ライフサイエンスコーパス: ATP-citrate lyase

1 (via acetyl-CoA synthetase) or citrate (via ATP citrate lyase).

2 on a cytosolic enzyme of citrate metabolism, ATP citrate lyase.

3 inhibitors of the recombinant human form of ATP-citrate lyase.

4 een observed with mammalian, yeast, and mold ATP-citrate lyase.

5 s of the reductive tricarboxylic acid cycle, ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreduct

6 Lowering ATP citrate lyase 88% did not inhibit glucose-induced in

7 n of these biosynthetic genes, which include ATP citrate lyase, ACC, FAS, and stearoyl-CoA desaturase

8 ATP citrate lyase (ACL) catalyzes an ATP-dependent biosy

9 in BNIP-H/Caytaxin links kinesin-1 (KLC1) to ATP citrate lyase (ACL), a key enzyme for ACh synthesis,

10 ondria-derived citrate through the action of ATP citrate lyase (ACL).

11 ells is dependent on adenosine triphosphate (ATP)-citrate lyase (ACL), the enzyme that converts gluco

12 d has been previously shown to modulate both ATP-citrate lyase (ACL) and AMP-activated protein kinase

13 ATP-citrate lyase (ACL) is an essential enzyme of the re

14 zyme A (acetyl-CoA) production by the enzyme ATP-citrate lyase (ACL).

15 cose concentration, and nuclear functions of ATP-citrate lyase (ACL).

16 r to the amino and carboxy portions of human ATP-citrate lyase (ACL).

17 nthase (FASN), acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY)].

18 ytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citra

19 ATP-citrate lyase (ACLY) is a cytosolic enzyme that cata

20 ATP-citrate lyase (Acly) is one of two cytosolic enzymes

21 In this study, we report that nuclear ATP-citrate lyase (ACLY) is phosphorylated at S455 downs

22 ATP-citrate lyase (ACLY) is upregulated or activated in

23 ATP-citrate lyase (ACLY), a key enzyme for lipid synthes

24 nding proteins in breast cancer, identifying ATP-citrate lyase (ACLY), an enzyme in the de novo lipog

25 tion leads to increased levels of endogenous ATP-citrate lyase (ACLY), and this is accompanied by inc

26 c acidosis is associated with an increase in ATP citrate lyase activity and protein abundance, and is

27 hypocitraturia and increased renal cortical ATP citrate lyase activity by 28%.

28 raturia in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d.

29 ali feeding was associated with no change in ATP citrate lyase activity.

30 Thus, human ATP:citrate lyase activity is regulated in vitro alloste

31 r weight loss, is a competitive inhibitor of ATP-citrate lyase, an extramitochondrial enzyme involved

32 l-length HCV RNAs express elevated levels of ATP citrate lyase and acetyl-CoA synthetase genes, both

33 and elongation in tumour cells by targeting ATP citrate lyase and fatty acid elongase 6, as well as

34 cumulation of citrate and the stimulation of ATP citrate lyase and fatty-acid synthase leading to de

35 expression by RNAi inhibits up-regulation of ATP citrate lyase and fatty-acid synthase.

36 fically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two ke

37 rom its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase.

38 fatty-acid synthase, acetyl-CoA carboxylase, ATP citrate lyase, and Glut-1 were significantly increas

39 m proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

40 Induction of spot 14, ATP citrate-lyase, and fatty acid synthase polypeptides,

41 The rates of phosphorylation of ATP-citrate lyase by nm23-H1(S120G) and nm23-H1(P96S) we

42 ynthesis of fatty acids from glucose include ATP-citrate lyase (CL) and fatty acid synthase (FAS).

43 Flux through ATP-citrate lyase, combined with malic enzyme activity,

44 nes encoding the alpha- and beta-subunits of ATP citrate lyase could be amplified from both organisms

45 the situation observed for other prokaryotic ATP-citrate lyase enzymes, the C. tepidum enzyme was not

46 ratio of ATP/ADP, phospholipid content, and ATP citrate lyase expression.

47 eam of FAS, acetyl-CoA carboxylase-alpha and ATP-citrate lyase, fails to activate caspase-8 or to eli

48 RNAs coding for key lipogenic (malic enzyme, ATP citrate-lyase, fatty acid synthase), glycolytic (pyr

49 ed induction of mRNAs encoding malic enzyme, ATP citrate-lyase, fatty acid synthase, liver-type pyruv

50 Both forms of RuBisCO, together with ATP citrate lyase genes in the rTCA cycle, increase with

51 enic genes, including SCD1, FAS, ACC1, ACC2, ATP-citrate lyase, glycerol kinase, and HMG-CoA reductas

52 the hypothesis that compounds which inhibit ATP-citrate lyase have the potential to be a novel class

53 These results suggest an important role for ATP citrate lyase in proximal tubular citrate metabolism

54 ved pyruvate through the citrate shuttle and ATP citrate lyase in the cytosol.

55 nase and fumarase and activate the cytosolic ATP-citrate lyase in vivo, acting as a direct regulator

56 gnificant differences from other prokaryotic ATP-citrate lyases, including the enzyme from the closel

57 with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T

58 Interestingly, the expression of ATP-citrate lyase is increased in Nat8l-silenced adipocy

59 Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, a

60 igh-fat diet (HFD) results in suppression of ATP citrate-lyase levels in tissues such as adipose and

61 Phosphorylation of C. tepidum ATP-citrate lyase occurred, presumably on a histidine re

62 atty acid synthase (FAS), and phosphorylated ATP-citrate lyase (pACL).

63 ATP citrate-lyase produces acetyl-CoA in the nucleus and

64 Renal cortical ATP citrate lyase protein abundance increased by 29% aft

65 ties, the catalytic properties of C. tepidum ATP-citrate lyase showed marked similarities to the euka

66 studies we show that the levels of mRNA for ATP citrate lyase, the enzyme that produces acetyl-CoA,

67 Recombinantly expressed human ATP:citrate lyase was purified from E. coli, and its kin

68 One of the key enzymes, ATP-citrate lyase, was purified to apparent homogeneity

69 Activity and protein of ATP citrate lyase, which uses anaplerotic products in th

70 Two cytosol ATP-citrate lyases, which take part in the cycle of citr

71 Inhibition of ATP citrate lyase with the competitive inhibitor, 4S-hyd