ライフサイエンスコーパス: African

1 nal cohort of ART-treated HIV-infected South Africans.

2 ncies among populations (allele frequencies: African = 0.0016; East Asian = 0.0045; European = 0.0036

3 proximate prevalence of HLA-B*53 carriage in African (20%) and Hispanic (6%) populations, the probabi

4 Twenty patients were Hispanic; 13, African; 8, white; and 2, Native American.

5 astome assemblies for a wilt-resistant South African accession of Mentha longifolia (L.) Huds., a dip

6 to uncover genes influencing skin colour in African-admixed individuals.

7 died these factors in 168 HIV-negative South African adolescent females aged 16 to 22 years.

8 ETATION: Although a large percentage of west African adolescents use some antenatal care for their fi

9 SPZ Vaccine showed significant protection in African adults against P falciparum infection throughout

10 ere due to pneumococci in HIV-infected South African adults.

11 was assessed by immunohistochemistry in 163 African American (AA) and 144 White TNBC tissue microarr

12 odds of educational attainment compared with African American (OR, 2.82; 95% CI, 1.77-4.50) and Hispa

13 s the odds of gainful activity compared with African American (OR, 5.17; 95% CI, 3.16-8.45) and Hispa

14 ertension in a US population-based sample of African American adults.

15 control subjects with European American and African American ancestry followed by metaanalysis.

16 63.0%) of the mothers identified as black or African American and 243 (18.3%) as Hispanic or Latino.

17 ects) and 298 subjects in the ICS- group (49 African American and 249 white subjects).

18 ere were 922 subjects in the ICS+ group (248 African American and 674 white subjects) and 298 subject

19 ed criterion counts of comorbid AD and MD in African American and European American data sets collect

20 Among African American and Hispanic participants, adjusted ris

21 ttern of airway inflammation differs between African American and white subjects is unclear.

22 Women's Circle of Health Study (WCHS) in the African American Breast Cancer Epidemiology and Risk Con

23 ving Forward, a weight loss intervention for African American breast cancer survivors (AABCS) on weig

24 n 614 cases and 743 controls enrolled in the African American Cancer Epidemiology Study (2010-2015).

25 rometry outcomes were compared with those of African American children from the third National Health

26 cancer mortality rates have been higher for African American compared with white American women sinc

27 eastfeeding women (OR >49.0; P < 0.001), but African American ethnicity was also associated with incr

28 hildren were assigned randomly to the Strong African American Families randomized prevention trial or

29 his prospective, community-based study, 2812 African American individuals aged 40 to 75 years without

30 ear ASCVD event rate in the presence of CAC, African American individuals not eligible for statins by

31 ion (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinic

32 less than 50 mg/dL (<55 mg/dL for women and African American individuals).

33 etin (TTR) gene (V122I), present in 3.43% of African American individuals.

34 Latent class analysis shows that African American males fared the worst, with lives chara

35 sting for PCA management, genetic testing of African American males, and addressing the value framewo

36 sh odds ratio 5.18, drinker odds ratio 3.62, African American odds ratio 0.24.

37 .52, porcine cadaveric mesh odds ratio 4.03, African American odds ratio 3.08, length of stay odds ra

38 In the rural southeastern United States, African American parents and their 11-year-old children

39 Seventy-eight of 5,825 African American patients (1.34%) had the Adult Comfort

40 dds ratio [OR], 1.28; 95% CI, 1.11-1.48) and African American patients (OR, 1.84; 95% CI, 1.24-2.73)

41 Twenty-seven African American patients and 9 patients with ATTR V122I

42 African American patients, Hispanic patients, and new hi

43 r vs a 5-year surveillance interval included African American race (relative risk [RR] to white, 1.41

44 African American race or PPI use with LDV/SOF +/- RBV wa

45 D, we performed a retrospective study of 899 African American Study of Kidney Disease and Hypertensio

46 Patients enrolled in the African American Study of Kidney Disease and Hypertensio

47 African American subjects exhibit greater eosinophilic a

48 ever, when adjusted for confounding factors, African American subjects were more likely to exhibit eo

49 African American women also have case fatality rates rel

50 For example, in the United States, African American women are more likely than non-Hispanic

51 sed risk of triple-negative breast cancer in African American women as well as western, sub-Saharan A

52 endocrine therapy that is less effective in African American women because of the higher prevalence

53 oor outcomes associated with preeclampsia in African American women.

