ライフサイエンスコーパス: Ascaris

1 serine protease inhibitors from the nematode Ascaris.

2 uclear RNA genes and the SL RNA homologue in Ascaris.

3 more open and accessible than is the case in Ascaris.

4 8)-like and gastrin-like immunoreactivity in Ascaris.

5 n observed in C. elegans but are not seen in Ascaris.

6 n different species of CCK-like molecules in Ascaris.

7 ted with the piRNA pathway have been lost in Ascaris.

8 In Hb Ascaris, a hydrogen bonding network that includes the E7

9 The oxygen-avid, homooctameric hemoglobin of Ascaris (AH) has an unusual structure.

10 Sensitization to Ascaris and D. pteronyssinus was independently associate

11 th those recently described for the nematode Ascaris and mammalian hemoglobins, and more generally su

12 Sensitization to the cross-reactive Ascaris and mite tropomyosins partially underlies this f

13 chromosome break sites are conserved between Ascaris and Parascaris, whereas only 10% are conserved i

14 ar immune response to adult and larval-stage Ascaris antigens in young adults with moderate infection

15 Th1 and Th2 cytokines in response to control ascaris antigens were observed over the same period.

16 IgE responses to Ascaris are associated with asthma symptoms in a populat

17 nths or nematodes (hookworms, whipworms, and Ascaris) are roundworms that infect more than 1 billion

18 By using embryos of the parasitic nematode Ascaris as a model, we developed methods to introduce an

19 The extent of natural cross-transmission of Ascaris between pig and human hosts in different geograp

20 antitative trait loci influence variation in Ascaris burden in humans.

21 e equilibrium conformational distribution of Ascaris dioxygen Hb.

22 Furthermore, as determined by RT-PCR, Ascaris does not express the transcript of the neuronal

23 In addition, we modeled the viability of Ascaris eggs as a function of uncharged carboxylic acid

24 Then, we inactivated Ascaris eggs through exposure to these carboxylic acids.

25 ic acids at these concentrations inactivated Ascaris eggs when the pH was below the pKa for the acids

26 We propose interactions between Ascaris eIF4E and the SL impact eIF4G and contribute to

27 Additional interactions occur between Ascaris eIF4E and the SL on binding the m(2,2,7)G-SL.

28 Using an Ascaris embryo cell-free translation system, we found th

29 ss both DNA and RNA during several stages of Ascaris embryogenesis.

30 n will facilitate experimental strategies in Ascaris embryos complementing other biochemical tools av

31 been used to study parasite transmission in Ascaris-endemic and -nonendemic regions of the world.

32 A comparison of the two classes of Ascaris endo-siRNAs, 22G-RNAs and 26G-RNAs, to those in

33 The Ascaris enzyme contains 30 additional residues at its am

34 erum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin)

35 Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shig

36 Here we show that Ascaris haemoglobin enzymatically consumes oxygen in a r

37 We propose that Ascaris haemoglobin functions as a 'deoxygenase', using

38 The structural and functional adaptations of Ascaris haemoglobin suggest that the molecular evolution

39 The results explain why Hb Ascaris has one of the highest oxygen affinities known (

40 uilibration within the distal heme pocket of Ascaris Hb and that the distribution of distal heme pock

41 e pocket conformers for the CO derivative of Ascaris Hb in the sol-gel is highly dependent on the his

42 rogen bonding interactions, and suggest that Ascaris Hb is uniquely designed for dioxygen capture.

43 of conformers in the dioxygen derivative of Ascaris Hb, by utilizing sol-gel encapsulation.

44 2) and distal residues in the oxy complex of Ascaris hemoglobin has been shown to result in a rigid s

45 high CO off rate relative to that of O(2) in Ascaris hemoglobin is attributed to a rapid equilibrium

46 A second Fe-CO stretching mode in Ascaris hemoglobin is observed at 515 cm(-1).

47 In contrast, the CO off rate in Ascaris hemoglobin is very similar to that in sperm whal

48 worms, infection intensity, types of worms (ascaris, hookworm, or trichuris), risk of bias, cluster

49 Ascaris-infected pigs had increased levels of liver mRNA

50 Foodborne Ascaris infection (12.3 million cases, 95% UI 8.29-22.0

51 ariants in a rural Chinese population, where Ascaris infection is prevalent, and an urban UK populati

52 of H. pylori seropositivity, as was current Ascaris infection, in keeping with recent evidence from

53 ar, significant effects on susceptibility to Ascaris infection.

