ライフサイエンスコーパス: Abelson

1 Abelson (Abl) family tyrosine kinases have been implicat

2 Abelson (Abl) tyrosine kinase is an important cellular e

3 Abelson family kinases (Abls) are key regulators of cell

4 Abelson family kinases (AFKs; Abl1, Abl2) are non-recept

5 Abelson murine leukemia virus (A-MuLV) is an acute trans

6 Abelson murine leukemia virus (Ab-MLV) arose from a reco

7 Abelson murine leukemia virus (Ab-MLV) encodes the v-Abl

8 Abelson murine leukemia virus (Ab-MLV) mutants expressin

9 Abelson murine leukemia virus (Ab-MLV) transforms NIH 3T

10 Abelson murine leukemia virus encodes the related oncoge

11 Abelson murine leukemia virus transforms pre-B cells in

12 Abelson murine leukemia virus, which encodes v-Abl/p160,

13 Abelson murine leukemia virus-transformed cell lines hav

14 Abelson non-receptor tyrosine kinases are also found in

15 Abelson tyrosine kinase may also help regulate myosin II

16 Abelson-transformed pre-B cell lines derived from these

17 c-Abl (v-Abl Abelson murine leukemia viral oncogene homolog 1) tyrosi

18 ally, forces applied to E-cadherin activated Abelson (Abl) tyrosine kinase to phosphorylate vinculin;

19 The foundation for this system is an Abelson virus-transformed cell line derived from RAG-1(-

20 cipitation analyses of bone marrow cells and Abelson murine leukemia virus-transformed pre-B cell lin

21 ELISA) using less than 5 muL of sample, and Abelson tyrosine kinase activity was detectable in sampl

22 e analyzed the solution conformations of apo Abelson tyrosine kinase (c-Abl) and c-Abl complexes with

23 deregulated breakpoint cluster region (Bcr)-Abelson tyrosine kinase (Abl) fusion protein.

24 c arena (eg, breakpoint cluster region [BCR]/Abelson [ABL] kinase inhibitors in chronic myeloblastic

25 Transformation of pre-B cells by Abelson murine leukemia virus (Ab-MLV) involves a balanc

26 The v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) induces pre-B-cel

27 The v-Abl protein encoded by Abelson murine leukemia virus (Ab-MLV) induces transform

28 The v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) induces transform

29 v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B

30 re-B cell transformation process mediated by Abelson murine leukemia virus (Ab-MLV), we examined the

31 be negatively regulated during oogenesis by Abelson kinase.

32 Transformation by Abelson murine leukemia virus (Ab-MLV) is a multistep pr

33 step process of pre-B-cell transformation by Abelson murine leukemia virus.

34 Pre-B-cell transformation by Abelson virus (Ab-MLV) is a multistep process in which p

35 gene involved in malignant transformation by Abelson virus.

36 of the nonreceptor tyrosine kinase cellular Abelson (c-Abl), and c-Abl inhibitors, including imatini

37 y, we investigated the roles of the cellular Abelson tyrosine kinase (c-Abl) and the related protein

38 9ARF was previously shown to be required for Abelson murine leukemia virus transformation of primary

39 reported at several loci including the gene Abelson's Helper Integration 1 (AHI1).

40 e most common breakpoint cluster region gene-Abelson murine leukemia viral oncogene homolog 1 (BCR-AB

41 in, the Src homology 3 (SH3) domain of human Abelson tyrosine kinase (Abl), was fused to green fluore

42 Recent studies suggest that the human Abelson helper integration site-1 (AHI1) gene on chromos

43 em was shown to be compatible with the human Abelson tyrosine kinase.

44 ronavirus replication in which we identified Abelson (Abl) kinase inhibitors, including the anticance

45 In Abelson murine leukemia virus (A-MuLV)-transformed cells

46 Ectopic expression of Blimp-1 in Abelson-transformed precursor B cells repressed endogeno

47 hat we show is crucial for Rag expression in Abelson pre-B cell lines.

48 found Ikaros localized to heterochromatin in Abelson-transformed pre-B lymphocytes by using immunogol

49 e Tp53 tumor suppressor gene plays a role in Abelson virus transformation, conformation-specific mono

50 d by the Ink4a/Arf locus also play a role in Abelson virus transformation.

51 ient to induce germline Igk transcription in Abelson-transformed pro-B cell lines.

52 n using isoform MIG-10A as bait and isolated Abelson-interactor protein-1 (ABI-1).

