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1 AV differences existed between SOSDEs with different gal
2 AV has anti-inflammatory, antioxidant, antimicrobial, hy
3 AV-1451 tau binding in the medial temporal, parietal, an
5 We quantified in vivo retention of [F-18]-AV-1451 and performed autoradiography, [H-3]-AV-1451 bin
6 radiography failed to show detectable [F-18]-AV-1451 binding in multiple brain regions examined, with
8 1451 phosphor screen autoradiography, [F-18]-AV-1451 nuclear emulsion autoradiography, and [H-3]-AV-1
12 gnificant correlation between in vivo [F-18]-AV-1541 retention and postmortem in vitro binding and ta
15 differential affinities for 11C-PBB3 and 18F-AV-1451, and higher availability of binding sites on pro
16 ndent regressions were performed between 18F-AV-1451 binding and each cognitive domain, and we used t
18 ve to patients with Alzheimer's disease, 18F-AV-1451 binding was elevated in the midbrain (t = 2.1, P
19 line with moderate 11C-PBB3 versus faint 18F-AV-1451 autoradiographic labelling of these tissues.
20 tomography tracers such as flortaucipir (18F-AV-1451, also known as 18F-T807) have made it possible t
21 ed highly associated patterns of greater 18F-AV-1451 binding and increased annualized change in corti
22 rain regions was associated with greater 18F-AV-1451 PET retention most prominently in the inferior t
25 in each domain was related to increased 18F-AV-1451 binding in specific brain regions conforming to
26 showed, relative to controls, increased 18F-AV-1451 uptake in the putamen, pallidum, thalamus, midbr
27 Overall, we confirm the potential of 18F-AV-1451 as a heuristic biomarker, but caution is indicat
28 elanin is an insufficient explanation of 18F-AV-1451 positron emission tomography data in vivo, at le
29 ng may contribute to disease profiles of 18F-AV-1451 positron emission tomography, especially in prim
33 B) positron emission tomography and tau (18F-AV-1451) positron emission tomography, and episodic and
36 mortem autoradiographic data showed that 18F-AV-1451 strongly bound to Alzheimer-related tau patholog
38 palsy, and a control case to assess the 18F-AV-1451 binding specificity to Alzheimer's and non-Alzhe
39 e-associated variability; and (iii) this 18F-AV-1451 positron emission tomography retention pattern s
40 mission tomography binding antecedent to 18F-AV-1451 positron emission tomography scans, and to what
41 in florbetapir retention, antecedent to 18F-AV-1451 positron emission tomography scans, in the parie
42 the positron emission tomography tracer 18F-AV-1451) associated with well-established Alzheimer's di
43 between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer
44 aging with fluorine 18-labeled AV-1451 ([18F]AV-1451) (formerly known as [18F]T807), [11C]PiB PET, ma
45 easured by fluorine 18-labeled AV-1451 ([18F]AV-1451) positron emission tomographic (PET) imaging are
47 Results: In patients with DLB, cortical [18F]AV-1451 uptake was highly variable and greater than in t
48 r DLB and PD-impaired patients, greater [18F]AV-1451 uptake in the inferior temporal gyrus and precun
50 rongly correlated with the magnitude of [18F]AV-1451 binding (3 patients with amnesic Alzheimer disea
51 18F]AV-1451 binding, the association of [18F]AV-1451 binding with [11C]PiB binding, and the associati
53 on of diagnostic groups on the basis of [18F]AV-1451 binding, the association of [18F]AV-1451 binding
54 vivo evidence that distribution of the [18F]AV-1451 signal as seen on results of PET imaging is a va
58 Abeta+ was associated with an elevated [18F]-AV-1451 SUVR in AD cortical signature regions (Abeta+ pa
60 nverse association between hippocampal [18F]-AV-1451 SUVR and volume was seen in Abeta+ participants
63 ndardized uptake value ratio (SUVR) of [18F]-AV-1451 in the hippocampus and a priori-defined AD corti
65 in mice vaccinated with AV-1959R or AV-1959R/AV-1980R combination, anti-tau titers were significantly
