ライフサイエンスコーパス: Ab

1 Ab initio calculations of spin dynamics demonstrate that

2 Ab initio calculations reveal that the primary assumptio

3 Ab initio calculations suggest that carbon-fluorine bond

4 Ab initio electronic structure calculations reveal that

5 Ab initio linear response computations of the dielectric

6 Ab initio metadynamics simulations of the conformational

7 Ab initio modelling suggests that it has negative stacki

8 Ab initio molecular dynamics (AIMD) simulations and mole

9 Ab initio molecular dynamics (AIMD)-informed EXAFS analy

10 Ab initio molecular dynamics simulations have confirmed

11 Ab initio molecular dynamics simulations suggest the for

12 Ab intio molecular dynamics simulations show that the el

13 Ab structure prediction has made great strides, but accu

14 Ab-dependent cellular cytotoxicity (ADCC) responses are

15 Ab-mediated enhancement of IFN production required Fc ga

16 Abs can elicit a number of mechanisms to delete target c

17 Abs directed against the HIV envelope that do not interf

18 Immunophenotyping revealed that anti-PD-1 Ab treatment did not alter immune effector cell numbers

19 infection and to determine whether anti-PD-1 Ab treatment improves fungal clearance.

20 By using an anti-reticulon-1 Ab, a role for reticulon-1 in macrophage migration towar

21 More than 1 Ab was detected in 7 patients (6.3%): 3 (2.7%) had TPO-A

22 mice with the chimerized and murinized DTA-1 Abs on a C57BL/6-matched IgG2c isotype resulted in reduc

23 (+) cells, mice were treated with anti-LFA-1 Abs to reduce the number of CD11c(+) cells in this space

24 th was prevented with neutralizing anti-IL-2 Ab or STAT5/JAK3 inhibitors, indicating that STAT5 signa

25 sed as the fluoresceinated secondary Ab (2nd-Ab), whereas IgG subclasses are monitored with Fc-specif

26 The fluorescent signal from the 2nd-Ab is measured as mean florescence intensity (MFI).

27 rtificial APCs in the presence of anti-TIM-3 Ab.

28 to deplete IgG Ab. alpha-Gal-specific IgG1-4 Ab in individuals with and without meat allergy were ass

29 Importantly, a monoclonal anti-TIM-4 Ab promoted allograft tolerance, and this was dependent

30 ter excluding TPO-Ab and low-titer GAD65-Ab, Abs strongly suggesting an autoimmune cause of epilepsy

31 d overexpression of ICOS results in aberrant Ab production resembling lupus.

32 T follicular helper numbers and the abnormal Ab production previously reported in these mice.

33 ined by using the square root of absorbance (Abs) in order to adjust the residues of the curve.

34 CD13 and VLA-4 blocking and activating Abs were used in flow-based adhesion assays, live-cell i

35 with various H1N1 or H3N2 strains, the acute Ab response against HA exhibited an inherent bias toward

36 ADCC-Abs titers directed against H7N9 HA or NA proteins.

37 we compared ADCC-mediating antibodies (ADCC-Abs) in sera collected from healthy infants, children an

38 High titers of ADCC-Abs against H7N9 virus-infected cells were detected in s

39 Targeting ADCC-Abs to internal proteins may be a potential mechanism of

40 Further analysis showed that ADCC-Abs titers were significantly higher toward H7N9 NP, as

41 proteins, and correlated strongly with ADCC-Abs titers against H7N9 virus-infected cells.

42 e of CX3CR1-mediated sampling did not affect Ab responses to a noninvasive S.

43 teractions, hexamer formation, and CDC after Ab binds cell-surface Ag.

44 uptake and presentation of in vivo-formed Ag-Ab complexes by i.v. injecting mice with Ag-specific Abs

45 nduced TNFR family-related protein agonistic Ab DTA-1 (rat or murinized IgG2a) can induce the develop

46 ion and antitumor activity of CD27 agonistic Abs have been well documented in mouse models.

