ライフサイエンスコーパス: B-cell epitope

1 aining a single amino acid substitution in a B cell epitope.

2 antibody to a second, independent native ZP3 B cell epitope.

3 es as the carrier for a defined heterologous B cell epitope.

4 (isoleucine) were implicated in a pathogenic B cell epitope.

5 clonal antibody that targets a protective Ft B cell epitope.

6 asting, high-avidity Ab response against the B cell epitope.

7 d particle is known to contain a predominant B-cell epitope.

8 minal sugar of the Ogawa LPS is a protective B-cell epitope.

9 4(+) T cell epitopes as well as CD8(+) T and B cell epitopes.

10 ogenic autoantibodies gain access to cryptic B cell epitopes.

11 mily, resulting in the expression of variant B cell epitopes.

12 ecule contains important CD8(+), CD4(+), and B cell epitopes.

13 tional structures and carbohydrate chains to B cell epitopes.

14 e, are known or expected to contain multiple B cell epitopes.

15 s to large-protein Ags that display numerous B cell epitopes.

16 elper epitopes genetically linked to defined B cell epitopes.

17 y in regions corresponding to defined linear B-cell epitopes.

18 vaccine carrier platforms for heterologous, B-cell epitopes.

19 These areas are commonly dubbed B-cell epitopes.

20 falciparum will need to contain both T- and B-cell epitopes.

21 at positions 44 to 63) contained both T- and B-cell epitopes.

22 the recombinant antigen contained T-cell and B-cell epitopes.

23 entral hypervariable region encoding variant B-cell epitopes.

24 the presence of immunogenic conserved linear B-cell epitopes.

25 RAP-1 homolog did not contain cross-reactive B-cell epitopes.

26 y distinct MSP-2 molecules which bear unique B-cell epitopes.

27 nces (VS1 to VS4) harboring serovar-specific B-cell epitopes.

28 fold to present conformationally constrained B-cell epitopes.

29 ant immunotoxins by identifying and removing B-cell epitopes.

30 ggested the presence of conserved and unique B-cell epitopes.

31 only low levels of antibodies to inhibitory B-cell epitope 1 (iB-1), an inhibitory epitope in RAP-1(

32 T-B MAPs displaying B-cell epitopes 304 to 319 (MAP304) or 305 to 319 (MAP30

33 ell determinant associated with a 12-residue B cell epitope, a process termed somatic transgene immun

34 nses against foreign antigens, we tested two B-cell epitopes: a novel neutralizing B-cell epitope, de

35 Active immunotherapy with conformational B cell epitopes affords the possibility of generating an

36 t the same polymorphism may control both the B cell epitope and constitute the MHC-bound peptide, we

37 anched core with a peptide module containing B cell epitopes and a universal T cell epitope of the Pl

38 esponse is triggered by recognition of T and B cell epitopes and is influenced by "danger" motifs tha

39 asizing the significance of virion-dependent B cell epitopes and the limitations of envelope protein-

40 acid repeats that comprise a surface-exposed B-cell epitope and (ii) the presence of a 32-amino-acid

41 es in surface electrostatic potential of HLA B-cell epitopes and applied this to explain HLA Bw4 and

42 identified in this study are immunodominant B-cell epitopes and may represent good candidates for se

43 One such polymorphic locus formed part of a B cell epitope, and antibodies from exposed individuals

44 ents to determine B cell domain specificity, B cell epitopes, and the relative importance of linear a

45 ural pan DR epitope (PADRE) and carbohydrate B cell epitopes are demonstrated to be potent immunogens

46 Up to 90% of B-cell epitopes are discontinuous in nature, yet most pr

47 However, gp45 B-cell epitopes are highly polymorphic among B. bigemina

48 Pseudomonas exotoxin A, in which immunogenic B-cell epitopes are silenced.

49 ort peptide antigens falsely classifies many B-cell epitopes as non-epitopes.

50 y synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunoge

51 pilin glycan, was found to be a major linear B-cell epitope, as determined by peptide epitope mapping

52 e murine Ab response as a model to study the B cell epitopes associated with PE38.

53 a prime vaccine candidate, but variation in B-cell epitopes at the dimer interface of DBP leads to i

54 imeric RHDV VLPs by insertion of the foreign B-cell epitopes at three different locations within VP60

55 59R), Tau (AV-1980R) or Abeta/tau (AV-1953R) B cell epitopes, based on immunogenic MultiTEP platform

56 ide biosynthetic approach, 30 precise linear B-cell epitopes (BCEs) were mapped on E6, E7 and L1 prot

57 e demonstrate that short 7-12-aa peptides of B-cell epitopes bind antibodies poorly; thus, epitope ma

58 e (same T cell epitopes) and structure (same B cell epitopes) but with different susceptibilities to

59 was chosen because it contains a functional B cell epitope, but lacks known T cell epitopes.