67 AV-1451 and performed autoradiography, [H-3]-AV-1451 binding assays, and quantitative tau measurement
68 nuclear emulsion autoradiography, and [H-3]-AV-1451 in vitro binding assays to the study of postmort
70 cided to generate vaccines, targeting Abeta (AV-1959R), Tau (AV-1980R) or Abeta/tau (AV-1953R) B cell
71 ac mutant photoreceptor terminals accumulate AV-lysosomal fusion intermediates, suggesting that Cac i
73 ti-tau titers were significantly lower after AV-1953R injection when compared to the AV-1980R or AV-1
81 AV-1953R, or the combination of AV-1959R and AV-1980R vaccines formulated with Advax(CpG) induced rob
83 tion of the phenolic compounds in HS, CA and AV extracts and was compared along with ten standard phe
86 ssociations between mean visit frequency and AV fistula creation or graft placement in the first 90 d
87 sitron emission tomography ligands, PBB3 and AV-1451, by fluorescence, autoradiography and homogenate
88 of non-ghost and ghost tangles with PBB3 and AV-1451, while dystrophic neurites were more clearly det
94 ional flortaucipir F 18 (previously known as AV 1451, T807) positron emission tomography (FTP-PET) im
96 dycardia (25 cases), ictal atrioventricular (AV)-conduction block (11 cases), postictal AV-conduction
100 stem (T3SS) is a well-studied and attractive AV target, given that it is widespread in more than 25 s
102 In this study, we examined audiovisual (AV) processing in normal and visually impaired individua
103 ness, in the context of natural audiovisual (AV) speech processing, relies on crossmodal integration
105 ides act on purinoceptors on cardiomyocytes, AV and SA nodes, cardiac fibroblasts, and coronary blood
108 other RCC subtypes are aorta-based corrected AV and aorta-based corrected relative contrast enhanceme
109 9-95 HU and renal parenchyma-based corrected AV of 87-95 HU showed a diagnostic accuracy of 81-86%, 8
110 ut-off AV of 86-89 HU, aorta-based corrected AV of 89-95 HU and renal parenchyma-based corrected AV o
113 clinical effectiveness of locally delivered AV gel used as an adjunct to scaling and root planing (S
115 in the SMART-AV study (SmartDelay Determined AV Optimization: A Comparison to Other AV Delay Methods
116 lure, left ventricular systolic dysfunction, AV block, atrial or ventricular arrhythmias, and sudden
117 as sufficient to induce formation of ectopic AV junction-like tissue as assessed by morphology, gene
121 tion 2 h after injection of 250 MBq of (18)F-AV-133, and the resulting images were quantitatively ass
123 ges were calculated from 80-100 minute (18)F-AV-1451 (also known as T807) positron emission tomograph
124 dults using the radioactive tau ligand (18)F-AV-1451 (previously known as T807) who also underwent a
125 erent strategies for quantification of (18)F-AV-1451 (T807) tau binding, including models with blood
128 R30-150 < 1.5), and for ROIs with high (18)F-AV-1451 binding (hROIs, mean of BPND + 1 and DVR30-150 >
129 in), for all values, for ROIs with low (18)F-AV-1451 binding (lROIs, mean of BPND + 1 and DVR30-150 <
130 bjective of this study was to evaluate (18)F-AV-1451 binding with full kinetic analysis using a metab
131 Quantitative region-based analysis of (18)F-AV-1451 images yielded region of interest and voxel leve
133 the novel tau-specific PET radioligand (18)F-AV-1451 in cognitively healthy control (HC) and Alzheime
141 - and sex-matched control subjects had (18)F-AV-1451 positron emission tomography using a Siemens hig
142 Results: AD demonstrated increased (18)F-AV-1451 retention compared with YHV and AHV based on bot
145 as decreased by 45% and the mean total (18)F-AV-1451 substantia nigra volume of distribution was decr
147 lusion: Our data suggest that although (18)F-AV-1451 SUVR curves do not reach a plateau and are still
149 here was no correlation between nigral (18)F-AV-1451 volume of distribution and age or time since dia
150 ed a 30% mean decrease in total nigral (18)F-AV-1451 volume of distribution compared with controls (P
