ライフサイエンスコーパス: African American

1 ubjects (65.83% European American and 34.17% African American).

2 s, 49 (45.8%) were male, and 43 (40.2%) were African American.

3 9 +/- 10 years, 66% were women, and 10% were African American.

4 = 8533) were women, and 44% (n = 6363) were African American.

5 and 273 (45.0%) were women; 231 (38.1%) were African American.

6 levels, higher body mass index, and who were African-American.

7 as 2.4, 73.3% were Caucasian, and 19.7% were African-American.

8 tivity and is the most frequent haplotype in African Americans.

9 ge of onset of cardiovascular diseases among African Americans.

10 nd blood-related traits in a sample of 1,860 African Americans.

11 ls of fasting or 2-hour glucose levels among African Americans.

12 failure, and peripheral artery disease among African Americans.

13 n American population, and the PTGES gene in African Americans.

14 using the GLI-2012 prediction equations for African Americans.

15 ity of self-report of periodontal disease in African Americans.

16 ic whites, Hispanic/Latinos, East Asians and African Americans.

17 ical bases of CRC incidence and mortality in African Americans.

18 the complex genetic history of Africans and African Americans.

19 and management of chronic HBV infection for African Americans.

20 eviously known signals are also risk loci in African Americans.

21 s, and psychosocial outcomes, yet few target African Americans.

22 prevalence among all populations, including African Americans.

23 5 participants of European descent and 2,119 African Americans.

24 nd mortality have not been shared equally by African Americans.

25 sleep duration and body weight regulation in Africans Americans.

26 Asian/Pacific Islander, 23 (29%) were black/African American, 11 (14%) were white, 16 (21%) were whi

27 tudy, 4995 (42%) were white, 3176 (26%) were African American, 1823 (15%) were Hispanic, and 1555 (13

28 rges, with 21,212 Caucasians (71.69%), 5,825 African Americans (19.69%), and 2,546 non-Caucasians/non

29 were 22.9 kg/m2 (CI, 19.5 to 26.3 kg/m2) in African Americans, 21.5 kg/m2 (CI, 18.5 to 24.5 kg/m2) i

30 We identified 100 patients (64 white, 8 African American, 25 Asian, and 3 Hispanic) with a mean

31 (n = 846 whites, 323 Chinese Americans, 334 African Americans, 252 Hispanics, and 195 South Asians),

32 from 4 race/ethnicity groups (white [38.5%], African American [27.5%], Hispanic [22.1%], and Chinese

33 1-89.8%), and there was a high proportion of African Americans (29.5-30%).

34 Adjusted HS prevalences among African American (296 per 100000; 95% CI, 291-300 per 10

35 child participants was 45% (n = 45) black or African American, 33% (n = 33) white, 4% (n = 4) Asian,

36 mong 83 racially diverse adult patients (61% African American, 34% Caucasian, and 5% Other) hospitali

37 ese Americans, 31.1% (CI, 26.3% to 36.3%) in African Americans, 38.5% (CI, 32.6% to 44.6%) in Hispani

38 te race/ethnicity, 26.9% (n = 54) were black/African American, 4.0% (n = 8) were Asian, 8.0% (n = 16)

39 y adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females).

40 drome over the course of 25 years among 1995 African Americans (56% women, 18-30 years old) in the Co

41 s [interquartile range, 53-71]; 57% men; 32% African American); 6-month follow-up was completed for 2

42 articipants were female (61.0%) and 550 were African-American (60.7%), with a mean age of 58.7 years.

43 icans (19.69%), and 2,546 non-Caucasians/non-African Americans (8.62%).

44 n) and 100 control individuals (58 white, 23 African American, 8 Asian, and 11 Hispanic) with a mean

45 on for rs1409568 in an independent cohort of African American (896 cases and 1591 controls; P=0.03) b

46 SVR was similar between African Americans (90.5% [546/603]) and all others (91.7

47 Subjects were mostly African Americans (94.9%) with a mean (standard deviatio

48 Participants were predominantly African American (95%), with a median age of 38 years.

49 was assessed by immunohistochemistry in 163 African American (AA) and 144 White TNBC tissue microarr

50 of DSM-IV nicotine withdrawal in a sample of African American (AA) and European American (EA) smokers

51 to which differences in sleep between black/African American (AA) and white/European American (EA) a

52 risk of acute rejection, particularly within African American (AA) kidney transplant recipients; litt

53 aggressiveness and therapeutic resistance in African American (AA) men.

