ライフサイエンスコーパス: Alternaria

1 function and airway eosinophilia induced by Alternaria.

2 mice were challenged once intranasally with Alternaria.

3 es, attenuated the eosinophils' responses to Alternaria.

4 o protease-containing aeroallergens, such as Alternaria.

5 ses and eosinophilia induced by the allergen Alternaria.

6 Exposure to Alternaria (adjusted odds ratio [aOR], 1.07; 95% CI, 1.0

7 id cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosin

8 Previously, Alternaria allergens were shown to produce a sustained i

9 Alternaria also strongly induced other activation events

10 /musty odour and increased concentrations of Alternaria alternata allergen, Aspergillus fumigatus ant

11 associated mold sensitivity, particularly to Alternaria alternata and Cladosporium herbarum, with the

12 e, and allergens that activate GPCRs such as Alternaria alternata and house dust mite.

13 tory treatment and frequent sensitization to Alternaria alternata and soybean.

14 ies identifying proteins from fungal species Alternaria alternata due to significant interspecies pro

15 ure to extract from the respiratory pathogen Alternaria alternata elicits profound epithelial cell (E

16 rmal and asthmatic subjects to extracts from Alternaria alternata evoked a rapid and sustained releas

17 (-/-) mice were challenged intranasally with Alternaria alternata extract for 4 consecutive days to i

18 by using IL-33, house dust mite extract, or Alternaria alternata extract.

19 linking apoptosis to this disease caused by Alternaria alternata f. sp. lycopersici.

20 Alternaria alternata f.sp. Lycopersici (AAL) toxin induc

21 and secretion in the phytopathogenic fungus Alternaria alternata in the presence of host-plant extra

22 Alternaria alternata is a clinically relevant allergen t

23 The fungal allergen Alternaria alternata is implicated in severe asthma and

24 Fusarium moniliforme toxins (fumonisins) and Alternaria alternata lycopersici (AAL) toxins are member

25 mice were subjected to acute challenge with Alternaria alternata or house dust mite, and secretion o

26 We found that Alternaria alternata produces aspartate protease(s) and

27 The tangerine pathotype of Alternaria alternata produces the A. citri toxin (ACT) a

28 ulated pomegranate fruits with six different Alternaria alternata species complex isolates, known to

29 ecretion of mannitol in the tobacco pathogen Alternaria alternata suggested that, like their animal c

30 ponses after exposure to the fungal allergen Alternaria alternata Thus, CysLT1R promotes LTC4- and Al

31 nst Phytophthora parasitica var. nicotianae, Alternaria alternata var. nicotianae and Rhizoctonia sol

32 c airways disease to the fungal aeroallergen Alternaria alternata was determined.

33 in the presence or absence of VCs emitted by Alternaria alternata We found that volatile emissions fr

34 iveness to cold dry air and sensitisation to Alternaria alternata were determined before age 6 years.

35 gic airway inflammation (house dust mice and Alternaria alternata) and OVA-induced models of active a

36 cts from seven environmental airborne fungi (Alternaria alternata, Aspergillus versicolor, Bipolaris

37 d, and specific IgE levels were measured for Alternaria alternata, cat, cockroach, dog, Dermatophagoi

38 whole extract fungal (Aspergillus fumigatus, Alternaria alternata, Cryptococcus neoformans and Candid

39 s farinae, dog, cat, timothy grass, ragweed, Alternaria alternata, egg, peanut, milk, and German cock

40 nically relevant ubiquitous fungal allergen, Alternaria alternata, increases bronchoalveolar lavage l

41 ommon environmental aeroallergen, the fungus Alternaria alternata, induces rapid release of IL-33 int

42 (NAPT) with Dermatophagoides pteronyssinus, Alternaria alternata, Olea europaea and grass pollen wer

43 n tests with Dermatophagoides pteronyssinus, Alternaria alternata, Olea europea, and a mix of grass p

44 esponse positivity to Aspergillus fumigatus, Alternaria alternata, or Cladosporium herbarum.

45 vigorously to a common environmental fungus, Alternaria alternata, which is implicated in the develop

46 skin infection with phaeohyphomycosis due to Alternaria alternata, which we treated with topical anti

47 inflammation induced by the fungal allergen Alternaria alternata.

48 ys were exposed to a common fungal allergen, Alternaria alternata.

49 for pathogenicity in the necrotrophic fungus Alternaria alternata.

50 asally on days 0, 3 and 6 with a filtrate of Alternaria alternata.