54 ubjects (65.83% European American and 34.17% African American).

55 s [interquartile range, 53-71]; 57% men; 32% African American); 6-month follow-up was completed for 2

56 Asian/Pacific Islander, 23 (29%) were black/African American, 11 (14%) were white, 16 (21%) were whi

57 mong 83 racially diverse adult patients (61% African American, 34% Caucasian, and 5% Other) hospitali

58 12.7% (5365) were Hispanic, 9.4% (3976) were African American, and 12.6% (5351) were other minorities

59 BeadChip in 17,010 individuals of European, African American, and Hispanic ancestry.

60 and 273 (45.0%) were women; 231 (38.1%) were African American.

61 articipants were female (61.0%) and 550 were African-American (60.7%), with a mean age of 58.7 years.

62 ations in somatic tumor genomics between the African-American and White-American populations is also

63 d diastolic blood pressure was greater among African-American children than among European-American c

64 In this African-American cohort, we found that aldosterone may m

65 ions from 243 healthy volunteers of Asian or African-American heritage using both the spectrophotomer

66 Sixty African-American patients with LAgP, aged 5 to 25 years,

67 assortative mating in European-American and African-American populations.

68 Age, hypertension, body mass index, and African-American race were independently associated with

69 rformed in urban settings with predominantly African-American women (n=27).

70 etween premenopausal hysterectomy and EOC in African-American women and explored whether hormone ther

71 y marked differences between White and Black/African-American women.

72 )-2010-in relation to ovarian cancer risk in African-American women.

73 rges, with 21,212 Caucasians (71.69%), 5,825 African Americans (19.69%), and 2,546 non-Caucasians/non

74 drome over the course of 25 years among 1995 African Americans (56% women, 18-30 years old) in the Co

75 icans (19.69%), and 2,546 non-Caucasians/non-African Americans (8.62%).

76 Subjects were mostly African Americans (94.9%) with a mean (standard deviatio

77 e high prevalence of vitamin D deficiency in African Americans (AAs) may be a contributing factor to

78 African Americans (AAs) tend to have higher plasma insul

79 ions for some tailored pharmacotherapies for African Americans (eg, heart failure medications), disea

80 re disparities in postoperative outcomes for African Americans after surgical intervention in the uni

81 ent are to describe cardiovascular health in African Americans and to highlight unique considerations

82 among African-ancestry populations, such as African Americans and western, sub-Saharan Africans, com

83 95% CI 0.43, 2.25) were encountered between African Americans and Whites receiving surgery at hospit

84 African Americans are at increased risk of iron deficien

85 riable linear regression analysis among 1554 African Americans from MESA (Multi-Ethnic Study of Ather

86 African Americans have a heightened risk of developing c

87 African Americans have the highest incidence and mortali

88 African Americans lost more spine BMD than did Caucasian

89 ixed cohort and an average of 5 of either 10 African Americans or 10 Europeans.

90 its significance is not well established in African Americans persons whose cardiac comorbidities an

91 omote equity in the cardiovascular health of African Americans require input from a broad set of stak

92 , genome-wide scans comprising 2345 cases of African Americans with IBD (1646 with CD, 583 with UC, a

93 performed a genome-wide association study of African Americans with IBD and identified loci associate

94 R = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, includ

95 (n = 846 whites, 323 Chinese Americans, 334 African Americans, 252 Hispanics, and 195 South Asians),

96 ese Americans, 31.1% (CI, 26.3% to 36.3%) in African Americans, 38.5% (CI, 32.6% to 44.6%) in Hispani

97 s receive on average 36% more callbacks than African Americans, and 24% more callbacks than Latinos.

