ライフサイエンスコーパス: B-cell antigen receptor

1 a lower threshold for activation through the B cell antigen receptor.

2 these cells in response to cross-linking the B cell antigen receptor.

3 22 modulates signal transduction through the B cell antigen receptor.

4 ues from the cancer microenvironment and the B cell antigen receptor.

5 tiple tyrosines after the aggregation of the B cell antigen receptor.

6 on is suppressed upon activation through the B cell antigen receptor.

7 s in the signaling pathways activated by the B cell antigen-receptor.

8 or capable of modulating signals through the B-cell antigen receptor.

9 egatively regulates B-cell activation by the B-cell antigen receptor.

10 signal transduction machinery coupled to the B-cell antigen receptor.

11 n B lymphocytes following aggregation of the B-cell antigen receptor.

12 til now was thought to be mediated mainly by B cell antigen receptors.

13 TAM)-coupled receptors, including the T- and B-cell antigen receptors.

14 ion pathway is similar to that of the T- and B-cell antigen receptors.

15 Thus, CD19 functions as a B cell antigen receptor accessory molecule that modifies

16 B-cell antigen receptor accumulates at the synapse, segr

17 , FcgammaRIIB, provides a signal that aborts B cell antigen receptor activation, blocking extracellul

18 eates distinct signaling effectors following B cell antigen receptor activation.

19 Ligation of the B cell antigen receptor also induced tyrosine phosphoryl

20 phoblastoid cells lack signaling through the B cell antigen receptor and concluded that the fault in

21 transmembrane signals generated through the B cell antigen receptor and other surface molecules regu

22 eficiency altered calcium response evoked by B cell antigen receptors and impaired CD40-evoked prolif

23 re lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repa

24 Constitutive signal transduction by B cell antigen-receptors and/or their surrogates appears

25 Soluble antigen binds to the B-cell antigen receptor and is internalized for subseque

26 is present in the cytoplasmic tail of T- and B-cell antigen receptors and mediates signaling during l

27 hat show enriched expression of autoreactive B-cell antigen receptors and that produce several types

28 gement of immunoreceptors such as T-cell and B-cell antigen receptors and the Fc receptors on mast ce

29 cell malignancies depend on signals from the B-cell antigen receptor, and Bruton tyrosine kinase (BTK

30 thus blocking production of both T cell and B cell antigen receptors; (b) syngeneic group in which t

31 Nfkb1(SSAA) mutation decreased B cell antigen receptor (BCR) activation of NF-kappaB in

32 ERK activity and CLL proliferation required B cell antigen receptor (BCR) activation, as inhibition

33 ergoes a rapid tyrosine phosphorylation upon B cell antigen receptor (BCR) activation.

34 controlled by signals generated through the B cell antigen receptor (BCR) and are associated with ch

35 itional and mature B cells requires both the B cell antigen receptor (BCR) and BLyS receptor 3 (BR3),

36 the relationship between the affinity of the B cell antigen receptor (BCR) and the immune response to

37 ive B cells via sequential engagement of the B cell antigen receptor (BCR) and Toll-like receptor (TL

38 splenic mouse B cells stimulated through the B cell antigen receptor (BCR) and/or CD38, a BCR corecep

39 Signals propagated through the B cell antigen receptor (BCR) are vital for the developm

40 ng pathways induced by the engagement of the B cell antigen receptor (BCR) as a negative regulator.

41 B cell antigen receptor (BCR) association with lipid raf

42 l-known mediator of inhibitory signals after B cell antigen receptor (BCR) coaggregation with the low

43 B cell antigen receptor (BCR) cross-linking activates bo

44 B cell antigen receptor (BCR) cross-linking activates th

45 SHIP is rapidly tyrosine phosphorylated upon B cell antigen receptor (BCR) cross-linking and forms a

46 cipitated with anti-Shc antibodies following B cell antigen receptor (BCR) cross-linking or interleuk

47 Recognition of antigen by the B cell antigen receptor (BCR) determines the subsequent

48 Cross-linking B cell antigen receptor (BCR) elicits early signal trans

49 The signal transduction events supporting B cell antigen receptor (BCR) endocytosis are not well u

50 B cell antigen receptor (BCR) engagement led to the prog

51 ivation of Akt by multiple stimuli including B cell antigen receptor (BCR) engagement requires phosph

52 of premalignant splenic B cells by means of B cell antigen receptor (BCR) engagement resulted in sig

53 cellular calcium mobilization in response to B cell antigen receptor (BCR) engagement.