51 tion by age 12, in response to environmental Alternaria and Aspergillus, was elevated in children wit

52 an rhinovirus infection and sensitization to Alternaria and Cladosporium and daily counts of ambient

53 tigated the roles of protease(s) produced by Alternaria and of PARs expressed on eosinophils in their

54 Alternaria and Penicillium induced calcium-dependent exo

55 ts mites, pollens, animal epithelia, moulds (alternaria) and others.

56 ne allergens, including the house dust mite, Alternaria, and Aspergillus, for up to 8 wk.

57 exposure to an environmental fungus, such as Alternaria, and asthma have been recognized clinically.

58 een exposure to environmental fungi, such as Alternaria, and development and/or exacerbation of asthm

59 ing Dermatophagoides pteronyssinus, pollens, alternaria, and dog epithelia, was performed in patients

60 iven inhaled house dust mite, cat dander, or Alternaria, and the effect of inhibiting allergen-specif

61 Except for Alternaria antigen in dust, concentrations of airborne m

62 Alternaria antigen was detected in dust from 98% of home

63 Although Alternaria, Arthrinium, Epicoccum and Curvularia were si

64 mechanisms of airway Th2 responses by using Alternaria as a clinically relevant model for environmen

65 The presence of Cladosporium, Alternaria, Aspergillus, and Penicillium species increas

66 Cladosporium, Alternaria, Aspergillus, and Penicillium species were fo

67 ight into the uniquely pathogenic aspects of Alternaria-associated asthma.

68 ally on skin test reactivity to the allergen Alternaria at age 6 from among a large population of chi

69 erence in detection rate or concentration of Alternaria between asthmatic homes and homes without an

70 such as sclerotinia stem rot, blackleg, and alternaria black spot resulting in significant loss of c

71 ression conferred greater protection against Alternaria brassicae, Leptosphaeria maculans and Sclerot

72 al plant pathogens (namely Botrytis cinerea, Alternaria brassicicola and Golovinomyces orontii).

73 resistance of gai to the necrotrophic fungus Alternaria brassicicola and susceptibility to the hemibi

74 immune responses to the necrotrophic fungus Alternaria brassicicola and the bacterial hemibiotroph P

75 the necrotrophic fungi Botrytis cinerea and Alternaria brassicicola as well as the generalist herbiv

76 necrotrophic fungal pathogens B. cinerea and Alternaria brassicicola based on increased pathogen grow

77 ore susceptible to the necrotrophic pathogen Alternaria brassicicola by suppression of the JA signali

78 rophic fungal pathogens Botrytis cinerea and Alternaria brassicicola concomitant with reduced express

79 rophic fungal pathogens Botrytis cinerea and Alternaria brassicicola in the Nossen-0 background but h

80 Alternaria brassicicola is a successful saprophyte and n

81 Alternaria brassicicola is an important, necrotrophic fu

82 gae pv tomato DC3000 and the fungal pathogen Alternaria brassicicola, although these phenotypes were

83 HDA19 was induced by wounding, the pathogen Alternaria brassicicola, and the plant hormones jasmonic

84 utants also show increased susceptibility to Alternaria brassicicola, another necrotrophic pathogen,

85 lly important necrotrophic fungi B. cinerea, Alternaria brassicicola, Fusarium graminearum, and Scler

86 arum, and the Arabidopsis thaliana pathogen, Alternaria brassicicola, resulted in reduced virulence a

87 the spread of another necrotrophic pathogen, Alternaria brassicicola, suggesting a common host respon

88 rophic fungal pathogens Botrytis cinerea and Alternaria brassicicola, whereas HUB1 overexpression con

89 ed susceptibility to the necrotrophic fungus Alternaria brassicicola.

90 rophic fungal pathogens Botrytis cinerea and Alternaria brassicicola.

91 ific susceptibility to the fungal necrotroph Alternaria brassicicola.

92 rophic fungal pathogens Botrytis cinerea and Alternaria brassicicola.

93 o desiccation and to infection by the fungus Alternaria brassicicola.

94 nfection by the necrotrophic fungal pathogen Alternaria brassicicola.

95 idopsis are resistant to the fungal pathogen Alternaria brassicicola.

96 e dipteran Bradysia impatiens and the fungus Alternaria brassicicola.

97 ompromises resistance to the fungal pathogen Alternaria brassicicola.

98 rophic fungal pathogens Botrytis cinerea and Alternaria brassicicola.

99 to the pathogenic fungi Botrytis cinerea and Alternaria brassisicola Both PAMPs and osmotic stress ac

100 mold strains of the genera Cladosporium and Alternaria but none on bacteria.

