used by the ATP synthase to make ATP.

288 cells were oligomycin resistant, suggesting ATP synthase uncoupling and bypass of the normal Fo-A6-s

289 into the mitochondrial matrix independent of ATP synthase, uncoupling nutrient metabolism from ATP ge

290 , is formed within the c-subunit ring of the ATP synthase, upon its dissociation from the catalytic d

291 The rotary motor enzyme FoF1-ATP synthase uses the proton-motive force across a membr

292 The enzymatic activities of Complex II and ATP synthase were also significantly reduced.

293 esulted in a mutant, termed mothra, in which ATP synthase which lacked light-dark regulation had rela

294 Purified dimers of the ATP synthase, which did not contain voltage-dependent an

295 ectively inhibits the hydrolysis activity of ATP synthase, which may render the protective role of IF

296 mitochondrial respiratory chain and in the F-ATP synthase, while adults had a COX-selective impairmen

297 Our results demonstrate that the mutant ATP synthases with either c12 or c13 can support ATP syn

298 ndria in HAP1-A12 cells assemble a vestigial ATP synthase, with intact F1-catalytic and peripheral st

299 opposed rotary molecular motors of the F0F1-ATP synthase work together to provide the majority of AT

300 NA transcription, ribosomal translation, and ATP synthase, yet differ in equally fundamental traits t