ライフサイエンスコーパス: Alder

1 Alder buckthorn (Frangula alnus) is one of Ireland's rar

2 an allene-enyne intermediate generated by an Alder-ene reaction in the first step.

3 ive (up to 99% ee) reductive cyclization and Alder-ene cycloisomerization of 1,6-enynes, respectively

4 h the formal [2+2] cycloaddition (major) and Alder-ene (minor) reaction products.

5 Comparable results were obtained for Ben Alder and Ben Gairn berries.

6 ramolecular aromatic ene and (3) bimolecular Alder ene.

7 Diels-Alder cycloadditions of 3-oxobut-1-enyl substituted orth

8 Diels-Alder reactions employing 1,2-azaborine heterocycles as

9 vantage of the decarbonylative [4 + 2] Diels-Alder cycloaddition reaction between ethynyl and tetraph

10 utility of this monomer in the [4 + 2] Diels-Alder cycloaddition to produce well-defined, sulfonated

11 which may proceed as a concerted [4+2] Diels-Alder reaction or a stepwise [6+4] cycloaddition followe

12 Cycloadditions, such as the [4+2] Diels-Alder reaction to form six-membered rings, are among the

13 lar versions of this tridehydro (-3H2) Diels-Alder reaction support a concerted mechanism for the par

14 derivative were synthesized by using a Diels-Alder cycloaddition followed by an addition-elimination

15 post-assembly modification (PAM) via a Diels-Alder cycloaddition of the anthracene panels of the cage

16 rms a unique covalent adduct through a Diels-Alder cycloaddition of three of its anthracene ligands w

17 This reaction sequence proceeds via a Diels-Alder cycloaddition reaction catalyzed by dimethylalumin

18 dergoes a wide range of reactions as a Diels-Alder diene, dienophile, and [2 + 2] addend.

19 quantitatively reproduce the KIEs in a Diels-Alder reaction and a catalytic glycosylation.

20 a natural enzyme evolved to catalyze a Diels-Alder reaction and shows how catalysis is achieved.

21 sence of light with suitable enes in a Diels-Alder reaction and undergoes a transformation into imine

22 closed complex are able to catalyze a Diels-Alder reaction between cyclopentadiene and methyl vinyl

23 s of 2,2'-bis(naphthoquinones) using a Diels-Alder reaction of conjugated ketene silyl acetals with b

24 e exhibits exceptional reactivity as a Diels-Alder reaction partner and engages in [4 + 2] cycloaddit

25 Using a Diels-Alder reaction, an anthracene unit with four functionali

26 tio calculations, which suggest that a Diels-Alder-type reaction may be involved with an allyl unit o

27 ere successfully synthesized through a Diels-Alder/oxidative cyclodehydrogenation approach.

28 ticipate in a second stage acylnitroso Diels-Alder cycloaddition.

29 Lewis acid catalyzed retro-Diels-Alder/Diels-Alder sequence, rather than bond rotation in an intimate

30 s sometimes dominates over the allowed Diels-Alder reaction.

31 ieved via an intramolecular amidofuran Diels-Alder cycloaddition/rearrangement followed by an iminium

32 s are used, maleimide deprotection and Diels-Alder cycloaddition can be simultaneously carried out to

33 tereoselective domino Pauson-Khand and Diels-Alder cycloaddition catalyzed by [RhCl(CO)2]2 under CO t

34 petition between self-dimerization and Diels-Alder cycloaddition with an external dienophile usually

35 Langmuir-Hinshelwood, Eley-Rideal, and Diels-Alder might be operating during the formation of PBDD/Fs

36 e recently proposed bis-pericyclic and Diels-Alder routes is blurred, and favorable transition states

37 new observations on catalytic aqueous Diels-Alder and Michael reactions in heterogeneous fashion emp

38 acene (4) that involves a tandem aryne Diels-Alder cycloaddition-deoxygenation strategy.

39 lkylidenecarbenes, were intercepted as Diels-Alder adducts.

40 ctivity of different reactions such as Diels-Alder cycloadditions or Bingel-Hirsch reactions.

41 alyst for iminium-ion based asymmetric Diels-Alder (DA) reactions has been rationally designed.