54 However, human Ascaris infections in Europe were of pig origin, and the

55 Ascaris is a large roundworm parasite that infects human

56 prevalent, and an urban UK population where Ascaris is largely unknown but asthma and allergy are pr

57 s, some of which are likely an adaptation to Ascaris' life cycle and parasitism.

58 atodes Ascaris suum, which infects pigs, and Ascaris lumbicoides, which infects humans.

59 accine CVD 103-HgR in children infected with Ascaris lumbricoides and investigated the effect of albe

60 Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection,

61 , and Entamoeba histolytica), and helminths (Ascaris lumbricoides and Trichuris trichiura), as well a

62 an immunodeficiency virus type 1 (HIV-1) and Ascaris lumbricoides co-infection has led to significant

63 ces of beta-carotene, extra dietary fat, and Ascaris lumbricoides infection on serum retinol concentr

64 To define the cytokine response to Ascaris lumbricoides infection, the cellular immune resp

65 The roundworm Ascaris lumbricoides infects 0.8 billion people worldwid

66 The parasitic nematode Ascaris lumbricoides infects one billion people worldwid

67 itors found in the nonhematophagous nematode Ascaris lumbricoides var. suum.

68 In species-specific analysis, Ascaris lumbricoides was associated with significantly i

69 Infection with roundworm (Ascaris lumbricoides) is associated with earlier first b

70 susceptibility to infection with roundworm (Ascaris lumbricoides).

71 Infection with malaria, Trichuris trichiura, Ascaris lumbricoides, and hookworms were all associated

72 ination in the parasitic nematode of humans, Ascaris lumbricoides, and the parasitic nematode of dogs

73 Soil-transmitted helminths (hookworm, Ascaris lumbricoides, and Trichuris trichiura) are the m

74 nfection with the soil-transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale an

75 Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura)

76 (>/=0.70 kU/L), whereas negative results for Ascaris lumbricoides, T gondii, herpes simplex virus, an

77 influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted i

78 ansmitted helminth infections (ie, hookworm, Ascaris lumbricoides, Trichuris trichiura) with the Kato

79 ions of improved WASH on infection with STH (Ascaris lumbricoides, Trichuris trichiura, hookworm [Anc

80 a coli, Iodamoeba butschlii, Endolimax nana, Ascaris lumbricoides, Trichuris trichiura, Strongyloides

81 the live oral cholera vaccine CVD 103-HgR in Ascaris lumbricoides-infected subjects randomized in a d

82 ors during early development of the nematode Ascaris lumbricoides.

83 ajor zygotic gene activation in the nematode Ascaris lumbricoides.

84 of scaling up a STH MDA programme targeting Ascaris lumbricoides.

85 Third, the Tas retroviral envelope (Ascaris lumricoides) may have been obtained from Herpesv

86 Furthermore, Ascaris maintained for 5 days contained a significant am

87 Unlike the mammalian enzyme, the Ascaris malic enzyme is not regulated by ATP, and no ATP

88 The Ascaris motility machinery can be studied conveniently i

89 As in Ascaris, mutagenesis of the bulge nucleotide in stem-loo

90 Extending the study to the Ascaris mutants allows for examination of the effect of

91 all of the antibodies recognize epitopes, in Ascaris neurons, that include some or all of the C-termi

92 ot eggs from Fasciolopsis buski, Enterobius, Ascaris or Clonorchis sinensis.