47 (ADA), directed against these anti-TNF-alpha Abs after just a few weeks of treatment.

48 nt an immune response against anti-TNF-alpha Abs, suggesting that immune complexes are a major determ

49 rgence of ADAs in the case of anti-TNF-alpha Abs.

50 aim was to test the potential in mice of an Ab that blocks the proteolytic capacity of uPA in the CI

51 -HLA complexes whereas CARs typically use an Ab-derived single-chain fragments variable that recogniz

52 he C3 tickover hypothesis by studies with an Ab (S77) that inhibits tickover in whole serum.

53 ted in increased germinal center B cells and Ab production.

54 restored levels of marginal zone B cells and Ab responses compared with deficiencies observed in CD22

55 production of Ag-specific memory B cells and Ab-secreting plasma cells.

56 tion with an MVA vector elicits cellular and Ab responses in the FRT.

57 iding new tools to study germinal center and Ab responses.

58 n that complement-dependent cytotoxicity and Ab-dependent cellular cytotoxicity favored a membrane-pr

59 ity, Ab-dependent cellular cytotoxicity, and Ab-dependent cellular phagocytosis.

60 connections between IG genomic diversity and Ab-expressed repertoires and structure.

61 ress this, we compared B cell phenotypes and Abs specific for the Plasmodium falciparum vaccine candi

62 fers enhanced FcRn interaction in vitro, and Abs harboring either the Q311R or TLQ mutations have ser

63 EDC) activated anti-LCN2 capture antibodies (Ab).

64 pathway, we conjugated SOD with antibodies (Ab/SOD, size 10nm) to plasmalemmal vesicle-associated p

65 Antibodies (Abs) produced by immunoglobulin (IG) genes are the most

66 People exposed to DENV develop antibodies (Abs) that strongly neutralize the serotype responsible f

67 ylglutaryl-CoA reductase (HMGCR) antibodies (Abs), and the titer of these Abs is correlated with dise

68 demic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis.

69 mily member lacking LTA-specific antibodies (Abs).

70 Here we show that antibodies (Abs) to the rat FRalpha administered during gestation pr

71 We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three

72 tive efficacy.IMPORTANCE Anti-V2 antibodies (Abs) correlated with reduced risk of HIV-1 infection in

73 ion of HIV-1 infection risk with antibodies (Abs) to the V1V2 region of gp120 with high antibody-depe

74 variants that escape cellular and antibody (Ab)-mediated immune pressure, yet possess contemporary f

75 valent immobilization of a coating antibody (Ab), a polyclonal anti-IgG, onto a treated PDMS surface.

76 ) covalently linked with anti-PSMA antibody (Ab) for target specificity.

77 space (where an interaction of the antibody (Ab) and the analog of E2 in the self-tuneable matrix tak

78 atients may develop Abs also called antidrug Abs (ADA), directed against these anti-TNF-alpha Abs aft

79 tive cohort of 76 aquaporin 4-antibody (AQP4-Ab)-positive patients from Oxford and Liverpool's nation

80 s, and demonstrate by ELISPOT that these are Ab-secreting cells (ASCs).

81 on of public clones, which may be defined as Ab or TCR clonal sequences shared across individuals.

82 ngiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA).

83 atients with a positive ECXM had higher AT1R-Ab levels compared to those with a negative ECXM (P = 0.

84 patients with a positive ECXM and with AT1R-Ab >17 U/ml, although this did not reach statistical sig

85 e prevalence of neurological autoantibodies (Abs) among adult patients with epilepsy of unknown etiol

86 captured by antibody-decorated silica beads (Ab-SiO2) onto the conjugate pad and the sample flows by

87 influenza viruses elicited an Igkappa-biased Ab response directed against the HA globular head and st

88 imultaneously measure FcgammaR dimer-binding Abs to 32 different HIV Ags, providing a measure of the

89 a measure of the breadth of FcgammaR-binding Abs induced by the RV144 trial.