151 hether (18)F-flortaucipir (also called (18)F-AV-1451) PET, targeting tau aggregates, detects these di
153 e not able to describe the kinetics of (18)F-AV-1451, with poor fits in 33%-53% of cortical regions a
154 e not able to describe the kinetics of (18)F-AV-1451, with poor fits in 33%-53% of cortical regions a
155 ssion tomography (PET) tracer known as (18)F-AV-1451; and (2) amyloid-beta, quantified with (11)C-PiB
156 s studied using the novel tau tracer [(18) F]AV-1451 in conjunction with [(11) C]Pittsburgh compound
157 nd throughout association neocortex, [(18) F]AV-1451 was selectively retained in posterior brain regi
159 nalysis, based on the distribution of [(18)F]AV-1451 binding potential, separated semantic dementia f
161 ll be useful to assess the utility of [(18)F]AV-1451 to differentiate and track different types of fr
162 oposed 'off target' binding sites for [(18)F]AV-1451, such as neuronal monoamine oxidase or neuromela
163 le this suggests a non-tau target for [(18)F]AV-1451, the pathological regions in semantic dementia d
164 vo binding of the putative tau ligand [(18)F]AV-1451, which is elevated in frontotemporal lobar degen
166 phoid cell death was detected by fluorescent AV-750 accumulation in the thorax and abdomen (in vivo),
173 e AD dementia group had significantly higher AV-1451 uptake than the probable DLB group, and medial t
174 Center underwent magnetic resonance imaging, AV-1451, and Pittsburgh compound-B (PiB) PET examination
179 resting aortic valve (AV) gradient, indexed AV area, METs, and heart rate recovery were 2.9+/-3%, 58
181 tudies approved of utilitarian AVs (that is, AVs that sacrifice their passengers for the greater good
182 nts (66%) underwent AV surgery (36% isolated AV surgery, 16% concomitant coronary bypass, and 58% aor
184 Exposures: Imaging with fluorine 18-labeled AV-1451 ([18F]AV-1451) (formerly known as [18F]T807), [1
185 gic findings measured by fluorine 18-labeled AV-1451 ([18F]AV-1451) positron emission tomographic (PE
186 at evaluating synchrony of auditory-leading (AV) versus visual-leading (VA) audiovisual stimulus pair
189 ith diabetes, reflecting the effect of lower AV fistula success rates and lower life expectancy.
194 d to the group of iLVESD <2.5 cm/m(2) and no AV surgery, the 2 groups of iLVESD <2.5 cm/m(2) with AV
195 ated posterior temporoparietal and occipital AV-1451 uptake in probable DLB and its association with
196 +/- 13 versus 91 +/- 9 ms, P < 0.01), and of AV node Wenckebach cycle length (230 +/- 19 versus 213 +
197 the temporal and spatial characteristics of AV processing and assess differences in neural responses
198 ope vaccine, AV-1953R, or the combination of AV-1959R and AV-1980R vaccines formulated with Advax(CpG
199 ter isolating the multisensory components of AV-VA event-related potentials (ERPs) from the sum of th
201 networks learned from a clinical dataset of AV-45 PET image and compare network properties of both u
204 showed slower and less accurate judgments of AV and V stimuli but more accurate responses in the A-al
206 ssociated with a 21% increase in the odds of AV fistula creation or graft placement during that perio
210 ing ccRCC from other RCC subtypes, a cut-off AV of 86-89 HU, aorta-based corrected AV of 89-95 HU and
215 to that in mice vaccinated with AV-1959R or AV-1959R/AV-1980R combination, anti-tau titers were sign
224 (AV)-conduction block (11 cases), postictal AV-conduction block (2 cases), (post)ictal atrial flutte
225 ne the correlation of in vivo and postmortem AV-1451 binding patterns in three autopsy-confirmed non-
229 t regulatory circuit that establishes proper AV delay, and these findings may have wider implications
233 ts show that IRD individuals exhibit reduced AV integration for concurrent audio and visual (AV) stim
234 high heritability in first-degree relatives, AV genetic determinants remain incompletely understood.