54 African American (AA) women (n = 312) had lower initial

55 Compared with white American (WA) women, African American (AA) women have a 2-fold higher inciden

56 sociations by breast cancer subtype or among African American (AA) women, who are disproportionately

57 African Americans (AA) are disproportionately affected b

58 ree ethnic groups: Caucasian Americans (CA), African Americans (AA), and Asian Americans (AS).

59 on acute rejection, graft loss and death in African-American (AA) kidney transplant (KTX) recipients

60 In African-American (AA) OD subjects (n=383), we identified

61 regions of 82 addiction-related genes in 256 African Americans (AAs) (117 cases with AD-ND codependen

62 o more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC,

63 e high prevalence of vitamin D deficiency in African Americans (AAs) may be a contributing factor to

64 African Americans (AAs) tend to have higher plasma insul

65 28,677 Europeans/European Americans and 9925 African Americans) across 15 studies.

66 articipants from the Jackson Heart Study, an African-American adult cohort, who were without diabetes

67 -based cohort study comprised exclusively of African American adults (n=5306).

68 y 2% (N = 0.65 million, 95% CI 0.55-0.74) of African American adults with T2D to remain undiagnosed w

69 fitness in this longitudinal study of young African American adults, suggesting the increased risk f

70 ertension in a US population-based sample of African American adults.

71 nic SBP/DBP >/=140/90 mm Hg are proposed for African American adults: daytime SBP/DBP >/=140/85 mm Hg

72 es of potassium and glucose metabolism.Among African-American adults with prediabetes, we conducted a

73 re disparities in postoperative outcomes for African Americans after surgical intervention in the uni

74 adults (1022 [50.7%] female and 479 [23.8%] African American) aged 5 to 19 years at study entry, the

75 control subjects with European American and African American ancestry followed by metaanalysis.

76 63.0%) of the mothers identified as black or African American and 243 (18.3%) as Hispanic or Latino.

77 ects) and 298 subjects in the ICS- group (49 African American and 249 white subjects).

78 ere were 922 subjects in the ICS+ group (248 African American and 674 white subjects) and 298 subject

79 t low risk for PTB, the second predominantly African American and at high-risk (n = 96).

80 y affects female patients, young adults, and African American and biracial patients.

81 ed criterion counts of comorbid AD and MD in African American and European American data sets collect

82 ciated with CKD was particularly large among African American and Hispanic individuals.

83 wer in patients >/=80 years), race (lower in African American and Hispanic participants), geographic

84 Among African American and Hispanic participants, adjusted ris

85 , presentation, and outcomes of PPCM between African American and non-African American women.

86 ttern of airway inflammation differs between African American and white subjects is unclear.

87 are sputum airway inflammatory phenotypes of African American and white subjects treated or not with

88 rmed a secondary analysis of self-identified African American and white subjects with asthma enrolled

89 e disequilibrium information in European and African Americans and applied these to large T2D case-co

90 sion in particular is highly prevalent among African Americans and contributes directly to the notabl

91 s found to be as low as what is reported for African Americans and Hispanics, and lower than what is

92 onents cite the reduction of disparities for African Americans and minorities as an expected benefit.

93 itecture of asthma in European Americans and African Americans and reinforces the need to study popul

94 ent are to describe cardiovascular health in African Americans and to highlight unique considerations

95 among African-ancestry populations, such as African Americans and western, sub-Saharan Africans, com

96 isparities in breast cancer outcomes between African Americans and White Americans.

97 ses by race revealed similar associations in African Americans and whites (all ps < 0.03).