90 Blockade Ab avidity to the GI.1 vaccine component peaked at day 3

91 m and monophosphoryl lipid A (MPL), blockade Ab titers peaked early, with no increase in titer follow

92 Either a blocking Ab to the IL-6 receptor or a neutralizing Ab to IL-6 sig

93 roduction was inhibited by a HLA-DR blocking Ab.

94 of risks in patients receiving IL-1 blocking Abs for treatment of chronic inflammatory disorders.

95 apeutic administration of anti-MSLN-blocking Abs attenuated BDL-induced fibrosis in WT mice.

96 rs expressing chimeric HA, aimed at boosting Ab reactivity against the HA stem region, also elicited

97 mice, which lack secreted and membrane-bound Ab, yet harbor marginal zone and follicular B cells.

98 le, when type I IFN signaling was blocked by Abs in Rag1(-/-) mice, the mice showed dramatic weight l

99 o neutralization, lysis of infected cells by Abs can effectively participate in HIV protection, as su

100 s-linking of Fcgamma receptors (FcgammaR) by Abs, which is required to initiate an ADCC response.

101 IgG from patients with anti-C3b Abs stabilized C3bBb and perturbed C3b binding to comple

102 the cortisol in the sample, for the capture Ab binding sites.

103 demonstrates that the movement of anti-CD11b Abs-decorated NPs (NPs-CD11b) into the tumor is mediated

104 or PS and photothermal therapy of anti-CD11b Abs-linked gold nanorods (GNRs-CD11b) are combined to tr

105 pared with the effect of a control anti-CD20 Ab (rituximab) at concentrations that triggered similar

106 Anti-CD20 Ab had a major effect on alloreactive CD4(+) T cells, in

107 Anti-CD20 Ab has recently been used to prevent alloimmunization.

108 Clinical testing of a human IgG1 anti-CD27 Ab, varlilumab (clone 1F5), is ongoing in cancer patient

109 l subsets after activation with CD3 and CD28 Abs (CD3/28), transduction and culture alone, or after r

110 3-deficient mice using nondepleting anti-CD4 Abs.

111 Anti-CD44 Ab and HA treatments reduced NF-kappaB translocation, IL

112 Anti-CD44 Ab treatment significantly reduced macrophage activation

113 els of IL-5, a potent stimulator of B-1 cell Ab production.

114 their physiologic target Ag, anti-chromatin Ab, into mice lacking Fcer1g, Myd88, or both and studied

115 ting a role for the BCR, but not circulating Ab, in DC-derived exosome responses.

116 , a possible role for the BCR or circulating Ab in mediating CTL responses to B cell-derived exosomes

117 distribution of the immunospecific complexes Ab(E2)x (x=0, 1, 2) dependent on E2 concentration.

118 significantly enhances otherwise compromised Ab production to inactivated influenza vaccine.

119 including complement-dependent cytotoxicity, Ab-dependent cellular cytotoxicity, and Ab-dependent cel

120 development is that cross-reactive anti-DENV Abs can be protective or potentially increase disease vi

121 /2 In a cynomolgus model of T cell-dependent Ab response, the CTLA4-Ig variant MEDI5265 could be form

122 a major concern because patients may develop Abs also called antidrug Abs (ADA), directed against the

123 ce consuming the Western diet had diminished Ab titers whereas the Western diet plus DHA improved tit

124 ne responses can be manipulated in directing Abs or T cells based on how efficiently the targeted Ag

125 scribe the identification of a single domain Ab fragment directed to the TCR of Vgamma9Vdelta2 T cell

126 ction of new rAb fragments and single-domain Abs have reinvigorated the concept of passive immunizati

127 osing because of an anti-idiotypic anti-drug Ab immune response.

128 oral effects, serum IL-4, IgE, and anti-drug Ab levels.

129 that can lead to the appearance of anti-drug Abs.

130 We show that EGFR Abs directed against clinically relevant epitopes can be

131 A did not directly target B cells to elevate Ab levels.

132 on strategy, including existing and emerging Ab therapeutics.