98 nt in 1.3% of European Americans and 8.4% of African Americans, and are candidates to contribute to o

99 was associated with lower risk for death in African Americans, Japanese Americans, Latinos, and whit

100 Yet, in African Americans, the X-linked G6PD G202A variant (T-al

101 , disease management is less effective among African Americans, yielding higher mortality.

102 tivity and is the most frequent haplotype in African Americans.

103 ic whites, Hispanic/Latinos, East Asians and African Americans.

104 y adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females).

105 gene are associated with kidney diseases in African ancestral populations; yet, the underlying biolo

106 -world cohorts of European ancestry (EA) and African ancestry (AA).

107 east cancer, including 154 black patients of African ancestry (mean [SD] age at diagnosis, 55.66 [13.

108 African ancestry alleles may contribute to CKD among His

109 genetic components of geographically defined African ancestry are associated with hereditary suscepti

110 People of African ancestry carrying certain APOL1 mutant alleles a

111 aits, we show that while genomic research in African ancestry populations is still in early stages, t

112 d in other populations, and diversity within African ancestry populations precludes summarizing risk

113 eased risk for kidney disease in sub-Saharan African ancestry populations.

114 to enroll 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, an

115 y (PPCM) disproportionately affects women of African ancestry, but well-powered studies to explore di

116 In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants

117 ied a novel independent signal suggesting an African ancestry-specific allele at KCNQ1 for T2D.

118 there are already many examples of novel and African ancestry-specific disease loci that have been di

119 dependent signal at KCNQ1, represented by an African ancestry-specific variant, rs1049549 (odds ratio

120 wo siblings with LQTS in a Spanish family of African ancestry.

121 ilitating large-scale GWAS in populations of African ancestry.

122 nsion-attributed ESRD among people of recent African ancestry.

123 k for T2D in Choco is correlated with higher African ancestry.

124 breast cancers (TNBCs) are more common among African-ancestry populations, such as African Americans

125 pertain to the burden of breast cancer among African-ancestry populations.

126 However, the distribution of African and Asian ancestry across the island reveals tha

127 tudies have shown that ZIKV has evolved into African and Asian lineages.

128 sing pneumococcal pneumonia in children in 9 African and Asian sites.

129 or eye and skin color due to the mix of West African and European ancestry.

130 t Ebola cases were exported to several other African and European countries as well as the United Sta

131 Comparative inferences with other East African and western Asia fat-tail and European sheep, re

132 i associated with BP in studies of European, African, and Asian ancestry generalize to Hispanics/Lati

133 dicated five Brazilian haplotypes had Asian, African, and European origins.

134 Furthermore, it is unknown whether African- and Asian-lineage ZIKV have different phenotypi

135 te robust anthropological evidence that West Africans are as tall as Europeans on average.

136 gical data indicating an origin from a North African Berber-like population [1, 4, 9].

137 The H3ABioNet pan-African bioinformatics network, which is funded to suppo

138 2015-2016 in two coastal cities at both the African (Bizerte, Tunisia) and European (Marseille, Fran

139 were isolated from 15 systemically diseased African bullfrogs (Pyxicephalus edulis), and were initia

140 Africans can be exposed to many risk factors facilitatin

141 African Canadians (hazard ratio [HR], 0.75; 95% CI: 0.62

142 In a third cohort of West African children with SCD, cluster 1 differentiated SCD

143 and cholinergic neurons in the brain of the African cichlid fish Astatotilapia burtoni using in situ

144 We chose from 200 southern African, clade C envelope-pseudotyped viruses with neutr

145 opean Mediterranean edge to the Northwestern African coast seems to be possible under favorable condi

146 ffect on treatment outcomes in a large South African cohort.

147 s African Americans and western, sub-Saharan Africans, compared with European-ancestry populations.

148 Here we show that the African continent has witnessed a long-term decline in t

149 rging across the vast equatorial belt of the African continent to cause epidemics of highly fatal hem

150 vidual variation in European and continental African contributions [36-39].