42 olyol chain, a Ti-catalyzed asymmetric Diels-Alder reaction to generate the cis-decalin skeleton, and

43 c acid delivers the products of an aza-Diels-Alder (Povarov) reaction with high endo-selectivity and

44 Thermal asymmetric aza-Diels-Alder reactions also proceeded in good yields and with h

45 alysis, asymmetric three-component aza-Diels-Alder reactions of 5-, 6-, and 7-membered cyclic ketones

46 ic enantioselective intramolecular aza-Diels-Alder reactions.

47 edox catalysis of radical cation based Diels-Alder cycloadditions mediated by the first-row transitio

48 These reactions lead to bicyclic Diels-Alder adducts that spontaneously lose N2.

49 A key biomimetic Diels-Alder dimerization was found to occur at ambient tempera

50 erminal alkynes yield products of both Diels-Alder and [2 + 2] cycloaddition.

51 wo ester substituents were prepared by Diels-Alder cycloadditions of cyclopentadiene with dimethyl fu

52 successive reactions of the silole by Diels-Alder dimerization, thus enabling the clean gas-phase sy

53 for the fusion of additional rings by Diels-Alder reactions.

54 t cucurbit[7]uril (CB[7]) can catalyse Diels-Alder reactions for a number of substituted and unreacti

55 a perfect molecular vessel to catalyze Diels-Alder reactions of 9-hydroxymethylanthracene with N-subs

56 for an asymmetric Lewis acid catalyzed Diels-Alder reaction.

57 recently reported Lewis acid-catalyzed Diels-Alder reactions of arylallenes and acrylates were studie

58 models proposed for related catalyzed Diels-Alder reactions.

59 d by the intermolecular radical cation Diels-Alder (RCDA) reaction.

60 hway suggest that a stepwise, cationic Diels-Alder cycloaddition is operative.

61 In the classic Diels-Alder [4 + 2] cycloaddition reaction, the overall degree

62 For example, in the classic Diels-Alder reaction, butadiene and ethylene combine to produc

63 identical withCR) for use in classical Diels-Alder (DA) reactions (with 1,3-cyclopentadiene).

64 ion flow in water, while the classical Diels-Alder mechanism contributes only approximately 17%.

65 rrier of 22 kcal/mol for the concerted Diels-Alder process and provide no evidence of a competitive s

66 ed two competing pathways, a concerted Diels-Alder reaction and a stepwise Michael addition, for the

67 In both cases the corresponding Diels-Alder adducts between these reagents and the edge groups

68 lbutadiene to afford the corresponding Diels-Alder products.

69 hetic gain in a cascade cross-coupling/Diels-Alder reaction, delivering borylated or non-borylated ca

70 ons as 2pi or 4pi components (covering Diels-Alder and 1,3-dipolar cycloadditions).

71 ucleotides were either cycloadditions (Diels-Alder, Cu(I)-catalyzed azide-alkyne) or the same Michael

72 rsors via an oxidative dearomatization/Diels-Alder cascade that may have biogenetic relevance.

73 omorphone by oxidative dearomatization/Diels-Alder cycloaddition was investigated.

74 ly prepared by using the photo-dehydro-Diels-Alder (DDA) reaction, access to (1,7)naphthalenophanes b

75 M06-2X) studies of a series of dehydro-Diels-Alder (DDA) reactions.

76 Although intramolecular dehydro-Diels-Alder (IMDDA) reactions have previously been employed fo

77 However, the inverse electron-demand Diels-Alder (DAinv) reaction between tetrazine (Tz) and norbor

78 bioorthogonal inverse electron demand Diels-Alder (IEDDA) cycloaddition, was developed.

79 The emerging inverse electron demand Diels-Alder (IEDDA) reaction stands out from other bioorthogon

80 on (SPAAC) and inverse electron demand Diels-Alder (iEDDA) reactions, have become increasingly popula

81 ficient PAM by inverse electron-demand Diels-Alder (IEDDA) reactions.

82 ork reports an inverse electron demand Diels-Alder (iEDDA)-type reaction to synthesize 1,3,5-trizines

83 ylation and/or inverse electron-demand Diels-Alder addition to residual functional groups within the

84 thiol-yne and inverse electron-demand Diels-Alder additions to independently create two interpenetra

85 pene-tetrazine inverse electron demand Diels-Alder cycloaddition reactions.