101 Alternaria, but not other common aeroallergens, possesse

102 Skin testing was performed for Alternaria, cat, cockroach, dog, Dermatophagoides farina

103 Intranasal administration of Alternaria challenge reduced ILC2 numbers in the bone ma

104 Z1 expression as early as 3 h after a single Alternaria challenge that persisted for >/=5 d and was s

105 ronchoalveolar lavage eosinophilia following Alternaria challenge when analyzed 24 h later.

106 epithelial cell brushings demonstrated that Alternaria-challenged naive WT mice had a >20-fold incre

107 ble levels of common aeroallergens including Alternaria, cockroach, dog, dust mite, cat, mouse, and r

108 Alternaria concentration was associated with any wheeze

109 Whereas in some cases (e.g., orchard grass, Alternaria, cypress, and Russian thistle) IL-5 productio

110 Alternaria-derived aspartate protease(s) cleaved PAR-2 t

111 did not induce eosinophil degranulation, and Alternaria did not induce neutrophil activation, suggest

112 black roots, symptoms similar to a Fusarium-Alternaria disease complex, recently characterized in a

113 duction by activated DCs, and DCs exposed to Alternaria enhanced Th2 polarization of CD4(+) T cells.

114 d the growth of all competing fungi, such as Alternaria, Epicoccum and Ulocladium species.

115 Alternaria-evoked ATP release exhibited a greater peak r

116 ease in [Ca2+]i typically observed following Alternaria exposure appeared to be independent of protea

117 grate from the circulation to the lung after Alternaria exposure is unknown.

118 lungs showed robust expression of IL-5 after Alternaria exposure.

119 ung lavage samples from mice challenged with Alternaria extract and in sputum from patients with mode

120 The eosinophil-stimulating activity in Alternaria extract was highly heat labile and had an M(r

121 Finally, treatment of Alternaria extract with aspartate protease inhibitors, w

122 n bronchial epithelial cells were exposed to Alternaria extract, TSLP was potently induced.

123 us administration of a PGI2 analog inhibited Alternaria extract-induced lung IL-5 and IL-13 protein e

124 were exposed to these Ags in the presence of Alternaria extract.

125 of these integrins before airway exposure to Alternaria in mice.

126 IL-33 release and Th2-type responses in the Alternaria-induced airway inflammation model in naive mi

127 lts indicate that an important mechanism for Alternaria-induced ATP release is Ca2+ dependent and inv

128 nd cysteine protease inhibitors also reduced Alternaria-induced ATP release; however, the sustained i

129 The Alternaria-induced eosinophil degranulation was pertussi

130 a alternata Thus, CysLT1R promotes LTC4- and Alternaria-induced ILC2 activation and lung inflammation

131 Thus, Alternaria induces STAT6-dependent acute airway eosinoph

132 lung inflammation in response to repetitive Alternaria inhalation challenges.

133 Importantly, Alternaria inhibited IL-12 production by activated DCs,

134 Alternaria is a potent inducer of cellular stress and th

135 We conclude that Alternaria is the major allergen associated with the dev

136 posure to ubiquitous airborne fungi, such as Alternaria, is implicated in the development and exacerb

137 The fungal allergen, Alternaria, is specifically associated with severe asthm

138 significant lagged effects up to 3 days with Alternaria, Leptosphaeria, Cladosporium, Sporormiella, C

139 te (Der p 1), cockroach (Bla g 1), and mold (Alternaria mix) allergens using ELISA.

140 ytical method for the determination of three Alternaria mycotoxins (alternariol, alternariol monometh

141 used for the routine monitoring of the major Alternaria mycotoxins in pomegranates.

142 The stability of two Alternaria mycotoxins, alternariol (AOH) and alternariol

143 ted porous polymer microspheres selective to Alternaria mycotoxins, alternariol (AOH) and alternariol

144 derstand the acute innate airway response to Alternaria, naive wild-type (WT) mice were challenged on

145 Inheritance patterns for Alternaria-negative asthma revealed a contribution from

146 ildren at age 6 into Alternaria-positive and Alternaria-negative groups identifies subphenotypes that

147 g Alternaria-positive subjects, asthma among Alternaria-negative subjects was associated with lower l

148 In contrast to Alternaria, neither Aspergillus nor Candida induced bron

149 were positively associated with indoor dust Alternaria [odds ratio (OR) = 1.83; 95% confidence inter

150 m EpC mucin release and swelling elicited by Alternaria or by intranasal LTE4 GPR99 expression is det

151 that human eosinophils respond vigorously to Alternaria organisms and to the secretory product(s) of

152 sts and sterile mycelium, were Cladosporium, Alternaria, Penicillium, Ulocadium, Fusarium, Arthrinium

153 s, dividing asthma in children at age 6 into Alternaria-positive and Alternaria-negative groups ident

154 ontributed approximately equivalent risk for Alternaria-positive asthma in the child.