151 were from Egypt and 1315 were from the other African countries (491 from Ghana, 363 from Nigeria, 277

152 s B virus was the leading cause in the other African countries (597 [55%] of 1082 patients).

153 nt diagnosis were conducted in 5 sub-Saharan African countries (Mozambique, Swaziland, South Africa,

154 This association was repeated across non-African countries (R(2) = 14.9%, P < 0.0001).

155 resolution of 5 x 5 km grid cells across 46 African countries for 2000, 2005, 2010, and 2015.

156 iated with poor survival were: being from an African countries other than Egypt (hazard ratio [HR] 1.

157 circumcision programmes in other sub-Saharan African countries.

158 two groups for analysis; Egypt versus other African countries.

159 nts were hosted at 20 institutions across 10 African countries.

160 cent and older first-time mothers in 13 west African countries.

161 entified palliative care development in most African countries.

162 t of palliative care services in a subset of African countries.

163 To investigate the demographic history of African-descendant Marron populations, we generated geno

164 ion markers) from 107 individuals from three African-descendant populations in South America, as well

165 xposure is not yet known, but individuals of African descent appear vulnerable.

166 s associated with IBD risk in only people of African descent demonstrates the importance of studying

167 ucoma vision loss and blindness in people of African descent living in resource-limited regions.

168 Patients of African descent were more likely to have an abnormal 10-

169 IV-driven kidney lesion among individuals of African descent, has largely disappeared in these region

170 anuary 20, 2011, to October 2, 2013, were of African descent, including 57 USAAs and 180 FBAAs (76%).

171 -like breast cancers in young individuals of African descent.

172 we studied the genome-wide diversity of the African-descent Makranis, who reside on the Arabian Sea

173 t variant within this region is common among African-descent populations but not among Europeans or N

174 Many South Africans diagnosed with RR-tuberculosis by Xpert initiat

175 aptive history of a neglected episode of the African Diaspora and illustrates the impact of recent ad

176 uences motility and limb bone growth in West African Dwarf crocodiles, producing altered limb proport

177 940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identi

178 0.30-0.61), and 0.34 (95% CI, 0.20-0.56) for African, East or South Asian Canadians and for patients

179 The West African Ebola virus disease (EVD) outbreak was the large

180 y or vaccination success.IMPORTANCE The West African Ebola virus epidemic was the largest to date, wi

181 ts an unprecedented input of nitrogen (N) to African ecosystems and will likely be accompanied by inc

182 ) show generally higher median levels at the African edge (2.1 and 0.2 pg m(-3), respectively) compar

183 c evidence presented by experts at the First African Endocrine Disruptors meeting.

184 of these occurred during the 2013-2016 West African epidemic.

185 precludes summarizing risk across different African ethnic groups.

186 reproductive-aged women presenting to 5 West African ETUs from September 2014 to September 2015.

187 urse in order to increase access to (mostly) African, expert bioinformatics trainers.

188 cant associations were replicated in a South African familial sample.

189 to 8p23.1-p22 (KWE critical region) in South African families.

190 With the revision of the South African food-based dietary guidelines (FBDGs) a new guid

191 ng trees that dominate the canopy of central African forests are now aging.

192 The African fossil record during the crucial time period, th

193 Further, African genetic admixture correlates with an index tabul

194 appreciation of the complex architecture of African genomes is critical to the global effort to unde

195 CASE PRESENTATION: A 22-year-old African gentleman presented with left nasal obstruction

196 ion consisting of people who worked in South African gold mines or lived in associated labor-sending

197 during nonpathogenic infection with SIV from African green monkeys (SIVagm), follicles remain general

198 African green monkeys immunized with two doses of the ve

199 y and protective efficacy in cotton rats and African green monkeys, which are among the best availabl

200 oost neutralization titers in RSV-preexposed African green monkeys.