98 95% CI 0.43, 2.25) were encountered between African Americans and Whites receiving surgery at hospit

99 se of disparities in life expectancy between African Americans and whites.

100 Analyses focused on 407 African-American and 264 European-American children who

101 tories across early childhood in a sample of African-American and European-American low-birth-weight

102 ations in somatic tumor genomics between the African-American and White-American populations is also

103 R = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, includ

104 12.7% (5365) were Hispanic, 9.4% (3976) were African American, and 12.6% (5351) were other minorities

105 2622 white, 803 Chinese American, 1893 African American, and 1496 Hispanic persons from MESA (M

106 s, 8955 (90.6%) were male, 7474 (75.6%) were African American, and 5376 (54.4%) were aged 15 to 24 ye

107 years and of whom 56% were female, 58% were African American, and 54% had hypertension, in Chicago,

108 s 49 +/- 14 years, 57% were female, 50% were African American, and 54% had hypertension.

109 cipants included 808 non-Hispanic Caucasian, African American, and Asian university students.

110 BeadChip in 17,010 individuals of European, African American, and Hispanic ancestry.

111 s receive on average 36% more callbacks than African Americans, and 24% more callbacks than Latinos.

112 13 years of age and included 39% women, 15% African Americans, and 36% persons with diabetes.

113 nt in 1.3% of European Americans and 8.4% of African Americans, and are candidates to contribute to o

114 in Caucasians, we separated their effects in African Americans, and found that rs1175550G and to a le

115 001), a finding that was stronger among men, African Americans, and Hispanics.

116 ung ages in boys of white race/ethnicity and African Americans, approximately age 8 years and age 25

117 African Americans are at increased risk of iron deficien

118 re) data (2006-2010) to measure outcomes for African Americans as compared with Whites after 12 major

119 mong those who enrolled in college, affirmed African Americans attended relatively more selective col

120 14.0 years (95% CI, 13.9-14.1 years) in non-African American boys (difference, -0.0 years; 95% CI, -

121 13.4 years (95% CI, 13.3-13.4 years) in non-African American boys (difference, -0.3 years; 95% CI, -

122 was 13.1 years (95% CI, 13.0-13.2 years) in African American boys vs 13.4 years (95% CI, 13.3-13.4 y

123 was 14.0 years (95% CI, 13.8-14.1 years) in African American boys vs 14.0 years (95% CI, 13.9-14.1 y

124 the group at highest risk for fracture, non-African American boys, peak fracture incidence occurred

125 Women's Circle of Health Study (WCHS) in the African American Breast Cancer Epidemiology and Risk Con

126 ving Forward, a weight loss intervention for African American breast cancer survivors (AABCS) on weig

127 n 614 cases and 743 controls enrolled in the African American Cancer Epidemiology Study (2010-2015).

128 descent recruited from the population-based African American Cancer Epidemiology Study.

129 6.3% in 2015 decreasing to 16.5% in 2060) to African American children (24.5% in 2015 and 22.0% in 20

130 rometry outcomes were compared with those of African American children from the third National Health

131 ed to enhance supportive parenting for rural African American children will ameliorate the associatio

132 at, and insulin kinetics in obese Latino and African American children with habitual high sugar consu

133 methylation patterns and gene expression in African American children with persistent atopic asthma

134 d diastolic blood pressure was greater among African-American children than among European-American c

135 c utility of heart rate in a community-based African American cohort in the Jackson Heart Study.

136 etween potassium and incident diabetes in an African-American cohort, and to determine the effect of

137 In this African-American cohort, we found that aldosterone may m

138 The burden of cardiovascular disease in the African American community remains high and is a primary

139 Differences in the breast cancer burden of African American compared with European/white American w

140 cancer mortality rates have been higher for African American compared with white American women sinc

141 linical cardiovascular disease among admixed African Americans compared with other populations, sugge

142 summary statistics for approximately 10 000 African Americans contributes to the broader goal of inc

143 es and 629 age- and site-matched controls of African-American descent recruited from the population-b

144 African Americans develop chronic kidney disease and pul

145 performed using the Illumina 5 M chip in 691 African American-Diabetes Heart Study participants (AA-D

