ライフサイエンスコーパス: Anaplasma

1 hilum, supporting its placement in the genus Anaplasma.

2 Thus, Anaplasma actively induces autophagy by secreting Ats-1

3 The JAK-STAT pathway exerts its anti-Anaplasma activity presumably through STAT-regulated eff

4 Rickettsial pathogens in the genera Anaplasma and Ehrlichia cause acute infection in immunol

5 Bacterial pathogens in the genera Anaplasma and Ehrlichia encode a protein superfamily, pf

6 obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking h

7 APH_1235 homologs are found in other Anaplasma and Ehrlichia species but not in other bacteri

8 porates melt curve analysis to differentiate Anaplasma and Ehrlichia species with blood smear and ser

9 24 amino acids and is conserved among other Anaplasma and Ehrlichia species.

10 th intracellular survival and replication of Anaplasma and Ehrlichia spp. in granulocytes or monocyte

11 ription of the three virB genes in these two Anaplasma and Ehrlichia spp. is regulated by factors tha

12 lection for divergence in Ank function among Anaplasma and Ehrlichia spp. is supported by both locus

13 Although the basic developmental cycle of Anaplasma and Ehrlichia spp. within the tick has been de

14 widely applicable to bacteria in the genera Anaplasma and Ehrlichia, removing a major technical impe

15 n fragmentation are common in the genomes of Anaplasma and other obligate intracellular bacteria.

16 Anaplasma and related Ehrlichia spp. are important tick-

17 ich is conserved among bacteria in the genus Anaplasma and the closely related genus Ehrlichia.

18 The assay was tested on various Anaplasma, Borrelia, Erhlichia, and Rickettsia species,

19 positive amplicons revealed the presence of Anaplasma bovis, an agent not known to be present in Nor

20 We provisionally nominate it "Anaplasma capra".

21 lasma marginale subsp. centrale (synonym for Anaplasma centrale) induces protection against severe di

22 atrix and gut barrier-critical obstacles for Anaplasma colonization.

23 The broad-range assay detected Ehrlichia or Anaplasma DNA in 20 (26%) of the symptomatic dogs and 2

24 Anaplasma (Ehrlichia) phagocytophila and Ehrlichia chaff

25 Anaplasma (Ehrlichia) phagocytophila's major immunodomin

26 roEL and gltA genes revealed the presence of Anaplasma, Ehrlichia, Candidatus Neoehrlichia, and Ricke

27 Organisms in the genus Anaplasma express an immunodominant major surface protei

28 Anaplasma (formerly Ehrlichia) phagocytophilum and Ehrli

29 hermal in situ technique to detect localized Anaplasma gene sequences by using rolling-circle amplifi

30 Bacterial pathogens in the genus Anaplasma generate surface coat variants by gene convers

31 Furthermore, Anaplasma growth arrest by the class III PI3K inhibitor

32 Prevalence of Anaplasma in the Minnesota ticks was 63.9%; 23 of 36 tic

33 utophagy proteins were also localized to the Anaplasma inclusion.

34 Ectopically expressed Ats-1 targeted the Anaplasma inclusions and enhanced infection, whereas hos

35 Cytospin preparations of uninfected or Anaplasma-infected cell cultures were examined using thi

36 nd preliminary immunofluorescent staining of Anaplasma-infected tissues suggest that endothelial cell

37 Population distributions of Anaplasma infection were assessed by targeting the p44 g

38 eterozygous-deficient mice were resistant to Anaplasma infection.

39 Following neutrophil binding, Anaplasma invasion requires at least 240 min.

40 incubated at 34 degrees C, and 8 days later, Anaplasma-like inclusions were demonstrated in Giemsa-st

41 coplasma spp. (79 to 83% similarity) than to Anaplasma marginale (72 to 75% similarity).

42 Anaplasma marginale (order Rickettsiales, family Anaplas

43 , major surface protein 2 (MSP2) and MSP3 of Anaplasma marginale and Anaplasma ovis, Anaplasma phagoc

44 an immunodominant outer membrane protein of Anaplasma marginale and Anaplasma phagocytophilum pathog

45 er membrane protein expression sites in both Anaplasma marginale and Anaplasma phagocytophilum.