53 The proto-oncogenic kinase Abelson (Abl) regulates actin in response to cell signal

54 at the conserved nonreceptor tyrosine kinase Abelson (Abl) contributes to rapid embryonic wound closu

55 ctivation of the nonreceptor tyrosine kinase Abelson (Abl) contributes to the development of leukemia

56 In Drosophila, the tyrosine kinase Abelson (Abl) interfaces with multiple signaling pathway

57 t to a possible role for the tyrosine kinase Abelson in cell-cell adhesive junctions in both the CNS

58 edicted that the nonreceptor tyrosine kinase Abelson murine leukemia viral oncogene (c-Abl) is a puta

59 gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS p

60 he small GTPase RAB5 and the tyrosine kinase Abelson tyrosine-protein kinase (ABL), to modulate endoc

61 two other SH3 domains (lymphoid cell kinase, Abelson kinase).

62 Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-ex

63 A necessary downstream element of Abelson murine leukemia virus (Ab-MLV)-mediated transfor

64 The temperature-sensitive form of Abelson murine leukemia virus offers a reversible model

65 mation of SCID temperature-sensitive form of Abelson murine leukemia virus pre-B cells.

66 Here, we report the identification of Abelson kinase (Abl) as a novel ventral furrow regulator

67 by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neuron

68 The absence of p53 shortens the latency of Abelson disease induction but does not affect the freque

69 nsformed by temperature-sensitive mutants of Abelson murine leukemia virus and PCR was used to identi

70 nsformed by temperature-sensitive mutants of Abelson virus that undergo kappa and lambda gene rearran

71 ansforming activity of the v-Abl oncogene of Abelson murine leukemia virus (A-MuLV) in immortal cell

72 ine kinase, encoded by the v-Abl oncogene of Abelson murine leukemia virus induces transformation of

73 In addition, the v-abl oncogene of Abelson murine leukemia virus, whose protein product lac

74 used to examine p53 expression in a panel of Abelson virus-transformed pre-B cells.

75 ay central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV) transformation.

76 s to the oncogenic Gag-Abl fusion protein of Abelson Murine Leukaemia Virus and found that in contras

77 ligated subdomains of the SH(32) segment of Abelson kinase in solution, using the orientational depe

78 mology type 3 and 2 domains (SH3 and SH2) of Abelson protein tyrosine kinase, which constitute the re

79 inhibition by imatinib and gene silencing of Abelson (Abl) tyrosine kinase reduced the lysosomal pH i

80 We report here that treatment of Abelson virus-transformed pre-B cell lines with the smal

81 d unique role in Breakpoint Cluster Region - Abelson 1 (BCR-ABL1)-driven neoplasias.

82 (CML) patients, a breakpoint cluster region-Abelson (BCR-ABL1) value >10% at 3 months of therapy is

83 o therapy with the breakpoint cluster region-Abelson murine leukemia (BCR/ABL) kinase inhibitor imati

84 to engraftment of breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-AB

85 Breakpoint cluster region/Abelson (BCR/ABL) tyrosine kinase enhances the ability o

86 Here, we grew breakpoint cluster region/Abelson murine leukemia (Bcr/Abl) P190 lymphoblasts on s

87 rom the oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 translo

88 opment of BCR-ABL (breakpoint cluster region/Abelson oncogene) tyrosine kinase domain mutations that

89 uence length polymorphism analysis to screen Abelson virus-transformed pre-B cells for evidence of LO

90 cell precursors with a temperature-sensitive Abelson murine leukemia virus mutant (ts-Ab-MLV).

91 ll precursors with the temperature-sensitive Abelson murine leukemia virus.

92 entify a novel type of temperature-sensitive Abelson virus.

93 s transformed with the temperature-sensitive Abelson-murine leukemia virus, we show that large quanti

94 ALL) is associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3-kina

95 ene)) is closely related to the well-studied Abelson kinase cABL.

96 specifically identified the imatinib target, Abelson tyrosine-protein kinase 2 (Abl2), as required fo

97 We also find that Abelson tyrosine kinase affects RP2 migration in a simil

98 Using live imaging, we found that Abelson (Abl) tyrosine kinase depletion causes apically

99 We also show that Abelson tyrosine kinase, a major regulator of Enabled in

100 We show that Abelson tyrosine-protein kinase 2 (Abl2) has a key role

101 Instead, our data suggest that Abelson kinase acts in parallel to UNC-34/Ena, antagoniz

102 The Abelson (Abl) family of non-receptor tyrosine kinases ha

103 The Abelson (ABL) tyrosine kinases were identified as driver

104 The Abelson murine leukemia virus (A-MuLV) expresses an alte

105 The Abelson Murine Leukemia Virus (A-MuLV) is the acute tran

106 The Abelson murine leukemia virus (Ab-MLV), like other retro

107 The Abelson tyrosine kinase (Abl) is integrated into signal

108 The Abelson tyrosine kinase (Abl) plays a crucial role in mu

109 The Abelson-interacting protein-1 (Abi-1) forms the core of

110 cooperative interactions between Eya and the Abelson (Abl) tyrosine kinase during development of the

111 d exhibited reduced binding to zyxin and the Abelson Src homology 3 domain.