146 onary Disease [COPD]; non-Hispanic white and African American), ECLIPSE (Evaluation of COPD Longitudi

147 ions for some tailored pharmacotherapies for African Americans (eg, heart failure medications), disea

148 Hispanic ethnicity (OR: 1.8; P < 0.001) and African American ethnicity (OR: 1.6; P < 0.001) were ass

149 eastfeeding women (OR >49.0; P < 0.001), but African American ethnicity was also associated with incr

150 t among those who participated in the Strong African American Families program (mean [SD] time, 2.61

151 hildren were assigned randomly to the Strong African American Families randomized prevention trial or

152 Of the 667 participants in the Strong African American Families randomized prevention trial, 1

153 n Americans (USAAs) to those of foreign-born African Americans (FBAAs) with chronic hepatitis B.

154 Among African Americans from 2 large, well-established cohorts

155 riable linear regression analysis among 1554 African Americans from MESA (Multi-Ethnic Study of Ather

156 In 822 African Americans from the Genetic Epidemiology Network

157 12.4 years (95% CI, 12.3-12.5 years) in non-African American girls (difference, -0.3 years; 95% CI,

158 11.6 years (95% CI, 11.5-11.6 years) in non-African American girls (difference, -0.6 years; 95% CI,

159 to increase in certain populations, such as African American girls and Hispanic boys.

160 and 11.0 years (95% CI, 10.8-11.1 years) in African American girls vs 11.6 years (95% CI, 11.5-11.6

161 and 12.1 years (95% CI, 12.0-12.3 years) in African American girls vs 12.4 years (95% CI, 12.3-12.5

162 dividuals with ophthalmic needs, focusing on African Americans >/=50 years of age at multiple inner-c

163 surance on reducing surgical disparities for African Americans has not previously been examined.

164 African Americans have a heightened risk of developing c

165 the equal access military healthcare system, African Americans have outcomes similar to Whites.

166 African Americans have the highest breast cancer mortali

167 African Americans have the highest incidence and mortali

168 ions from 243 healthy volunteers of Asian or African-American heritage using both the spectrophotomer

169 rable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the conco

170 primary outcome was use of IPBR among white, African American, Hispanic, and other minority groups be

171 erosis, a multicenter US study of Caucasian, African-American, Hispanic, and Chinese-American adults

172 Individuals were recruited who were African-American, Hispanic/Latino, or Asian over age 40

173 African Americans in California who were uninsured or on

174 recent research suggests that disadvantaged African Americans in the rural Southeast who attend coll

175 50 years in average-risk persons, except in African Americans in whom limited evidence supports scre

176 The USPSTF guidelines captured 404 of 732 African American individuals (55.2%) with a CAC score gr

177 andomized prevention trial, 119 right-handed African American individuals aged 25 years living in rur

178 his prospective, community-based study, 2812 African American individuals aged 40 to 75 years without

179 reatment recommendations on 38% of high-risk African American individuals at the expense of not recom

180 urther study is needed to understand whether African American individuals benefit from interventions

181 not recommending treatment in nearly 25% of African American individuals eligible for statins by ACC

182 rain development in low socioeconomic status African American individuals from the rural South.

183 ear ASCVD event rate in the presence of CAC, African American individuals not eligible for statins by

184 The inverse associations were less strong in African American individuals than in the other 4 racial/

185 ion (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinic

186 less than 50 mg/dL (<55 mg/dL for women and African American individuals).

187 rving a population with a high proportion of African American individuals, included 220 women with PP

188 unication for some subpopulations, including African American individuals.

189 etin (TTR) gene (V122I), present in 3.43% of African American individuals.

190 genetic index of PTSD-for both European- and African-American individuals-and can be used in polygeni

191 was associated with lower risk for death in African Americans, Japanese Americans, Latinos, and whit

192 African Americans lost more spine BMD than did Caucasian

193 Latent class analysis shows that African American males fared the worst, with lives chara

194 sting for PCA management, genetic testing of African American males, and addressing the value framewo

195 d in the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium.