235 Aaron CP, Chervona Y, Kawut SM, Diez Roux AV, Shen M, Bluemke DA, Van Hee VC, Kaufman JD, Barr RG.
236 rved peptide motifs, [GS]LFXG[ML]X[LV] and S[AV]F[SA]FLN, within its C-terminal unstructured region,
237 urvived for 4 weeks and significantly slowed AV conduction and ventricular rate in acutely induced AF
238 tively in 426 patients enrolled in the SMART-AV study (SmartDelay Determined AV Optimization: A Compa
239 x assembly with the SNARE motif mutant Stx1A(AV) (A240V, V244A) was not sufficient to rescue neurotra
241 e vaccines, targeting Abeta (AV-1959R), Tau (AV-1980R) or Abeta/tau (AV-1953R) B cell epitopes, based
242 eta (AV-1959R), Tau (AV-1980R) or Abeta/tau (AV-1953R) B cell epitopes, based on immunogenic MultiTEP
243 Building upon this idea, we proposed that AV integration in spoken language reflects visually indu
245 eal data to index the similarity between the AV and VA maps at each time point (500 ms window after s
247 investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood f
248 despite a large number of injections in the AV nodal area and marked effects on AV conduction, AV bl
250 cted under electroanatomical guidance in the AV nodal area, with continuous 28-day ECG recording.
251 s dermal fibroblast (ADF) injection into the AV nodal area would reduce ventricular response during A
258 s with less than a complete response (CR) to AV-PC received 21-Gy involved-field radiation therapy (I
259 attempt strategy was found to be superior to AV grafts and CVCs in regard to mortality and cost for t
260 at positron emission tomography (PET) tracer AV-1451 exhibits high binding affinity for paired helica
261 ositron emission tomography (PET) tau tracer AV-1451 uptake in patients with probable DLB, compared t
264 .6 +/- 3 years, 933 patients (66%) underwent AV surgery (36% isolated AV surgery, 16% concomitant cor
266 hanical Turk studies approved of utilitarian AVs (that is, AVs that sacrifice their passengers for th
270 of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lys
271 pendent accumulation of autophagic vacuoles (AVs) in photoreceptor terminals and eventually a degener
273 evaluated in terms of CT attenuation values (AV) and differences in contrast density; the aorta or re
275 jection fraction, mean resting aortic valve (AV) gradient, indexed AV area, METs, and heart rate reco
278 simultaneity judgment task including various AV-VA asynchronies and unisensory control conditions (vi
279 ables suppression of allograft vasculopathy (AV) after aorta transplantation, a DSA-mediated process.
281 based model for estimating angular velocity (AV) in the bee brain, capable of quantitatively reproduc
282 ium anterius (AA), the arcopallium ventrale (AV), the arcopallium dorsale (AD), the arcopallium inter
284 ntella asiatica (CA) and Amaranthus viridis (AV) extracts and investigate their respective antioxidan
286 integration for concurrent audio and visual (AV) stimuli but increased brain activity during the unim
293 d with higher longer-term mortality, whereas AV replacement (time-dependent covariate, hazard ratio,
294 sociated with longer-term mortality, whereas AV replacement was associated with improved survival.
295 sual-only, auditory-only) and tested whether AV and VA processing generate different patterns of brai
296 ilencing of miR-214 by anti-miR-214 in whole AV leaflets with the fibrosa exposed to OS significantly
297 ry, the 2 groups of iLVESD <2.5 cm/m(2) with AV surgery and iLVESD >/=2.5 cm/m(2) with AV surgery wer
298 th AV surgery and iLVESD >/=2.5 cm/m(2) with AV surgery were associated with improved survival (hazar
299 were similar to that in mice vaccinated with AV-1959R or AV-1959R/AV-1980R combination, anti-tau tite
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