155 When compared with asthma among Alternaria-positive subjects, asthma among Alternaria-ne

156 hus, the asthma-related environmental fungus Alternaria produces potent Th2-like adjuvant effects in

157 ation machinery that directly responds to an Alternaria protein product(s).

158 ty to utilize sole carbon sources suggesting Alternaria regulates expression of cell wall-degrading e

159 Zygomycetes (RR = 1.96; CI, 1.35, 2.83), and Alternaria (RR = 1.51; CI, 1.00, 2.28), after controllin

160 Furthermore, this Alternaria serine protease-IL-33 axis triggered a rapid,

161 had been pulsed with OVA in the presence of Alternaria, showed that the recipient mice had enhanced

162 (diagnosed after age 6) was associated with Alternaria skin tests at age 6 but not at age 11.

163 ore age 6) was independently associated with Alternaria skin tests at both ages 6 and 11, whereas new

164 onferred tolerance to salt stress and fungus Alternaria solani infection.

165 Alternaria solani severely affects tomato (Solanum lycop

166 the fungal necrotrophs Botrytis cinerea and Alternaria solani, bacterial pathogen Pseudomonas syring

167 thium irregulare, Fusarium oxysporum solani, Alternaria solani, Trichoderma reesei, and Trichoderma h

168 al pathogens, Fusarium brachygibbosum U4 and Alternaria sp. U10, and the specialist herbivore Manduca

169 corymbifera, Aspergillus sp. (five species), Alternaria sp., Bipolaris spicifera, Fusarium sp. (three

170 is of the mycobiota showed a predominance of Alternaria sp., Fusarium sp. and Epicoccum sp. Microdoch

171 Alternaria species are widespread microfungi the seconda

172 Alternaria species is one of the most common molds assoc

173 Finally, LTD(4) was coadministered with Alternaria species repetitively to RAG2(-/-) mice (with

174 Penicillium, Aspergillus, Cladosporium, and Alternaria species, although further work should conside

175 ld-type, RAG2(-/-), and STAT6(-/-) naive and Alternaria species-challenged mice.

176 Additionally, LTD(4) potentiates Alternaria species-induced eosinophilia and ILC2 prolife

177 Finally, LTD(4) potentiated Alternaria species-induced eosinophilia, as well as ILC2

178 rected toward new forms of immunotherapy for Alternaria species-sensitive allergic patients.

179 ssociated with allergic diseases, and 80% of Alternaria species-sensitive patients produce IgE antibo

180 Alternaria-specific serine protease activity causes rapi

181 AAL-toxin is the primary determinant of the Alternaria stem canker disease of tomato, thus linking a

182 Alternaria stimulated bone marrow-derived dendritic cell

183 efeldin A and BAPTA-AM significantly blocked Alternaria-stimulated incorporation of fluorescent lipid

184 persensitive to grass pollen, cat dander and Alternaria tenuis with a history of urticaria and dyspno

185 muli, including innate stimuli (TLR ligands, Alternaria), Th2 cytokines (IL-4, IL-13), and adaptive i

186 ellular calcium concentration in response to Alternaria that was desensitized by peptide and protease

187 The unique capacity of Alternaria to drive this early IL-33 release resulted in

188 Besides the zearalenone group, the Alternaria toxin alternariol (AOH) has been described as

189 to sauces) resulted positive to at least one alternaria toxin investigated.

190 toxin (TEN), and tenuazonic acid (TeA), five alternaria toxins (ATs) was developed by liquid chromato

191 rst report about possibility of reduction of Alternaria toxins in wheat using the extrusion process.

192 However, the estrogenicity of Alternaria toxins is still largely overlooked and furthe

193 ptimal parameters for reduction of all three Alternaria toxins were as follows: w=24g/100g, q=25kg/h,

194 e maximum increase in [Ca2+]i resulting from Alternaria treatment was greater in cells from asthmatic

195 re associated with more common rhinitis, and Alternaria was associated with asthma.

196 sought to investigate the mechanism whereby Alternaria was capable of initiating severe, rapid onset

197 Although Alternaria was commonly found in both kinds of homes, th

198 The TSLP-inducing activity of Alternaria was partially blocked by treating the extract

199 By logistic regression, Alternaria was the only allergen independently associate

200 organisms and to the secretory product(s) of Alternaria with eosinophils releasing their proinflammat

201 te before subsequently being challenged with Alternaria (with or without serine protease activity), a