196 r in two separate cohorts, and maintained in African American men.

197 mg for white women, 3,454 (SD, 1,651) mg for African-American men, and 3,397 (SD, 1,641) mg for Afric

198 This interaction is replicated in African-American mothers (PG x E=0.01) from an independe

199 amples of European-American ( n = 4,402) and African-American ( n = 908) participants of the Atherosc

200 entified as non-Hispanic White (n = 32,103), African American (n = 30,209), Japanese (n = 35,987), Na

201 characterize the ages at which self-reported African American (n = 4973), white American (n = 8886),

202 We analyzed data from 190,949 African American, Native Hawaiian, Japanese American, La

203 185 855 African Americans, Native Hawaiians, Japanese Americans,

204 sh odds ratio 5.18, drinker odds ratio 3.62, African American odds ratio 0.24.

205 .52, porcine cadaveric mesh odds ratio 4.03, African American odds ratio 3.08, length of stay odds ra

206 In 1,552 European Americans and 1,872 African Americans of the Atherosclerosis Risk in Communi

207 ixed cohort and an average of 5 of either 10 African Americans or 10 Europeans.

208 experiment of hiring discrimination against African Americans or Latinos (n = 28).

209 odds of educational attainment compared with African American (OR, 2.82; 95% CI, 1.77-4.50) and Hispa

210 s the odds of gainful activity compared with African American (OR, 5.17; 95% CI, 3.16-8.45) and Hispa

211 n the level of hiring discrimination against African Americans over the past 25 years, although we fi

212 (OR), 2.4, P = .02; Asian, OR, 3.1, P = .02; African American, P < .001; paternal education less than

213 In the rural southeastern United States, African American parents and their 11-year-old children

214 ns in 7,550 European ancestry (EA) and 2,030 African American participants (AA) free of diagnosed dia

215 enn 1 and Yale-Penn 2 samples) totaling 4653 African American participants and 3169 European American

216 ity and heart failure hospitalizations among African American participants in the Jackson Heart Study

217 icably associated with comorbid AD and MD in African American participants.

218 METHODS AND We analyzed African Americans participants with chronic kidney disea

219 wide association study of positive affect in African-American participants, we identify a single-nucl

220 Seventy-eight of 5,825 African American patients (1.34%) had the Adult Comfort

221 The study included more African American patients (55.4%) compared with white (3

222 dds ratio [OR], 1.28; 95% CI, 1.11-1.48) and African American patients (OR, 1.84; 95% CI, 1.24-2.73)

223 ormed at a tertiary care referral center, 50 African American patients 60 years or older with nonamyl

224 Twenty-seven African American patients and 9 patients with ATTR V122I

225 isparity for race and educational level with African American patients less likely to start on APD (O

226 cioeconomic differences and how treatment of African American patients might be tailored to improve h

227 ication of ATTR V122I amyloidosis in elderly African American patients with HF.

228 ercentage of joint replacements performed on African American patients, and median income of the hosp

229 African American patients, Hispanic patients, and new hi

230 Sixty African-American patients with LAgP, aged 5 to 25 years,

231 expression differences between Caucasian and African-American patients with triple-negative breast ca

232 rs12252 was genotyped in 54 African-American pediatric outpatients with influenza (F

233 roximately 5%) in FEV1 and FVC compared with African American peers from the third National Health an

234 its significance is not well established in African Americans persons whose cardiac comorbidities an

235 ocus that was independently replicated in an African-American population.

236 ere found in areas with low-income and black/African American populations.

237 y factors of asthma in European American and African American populations.

238 ulations but not, to our knowledge, in large African American populations.

239 assortative mating in European-American and African-American populations.

240 in the Northeast, the intervention increased African Americans' probability of college enrollment 7-9

241 r vs a 5-year surveillance interval included African American race (relative risk [RR] to white, 1.41

242 African American race or PPI use with LDV/SOF +/- RBV wa

243 d with PGD included ischemic time, recipient African American race, and recipient amiodarone treatmen

244 e > 60 years, panel-reactive antibody > 20%, African American race, Kidney Donor Profile Index > 50%,

245 d to test for differences related to sex and African American race.