46 to the model obligate intracellular pathogen Anaplasma marginale and the human pathogen Anaplasma pha

47 red unique to the intraerythrocytic agent of Anaplasma marginale and the intragranulocytic agent of A

48 of the persistent bovine ehrlichial pathogen Anaplasma marginale are immunodominant proteins that und

49 Major surface proteins of Anaplasma marginale are vaccine candidates.

50 The rickettsial pathogen Anaplasma marginale assembles an actin filament bundle d

51 Anaplasma marginale causes bovine anaplasmosis, a debili

52 Anaplasma marginale colonies differed in their developme

53 SP1a and MSP1b) of the erythrocytic stage of Anaplasma marginale conferred protection against homolog

54 Strains of the tick-borne rickettsia Anaplasma marginale differ markedly in transmission effi

55 The rickettsial pathogen Anaplasma marginale establishes lifelong persistent infe

56 Anaplasma marginale establishes persistent infection cha

57 The rickettsial pathogen Anaplasma marginale expresses a variable immunodominant

58 the hypothesis that challenge of cattle with Anaplasma marginale expressing MSP2 variants to which th

59 Immunization of cattle with an Anaplasma marginale fraction enriched in outer membranes

60 In addition, Anaplasma marginale generates variants by recombination

61 Like several other bacterial pathogens, Anaplasma marginale has an outer membrane that induces c

62 ive immunity against the ehrlichial pathogen Anaplasma marginale has been hypothesized to require ind

63 Anaplasma marginale illustrates this transition: in the

64 he highly transmissible St. Maries strain of Anaplasma marginale in Dermacentor andersoni as a positi

65 protein 1 (MSP1) of the ehrlichial pathogen Anaplasma marginale induces protective immunity in calve

66 r membranes induces protection against acute Anaplasma marginale infection and disease, and a proteom

67 -cell response is central for the control of Anaplasma marginale infection in cattle.

68 Throughout Anaplasma marginale infection, recombination results in

69 acterize tick genes regulated in response to Anaplasma marginale infection.

70 ve major surface protein 1 (MSP1) complex of Anaplasma marginale is a heteromer of MSP1a and MSP1b, e

71 The St. Maries strain of Anaplasma marginale is a high-transmission-efficiency st

72 Anaplasma marginale is a tick-borne pathogen, one of sev

73 Anaplasma marginale is a tick-transmitted pathogen of ca

74 Anaplasma marginale is an ehrlichial pathogen of cattle

75 Anaplasma marginale is an ehrlichial pathogen of cattle,

76 Anaplasma marginale is an intraerythrocytic rickettsial

77 y the intraerythrocytic rickettsial pathogen Anaplasma marginale is endemic in South Africa.

78 ly variant major surface protein 2 (MSP2) of Anaplasma marginale is expressed from a 3.5-kb operon th

79 The rickettsia Anaplasma marginale is the most prevalent tick-borne liv

80 nalyzing the CD4(+) T lymphocyte response to Anaplasma marginale major surface protein 1a (MSP1a).

81 Antigenic variants of Anaplasma marginale major surface protein 2 (MSP-2), a t

82 Specific Anaplasma marginale major surface protein 2 (MSP2) varia

83 erogeneity in this species, the homologue of Anaplasma marginale major surface protein 4 gene (msp4)

84 gene family, with sequence similarity to the Anaplasma marginale msp-2 genes.

85 termini of the Cowdria ruminantium MAP-1 and Anaplasma marginale MSP-4 proteins.

86 ly unique strains of the tick-borne pathogen Anaplasma marginale occur and are transmitted within reg

87 trol of acute anaplasmosis and cultured with Anaplasma marginale organisms.

88 In this study we demonstrate that in Anaplasma marginale outer membrane-vaccinated cattle, Vi

89 1b1 occur as naturally complexed OMPs in the Anaplasma marginale outer membrane.

90 Immunization with purified Anaplasma marginale outer membranes induces complete pro

91 n superinfections of the tick-borne pathogen Anaplasma marginale predominate.