112 ein CT10 regulator of kinase (CrkII) and the Abelson-interacting protein Abi1, a component of the WAV

113 ene occurs during the generation of both the Abelson murine leukemia virus and the bcrabl fusion gene

114 The v-Abl tyrosine kinase encoded by the Abelson murine leukemia virus (A-MuLV) can either stimul

115 ncoprotein, a tyrosine kinase encoded by the Abelson murine leukemia virus, is a multi-step process r

116 ortant in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and I

117 ect on transformation of NIH3T3 cells by the Abelson murine leukemia virus.

118 minal center in response to infection by the Abelson murine leukemia virus.

119 tein that binds and is phosphorylated by the Abelson protein tyrosine kinase.

120 show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in endothelia

121 Mutations in the Abelson helper integration site 1 gene, which encodes th

122 nant genetic suppressors of mutations in the Abelson tyrosine kinase (Abl), suggesting that Ena and A

123 as a genetic suppressor of mutations in the Abelson tyrosine kinase and subsequently was shown to be

124 inant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member

125 Mutations in the Abelson-helper integration site-1 gene (AHI1) cause JBTS

126 all molecule drug that in vitro inhibits the Abelson (Abl), Arg (abl-related gene), stem cell factor

127 ial for transformation by derivatives of the Abelson (abl) gene.

128 duced fibrosis mediated by activation of the Abelson (Abl) tyrosine kinase.

129 iated protein Orbit/MAST as a partner of the Abelson (Abl) tyrosine kinase.

130 which represent the mammalian members of the Abelson family of nonreceptor protein tyrosine kinases (

131 c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases.

132 c-Abl represent the mammalian members of the Abelson family of nonreceptor protein-tyrosine kinases.

133 rg is a ubiquitously expressed member of the Abelson family of nonreceptor protein-tyrosine kinases.

134 c-Abl represent the mammalian members of the Abelson family of protein-tyrosine kinases.

135 he effects of the combined inhibition of the Abelson kinase (c-Abl) and platelet-derived growth facto

136 id cells, introduction and expression of the Abelson leukemia virus causes growth factor independence

137 The v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) encodes a cytopla

138 of apoptosis is an important feature of the Abelson murine leukemia virus (Ab-MLV) transformation pr

139 used to prepare NMR sample quantities of the Abelson protein tyrosine kinase-SH(32) domain pair, in w

140 The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous

141 Two novel dosage-sensitive modifiers of the Abelson tyrosine kinase (Abl) mutant phenotype have been

142 (AKAPs), which bind to the SH3 domain of the Abelson tyrosine kinase (Abl).

143 that the N-terminal cap (NCap) region of the Abelson tyrosine kinase (c-Abl) is important for maintai

144 es of model protein-peptide complexes of the Abelson tyrosine kinase SH3 domain (abl-SH3) and the S-P

145 binding to the src homology 3 domain of the Abelson tyrosine kinase.

146 We report that the Abelson (Abl) and Abl-related gene (Arg) nonreceptor tyr

147 s study, we show for the first time that the Abelson (Abl) kinases regulate proximal signaling downst

148 nt genetic and biochemical evidence that the Abelson (Abl) tyrosine kinase and its substrate Enabled

149 Here we show that the Abelson helper integration site 1 (Ahi1) gene, whose hum

150 2(dok) bind through their PTB domains to the Abelson tyrosine kinase in a kinase-dependent manner in

151 The molecular mechanisms by which the Abelson (Abl) or Abl-related gene (Arg) kinases interfac

152 covered as the proto-oncogene from which the Abelson leukemia virus derived its Gag-v-Abl oncogene, r

153 vely activated in cells transformed with the Abelson murine leukemia virus.

154 Differences to Abelson kinase (ABL) are observed in the DDR1 P-loop, wh

155 Using Abelson murine leukemia virus-transformed B cells to mod

156 Using Abelson transformed pre-B cell lines, we find that H2AX

157 transcription during clonal expansion using Abelson murine leukemia virus-transformed B cells.

158 blished lambda5(-/-)/VpreB1(-/-)/VpreB2(-/-) Abelson virus-transformed cell lines and reconstituted t

159 rovide insights into the mechanisms by which Abelson non-receptor tyrosine kinases relay information

160 in bone marrow B cells after infection with Abelson murine leukemia retrovirus (Ab-MLV), and in huma