54 Btk and BAP-135 exist in a complex before B cell antigen receptor (BCR) engagement; in response to

55 The B cell antigen receptor (BCR) functions to initiate sign

56 Ligation of the B cell antigen receptor (BCR) induces a cascade of signa

57 Binding of antigen to the B cell antigen receptor (BCR) initiates a multitude of e

58 Antigen binding to the B cell antigen receptor (BCR) initiates an array of sign

59 The binding of antigen to the B cell antigen receptor (BCR) initiates two major cellul

60 The B cell antigen receptor (BCR) is a large complex that co

61 Signaling through the B cell antigen receptor (BCR) is amplified and prolonged

62 The B cell antigen receptor (BCR) is coupled to the mobiliza

63 Signal transduction through the B cell antigen receptor (BCR) is determined by a balance

64 In this disease, the B cell antigen receptor (BCR) is intimately linked to di

65 this study, we demonstrate that ligation of B cell antigen receptor (BCR) leads to activation of Akt

66 Cross-linking of the B cell antigen receptor (BCR) leads to the activation of

67 f cytosolic Ca(2+) following ligation of the B cell antigen receptor (BCR) led to the assumption that

68 B cell antigen receptor (BCR) ligation leads to receptor

69 Bam32 is tyrosine-phosphorylated upon B cell antigen receptor (BCR) ligation or pervanadate st

70 d stimulation, antigen aggregation occurs in B cell antigen receptor (BCR) microclusters containing i

71 ow that ligation of either beta1 integrin or B cell antigen receptor (BCR) on human tonsillar B cells

72 Cross-linking of the B cell antigen receptor (BCR) on immature WEHI 231 B cel

73 murine strains, sequential engagement of the B cell antigen receptor (BCR) on the cell surface and to

74 Crosslinking of the B cell antigen receptor (BCR) or the mast cell Fcepsilon

75 Signals transduced by the B cell antigen receptor (BCR) play a central role in reg

76 In B cells, stimulation of the B cell antigen receptor (BCR) results in the production

77 The B cell antigen receptor (BCR) serves both to initiate si

78 s the BLNK (B cell linker) linker protein in B cell antigen receptor (BCR) signal transduction and B

79 B cell activation is regulated by B cell antigen receptor (BCR) signaling and antigen inte

80 or on the surface of B cells that attenuates B cell antigen receptor (BCR) signaling and, therefore,

81 Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essent

82 Notch2 and B cell antigen receptor (BCR) signaling determine whethe

83 s Cbl-b functions as a negative regulator of B cell antigen receptor (BCR) signaling during the norma

84 The strength of B cell antigen receptor (BCR) signaling in response to a

85 1 complex functions to significantly enhance B cell antigen receptor (BCR) signaling in response to c

86 anism of Lin28b action nor the importance of B cell antigen receptor (BCR) signaling in this process

87 B cell antigen receptor (BCR) signaling is critical for

88 ronic exposure to self-antigens desensitizes B cell antigen receptor (BCR) signaling on anergic B cel

89 , the Fc gammaRIIB1 is a potent inhibitor of B cell antigen receptor (BCR) signaling when coligated t

90 were generated to analyze the role of Lyn in B cell antigen receptor (BCR) signaling.

91 ubpopulation of lymphoma cells with impaired B cell antigen receptor (BCR) signaling.

92 ted in the regulation of genes important for B cell antigen receptor (BCR) signaling.

93 rogression, and proliferation in response to B cell antigen receptor (BCR) stimulation.

94 s tyrosine phosphorylated and activated upon B cell antigen receptor (BCR) stimulation.

95 ablished that BTK transmits signals from the B cell antigen receptor (BCR) to transcription factor NF

96 atibility complex class II molecules and the B cell antigen receptor (BCR) transduce similar signals

97 Binding of antigen to the B cell antigen receptor (BCR) triggers both BCR signalin

98 Binding of antigen to the B cell antigen receptor (BCR) triggers signaling that ul

99 studies of the structure and function of the B cell antigen receptor (BCR) used by these leukemic cel

100 Nck bound directly to the B cell antigen receptor (BCR) via the non-immunoreceptor

101 Ligation of the B cell antigen receptor (BCR) with antigen induces lipid

102 e kinase is essential for signaling from the B cell antigen receptor (BCR), and thus for antibody res

103 IRF8 dampened signaling via the B cell antigen receptor (BCR), facilitated antigen-speci

104 cell development requires expression of the B cell antigen receptor (BCR), it remains unclear whethe