133 sts a mechanism by which anti-HIV-1 envelope Abs can contribute to protective efficacy.IMPORTANCE Ant

134 Exon Ab inclusion correlated with predicted free energies of

135 helix of U2AF35, and was fine-tuned by exon Ab/3 variants.

136 next to a long polypyrimidine tract of exon Ab.

137 nclusion, the prevalence of anti-C3b/anti-FB Abs and alternative pathway activation is similar in Ig-

138 ity; IgG from patients with anti-C3b/anti-FB Abs enhanced C3 and C5 cleavage.

139 tro, IgG purified from patients with anti-FB Abs selectively enhanced C3 convertase activity; IgG fro

140 er MAbs specific for V3, CD4bs, and gp41 for Ab-dependent cellular phagocytosis (ADCP) activity, impl

141 les containing proinsulin in beta-cells from Ab+ donors, suggesting a defect in proinsulin conversion

142 In addition, islets from Ab+ donors were larger and contained a higher number of

143 a IgG contains approximately 94% fucosylated Abs, but alloantibodies against, for example, Rhesus D (

144 or integrating IG genotyping with functional Ab profiling data as a means to better predict and optim

145 AD65-Ab and VGKCc-Ab, 1 had TPO-Ab and GAD65-Ab, and 1 had anti-Hu Ab and GAD65-Ab.

146 and GAD65-Ab, and 1 had anti-Hu Ab and GAD65-Ab.

147 annel complex (VGKCc) Ab, 2 (1.8%) had GAD65-Ab and VGKCc-Ab, 1 had TPO-Ab and GAD65-Ab, and 1 had an

148 n after excluding TPO-Ab and low-titer GAD65-Ab, Abs strongly suggesting an autoimmune cause of epile

149 njection of immunocytokine (IC), an anti-GD2 Ab linked to IL-2, can activate T and NK cells resulting

150 enerate long-lived plasma cells and generate Abs capable of neutralizing variant hemagglutinin-expres

151 munized mice; thus, vaccination can generate Abs to regions that are not targeted in natural infectio

152 A-Ag and the HRP labeled HA antibody (HRP-HA-Ab).

153 sociation of the K409R parental Ab into half-Ab controls the rate of the reaction.

154 Indeed, MFIs of the de novo allo-HLA Abs were markedly higher with FcMonoIgG than with IgHPol

155 Fab than with FcMonoIgG The MFIs of anti-HLA Abs also remained higher with IgHPolyFab in the normal s

156 Comparing the MFIs of anti-HLA Abs obtained with IgHPolyFab and FcMonoIgG against norma

157 sera, it was observed that the number of HLA-Abs was notably higher with IgHPolyFab than with FcMonoI

158 In the presence of anti-SRP or anti-HMGCR Abs, mechanisms involved in muscle regeneration were als

159 patients with anti-SRP(+) and anti-HMGCR(+) Abs, a large number of small fibers corresponding to bot

160 1 had TPO-Ab and GAD65-Ab, and 1 had anti-Hu Ab and GAD65-Ab.

161 w glycan-specific maturation enables a human Ab to cope with pathogen escape mechanisms and will aid

162 ICAM-1 clustering in response to HLA class I Ab and prevents macrophage infiltration into cardiac all

163 nd they were not blocked by anti-HLA class I Abs, suggesting that KIR2DL3, in addition to the traditi

164 The response of EF4.1 mice to an I-Ab-associated epitope of the F-MuLV envelope protein is

165 hat complements the mucous and secretory IgA Ab-mediated system in the protection of intestinal mucos

166 cation of important residues for mAb and IgE Ab recognition in group 1 mite allergens.

167 o engineer allergen mutants with reduced IgE Ab binding for immunotherapy.

168 alpha-Gal-specific IgE Ab cause a special form of meat allergy characterized by

169 lowed the induction of allergen-specific IgE Ab responses without allergen-specific T cell help.