86 train-promoted inverse electron-demand Diels-Alder cycloaddition, that is, tetrazine ligation, is rep

87 dicated on the inverse electron demand Diels-Alder reaction as well as the use of this approach to vi

88 employed in an inverse-electron-demand Diels-Alder reaction for heterobiaryl synthesis.

89 rmations (e.g. inverse electron demand Diels-Alder reaction) between the tumour bound antibody and ra

90 by means of an inverse-electron-demand Diels-Alder reaction.

91 e mechanism of inverse electron-demand Diels-Alder reactions of 1,2,3-triazines, and that these mecha

92 talysis of the inverse electron demand Diels-Alder reactions of heterocyclic azadienes has been intro

93 These inverse electron-demand Diels-Alder reactions of triazines have wide applications in b

94 adiene and the inverse electron-demand Diels-Alder reactions with 3,6-bis(trifluoromethyl)tetrazine w

95 The normal electron-demand Diels-Alder reactions with cyclopentadiene and the inverse ele

96 ith alkenes in inverse-electron-demand Diels-Alder reactions.

97 exploiting the inverse electron demand Diels-Alder reactivity of the tetrazine.

98 described employing diastereoselective Diels-Alder and selenocyclization reactions, starting from (R)

99 imetic total synthesis of the dimeric, Diels-Alder natural product griffipavixanthone from a readily

100 We further report that double Diels-Alder reactions under solvent-free condition provide fac

101 We demonstrate a C-F bond driven Diels-Alder reaction of a fluorinated dienophile and a borole

102 c sequence features a highly effective Diels-Alder reaction using a carbamate-substituted siloxy dien

103 nium precursor 22a underwent efficient Diels-Alder cycloaddition with a range of simple and complex d

104 capable of unlocking new and efficient Diels-Alder reactions would have major impact.

105 his study is a highly enantioselective Diels-Alder reaction of a versatile cyclic carbamate siloxy di

106 highly diastereo- and enantioselective Diels-Alder/lactonization organocascade that generates cis- an

107 Few examples of oximino ether Diels-Alder reactions have been reported previously, and norma

108 te disfavored enolate addition and exo Diels-Alder reactions enantioselectively.

109 in one step, and a stereoselective exo-Diels-Alder reaction to form the 6-membered ring.

110 A first Diels-Alder condensation followed by a Stille cross-coupling i

111 Asymmetric syntheses of the flavonoid Diels-Alder natural products sanggenons C and O have been achi

112 to-type cyclization followed by 6-fold Diels-Alder cycloaddition, C216 was obtained by oxidative cycl

113 cyclopropene moiety were designed for Diels-Alder reactions with inverse electron demand, and one tr

114 ters and amides are classic dienes for Diels-Alder reactions.

115 trapped with 3 equiv of furan to form Diels-Alder tris-adduct 3.

116 s experimentally leads to three formal Diels-Alder (DA) cycloaddition products, two of which (involvi

117 dimerization sequence to afford formal Diels-Alder adducts that undergo a smooth gold-catalyzed doubl

118 s subsequently undergo either a formal Diels-Alder cycloaddition or a competitive Michael addition/re

119 antioselective prototropic shift/furan Diels-Alder (IMDAF) cascade to construct the ACD tricyclic cor

120 gel condensation/intramolecular hetero Diels-Alder reaction using O-(arylpropynyloxy)-salicylaldehyde

121 ly arise from an intramolecular hetero Diels-Alder reaction.

122 idines and alkenes, and [4 + 2] hetero-Diels-Alder cycloaddition of aldehydes with dienes.

123 reaction proceeds via a tandem hetero-Diels-Alder cycloaddition of N,N'-bis(benzenesulfonyl)sulfur d

124 s on-water, is a regioselective hetero-Diels-Alder cycloaddition reaction of enol ethers to 4-phosphi

125 ion sequence over the alternate hetero-Diels-Alder cycloaddition reaction.

126 -6pi electrocyclic ring-opening/hetero-Diels-Alder pericyclic cascade.

127 olving the hemiaminal formation/hetero-Diels-Alder reaction affords the bicyclic products in a highly

128 lecular inverse electron-demand hetero-Diels-Alder reaction followed by air oxidation to furnish the

129 ketothioesters participating in hetero-Diels-Alder reaction has remained unexplored.