105 Within the B cell antigen receptor (BCR), the cytoplasmic tails of

106 sphotyrosine phosphatase that down-regulates B cell antigen receptor (BCR)- and CD19-generated signal

107 ing ligand (APRIL), which are related, block B cell antigen receptor (BCR)-induced apoptosis upstream

108 e Bam32(-/-) cells exhibited lower levels of B cell antigen receptor (BCR)-induced calcium mobilizati

109 reportedly mediated in part by inhibition of B cell antigen receptor (BCR)-mediated p21ras activation

110 nctions as a Ca2+ release channel during the B cell antigen receptor (BCR)-stimulated Ca2+ signaling

111 gnaling by multiple receptors, including the B cell antigen receptor (BCR).

112 blished in mature B cells stimulated via the B cell antigen receptor (BCR).

113 l transducer of signals originating from the B cell antigen receptor (BCR).

114 ponses are signaled by receptors such as the B cell antigen receptor (BCR).

115 ose effects are switched by signals from the B cell antigen receptor (BCR).

116 ling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR).

117 (Dok-3) attenuates signals transduced by the B cell antigen receptor (BCR).

118 ies by selection of somatically hypermutated B cell antigen receptors (BCR) on immune complexes (ICs)

119 periments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)- and TCR-mediated signalin

120 s respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through

121 enes encoding the variable (V) region of the B-cell antigen receptor (BCR) are assembled from V, D (d

122 Signals through the B-cell antigen receptor (BCR) are important for the surv

123 se human tonsillar B cells ligated via their B-cell antigen receptor (BCR) but not proliferation via

124 crobial molecules, enhance signalling by the B-cell antigen receptor (BCR) by activating the actin-se

125 Mature B cells coexpress both IgM and IgD B-cell antigen receptor (BCR) classes, which are organiz

126 CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling mol

127 Similar to resting mature B cells, where the B-cell antigen receptor (BCR) controls cellular survival

128 Finally, B-cell antigen receptor (BCR) cross-linking was less sen

129 CD19 is rapidly phosphorylated upon B-cell antigen receptor (BCR) cross-linking, leading to

130 nt of extracellular calcium influx following B-cell antigen receptor (BCR) cross-linking.

131 ease glucose uptake and glycolysis following B-cell antigen receptor (BCR) crosslinking.

132 B-cell antigen receptor (BCR) expression is a key featur

133 Cross-linking of the B-cell antigen receptor (BCR) induces tyrosine phosphory

134 Engagement of the B-cell antigen receptor (BCR) initiated by the Src kinas

135 The B-cell antigen receptor (BCR) internalizes bound antigen

136 Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote t

137 an early event in signal transduction by the B-cell antigen receptor (BCR) is its translocation to sp

138 Binding of antigen to B-cell antigen receptor (BCR) leads to antigen internali

139 Following B-cell antigen receptor (BCR) ligation, the cytoplasmic

140 T-independent type II immune responses, and B-cell antigen receptor (BCR) proliferative responses.

141 Kinases downstream of B-cell antigen receptor (BCR) represent attractive targe

142 osis with CD40 stimulation, independent of a B-cell antigen receptor (BCR) rescue signal.

143 ed kinase (Erk) activation mediated by tonic B-cell antigen receptor (BCR) signaling and that this si

144 e cooperation between MYC overexpression and B-cell antigen receptor (BCR) signaling for the initiati

145 aracterizing the immature B-cell response to B-cell antigen receptor (BCR) signaling in vitro and in

146 In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for

147 Activation of the B-cell antigen receptor (BCR) signaling pathway contribu

148 regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR) signaling through modulati

149 ways to gene activation and are activated by B-cell antigen receptor (BCR) signaling, we examined whe

150 In immature B lymphocytes, B-cell antigen receptor (BCR) signalling stimulates immu

151 ls are selected for an intermediate level of B-cell antigen receptor (BCR) signalling strength: atten

152 Small-molecule drugs that target the B-cell antigen receptor (BCR) signalosome show clinical

153 B-cell antigen receptor (BCR) signals are crucial for in

154 des a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream acti

155 CD21 and CD35) on B cells cooperate with the B-cell antigen receptor (BCR) to efficiently recognize a

156 Studies of model B-cell antigen receptor (BCR) transgenic systems have hi

157 raction of a B cell expressing self-specific B-cell antigen receptor (BCR) with an auto-antigen resul

158 in-positive B cells (Ramos), ligation of the B-cell antigen receptor (BCR) with anti-IgM antibodies c

159 proteins, pro-apoptotic family members, the B-cell antigen receptor (BCR), and histone deacetylase.

