ライフサイエンスコーパス: AmpC beta-lactamase

1 llowing detection of the beta-lactam, of the AmpC beta-lactamase.

2 n organisms lacking a chromosomally mediated AmpC beta-lactamase.

3 1 nM inhibitor (compound 1) in complex with AmpC beta-lactamase.

4 o detect phenotypically isolates that harbor AmpC beta-lactamase.

5 extended-spectrum beta-lactamases (ESBL) and AmpC beta-lactamases.

6 ve infections caused by organisms expressing AmpC beta-lactamases.

7 sensitive and specific for detecting SHV and AmpC beta-lactamases.

8 btained only for isolates producing ESBLs or AmpC beta-lactamases.

9 Using AmpC beta-lactamase, an enzyme that is well-characterize

10 ere obtained for seven of eight producers of AmpC beta-lactamase and no ESBL producers.

11 g/ml were obtained for all strains producing AmpC beta-lactamase and only 1 of 33 strains producing E

12 correlate well for isolates containing both AmpC beta-lactamases and ESBLs.

13 um beta-lactamases (ESBLs), plasmid-mediated AmpC beta-lactamases and KPC carbapenemases in Enterobac

14 o be very potent inhibitors of the TEM-1 and AmpC beta-lactamases and less so against the class B met

15 sistent with production of both a TEM and an AmpC beta-lactamase, and representative isolates of seve

16 ectrum beta-lactamases (ESBLs), transferable AmpC beta-lactamases, and carbapenemases are associated

17 isolates) producing non-MBL carbapenemases, AmpC beta-lactamases, and extended-spectrum beta-lactama

18 ted antibiotic-resistant proteins, including AmpC, beta-lactamase, and carO, in clinical resistant st

19 AmpC beta-lactamases are cephalosporinases that confer r

20 gative organisms expressing plasmid-mediated AmpC beta-lactamases are limited because these organisms

21 Unlike ESBLs, however, AmpC beta-lactamases are not inhibited by clavulanic aci

22 AmpC beta-lactamases are related to the chromosomal enzy

23 For AmpC beta-lactamase, binding to aggregates of the small

24 MY-2 antibody was tested against a number of AmpC beta-lactamases by assaying known quantities of pur

25 e m-aminophenylboronic acid-Escherichia coli AmpC beta-lactamase complex to suggest modifications tha

26 tibiotic resistance genes, including a FOX-5 AmpC beta-lactamase encoded on a large IncA/C plasmid.

27 g family-specific ampC genes responsible for AmpC beta-lactamase expression in organisms with or with

28 deficient Q120L/Y150E variant of the class C AmpC beta-lactamase from Escherichia coli was solved at

29 The structures of AmpC beta-lactamase from Escherichia coli, alone and in

30 ositive isolates were positive by PCR for an AmpC beta-lactamase gene.

31 n in organisms with or without a chromosomal AmpC beta-lactamase gene.

32 r the purpose of identifying family-specific AmpC beta-lactamase genes within gram-negative pathogens

33 Plasmid-mediated AmpC beta-lactamases have been associated with false in

34 Plasmid-mediated CMY-2 AmpC beta-lactamases have been identified in Salmonella

35 Six families of plasmid-mediated AmpC beta-lactamases have been identified, but no phenot

36 eumoniae bloodstream isolates harbor ESBL or AmpC beta-lactamases, (ii). confirmatory tests are neces

37 a 1.07 A X-ray crystallographic structure of AmpC beta-lactamase in complex with a boronic acid deacy

38 ng frequency, the true rate of occurrence of AmpC beta-lactamases in Escherichia coli, Klebsiella pne

39 in all gram-negative isolates, transferable AmpC beta-lactamases in Klebsiella pneumoniae, and carba

40 ere evaluated for detecting plasmid-mediated AmpC beta-lactamases in Klebsiella spp., Escherichia col

41 nient means of detection of plasmid-mediated AmpC beta-lactamases in organisms lacking a chromosomall

42 The diagnostic utility of the AmpC beta-lactamase inhibitors LN-2-128, 48-1220, and Sy

43 In particular, derepression of the AmpC beta-lactamase is a common mechanism of beta-lactam

44 Inducible expression of chromosomal AmpC beta-lactamase is a major cause of beta-lactam anti

45 boronic acid (BZB), a nanomolar inhibitor of AmpC beta-lactamase (K i = 27 nM), we have identified an

46 ither the class C Citrobacter freundii CMY-2 AmpC beta-lactamase nor the class A TEM-1 beta-lactamase

47 ta-lactam antibiotics induce the chromosomal ampC beta-lactamase of many gram-negative bacteria.

48 ae P99, Klebsiella pneumoniae ACT-1, and the AmpC beta-lactamases of Enterobacter aerogenes, Morganel

49 wn quantities of purified enzymes in ELISAs (AmpC beta-lactamases of M. morganii, C. freundii, E. col

50 x, and periplasmic degradation (catalyzed by AmpC beta-lactamase) of these two compounds, and correla

51 m beta-lactamase (ESBL) and plasmid-mediated AmpC beta-lactamase (pAmpC) genes.

52 f Klebsiella spp. producing plasmid-mediated AmpC beta-lactamases (pAmpCs) was evaluated.

53 In patients with organisms hyperproducing AmpC beta-lactamases (positive by both methods), clinica

54 ity score matching of patients infected with AmpC beta-lactamase-positive organisms treated with cefe

55 extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producers.

56 AmpC beta-lactamase-producing organisms are associated w

57 spectrum beta-lactamase-producing organisms, AmpC beta-lactamase-producing organisms, carbapenem-resi

58 the treatment of invasive infections due to AmpC beta-lactamase-producing organisms, particularly wh

59 eria, 96 (24%) had confirmed infections with AmpC beta-lactamase-producing organisms.

60 cloxacillin Etest to identify organisms with AmpC beta-lactamase production from February 2010 to Jan

61 vious microarray studies have shown that the AmpC beta-lactamase regulator AmpR, a member of the LysR

62 did not recognize TEM-1, K-1, OXA-1, or any AmpC beta-lactamase tested.

63 tion of organisms producing plasmid-mediated AmpC beta-lactamases, we evaluated the diagnostic utilit

64 Transferable AmpC beta-lactamases were detected in 3.3% of K. pneumon

65 Although plasmid-mediated AmpC beta-lactamases were first reported in the late 198

66 , organisms producing ESBLs and transferable AmpC beta-lactamases were widespread.