130 ene in metal-free base-assisted hetero-Diels-Alder reaction is exploited to quickly assemble an impor

131 Bronsted acid catalysts of the hetero-Diels-Alder reaction of a wide variety of aldehydes and dienes

132 lective inverse electron demand hetero-Diels-Alder reaction of beta,gamma-unsaturated alpha-ketothioe

133 lective inverse-electron-demand hetero-Diels-Alder reaction of the remote olefin functionality in die

134 through a one-pot sequence of a hetero-Diels-Alder reaction, an oxidative carbon-hydrogen bond cleava

135 intramolecular Diels-Alder and hetero-Diels-Alder reactions via a single ambimodal transition state,

136 c carbene (NHC)-catalyzed redox hetero-Diels-Alder reactions with azolium enolates generated from alp

137 e-enone cyclizations via formal hetero-Diels-Alder reactions.

138 The domino aldol/hetero-Diels-Alder synthesis of some new tricyclic pyrano[3,4-c]chrom

139 tandem inverse-electron-demand hetero-Diels-Alder/oxa-Michael reaction catalyzed by modularly design

140 2) boron substituent, a one-pot hetero-Diels-Alder/ring contraction cascade occurred to afford N-aryl

141 ising three reactions: (1) hexadehydro-Diels-Alder (for aryne generation), (2) intramolecular aromati

142 eps by capitalizing on the hexadehydro-Diels-Alder (HDDA) cycloisomerization reaction in which an int

143 periments showing that the hexadehydro-Diels-Alder (HDDA) cycloisomerization reaction proceeds in a s

144 We demonstrate that the hexadehydro-Diels-Alder (HDDA) cycloisomerization reaction to produce reac

145 thermally generated by the hexadehydro-Diels-Alder (HDDA) cycloisomerization.

146 stepwise mechanisms of the hexadehydro-Diels-Alder (HDDA) reaction are competitive with activation ba

147 e we report the use of the hexadehydro-Diels-Alder (HDDA) reaction for the de novo construction of a

148 t benzynes produced by the hexadehydro-Diels-Alder (HDDA) reaction react with many secondary metaboli

149 nism of the intramolecular hexadehydro-Diels-Alder (HDDA) reaction, validated against prior and newly

150 benzynes generated by the hexadehydro-Diels-Alder (HDDA) reaction.

151 r (TDDA) and by six in the hexadehydro-Diels-Alder (HDDA) reactions.

152 N-acyl iminium ions as dienophiles in Diels-Alder reactions and electrophilic alkylating agents are

153 eactivity of macrocyclic bis-enones in Diels-Alder reactions was examined using quantum chemical calc

154 their 1-aza- and 2-aza-derivatives in Diels-Alder reactions with ethylene and fumaronitrile were inv

155 The replacement of CH with N increases Diels-Alder reactivity due not only to the more favorable orbi

156 gage diverse dienophiles in an initial Diels-Alder or metal-catalyzed [4 + 2] cycloaddition, triggeri

157 ane structures using an intermolecular Diels-Alder cycloaddition between a pyrazinone and commerciall

158 A stereoselective intermolecular Diels-Alder cycloaddition of an intermediate pyrazinone with b

159 highly stereoselective intramolecular Diels-Alder (IMDA) reaction of the camphanate-containing trien

160 cyclic transformations: intramolecular Diels-Alder and hetero-Diels-Alder reactions via a single ambi

161 ization cascade and the intramolecular Diels-Alder cascade.

162 blished by a late-stage intramolecular Diels-Alder cyclization catalyzed by Me2AlCl or La(OTf)3.

163 mpleted by a late-stage intramolecular Diels-Alder furan (IMDAF) cycloaddition to install the indole.

164 +)-citronellal using an intramolecular Diels-Alder reaction as the key step.

165 The intramolecular Diels-Alder reaction has been used as a powerful method to acc

166 An approach to the intramolecular Diels-Alder reaction has led to a cascade synthesis of complex

167 te-templated asymmetric intramolecular Diels-Alder reaction of a masked o-benzoquinone (MOB) 9 and an

168 hly diastereoselective, intramolecular Diels-Alder reaction of a silicon-tethered acrylate; an effici

169 hydrate template in the intramolecular Diels-Alder reaction of MOBs were revised.

