ライフサイエンスコーパス: Antennapedia

1 he Scx allele of the flanking homeotic gene, Antennapedia.

2 We show that the Antennapedia and Abdominal-B homeodomains bind to TFIIEb

3 gulator of the segment identity genes of the Antennapedia and Bithorax complexes.

4 y the presence of the N-terminal arm for the Antennapedia and NK-2 domains.

5 he OSA protein may target the BRM complex to Antennapedia and other regulated genes.

6 to short highly basic peptides, such as TAT, antennapedia and transportan, results in their rapid tra

7 atives of this family, MATalpha2, engrailed, Antennapedia, and NK-2, and truncated forms of the last

8 of phosphorothioate oligomers linked to the Antennapedia (Ant) delivery peptide.

9 onal repression of the homeotic genes of the Antennapedia (ANT-C) and bithorax (BX-C) complexes.

10 tant flies that are heterozygous for certain Antennapedia (Antp) alleles have thoracic defects that m

11 ied early in the embryo by the homeotic gene Antennapedia (Antp) and expresses the signalling molecul

12 tations of the homeobox transcription factor Antennapedia (Antp) and underlie defects previously attr

13 s, including homeobox genes belonging to the Antennapedia (ANTP) class, which in bilaterians encompas

14 oteins, such as the third alpha-helix of the Antennapedia (Antp) homeodomain, can cross the cell memb

15 that the in vivo activity of the HOX protein Antennapedia (ANTP) is modified because of phosphorylati

16 oglobulin heavy chain binding protein (BiP), Antennapedia (Antp) ofDrosophilaand human fibroblast gro

17 ranscription factors Ultrabithorax (Ubx) and Antennapedia (Antp) respectively direct first abdominal

18 ng the leg selector gene Distalless, whereas Antennapedia (Antp), a thoracic Hox protein, does not re

19 element, fkh[250(con)], is activated by Scr, Antennapedia (Antp), and Ultrabithorax (Ubx) but repress

20 tion factor Collier (Col) and the HOX factor Antennapedia (Antp), has been proposed to form a niche r

21 A single Hox gene, Antennapedia (Antp), is primarily responsible for MN sur

22 Antennapedia (Antp), Ultrabithorax (Ubx), abdominal-A (a

23 e beta-galactosidase or the homeotic protein Antennapedia (ANTP), under various conditions of tetracy

24 d from the third helix of the homeodomain of antennapedia (Antp), we tested TFO-peptide conjugates co

25 lop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax

26 from each other as a result of the Hox gene Antennapedia (Antp), which promotes leg identities by re

27 Antennapedia (Antp)-class homeobox genes are involved in

28 proximal limit of expression, and by ectopic Antennapedia (Antp).

29 v) fused to an internalization sequence from Antennapedia (AP) blocks NO release in vitro and inflamm

30 We used the cell-permeant antennapedia (AP)-conjugated CSD peptide, which competes

31 omain of the Drosophila transcription factor antennapedia (AP; 2.5 mg x kg(-1) x d(-1)), or a peptide

32 formed, Sex combs reduced, fushi tarazu, and Antennapedia, as well as two orthologs of zerknullt.

33 Treatment of HeLa cells with the Antennapedia-BH3 fusion peptide resulted in peptide inte

34 roper spatial and temporal expression of the Antennapedia-bithorax homeotic genes determining the fru

35 depends on Deformed, Sex combs reduced, and Antennapedia but not labial.

36 critical for activation of the homeotic gene Antennapedia, but does not affect a gradient of Hb repre

37 Regulation of Antennapedia by BRM and OSA proteins requires sequences

38 and, remarkably, a Traf6 interacting peptide-antennapedia chimera was more effective than LPS in stim

39 MSX and DLX are members of the Antennapedia class of non-Hox homeodomain transcription

40 In comparison, in insects, the Antennapedia-class genes of the homeotic clusters are mo

41 pends on two clusters of homeotic genes: the Antennapedia complex (ANT-C) and the bithorax complex (B

42 chromatin boundary located in the Drosophila Antennapedia complex (ANT-C), can insulate the transgeni

43 genes results in reduced expression of both Antennapedia Complex and Bithorax Complex genes.

44 es results in the ectopic expression of both Antennapedia Complex and Bithorax Complex genes.

45 ng, and is not split into equivalents of the Antennapedia complex and the bithorax complex of Drosoph

46 mutation and a heterozygous deletion of the Antennapedia complex exhibit a transformation of mouthpa

47 e gene proboscipedia (pb) is a member of the Antennapedia complex in Drosophila and is required for t

48 ory region of the Scr gene in the Drosophila Antennapedia complex is interrupted by the neighboring f

49 Homeotic genes in the Antennapedia Complex of Drosophila specify identity of t

50 In the case of the Drosophila Antennapedia complex, the T1 enhancer bypasses the neigh

51 We demonstrate that penetratin, an antennapedia-derived peptide, can be displayed on the ph

52 ction in the Drosophila CNS, but full-length Antennapedia did not rescue CNS defects.