160 Remarkably, when antigen is bound to the B-cell antigen receptor (BCR), processing can trigger a

161 the nature of negative responses through the B-cell antigen receptor (BCR), we have screened an expre

162 ed into cytoplasmic signaling events through B-cell antigen receptor (BCR)-based signalosomes at the

163 al experiments have invoked a model in which B-cell antigen receptor (BCR)-Fc receptor for immunoglob

164 The influence of ligand:receptor affinity on B-cell antigen receptor (BCR)-induced apoptosis in the I

165 Concomitant FcRH1 ligation enhances B-cell antigen receptor (BCR)-induced Ca(2+) mobilizatio

166 PKCbeta is indispensable for B-cell antigen receptor (BCR)-induced NF-kappaB activati

167 B-cell antigen receptor (BCR)-mediated signaling plays a

168 tion compromises the activity of the pivotal B-cell antigen receptor (BCR)-proximal effector spleen t

169 les in initiating signal transduction by the B-cell antigen receptor (BCR).

170 responses following stimulation through the B-cell antigen receptor (BCR).

171 signaling pathways, some emanating from the B-cell antigen receptor (BCR).

172 KD3, which are both rapidly activated by the B-cell antigen receptor (BCR).

173 y mutated IgV genes, with strikingly similar B cell antigen receptors (BCRs) arising from the use of

174 Surface expression of B cell antigen receptors (BCRs) containing Ig and Igalph

175 Studies of B cell antigen receptors (BCRs) expressed by leukemic ly

176 rvival and transcription of IgG2a-containing B cell antigen receptors (BCRs).

177 ursors of these antibodies act as functional B-cell antigen receptors (BCRs) that initiate subsequent

178 ell survival relies on signals transduced by B-cell antigen receptors (BCRs).

179 Gnathostomes use T- and B-cell antigen receptors belonging to the immunoglobulin

180 reus (SpA), a virulence factor with targeted B cell antigen receptor-binding properties, we found tha

181 of immature B cells after engagement of the B cell antigen receptor by suppressing the expression of

182 in a dose-dependent fashion, also reduced a B-cell antigen receptor calcium signal, indicating this

183 In some cells, ligating the B cell antigen receptor can protect the cell from apopto

184 r Bob-1) is regulated synergistically by the B-cell antigen receptor, CD40L and interleukin signaling

185 s of D mu chain with other components of the B cell antigen receptor complex and suggest possible mec

186 The B cell antigen receptor complex contains heterodimers of

187 intensity to that induced by the endogenous B cell antigen receptor complex.

188 al for Ig-mediated B-cell activation via the B-cell antigen receptor complex (BCR) on human and murin

189 y signals derived from the surface expressed B cell antigen receptor controls B cell development, sur

190 ions affecting Toll-like receptor signaling, B-cell antigen receptor coreceptors (eg, CD19), or enzym

191 Proliferative response to B cell antigen receptor cross-linking in vitro was chose

192 The same two sites were phosphorylated upon B cell antigen receptor cross-linking.

193 m Staphylococcus aureus (SpA) interacts with B cell antigen receptors encoded by variable region heav

194 ntibodies requires additional stimulation by B cell antigen receptor engagement and IL-15.

195 CD22 phosphorylation is an early event of B cell antigen receptor engagement and results in the re

196 ted the phosphorylation of Akt downstream of B cell antigen receptor engagement in SHIP1-null DT40 B

197 Co-ligation of wild-type PECAM-1 with the B-cell antigen receptor expressed on chicken DT40 B cell

198 or zeta, CD3epsilon, CD3delta, and CD3gamma, B cell antigen receptor Igalpha and Igbeta, and Fc recep

199 n response to activation signals through the B cell antigen receptor in the presence of CD40 engageme

200 in intact cells following aggregation of the B-cell antigen receptor in a reaction that was inhibited

201 ntial deficit in both lipopolysaccharide and B cell antigen receptor-induced proliferation and signal

202 the marginal zone B cell population, optimal B cell antigen receptor-induced proliferation, and B cel

203 e biochemical pathways involved in directing B cell antigen receptor-induced signals to processes lea

204 In normal B cells, antigen receptor-induced NF-kappaB activation r

205 signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a

206 We demonstrate that signaling by B cell antigen receptors leads to distinct and mutually

207 Aggregation of the B-cell antigen receptor leads to the activation of the 7

208 B cell antigen receptor ligation resulted in enhanced ty

209 ive regulation of calcium mobilization after B cell antigen receptor ligation, CD22 phosphorylation,

210 provided evidence that signaling through the B cell antigen receptor may play a role in the clinicall

211 d tonsillar B cells with anti-CD95 abolished B cell antigen receptor-mediated calcium mobilization.