93 whether infection with the common roundworm Ascaris or its bystander immunological effects influence

94 Adult Ascaris organisms were obtained from humans and pigs in

95 Fractionation of Ascaris peptide extracts by high performance liquid chro

96 n conducting an analysis of variation within Ascaris populations from pig and human hosts across the

97 have any nematodes (prevalence ratio, 0.19), ascaris (prevalence ratio, 0.06), hookworm (prevalence r

98 also exhibited oral efficacy in a naturally Ascaris-sensitized sheep asthma model showing significan

99 Ascaris sperm cells lack actin and associated motors, an

100 The dynamics of the Ascaris sperm cytoskeleton can be studied in a cell-free

101 tein-based motility apparatus assembled from Ascaris sperm extracts.

102 Although Ascaris sperm locomotion closely resembles that seen in

103 Although Ascaris sperm motility closely resembles that seen in ma

104 ialization of the cell motility machinery of Ascaris sperm provides a powerful system in which to pro

105 In Ascaris sperm, protrusion and retraction are powered by

106 e developed an in vitro motility system from Ascaris sperm, unique amoeboid cells that use filament a

107 is consistent with its essential role in the Ascaris spliced leader RNA, whereas in Leptomonas mutati

108 IgG4 and Ascaris spp.

109 Anti-Ascaris spp.

110 describe the prevalence of Toxocara spp. and Ascaris spp. seropositivity and associations with allerg

111 as the morphine-like tissue localization in Ascaris, suggests that the endogenous morphine is intend

112 Mice were inoculated with Ascaris suum (A. suum) eggs concurrent with ragweed (RW)

113 emodeling after chronic antigen challenge in Ascaris suum (AA)-sensitized cats.

114 rotected mice recovering from infection with Ascaris suum against subsequent infection with the phylo

115 embryo development in the parasitic nematode Ascaris suum and compared them with known small RNAs of

116 were also found in two parasitic nematodes, Ascaris suum and Oesophagostomum dentatum.

117 f the DNA eliminating pig parasitic nematode Ascaris suum and the horse parasite Parascaris univalens

118 two such hemoglobins, one from the nematode Ascaris suum and the other from the sulfide-fixing clam

119 4.5%, respectively, 4 h after challenge with Ascaris suum antigen (Ag).

120 ore and serially after airway challenge with Ascaris suum antigen alone, or after pretreatment with a

121 before and 24 h after aerosol challenge with Ascaris suum antigen in seven sheep hypersensitive to th

122 r as long as 2 h after airway challenge with Ascaris suum antigen, without and after pretreatment wit

123 ergic sheep undergoing airway challenge with Ascaris suum antigen.

124 ly after, and up to 2 h after challenge with Ascaris suum antigen.

125 to six sheep with airway hypersensitivity to Ascaris suum antigen.

126 acute responses or dual responses to inhaled Ascaris suum antigen.

127 The NAD-malic enzyme from Ascaris suum catalyzes the divalent metal ion-dependent

128 The parasitic worm Ascaris suum contains the opiate alkaloid morphine as de

129 onance (NMR) data indicate that the nematode Ascaris suum eIF4E binds the two different caps in a sim

130 -avid hemoglobin from the parasitic nematode Ascaris suum exhibits one of the slowest known O(2) off

131 ties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its de

132 AD-malic enzyme from the parasitic roundworm Ascaris suum has been studied using a steady-state kinet

133 he AF8 and AF2 neuropeptides of the nematode Ascaris suum have been identified, cloned, and sequenced

134 Pharmacological experiments on Ascaris suum have demonstrated the presence of three (N-

135 ecular studies in Caenorhabditis elegans and Ascaris suum have identified key steps and factors invol

136 er distribution in the distal heme pocket of Ascaris suum hemoglobin (Hb) studied by resonance Raman

137 n Fe-CO stretching mode in the CO complex of Ascaris suum hemoglobin as compared to vertebrate hemogl

138 hat protection from allergic inflammation by Ascaris suum infection was characterized by a global inc

139 es infects 0.8 billion people worldwide, and Ascaris suum infects innumerable pigs across the globe.