201 lly active in 293T (embryonic kidney), Vero (African-green monkey kidney epithelial), 3T12 (mouse fib

202 and approximately 2.8% of Europeans whereas Africans have no homozygous HAQ individuals.

203 We therefore initiated an African hepatocellular carcinoma consortium aiming to de

204 te rhinoceros (Ceratotherium simum), a large African herbivore with lips specialized for grazing in o

205 rican Mima mounds, Brazilian murundus, South African heuweltjies, and, famously, Namibian fairy circl

206 up to 9,594 women and 8,738 men of European, African, Hispanic and Chinese ancestry, with and without

207 e the start of the SEARCH trial, 51% of east African HIV-positive adults had viral suppression, refle

208 African horse sickness virus (AHSV) is a lethal arboviru

209 ied and unmodified, traditional, sub-Saharan African houses.

210 , 37.62%), Haarlem (N = 76, 25.08%) and East African-Indian (EAI) (N = 42, 13.86%).

211 African indigenous sheep are classified as fat-tail, thi

212 and, to a lesser extent, in PBMC from South African infants.

213 wildlife research programs led and funded by African institutes and private companies.

214 The volatile fingerprints of South African lamb meat and fat were measured by proton-transf

215 Verde, whose Kriolu language traces to West African languages and Portuguese [29, 32-35] and whose g

216 cephaly is not associated with the original, African lineage of ZIKV.

217 ers (multiplicity of infection > 0.07) of an African lineage strain (MR766 Uganda: ZIKV(U)) considere

218 pe (E) protein, whereas many isolates of the African lineage virus lack this site.

219 tes in the Brazilian lineage compared to the African lineage, mainly in nonstructural proteins, espec

220 The deepest diversifications of African lineages were complex, involving either repeated

221 low luminosity increasing hunting success of African lions.

222 two representative species of lungfishes, an African lungfish (Protopterus dolloi) and the Australian

223 roughout the Americas, thousands of enslaved Africans managed to escape captivity and establish lasti

224 d determined the spatial resolution of eight African megachiropterans with distinct roosting and feed

225 ish), and although black Caribbean and black African men reported greater proportions of concurrent p

226 the proportions of black Caribbean and black African men reporting being sexually competent at sexual

227 group A conjugate vaccine developed for the African meningitis belt, an enhanced meningitis surveill

228 tudy (Research on Obesity and Diabetes Among African Migrants) conducted among Ghanaian adults residi

229 This study used cost data from 18 African monitoring institutions (piped water suppliers a

230 Circulation (AMOC) and collapses of the West African Monsoon (WAM).

231 Fossil evidence points to an African origin of Homo sapiens from a group called eithe

232 ad of the virus, very likely from an initial African origin.

233 x tabulating idiolectal features with likely African origins.

234 reveal substantial subsequent gene flow with African palm populations.

235 patients being HLA-B*53 carriers, and 2 of 3 African patients being homozygous for HLA-B*53:01, is ap

236 In a prospective cohort study, 273 South African patients with extensively drug-resistant tubercu

237 We satellite tracked postnatal dispersal in African penguins (Spheniscus demersus) from eight sites

238 Genetic diversity is high in African populations ( 0.13), low in Asian populations (

239 e C (PRDM9c) is the second-most common among African populations and differs from PRDM9a by an argini

240 -wide genetic structure analysis of southern African populations of An. funestus from Zambia, Malawi,

241 r basis of pyrethroid resistance in southern African populations of this species is associated with a

242 Fine-mapping of these components in southern African populations reveals admixture and cultural rever

243 nt study cataloging variation in continental African populations suggests this type of African-specif

244 of the San contributing more to some western African populations than to others.

245 ts in lymphoblastoid cell lines across three African populations.

246 monomorphic in the 1000 Genomes European and African populations.

247 ca, as well as 124 individuals from six west African populations.

248 made about the demographic histories of non-African populations.

249 nt episodes of natural selection in southern African populations.

250 es was lower compared to New World and Asian-African primate communities.

251 mary attractor of ecotourists to sub-Saharan African protected areas.