92 Comparison between A. platys and Anaplasma marginale proteins showed sequence identities

93 sed an unbiased proteomic screen to identify Anaplasma marginale proteins specifically upregulated in

94 In Anaplasma marginale pseudogenes for two antigenically va

95 Live vaccination with Anaplasma marginale subsp. centrale (synonym for Anaplas

96 Anaplasma marginale subsp. centrale is a naturally atten

97 s were fed on animals superinfected with the Anaplasma marginale subsp. centrale vaccine strain (low

98 Anaplasma marginale subsp. centrale was the first vaccin

99 ody isotype induced by live vaccination with Anaplasma marginale subsp. centrale.

100 Anaplasma marginale subspecies centrale also infects cat

101 Anaplasma marginale superinfection occurs when the secon

102 distinct strains of the tick-borne pathogen Anaplasma marginale that encode distinctly different sur

103 Anaplasma marginale utilizes gene conversion of a repert

104 This question was addressed by tracking the Anaplasma marginale variant population and corresponding

105 We examined allelic usage in generating Anaplasma marginale variants during in vivo infection in

106 the conservation of MSP3 between strains of Anaplasma marginale was evaluated by using immunoblots o

107 ofluorescence, Anaplasma phagocytophilum and Anaplasma marginale were successfully localized in situ

108 e protein 2 (MSP2) variants are expressed by Anaplasma marginale within the tick salivary gland and,

109 t study, we examined the strain structure of Anaplasma marginale, a genogroup II ehrlichial pathogen,

110 , broad population immunity develops against Anaplasma marginale, a highly antigenically variant rick

111 immunodominant surface proteins, we examined Anaplasma marginale, a rickettsia with two highly immuno

112 Anaplasma marginale, a rickettsial pathogen, evades clea

113 We investigated this by using infection with Anaplasma marginale, a ruminant pathogen that replicates

114 Anaplasma marginale, a tick-borne rickettsial pathogen o

115 In this study, the surface proteome of Anaplasma marginale, a tick-transmitted bacterial pathog

116 Anaplasma marginale, an intraerythrocytic ehrlichial pat

117 nulocytic ehrlichiosis, msp-2 and msp-4 from Anaplasma marginale, and map-1 from Cowdria ruminantium.

118 s on three unrelated vector-borne pathogens, Anaplasma marginale, Borrelia hermsii and Trypanosoma br

119 The tick-borne rickettsial organism, Anaplasma marginale, causes a disease in cattle of world

120 Native major surface protein 1 (MSP1) of Anaplasma marginale, composed of covalently associated M

121 chia phagocytophila, and the bovine pathogen Anaplasma marginale, express a markedly immunodominant o

122 protein 2 (Msp2) of the tick-borne pathogen, Anaplasma marginale, is thought to be involved in antige

123 In the related organism Anaplasma marginale, persistence is associated with anti

124 Anaplasma marginale, the causative agent of bovine anapl

125 f template DNA from closely related species (Anaplasma marginale, the white-tailed deer agent, and ad

126 We examined this balance using Anaplasma marginale, which generates antigenic variants

127 ydiae, Orientia tsutsugamushi, Wolbachia and Anaplasma marginale.

128 a hallmark of the tick transmitted pathogen Anaplasma marginale.

129 tein in the outer membrane of the rickettsia Anaplasma marginale.

130 perate-region strains of the cattle pathogen Anaplasma marginale.

131 of world-wide economic importance caused by Anaplasma marginale.

132 protein homologous to the MSP-2 proteins of Anaplasma marginale.

133 Ehrlichia species but distinct from that of Anaplasma marginale.

134 d antigenically polymorphic among strains of Anaplasma marginale.

135 ces of selected amplicons from the assay for anaplasma matched sequences of the white-tailed deer age

136 s technique to detect, localize, and analyze Anaplasma nucleotide sequences in the tissues of infecte

137 heart base, and skin of coinfected mice, but Anaplasma numbers remained constant.

138 Anaplasma phagocytophilum and Anaplasma ovis cause human infections.

139 Goats which have recovered from acute Anaplasma ovis infection remain seropositive, although i

140 2 (MSP2) and MSP3 of Anaplasma marginale and Anaplasma ovis, Anaplasma phagocytophilum MSP2 (p44), Eh

141 Immune sera from animals infected with Anaplasma ovis, Ehrlichia risticii, and Ehrlichia ewingi

142 netically distinct A. marginale strains, and Anaplasma ovis.