53 By contrast, Antennapedia does not act as a switch between leg and an

54 ene products derived from members within the Antennapedia family does not increase binding site selec

55 hylogenetic reconstructions suggest that the Antennapedia family of Hox genes had already expanded to

56 Three members of the Antennapedia family, Hoxc-6, Hoxb-7, and Hoxb-8, select

57 Both the AE1 enhancer from the Drosophila Antennapedia gene complex (ANT-C) and the IAB5 enhancer

58 The Scr-ftz region of the Antennapedia gene complex includes two known enhancers,

59 Similarities to a splice site in the Antennapedia gene of Drosophila suggest that this varian

60 (YGRKKRRQRRRPP-LRK(5)H, DT-2) or Drosophila Antennapedia homeo-domain (RQIKIWFQNRRMKWKK-LRK(5)H, DT-

61 ears to have given rise to Dfd, Scr, and the Antennapedia homeobox-class homeotic genes.

62 ultured cells, TetR fused to the full-length Antennapedia homeodomain (AntpHD) from Drosophila (TetRA

63 the translocating segment of the Drosophila Antennapedia homeodomain and examined each peptide for t

64 n approximately threefold when linked to the Antennapedia homeodomain carrier sequence.

65 d of the translocating segment of Drosophila antennapedia homeodomain fused with BB loop sequences of

66 ino-acid peptide from the third helix of the Antennapedia homeodomain protein has recently been shown

67 enetratin, a 16-residue CPP derived from the Antennapedia homeodomain protein of Drosophila, was meas

68 kinks the DNA, and the transcription factor Antennapedia homeodomain protein, which binds DNA throug

69 synthesized in tandem with a cell-permeating Antennapedia homeodomain sequence and tested for the abi

70 The Antennapedia homeodomain substituted for Ftz homeodomain

71 ermeable fusion peptides with the Drosophila antennapedia homeodomain which effectively traverse the

72 ermeable fusion peptides with the Drosophila antennapedia homeodomain which effectively traverse the

73 ically characterized this phenomenon for the Antennapedia homeodomain-DNA complex by integrated use o

74 ologous to the third helix of the Drosophila Antennapedia homeodomain.

75 inked to the cell-penetrating segment of the antennapedia homeodomain.

76 site-infected red blood cells (RBCs) via the Antennapedia homeoprotein internalization domain.

77 elivered into intact cells via fusion to the Antennapedia homeoprotein internalization domain.

78 We find that the C. elegans Antennapedia homolog, mab-5, sequentially programs many

79 of the selector gene tiptop and the Hox gene Antennapedia in Oncopeltus fasciatus embryogenesis is pr

80 transcription, causing ectopic expression of Antennapedia in the eye-antenna imaginal disc.

81 We conclude that the function of Antennapedia in the leg is not to repress homothorax, as

82 ion and for maintenance of the homeotic gene Antennapedia in the visceral mesoderm.

83 PTD derived from the third helix sequence of antennapedia, inhibited tumor necrosis factor (TNF)-indu

84 We find that the gene Antennapedia is required for the identity of all three t

85 We show that Antennapedia is required in the leg only within a proxim

86 t PDX-1 protein can permeate cells due to an Antennapedia-like protein transduction domain sequence i

87 nic cell-penetrating peptides, alpha-helical antennapedia-like, or VP22 type peptides, p18 and p28 ar

88 We have reported that the antennapedia-linked apoE-mimetic peptide COG112 inhibits

89 onic epithelial cells to study effects of an antennapedia-linked apoE-mimetic peptide, COG112, on C.

90 Both an antennapedia-linked inhibitor of c-Myc binding (Int-H1-S

91 inhibitor of IkappaBalpha kinase (IKK2), 2) antennapedia-linked NF-kappaB essential modulator-bindin

92 Antennapedia-mediated delivery of Hck Src homology domai

93 scaffolding domain, which was coupled to an antennapedia motif of a Drosophila transcription factor

94 ory neurons from homeotic mutant appendages (Antennapedia) of Drosophila melanogaster were compared w

95 eported that mutations in the beetle Scr and Antennapedia orthologs cause the labial and thoracic app

96 he Antennapedia P1 promoter, inactivates the Antennapedia P1 and P2 promoters in cis and derepresses

97 ich is associated with an insertion near the Antennapedia P1 promoter, inactivates the Antennapedia P

98 gene, osa, to regulate the expression of the Antennapedia P2 promoter.

99 erivatives that were chemically linked to an antennapedia peptide, the latter segment acting as a cel

100 f the NS5B transmembrane domain fused to the antennapedia peptide, the membrane association of NS5B w

101 ex-forming molecules, a peptide nucleic acid-antennapedia (PNA-Antp), and a TFO (AG30), as well as tw

102 ax, and extradenticle, and that the Hox gene Antennapedia prevents activation of antennal genes in th

103 Introgression of Antennapedia produces lines with heritable phenotypes ra

104 es consisting of a portion of the Drosophila antennapedia protein, previously shown to enter cells ef

105 Surprisingly, Antennapedia represses the enhancer directly, at least i

106 TT sequence, matching the consensus site for Antennapedia superclass homeodomain proteins.

107 -26) fused to the Drosophila carrier protein Antennapedia was the most effective.