170 ghly diastereoselective intramolecular Diels-Alder reaction of the formed ene-diene to generate the t

171 chiral amine-catalyzed intramolecular Diels-Alder reaction to afford 22 in excellent diastereoselect

172 on the organocatalyzed intramolecular Diels-Alder reaction to form the isobenzofuran core of the eun

173 e, susbtrate-controlled intramolecular Diels-Alder reaction, a transannular enolate alkylation, an ef

174 enzymatic examples (the intramolecular Diels-Alder reaction, and the Cope and the Claisen rearrangeme

175 taking advantage of an intramolecular Diels-Alder reaction, we have developed a prodrug strategy for

176 t course of the central intramolecular Diels-Alder reaction, which is dependent on the nature of the

177 ion step followed by an intramolecular Diels-Alder reaction.

178 ose for bimolecular and intramolecular Diels-Alder reactions in order to investigate the controlling

179 be constructed through intramolecular Diels-Alder reactions of propiolate-derived enynes followed by

180 eral Lewis acid induced intramolecular Diels-Alder reactions remained fruitless, dialkylaluminum chlo

181 Nitrofurans undergo intramolecular Diels-Alder reactions with tethered electron-poor dienophiles

182 a common biomimetic strategy involving Diels-Alder reactions of unusual double diene containing linea

183 cient dienophiles undergo irreversible Diels-Alder reactions, a reversible Diels-Alder reaction with

184 wickerol A (1) that is based on a Jung Diels-Alder reaction, an intramolecular alkylation to complete

185 NH4OAc mediated domino Knoevenagel/Diels-Alder cyclocondensation of beta-ketosulfones 1 and o-for

186 ecies which can be used to effect many Diels-Alder reactions in >95% yield and >95% ee using catalyst

187 key-step, a chiral auxiliary-mediated Diels-Alder cycloaddition was developed, introducing the three

188 ocatechol in inter- or intra-molecular Diels-Alder reactions.

189 ynthetic procedures involving multiple Diels-Alder reactions under harsh extended reaction conditions

190 and control organic reactions, namely Diels-Alder reaction, Claisen rearrangement, and Cope-type hyd

191 und, five of which used a thermal, net Diels-Alder [4+2] cycloaddition and dehydration at 110 degrees

192 The discovery of new Diels-Alder cycloaddition/dehydration routes and experimental

193 in situ, which were trapped in nitroso-Diels-Alder (NDA) reactions with various dienes to afford the

194 through the one-pot oxidative nitroso-Diels-Alder reaction of N-arylhydroxylamines with diene carbam

195 oric acid-catalyzed asymmetric nitroso-Diels-Alder reaction of nitrosoarenes with carbamate-dienes af

196 electivity of the noncatalyzed nitroso-Diels-Alder reaction.

197 nd leads directly to both the observed Diels-Alder and an unobserved [6+4] cycloadduct.

198 The previously observed Diels-Alder reactions of arynes with arene were not observed u

199 the complexity-increasing benefits of Diels-Alder and metal-catalyzed cycloadditions.

200 tatistical effects on the lifetimes of Diels-Alder intermediates.

201 The mechanisms of Diels-Alder reactions between 1,2,3-triazines and enamines hav

202 The activation energy of Diels-Alder reactions correlates very well with reaction energ

203 esumably formed through an initial oxa-Diels-Alder reaction, followed by an elimination of amine.

204 oselective inverse electron demand oxa-Diels-Alder reactions of resorcinarene ortho-quinone methide w

205 cyclic reactions, including the parent Diels-Alder cycloaddition of butadiene with ethylene, electroc

206 loisomerization process a pentadehydro-Diels-Alder (PDDA) reaction-a nomenclature chosen for chemical

207 hrough an intramolecular photochemical Diels-Alder reaction.

208 We intercepted a pre-Diels-Alder intermediate in lovastatin synthesis for the first

209 An intramolecular strain-promoted Diels-Alder methylenecyclopropane (IMDAMC) reaction provided a

210 e of oxidation of naphthazarin quinone Diels-Alder adduct 10 is additionally demonstrated and enables

211 diated [3,3]-sigmatropic rearrangement/Diels-Alder reaction of 1,9-dien-4-yne esters is described.