143 sms in the genera Rickettsia, Ehrlichia, and Anaplasma, persists in ticks and mammalian hosts; howeve

144 burgdorferi (33.6%), Babesia microti (8.4%), Anaplasma phagocytophila (1.9%), and Bartonella spp. (34

145 a low prevalence of antibodies reactive with Anaplasma phagocytophila (2 of 112; 2%).

146 nant 44 kDa major outer membrane proteins of Anaplasma phagocytophila (human granulocytic ehrlichiosi

147 ck-vectored pathogen transmission, including Anaplasma phagocytophila an etiologic agent of granulocy

148 ng tick-borne zoonosis caused by a strain of Anaplasma phagocytophila called the HGE agent, an obliga

149 Anaplasma phagocytophila is an obligatory intragranulocy

150 Anaplasma phagocytophila persists within neutrophils and

151 Anaplasma phagocytophila, an obligately intracellular ba

152 The human granulocytic ehrlichiosis agent, Anaplasma phagocytophila, resides and multiplies exclusi

153 determined the frequencies of antibodies to Anaplasma phagocytophila, the agent of human granulocyti

154 Anaplasma phagocytophila, the etiologic agent of human g

155 Anaplasma phagocytophilum (Ap) is an obligate intracellu

156 Anaplasma phagocytophilum (Ap), the agent of the tick-bo

157 Anaplasma phagocytophilum (Ap), the etiologic agent of t

158 ing of the region directly downstream of the Anaplasma phagocytophilum (strain MRK) 16S rRNA gene ide

159 relia burgdorferi and the rickettsial agents Anaplasma phagocytophilum and A. marginale.

160 nd von Willebrand factor immunofluorescence, Anaplasma phagocytophilum and Anaplasma marginale were s

161 Anaplasma phagocytophilum and Anaplasma ovis cause human

162 Pennsylvania and tested for the presence of Anaplasma phagocytophilum and Borrelia burgdorferi by PC

163 developed for the simultaneous detection of Anaplasma phagocytophilum and Borrelia burgdorferi.

164 amine TH 1 and TH 17 immunity infection with Anaplasma phagocytophilum and Citrobacter rodentium resp

165 Ehrlichia chaffeensis and Anaplasma phagocytophilum are agents of human monocytic

166 nt outer membrane proteins (P44 proteins) of Anaplasma phagocytophilum are encoded by the p44 polymor

167 The mechanisms used by the tick to control Anaplasma phagocytophilum are not known.

168 ngton State suspected of being infected with Anaplasma phagocytophilum because of the finding of moru

169 The intracellular organism Anaplasma phagocytophilum causes human granulocytic ehrl

170 Anaplasma phagocytophilum causes human granulocytic ehrl

171 Colonization of neutrophils by the bacterium Anaplasma phagocytophilum causes the disease human granu

172 The tick-borne rickettsial pathogen Anaplasma phagocytophilum develops within membrane-bound

173 Anaplasma phagocytophilum DNA was detected in one dog, a

174 A polymorphic multigene family (p44) of Anaplasma phagocytophilum encodes the immunodominant 44-

175 from 16S rRNA gene-based genetic variants of Anaplasma phagocytophilum from dogs in the western Unite

176 to determine the presence and prevalence of Anaplasma phagocytophilum human agent (AP-ha) and a gene

177 Anaplasma phagocytophilum immunodominant polymorphic maj

178 Infection with Anaplasma phagocytophilum in white-footed mice results i

179 Anaplasma phagocytophilum infection induces functional n

180 A total of 60 sheep were exposed to Anaplasma phagocytophilum infection on an enclosed area

181 auses meningoencephalitis, this is rare with Anaplasma phagocytophilum infection.