170 fector cells via low-affinity anti-human IgE Abs with dissociation constants in the 10(-6) to 10(-8)

171 ith delayed meat allergy display IgE and IgG Ab that selectively recognize the alpha-gal epitope on B

172 d with alpha-gal or protein G to deplete IgG Ab. alpha-Gal-specific IgG1-4 Ab in individuals with and

173 b nor the addition of alpha-gal-specific IgG Ab from nonallergic individuals changed the IgE recognit

174 pletion of autologous alpha-gal-specific IgG Ab nor the addition of alpha-gal-specific IgG Ab from no

175 To monitor IgG Abs, fluoresceinated IgG constant H chain-binding polycl

176 uced V-gene-matched recombinant anti-RhD IgG Abs of the four different subclasses (IgG1-4) with and w

177 Additionally, passive anti-PC IgM Abs administered intratracheally with HDMs decreased all

178 e produce significantly less Ag-specific IgM Abs upon immunization with T cell-independent Ags, and t

179 of the antitumor efficacy of immunomodulator Abs in syngeneic models.

180 , the mechanisms by which targeting improves Ab responses are poorly understood.

181 e envisage the ICA as being a useful tool in Ab repertoire analysis for future clinical trials.

182 city as assessed by their ability to inhibit Ab responses in vitro.

183 g error-prone immunosequencing datasets into Ab repertoires is a fundamental problem in immunogenomic

184 provide help to B cells for developing into Ab-secreting cells, were similar between responders and

185 bodies: the visual immunogold OnSite Leprosy Ab Rapid test [Gold-LFA] and the quantitative, luminesce

186 The lineage Abs bore an anionic heavy chain complementarity-determin

187 nodes and bone marrow, correlating with low Ab titers.

188 Combined TIRAP and anti-LTA Ab deficiencies underlie staphylococcal disease in this

189 nger induction of neutralizing Abs, and more Ab-secreting cells in bone marrow.

190 lpha antibody and horseradish peroxidase (MP-Ab-HRP) were used to efficiently capture ERalpha from th

191 The mutant Abs have normal thermal stability and Fcgamma receptor i

192 rived hematopoiesis, responsible for natural Ab production and rapid immune responses.

193 uction by T cells and thereby limits natural Ab production by B-1 cells.

194 We show by this natural Ab-mediated Ag targeting system that uptake by splenic A

195 For example, although natural Abs (NA) and complement are key components of the innate

196 (PD-L2) regulates the production of natural Abs against phosphorylcholine (PC).

197 Neutralizing Ab to IFN-gamma, but not IL-17, inhibited nevus developm

198 ng Ab to the IL-6 receptor or a neutralizing Ab to IL-6 significantly reduced in vitro basal crypt or

199 the pretreatment with TGF-beta neutralizing Ab or re-expression of Fli1.

200 ing, high-affinity, and broadly neutralizing Ab responses against pathogens.

201 ancestor of a V2-glycan broadly neutralizing Ab, but this Ab type was not induced in the RV144 trial.

202 Avidity of potentially neutralizing Ab may be an important metric for evaluating vaccine res

203 e subdominant V2-glycan broadly neutralizing Abs to develop.

204 ch as the injection of integrin-neutralizing Abs that inhibit the entry of circulating lymphocytes in

205 Treatment with anti-Marco-neutralizing Abs and the class A scavenger receptor antagonist polyin

206 ated with stronger induction of neutralizing Abs, and more Ab-secreting cells in bone marrow.

207 NMDAR-Ab from patients and healthy subjects do not compete for

208 We unveil that NMDAR-Ab from psychotic patients alter NMDAR synaptic transmis

209 sis and ocular pathology, yet the ability of Ab to protect against HSV-1 is deemed limited due to the

210 R9, which was not utilized in the absence of Ab.

211 To test the functional consequences of Ab fucosylation, we produced V-gene-matched recombinant

212 Recognition of Ab-opsonized pathogens by immune cells triggers both TLR

213 , among the shortest known for this class of Abs, and achieved breadth with only 10% nucleotide somat

214 erence may explain the enhanced induction of Abs when targeting Ag to cDC1 using hXCL1 and hXCL2, and

215 while simultaneously inducing high levels of Abs toward hemagglutinin.