212 which the key step is a regioselective Diels-Alder reaction between a pyranobenzoquinone dienophile a

213 tered upon a late-stage regioselective Diels-Alder reaction.

214 l-molecule cargo was achieved by retro-Diels-Alder cleavage of an oxanorbornadiene linkage, presumabl

215 ion of bromo-ethylmalonate and a retro-Diels-Alder cycloaddition reaction.

216 f which undergo fragmentation by retro-Diels-Alder reaction at rates that vary with the substitution

217 retro-Diels-Alder reaction of its adduct with N-benzylpyrrole has ma

218 lic gamma-butyrolactones via the retro-Diels-Alder reaction/intramolecular conjugate ene cascade (RDA

219 on the rate of force-accelerated retro-Diels-Alder reactions of furan/maleimide adducts.

220 ccurs via a Lewis acid catalyzed retro-Diels-Alder/Diels-Alder sequence, rather than bond rotation in

221 erated by the NIR light induce reverse Diels-Alder reactions.

222 modynamic parameters of the reversible Diels-Alder reaction between 1,2-azaborines and methyl acrylat

223 le Diels-Alder reactions, a reversible Diels-Alder reaction with the less electron-deficient methyl a

224 yl sulfoxides undergo highly selective Diels-Alder cycloadditions with N-phenylmaleimide with remarka

225 Sequential Diels-Alder reactions on a tautomerized naphthazarin core were

226 furan in situ, and the obtained stable Diels-Alder adducts were subjected to the series of further ch

227 Upon tandem Diels-Alder reactions with several symmetrical as well as unsy

228 for example, four in the tetradehydro-Diels-Alder (TDDA) and by six in the hexadehydro-Diels-Alder (

229 The use of the Diels-Alder adduct of alpha-terpinene and maleic anhydride as

230 Manipulation of the Diels-Alder adducts provides the desired geometrically defined

231 yzed intramolecular cyclization of the Diels-Alder adducts was identified for the efficient formation

232 sequent reductive deoxygenation of the Diels-Alder adducts with Fe2(CO)9 followed by oxidative aromat

233 e furan is a key step facilitating the Diels-Alder and dehydration reactions in the acid sites of the

234 h the gas phase, the enzyme lowers the Diels-Alder barrier significantly, consistent with experimenta

235 The Diels-Alder chemistry of these new dendralenes (as multidienes

236 Both are produced by the Diels-Alder condensation of hexachlorocyclopentadiene with cyc

237 The key steps involve the Diels-Alder cycloaddition of cyclopent-2-en-1-one to the aceto

238 tric Lewis-acid organocatalysis of the Diels-Alder cycloaddition of cyclopentadiene to cinnamates ari

239 A case study of the Diels-Alder cycloaddition of cyclopentadiene with ethylene ser

240 hyde motif that is inaccessible by the Diels-Alder cycloaddition.

241 rd, the superoxide species reduces the Diels-Alder cycloadduct radical cation to the final product an

242 t decrease in selectivity/yield of the Diels-Alder dehydration product is observed.

243 framework tin (Sn-Beta) to produce the Diels-Alder dehydration product, 4-(hydroxymethyl)benzoic acid

244 The Diels-Alder dimer of cyclopentadiene carboxylate, Thiele's aci

245 certain if any of them proceed via the Diels-Alder mechanism.

246 tly proposed mechanisms (including the Diels-Alder one) for this reaction in water (as a first-order

247 free energy simulations show that the Diels-Alder pathway is favored in the enzyme environment.