182 Anaplasma phagocytophilum is a bacterium that is transmi

183 Anaplasma phagocytophilum is a gram-negative obligate in

184 Anaplasma phagocytophilum is a tick-borne rickettsial pa

185 Anaplasma phagocytophilum is an intragranulocytic bacter

186 Anaplasma phagocytophilum is an obligate intracellular b

187 Anaplasma phagocytophilum is an obligate intracellular b

188 Anaplasma phagocytophilum is an obligate intracellular b

189 Anaplasma phagocytophilum is an obligate intracellular b

190 Anaplasma phagocytophilum is an obligate intracellular p

191 Anaplasma phagocytophilum is an obligate intracellular t

192 Anaplasma phagocytophilum is an obligate vacuolar bacter

193 Anaplasma phagocytophilum is an obligatory intracellular

194 Anaplasma phagocytophilum is an obligatory intracellular

195 heterogeneity of anthropozoonosis caused by Anaplasma phagocytophilum is poorly understood.

196 Anaplasma phagocytophilum is the agent of human anaplasm

197 Anaplasma phagocytophilum is the causative agent of an e

198 Anaplasma phagocytophilum is the etiologic agent of huma

199 Anaplasma phagocytophilum is the etiologic agent of huma

200 Anaplasma phagocytophilum is the tick-transmitted obliga

201 during infection with the rickettsial agent Anaplasma phagocytophilum Macrophages deficient in annex

202 3 of Anaplasma marginale and Anaplasma ovis, Anaplasma phagocytophilum MSP2 (p44), Ehrlichia chaffeen

203 membrane protein of Anaplasma marginale and Anaplasma phagocytophilum pathogens that cause bovine an

204 The human intragranulocytic bacterium Anaplasma phagocytophilum promotes variation of P44s, wh

205 Anaplasma phagocytophilum propagates within neutrophils

206 Borellia burgdorferi, Babesia microti and Anaplasma phagocytophilum rely almost exclusively on a s

207 et al. demonstrate that ticks infected with Anaplasma phagocytophilum show enhanced fitness against

208 first tissue culture isolates of the unique Anaplasma phagocytophilum strain, Ap-Variant 1, were obt

209 owledge regarding the strategies employed by Anaplasma phagocytophilum to evade or subvert neutrophil

210 ce-exposed major membrane proteins, P44s, of Anaplasma phagocytophilum were hypothesized to be garner

211 he agent of human granulocytic ehrlichiosis (Anaplasma phagocytophilum) is intensely enzootic in rabb

212 Infection with Anaplasma phagocytophilum, a gram-negative, lipopolysacc

213 Anaplasma phagocytophilum, a member of the family Anapla

214 Anaplasma phagocytophilum, a recently reclassified bacte

215 he agent of human granulocytic anaplasmosis, Anaplasma phagocytophilum, among other pathogens.

216 The natural life cycle of Anaplasma phagocytophilum, an obligatory intracellular b

217 Anaplasma phagocytophilum, an obligatory intracellular b

218 Anaplasma phagocytophilum, an unusual obligate intracell

219 y pathogens, including Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti.

220 gen, seventy-four (40%) were seroreactive to Anaplasma phagocytophilum, and five (2.7%) were seroposi

221 ate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is delivered into the h

222 intracellular bacteria such as Ehrlichia and Anaplasma phagocytophilum, as well as obligate intracell

223 egative for all tick-borne pathogens tested (Anaplasma phagocytophilum, Ehrlichia canis, and Ricketts

224 hogens in the order Rickettsiales, including Anaplasma phagocytophilum, Ehrlichia canis, E. chaffeens

225 ighly conserved with orthologous proteins in Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Eh

226 ptional regulator, tr1, and a homolog of the Anaplasma phagocytophilum, identified here as A. platys

227 n Anaplasma marginale and the human pathogen Anaplasma phagocytophilum, in order to examine the abili

228 marginale and the intragranulocytic agent of Anaplasma phagocytophilum, respectively.