140 ing edge protrusion in the amoeboid sperm of Ascaris suum is driven by the localized assembly of the

141 The major sperm protein (MSP) of Ascaris suum mediates amoeboid motility by forming an ex

142 The major sperm protein (MSP) of Ascaris suum mediates amoeboid motility by forming an ex

143 The structure of the Ascaris suum mitochondrial NAD-malic enzyme in binary co

144 ectrophysiological and anatomical studies of Ascaris suum motor neurons demonstrated a strong correla

145 ructures of dimers and helical assemblies of Ascaris suum MSP has identified five conserved interacti

146 In vivo and in vitro studies of Ascaris suum MSP have demonstrated that motility occurs

147 d mutagenesis was used to change K199 in the Ascaris suum NAD-malic enzyme to A and R and Y126 to F.

148 meters of several active site mutants of the Ascaris suum NAD-malic enzyme was investigated to determ

149 al antibody, AF1-003, highly specific to the Ascaris suum neuropeptide AF1 (KNEFIRFamide), was genera

150 Diminution in the nematode Ascaris suum occurs during early embryonic cleavages and

151 Pigs infected with Ascaris suum or controls were given 100 microg (low-dose

152 no significant difference in inactivation of Ascaris suum ova in digesters operated at different soli

153 ed the fate of embryonated and unembryonated Ascaris suum ova in six laboratory-scale mesophilic (35

154 been used to study the kinetic mechanism of Ascaris suum phosphofructokinase (PFK) at pH 8.0 for the

155 The nematode Ascaris suum primarily infects pigs, but also causes dis

156 erm protein (MSP)-based amoeboid motility of Ascaris suum sperm requires coordinated lamellipodial pr

157 extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generate

158 racted development of the parasitic nematode Ascaris suum to provide a comprehensive time course of m

159 lecular weight SPIs originally isolated from Ascaris suum where they are believed to protect the para

160 The NAD-malic enzyme from Ascaris suum will utilize L-aspartate, (2S,3R)-tartrate,

161 as 4 and 24 h after inhalation challenge by Ascaris suum) abolished both late-phase bronchoconstrict

162 The hemoglobin from Ascaris suum, a parasitic nematode, has a spontaneous di

163 ptides in the nervous system of the nematode Ascaris suum, AMRNALVRFamide (AF21), NGAPQPFVRFamide (AF

164 y important parasites, Toxoplasma gondii and Ascaris suum, and gene expression in 11 different tissue

165 ester (L-NAME) before aerosol challenge with Ascaris suum, and the effect on antigen-induced airway r

166 e of the mitochondrial NAD-malic enzyme from Ascaris suum, in a quaternary complex with NADH, tartron

167 Early development of the parasitic nematode, Ascaris suum, occurs inside a highly resistant eggshell,

168 hes in the genome of the parasitic nematode, Ascaris suum, revealed a chimeric protein that is simila

169 oduction of branched acids in the roundworm, Ascaris suum, that demonstrates selectivity for forming

170 two closely related parasites, the nematodes Ascaris suum, which infects pigs, and Ascaris lumbicoide

171 r macrophages, and airway-derived cells from Ascaris suum-allergic cynomolgus monkeys did not produce

172 l acid residues of the NAD-malic enzyme from Ascaris suum.

173 mplex (PDC) of the adult parasitic nematode, Ascaris suum.

174 otonin-like immunoreactivity in the nematode Ascaris suum.

175 mintic properties against the swine nematode Ascaris suum.

176 the nervous system of the parasitic nematode Ascaris suum.

177 in the nematodes Caenorhabditis elegans and Ascaris suum.

178 in vitro in cell-free extracts of sperm from Ascaris suum: inside-out vesicles derived from the plasm

179 ode small RNAs as well as features unique to Ascaris that illustrate significant flexibility in the u

180 However, in the nematode Ascaris the zygotic genome is never silent, and the mate

181 supporting further investigation of zoonotic Ascaris transmission in the United States.

182 Ascaris worm burden as assessed by egg counts was measur

183 the transmission dynamics and speciation of Ascaris worms from humans and pigs that are of importanc