248 35 nm) "gate" the reversibility of the Diels-Alder reaction and turn the self-healing properties of t

249 The Diels-Alder reaction between 1 and 6 occurs under the selected

250 The Diels-Alder reaction between 2-methylfuran and 3-bromobenzyne

251 endable polymer was synthesized by the Diels-Alder reaction between dithienylfuran and maleimide mono

252 products with a dienophile through the Diels-Alder reaction confirmed the formation of vitamin D3 iso

253 The Diels-Alder reaction enables introduction of new functionaliti

254 Although the Diels-Alder reaction has long been utilized for the preparatio

255 The Diels-Alder reaction is a cornerstone of modern organic synthe

256 hemist engaged in total synthesis, the Diels-Alder reaction is among the most powerful and well under

257 The Diels-Alder reaction is one of the most common methods to chem

258 Thus, calculations predict that the Diels-Alder reaction is privileged in the case of ethyl nitros

259 rein, we review the application of the Diels-Alder reaction of quinones in the total synthesis of nat

260 It is observed that the Diels-Alder reaction only displays high diastereoselectivity w

261 The Diels-Alder reaction represents one of the most thoroughly stu

262 The distortion energy of the Diels-Alder reaction transition states mostly arises from the

263 e origins of chirality transfer in the Diels-Alder reaction using chiral arylallenes are uncovered, a

264 taining CPP precursor was used for the Diels-Alder reaction with the parent benzyne or 3,6-dimethoxyb

265 The Diels-Alder reaction, a [4 + 2] cycloaddition of a conjugated

266 are attached to this module using the Diels-Alder reaction, which also forms one of the acene rings.

267 to the enhancement of the rate of the Diels-Alder reaction.

268 the distortion of the reactants in the Diels-Alder reactions are nearly identical and that the reacti

269 The Diels-Alder reactions between 2 equiv of (E,E)-1,4-bis(4-bromo

270 tivity and endo/exo selectivity of the Diels-Alder reactions involving 1,2-azaborines have been compu

271 The activation free energies for the Diels-Alder reactions of cyclic 1-azadienes are 10-14 kcal mol

272 The Diels-Alder reactions of cyclopentadiene, cyclohexadiene, and

273 that the barriers associated with the Diels-Alder reactions of ethyl nitrosoacrylate are over 30 kJ/

274 ivities and stereoselectivities in the Diels-Alder reactions of substituted cyclopropenes with butadi

275 of alkenes compared to alkynes in the Diels-Alder reactions with tetrazines arise from the differenc

276 The Diels-Alder reactivities of a series of cycloalkenes, from the

277 The physical factors governing the Diels-Alder reactivity of (2,7)pyrenophanes have been computat

278 The Diels-Alder reactivity of C59NH azafullerene has been explored

279 The Diels-Alder step was studied by density functional theory (DFT

280 The Diels-Alder substrate is built up in an efficient manner by rh

281 to smaller distortion energies in the Diels-Alder transition states.

282 cause they are predistorted toward the Diels-Alder transition structures.

283 Thermal Diels-Alder reactions of alpha-amido acrylates with N-Cbz-1,2-

284 nal investigations revealed that these Diels-Alder reactions proceed via transition state structures

285 performed on a set of 13 transannular Diels-Alder (TADA) reactions with 10-18-membered rings.

286 cule featured a novel bis-transannular Diels-Alder reaction that casted stereoselectively the decalin

287 f spinosyn A, catalyzes a transannular Diels-Alder reaction.

288 te for a successful diene transmissive Diels-Alder (DTDA) reaction by employing two different dienoph

289 ingle synthetic step that includes two Diels-Alder additions, two decarbonylations, and two dehydroge

290 mycinone were achieved by means of two Diels-Alder reactions.

291 ceptibility of [5]radialene to undergo Diels-Alder dimerization/polymerization.

292 e, respectively, were found to undergo Diels-Alder reactions to afford mixtures of regioisomeric cycl

293 f chiral dienophiles for the venerable Diels-Alder (DA) cycloaddition.

294 een phosphors and polymer matrices via Diels-Alder click chemistry is devised as a method.

295 Aromatics are formed via Diels-Alder cycloaddition with ethylene, which is produced in

296 n iterative reaction sequence, wherein Diels-Alder reactions and a subsequent aromatization afford hi

297 ntrolled "click-unclick" oxazole-ynone Diels-Alder cycloaddition/cycloreversion and ensuing 2-alkoxyf

298 The key steps are an intramolecular Alder-ene (IMAE) reaction and a lactam-to-lactone rearra

299 cted to a palladium-catalyzed intramolecular Alder-ene (IMAE) reaction, thus producing the isomeric a

300 best match is for an age of 1.186 Ma for the Alder Creek Rhyolite sanidine and 28.201 Ma for the Fish