229 ated first to Anaplasma platys and second to Anaplasma phagocytophilum, supporting its placement in t

230 recent studies of the granulocyte pathogen, Anaplasma phagocytophilum, the agent of granulocytic ehr

231 burgdorferi, the agent of Lyme disease, and Anaplasma phagocytophilum, the agent of human anaplasmos

232 Anaplasma phagocytophilum, the agent of human anaplasmos

233 s harbor numerous human pathogens, including Anaplasma phagocytophilum, the agent of human granulocyt

234 Anaplasma phagocytophilum, the agent of human granulocyt

235 y proteomics and transcriptome sequencing to Anaplasma phagocytophilum, the agent of human granulocyt

236 Anaplasma phagocytophilum, the agent of human granulocyt

237 Anaplasma phagocytophilum, the causative agent of human

238 Anaplasma phagocytophilum, the causative agent of human

239 Infection of neutrophil precursors with Anaplasma phagocytophilum, the causative agent of human

240 increases tick colonization by the bacterium Anaplasma phagocytophilum, the causative agent of human

241 Anaplasma phagocytophilum, the causative agent of human

242 ertain Ixodes ticks, which can also transmit Anaplasma phagocytophilum, the cause of human granulocyt

243 des scapularis tick, which can also transmit Anaplasma phagocytophilum, the cause of human granulocyt

244 Anaplasma phagocytophilum, the etiologic agent of human

245 Anaplasma phagocytophilum, the etiologic agent of human

246 Anaplasma phagocytophilum, the etiologic agent of human

247 Anaplasma phagocytophilum, the etiologic agent of human

248 However, Anaplasma phagocytophilum, the obligatory intracellular

249 ic ehrlichiosis was recently reclassified as Anaplasma phagocytophilum, unifying previously described

250 his report, we show that the AnkA protein of Anaplasma phagocytophilum, which is translocated into th

251 using DNA extracted from serial dilutions of Anaplasma phagocytophilum-infected HL-60 cells.

252 Anaplasma phagocytophilum-infected neutrophil degranulat

253 used by the obligate intracellular bacterium Anaplasma phagocytophilum.

254 a critical role in the early eradication of Anaplasma phagocytophilum.

255 sease, or a variant strain, Ap-Variant 1, of Anaplasma phagocytophilum.

256 ession sites in both Anaplasma marginale and Anaplasma phagocytophilum.

257 used by the obligate intracellular bacterium Anaplasma phagocytophilum.

258 host stimulation with the rickettsial agent Anaplasma phagocytophilum.

259 aris transmits the human anaplasmosis agent, Anaplasma phagocytophilum.

260 All positive specimens were Anaplasma phagocytophilum; no Ehrlichia species were ide

261 he isolate was most closely related first to Anaplasma platys and second to Anaplasma phagocytophilum

262 Anaplasma platys infects peripheral blood platelets and

263 Anaplasma platys is an obligate intracellular rickettsia

264 cells and other potentially cryptic sites of Anaplasma sp. infection in mammalian tissues, a sensitiv

265 Transmission electron microscopy of this Anaplasma sp. organism in tick cell cultures revealed la

266 Tick cells infected with the Anaplasma sp. organism were used to successfully infect

267 3%), Ehrlichia ewingii (44 of 217; 20%), and Anaplasma species (214 of 217; 99%).

268 tients assessed were infected with the novel Anaplasma species according to PCR and sequencing.

269 antibody (MAb) ANAF16C1, is conserved among Anaplasma species and is expressed in the salivary gland

270 May 1, to June 10, 2014, to detect the novel Anaplasma species by PCR.

271 ota and represent the first isolations of an Anaplasma species directly from ticks.

272 l for cross-reactivity among closely related Anaplasma species has made the accurate determination of

273 or human pathogenicity of a newly discovered Anaplasma species infecting goats in China.

274 hat the pathogen was distinct from all known Anaplasma species.

275 ajor outer membrane protein gene families in Anaplasma species.

276 ealed A. pullorum is most closely related to Anaplasma spp.

277 Infectivity of Anaplasma spp. develops when infected ticks feed on a ma

278 r membrane suggests that the porin feeds the Anaplasma TCA cycle and that the relatively large pore s

279 In humans and ruminants infected with Anaplasma, the major surface protein 2 (MSP2) is immunod

280 ts known pathogenic species of Ehrlichia and ANAPLASMA: The species was determined by using species-s

281 Here, we found that Anaplasma translocated substrate 1 (Ats-1), a type IV se

282 that the relatively large pore size provides Anaplasma with the necessary metabolic intermediates fro