212 ll lymphoma line, Daudi, less susceptible to B cell antigen receptor-mediated cell death, responded t

213 pha phosphorylation correlates with impaired B cell antigen receptor-mediated induction of the pro-su

214 for both T and B cell development and T and B cell antigen receptor-mediated signal transduction.

215 BTK plays a nonredundant and pivotal role in B cell antigen receptor-mediated STAT5A activation in B

216 sphorylation of RAFTK following integrin- or B cell antigen receptor-mediated stimulation was decreas

217 In B cells, antigen receptor-mediated death can be rescued

218 B-cell antigen receptor mediates the gathering of antige

219 immunoglobulin G internalized as antigens by B cell antigen receptors or transfected Fc receptors.

220 eceptors, a consequence of coligation of the B-cell antigen receptor or Fc(epsilon)RI, respectively,

221 In addition, we present the B Cell Antigen Receptor Pathway, an STKE Connections Map

222 r-292 or -492 demonstrate hyperactive T- and B-cell antigen receptor phenotypes.

223 requires expression of the precursor to the B cell antigen receptor (pre-BCR) and escape from signal

224 Signals through the pre-B cell antigen receptor (pre-BCR) and interleukin 7 rece

225 7 receptor (IL-7R) and the precursor to the B cell antigen receptor (pre-BCR) in B lymphopoiesis has

226 signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in

227 through the pre-B stage triggered by the pre-B-cell antigen receptor (pre-BCR).

228 to regulate Src kinases required for T- and B-cell antigen receptor signal transduction.

229 rowth factor signaling in endothelium and in B cell antigen receptor signaling in B lymphocytes.

230 show that CD19 plays a key accessory role in B cell antigen receptor signaling independent of CR2 col

231 onstrate that Btk is a limiting component of B cell antigen receptor signaling pathways and suggest t

232 CD22, a negative regulator of B cell antigen receptor signaling, binds glycoconjugates

233 s and B cells with mutations that exaggerate B cell antigen receptor signaling.

234 evelopmental or differentiation state of the B cell, antigen receptor signaling can promote either ap

235 LV-treated B cells exhibited enhanced B-cell antigen receptor signaling and an in vivo selecti

236 The negative regulation of T- or B-cell antigen receptor signaling by CD5 was proposed ba

237 ells, and the crucial requirement for strong B-cell antigen receptor signaling in the maturation of B

238 ses (PTKs), the Src- and Syk-PTKs, in T- and B-cell antigen receptor signaling.

239 required for pre-B cell clonal expansion and B-cell antigen receptor signaling.

240 the absence of Syk, a kinase that transduces B cell antigen receptor signals required for positive se

241 CD79a and CD79b function as transducers of B cell antigen receptor signals via a cytoplasmic sequen

242 AF2 participates in synergy between CD40 and B cell antigen receptor signals, and in CD40-mediated, T

243 e-phosphorylated following beta1 integrin or B cell antigen receptor stimulation in human B cells.

244 Crosslinking of the B cell antigen receptor surface immunoglobulin induces t

245 tyrosine in response to cross-linking of the B cell antigen receptor, thereby generating phosphotyros

246 re B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunog

247 s functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host de

248 n, and involving synergistic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), a

249 Previous work using B cell antigen receptor transgenic animals suggested tha

250 Ligation of the B cell antigen-receptor triggers an intricate maze of in

251 Herein, we report that ablation of B cell antigen receptor ubiquitination in vivo uncouples

252 s known to provide a confined space in which B-cell antigen receptors undergo selection.

253 Activation of the B cell antigen receptor up-regulated Btk protein level 1

254 In B cells, engagement of the B cell antigen receptor was required for presentation of

255 f ITAM-containing cytoplasmic regions of the B-cell antigen receptor was expressed in immortalized mu

256 ated by coligation of the coreceptor and the B cell antigen receptor, which dramatically increases fo

257 trategies to generate a repertoire of T- and B-cell antigen receptors with sufficient diversity to re