252 uentially diagnosed RR-TB patients per South African province, were drawn from the years 2011 and 201

253 NOHARM (Novel use Of Hydroxyurea in an African Region with Malaria) was a randomized, double-bl

254 A multiagency team, including staff from the African Region, developed a comprehensive list of outcom

255 all seeds and loss of seed shattering during African rice domestication.

256 -control study nested within the multicenter African RTS,S/AS01E phase 3 trial.

257 is significantly higher in European than in African samples.

258 African Sanga cattle are an intermediate type of cattle

259 , and central Asia (16%) and decline in many African savannas (e.g., -18% in sub-Saharan western Afri

260 In the dry tropics, including African savannas, many trees grow new leaves during the

261 of blood culture-based febrile illness in 13 African sentinel sites with previous reports of typhoid

262 e drive approach in a variety of sub-Saharan African settings.

263 We examined social air-breathing in African sharptooth catfish Clarias gariepinus, to determ

264 The north African site of Jebel Irhoud contains one of the earlies

265 ; Trypanosoma brucei, the causative agent of African sleeping sickness; and Plasmodium spp., the caus

266 of Genetic Counselors in Asia, and Southern African Society for Human Genetics, endorsed the final s

267 al African populations suggests this type of African-specific genotyping array is both necessary and

268 malian model of epimorphic regeneration, the African spiny mouse, to examine cell-based inflammation

269 cted from day 10 postimmunization.IMPORTANCE African swine fever (ASF) is endemic in Africa, parts of

270 African swine fever is a contagious and often lethal dis

271 African swine fever virus (ASFV) is a highly pathogenic,

272 African swine fever virus (ASFV) is a macrophage-tropic

273 The etiological agent, African swine fever virus (ASFV), is a highly structural

274 for foot-and-mouth disease virus (FMDV) and African swine fever virus (ASFV).

275 new group or cluster of viruses encompassing African swine fever virus, faustovirus, pacmanvirus, and

276 African tick bite fever is the most commonly encountered

277 Exposure of Africans to fatal pathogens, such as Plasmodium falcipar

278 otavirus vaccine at different doses in South African toddlers and infants.

279 otein that confers innate resistance to most African trypanosomes, but not Trypanosoma brucei rhodesi

280 i (T. brucei), the causative agent for human African trypanosomiasis (HAT) or sleeping sickness.

281 Trypanosoma brucei causes human African trypanosomiasis (HAT).

282 Trypanosoma brucei causes African trypanosomiasis and contains three full-length o

283 Trypanosoma brucei causes fatal human African trypanosomiasis and evades the host immune respo

284 ffolds within the GlaxoSmithKline HAT (Human African Trypanosomiasis) and Chagas chemical boxes, two

285 causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast wi

286 esiense or T.b. gambiense, which cause human African trypanosomiasis.

287 anosoma brucei, the causative agent of human African trypanosomiasis.

288 African USA300 isolates have aberrant spa-types (t112, t

289 1997-2013) and mortality data from the South African vital registration system (1997-2014), using a B

290 87 isolates, representing the global VNI and African VNB lineages, highlighted a deep, nonrecombining

291 4] for black Caribbean and 2 [1-5] for black African vs 1 [1-2] for white British), and although blac

292 6.5% for black Caribbean and 38.9% for black African vs 14.8% for white British), these differences w

293 2.9% for black Caribbean and 21.9% for black African vs 47.4% for white British) and the number of pa

294 erican women as well as western, sub-Saharan African women compared with white American, European, an

295 ared with white American, European, and east African women furthermore suggests that selected genetic

296 INTERPRETATION: Among African women with a high prevalence of bacterial vagino

297 a prospective cohort of young, healthy South African women, we found that individuals with diverse ge

298 n vaginal microbiota and immune mediators in African women.

299 shown that the Guanches carried common North African Y chromosome markers (E-M81, E-M78, and J-M267)

300 r side-by-side comparison uncovered that the African ZIKV isolate (MR-766) is more potent at causing