216 This variable domain of an H chain-only Ab (VHH or nanobody) significantly inhibited both phosph

217 ement, either through lymphocyte adhesion or Ab-mediated clustering.

218 we studied B cell cytokine secretion and/or Ab production across obesity models.

219 ns, where dissociation of the K409R parental Ab into half-Ab controls the rate of the reaction.

220 ospholipase A2 receptor antibody (anti-PLA2R-Ab) depletion in NIAT-rituximab and NIAT groups were 14

221 differs between patients positive for PLA2R1-Ab or THSD7A-Ab.

222 nced GC B cell responses and anti-Plasmodium Ab production.

223 These include the primary Ab concentrations and order within the multiplex panel,

224 ctivating B cells to proliferate and produce Abs and inflammatory cytokines.

225 s, failure to establish long-term protective Ab titers against S. aureus was not a consequence of dim

226 vial tissues from anti-citrullinated protein Ab-positive arthralgia, undifferentiated arthritis (UA),

227 at is altered upon binding of PSMA with PSMA-Ab immobilized on N-AuNPs/ITO.

228 the presence of antibody-functionalized QDs (Ab-QDs) onto the test line.

229 mmune activation is often explored using rat Abs in immunocompetent mouse models.

230 g a B-1a phenotype, and produced PC-reactive Abs largely of the T15 Id.

231 serum level of natural Igs and self-reactive Abs.

232 In this study, anti-sclerostin antibody (Scl-Ab) treatment effectively improved bone mass and dramati

233 ab) is used as the fluoresceinated secondary Ab (2nd-Ab), whereas IgG subclasses are monitored with F

234 ted B cells in vitro to proliferate, secrete Abs and IL-6, and that neither CpG-B nor CpG-A alone ind

235 lymphocytes was blocked with anti-P-selectin Abs, and when this occurred we observed higher IFN-gamma

236 Serum Abs suggesting a potential autoimmune etiology were dete

237 a significant minority had detectable serum Abs suggesting an autoimmune etiology.

238 Immunoprecipitation with Sesn2 Ab revealed that cardiac Sesn2 forms a complex with AMPK

239 Thirty-two patients (28.6%) had a single Ab marker.

240 We also prepared a specific Ab against the purified recombinant NC1 domain peptide.

241 Allergen-specific Ab responses were subsequently boosted with molecules co

242 ted with a difference in serum AMA1-specific Ab levels.

243 n the presence or absence of a CD44-specific Ab or hyaluronan (HA).

244 f CD44 by its ligand (HA) or a CD44-specific Ab reduced NF-kappaB translocation and downstream proinf

245 In addition, Chlamydia-specific Ab responses were dysregulated in CCR7-deficient mice, d

246 We hypothesized that HIV-specific Ab responses regulate late IFN production.

247 racterized by short-lived, parasite-specific Ab responses.

248 with flagellin did not affect SseB-specific Ab responses, it modestly boosted CD4 responses.

249 , plasma cell generation, and virus-specific Ab responses.

250 ciated with low frequencies of ZIKV-specific Ab-secreting cells in lymph nodes and bone marrow, corre

251 exes by i.v. injecting mice with Ag-specific Abs followed by the cognate Ag.

252 ifficult to measure the titer of Ag-specific Abs or the expansion of Ag-specific B cells after immuni

253 ized with SERCA2a 971-990 showed Ag-specific Abs with enhanced production of IgG2a and IgG2b isotypes

254 ive immune response by producing Ag-specific Abs.

255 2 is internalized after ligation by specific Abs, including H4B4, and traffics rapidly but transientl

256 verified by Western blotting using specific Abs.

257 validated by Western blotting using specific Abs.

258 and CD19(neg) ASCs secrete vaccine-specific Abs and show linked IGHV repertoires.