246 African-American race was the only factor associated wit

247 Age, hypertension, body mass index, and African-American race were independently associated with

248 On multivariate analysis, male sex, African-American race, and non-Hispanic white race/ethni

249 African-American race/Hispanic ethnicity and requirement

250 omote equity in the cardiovascular health of African Americans require input from a broad set of stak

251 ver, the TSNAX-DISC1 locus replicated in the African-American sample (rs149133391, minor allele frequ

252 To determine whether African American Study of Kidney Disease and Hypertensio

253 tes, rs653747 in LINC00923 replicated in the African American Study of Kidney Disease and Hypertensio

254 ammonium excretion and clinical outcomes in African American Study of Kidney Disease and Hypertensio

255 Patients enrolled in the African American Study of Kidney Disease and Hypertensio

256 D, we performed a retrospective study of 899 African American Study of Kidney Disease and Hypertensio

257 Among 1018 participants, African American subjects (n = 264) had a lower FEV1 per

258 African American subjects exhibit greater eosinophilic a

259 African American subjects have a greater burden from ast

260 ever, when adjusted for confounding factors, African American subjects were more likely to exhibit eo

261 In African-American subjects, we identified an interaction

262 Yet, in African Americans, the X-linked G6PD G202A variant (T-al

263 id declines in ideal BP observed in boys and African Americans, thus introducing disparities.

264 , and virological characteristics of US-born African Americans (USAAs) to those of foreign-born Afric

265 monstrates a different profile of disease in African American vs non-African American women.

266 lly modifiable risk factor, particularly for African Americans.We sought to determine the effects of

267 Patch-tested patients designated as Asian or African American were more likely to have concurrent AD

268 007-2008, 2009-2010, and 2011-2012) of 17747 African American, white American, and Mexican American p

269 al African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signa

270 , genome-wide scans comprising 2345 cases of African Americans with IBD (1646 with CD, 583 with UC, a

271 performed a genome-wide association study of African Americans with IBD and identified loci associate

272 ion fraction less than 30% compared with non-African American women (48 [56.5%] vs 30 [39.5%], P = .0

273 African American women also have case fatality rates rel

274 ong obesity, metabolic syndrome, and TNBC in African American women and mechanistic studies that link

275 For example, in the United States, African American women are more likely than non-Hispanic

276 sed risk of triple-negative breast cancer in African American women as well as western, sub-Saharan A

277 endocrine therapy that is less effective in African American women because of the higher prevalence

278 rences in prevalence may be, in part, due to African American women being disproportionally affected

279 ations: Preeclampsia is more prevalent among African American women than among white women.

280 African American women were also more likely to worsen a

281 African American women were diagnosed with PPCM at a you

282 Purpose African American women with breast cancer have higher ca

283 rofile of disease in African American vs non-African American women.

284 e potential link between obesity and TNBC in African American women.

285 mes of PPCM between African American and non-African American women.

286 of TNBC in premenopausal and postmenopausal African American women.

287 oor outcomes associated with preeclampsia in African American women.

288 t genome-wide G x E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of ter

289 rformed in urban settings with predominantly African-American women (n=27).

290 etween premenopausal hysterectomy and EOC in African-American women and explored whether hormone ther

291 In a population of African-American women diagnosed after 2000, our overall

292 ith LTL in a sample of 1,481 older white and African-American women from the Women's Health Initiativ

293 n-American men, and 3,397 (SD, 1,641) mg for African-American women, and did not differ significantly

294 ry pattern may reduce ovarian cancer risk in African-American women, and particularly among postmenop

295 women, and particularly among postmenopausal African-American women.

296 )-2010-in relation to ovarian cancer risk in African-American women.

297 in white women with little representation of African-American women.

298 y marked differences between White and Black/African-American women.

299 , disease management is less effective among African Americans, yielding higher mortality.

300 abilities for ages 8 to 30 years occurred in African American young men, among whom a net 2.9% (95% C