259 , highlighting the interest in inducing such Abs in future HIV vaccine trials.

260 d (95% mouse sequence) DTA-1-based surrogate Abs with a murine IgG2c H chain isotype were created.

261 ype are critical to generate ideal surrogate Abs for testing immuno-oncology mechanisms in vivo.

262 Immunogenicity of surrogate Abs may therefore represent an important obstacle to the

263 Anti-TbKHC1 Ab also inhibited T. musculi growth, both in vitro and i

264 e BM survival niches and sustained long-term Ab titers.

265 Ab lineage targeting the Env V2 apex and the Ab-Env co-evolution that led to development of neutraliz

266 n serum and to evaluate L chain usage of the Ab response against the hemagglutinin (HA) protein elici

267 oded and somatically mutated residues on the Ab heavy chain.

268 Additionally, we profiled the Ab responses to NS1 of humans naturally infected with DE

269 ) titers are associated with protection, the Ab repertoire induced by LATVs remain uncharacterized.

270 To further understand the role of the Abs in the pathology, we performed muscle cell coculture

271 we performed muscle cell coculture with the Abs.

272 CR) antibodies (Abs), and the titer of these Abs is correlated with disease activity.

273 V2-glycan broadly neutralizing Ab, but this Ab type was not induced in the RV144 trial.

274 d specific measurement of circulating THSD7A-Ab in patients with MN.

275 The prevalence of THSD7A-Ab-positive patients is unknown, and it is unclear wheth

276 en patients positive for PLA2R1-Ab or THSD7A-Ab.

277 lly, V1V2 can be rendered more accessible to Abs via specific mutations, facilitating the development

278 The K169 V2 response was restricted to Abs bearing Vlambda rearrangements that expressed aspart

279 Even after excluding TPO-Ab and low-titer GAD65-Ab, Abs strongly suggesting an au

280 (1.8%) had GAD65-Ab and VGKCc-Ab, 1 had TPO-Ab and GAD65-Ab, and 1 had anti-Hu Ab and GAD65-Ab.

281 ected in 7 patients (6.3%): 3 (2.7%) had TPO-Ab and voltage-gated potassium channel complex (VGKCc) A

282 Traditional Ab formats (IgG, IgM) are expensive and laborious to pro

283 Trispecific Abs thus constitute a platform to engage multiple therap

284 he same human VH gene segment as an RV144 V2 Ab but paired with a mouse lambda L chain.

285 In these mice, the V2 Ab response was focused on a linear epitope that did not

286 V2 Abs were isolated that used the same human VH gene segme

287 ructural characterization of one of these V2 Abs revealed how the linear V2 epitope could be engaged,

288 that the staining intensity by anti-Valpha24 Abs depends on whether Ser or Arg is encoded.

289 tage-gated potassium channel complex (VGKCc) Ab, 2 (1.8%) had GAD65-Ab and VGKCc-Ab, 1 had TPO-Ab and

290 (VGKCc) Ab, 2 (1.8%) had GAD65-Ab and VGKCc-Ab, 1 had TPO-Ab and GAD65-Ab, and 1 had anti-Hu Ab and

291 otective or potentially increase disease via Ab-dependent enhancement.

292 Typhimurium infection via Ab.

293 Furthermore, in vitro, Abs directed against C1q and C3a reversed the fate and m

294 tion on endothelial cells, or by an anti-VWF Ab.

295 Thus, the corresponding equation was: Abs=4.00(+/-0.16) [tannic acid]+0.17(+/-0.017).

296 Patients who were Ab positive were more likely to have good seizure outcom

297 favored a membrane-proximal epitope, whereas Ab-dependent cellular phagocytosis favored an epitope po

298 onist-treated neonates could be blocked with Abs against CD80 and CD86.

299 reased transmission risk was correlated with Abs that reacted with a linear epitope at a lysine resid

300 exosomes were significantly inhibited within Ab-deficient DHLMP2A mice compared with wild-type mice.