60 t a peptide vaccine containing minimal T and B cell epitopes composed of only 5 amino acids (N, A, V,

61 e surface as well as rhoptries and expresses B-cell epitopes conserved among otherwise antigenically

62 All four dominant B-cell epitopes contained polymorphic residues, three of

63 ecies specific and identified three distinct B-cell epitopes containing sequences DRYI, CHPSDGKC, and

64 t a useful approach to map the discontinuous B cell epitope-containing regions of proteins.

65 Identification of surface-accessible B-cell epitopes could be important to efforts to develop

66 -epitopes, are over-represented in published B-cell epitope datasets that are commonly used for devel

67 MOMP B-cell epitopes defined by 22 different serovar-specific

68 red binding kinetics identified "functional" B-cell epitopes, defined as those residues contributing

69 humoral responses against displayed foreign B-cell epitopes, demonstrated by both, in vitro neutrali

70 d an Ad-based malaria vaccine by inserting a B cell epitope derived from a Plasmodium yoelii circumsp

71 were genetically fused to an immunodominant B cell epitope derived from the N-terminal region I and

72 profile, and immunogenicity of two chimeric, B-cell epitopes derived from the human epidermal growth

73 ed two B-cell epitopes: a novel neutralizing B-cell epitope, derived from feline calicivirus capsid p

74 A B cell epitope-derived peptide of Phl p 1 devoid of alle

75 uently boosted with molecules containing the B cell epitope-derived peptide without carrier or linked

76 pCol(28-40); that is, 1) elimination of the B cell epitope, either by substitution of the critical r

77 approach for quantitating differences in HLA B-cell epitope electrostatic potential.

78 ent malaria models have shown that CS repeat B-cell epitopes expressed in a recombinant hepatitis B v

79 The importance of conformational B cell epitopes for pathogenic autoantibodies recapitula

80 1, a novel conjugate of Abeta1-15 peptide (a B-cell epitope fragment) conjugated to an immunogenic ca

81 We use a B-cell epitope from Bacillus anthracis protective antige

82 enovirus 5 (Ad5) recombinant that displays a B-cell epitope from the circumsporozoite protein (CSP) o

83 MAP (T3-CS-T1) containing T3-T1 and a potent B-cell epitope from the circumsporozoite protein central

84 rus capsid protein, and a well characterized B-cell epitope from the extracellular domain of influenz

85 nt BepiPred-2.0, a web server for predicting B-cell epitopes from antigen sequences.

86 date, termed ICC-1132, which contains T- and B-cell epitopes from the repeat region and a universal T

87 sis for the cryptic nature (crypticity) of a B cell epitope harbored by an autoantigen is unknown.

88 Our results show that this novel EGFR B cell epitope has great potential to be used as a vacci

89 ubsequent transfusion with RBCs expressing a B-cell epitope (hen egg lysozyme [HEL]) fused to (OVA)(3

90 een mounted an antibody response against the B-cell epitope higher than mice receiving the gene codin

91 Second, B cells specific to the peptidic B cell epitope in pCol(28-40) were absent among expandin

92 ane protein (MOMP) contains serovar-specific B cell epitopes in four regions of the molecule whose am

93 Convergence of T and B cell epitopes in H1'(22-42) and its ability to elicit

94 itope mapping revealed major and minor T and B cell epitopes in the N-terminal, first, and second loo

95 ug delivery vehicle, T cell responses, T and B cell epitopes in the protein drug, and the associated

96 Moreover, the proximity of TH and B cell epitopes in this restriction may have to be consi

97 rs, we investigated how the accessibility of B cell epitopes in vivo influences the development of gl

98 ised against a peptide derived from a linear B-cell epitope in the N-terminal region of gelsolin iden

99 A, S462A, and D465A mutations targeting on a B-cell epitope in the OTU domain region generated the vi

100 mal model studies are identifying T-cell and B-cell epitopes in FVIII and characterizing the presenta

101 g assays demonstrated the presence of unique B-cell epitopes in MSA-2a(1), -2b, and -2c.

102 ole of TCP presentation in the generation of B-cell epitopes in order to optimize TcpA-based cholera

103 297 to 314) comprises a region of end-to-end B-cell epitopes in some serovars of the B and F/G serogr

104 s overcome by inclusion of additional TH and B-cell epitopes in the immunizing protein.

105 Cross-reactive B-cell epitopes in the PA-binding domains of whole rLF a

106 st of these antigens showed conserved T- and B-cell epitopes in the parasite population.

107 ion and amino acid composition of all of the B-cell epitopes in the remaining 25-kDa portion of Pseud

108 sults in which we identify and silence human B-cell epitopes in the RIT HA22.

109 We previously identified seven major mouse B-cell epitopes in the toxin, and subsequently silenced

110 The presence of linear B-cell epitopes in the V protein was investigated by usi

111 amino acid residues which form autoreactive B-cell epitopes in this molecule.

112 nd their deamidated forms, as immunodominant B-cell epitopes in wheat and related cereal proteins.

113 rovide useful but incomplete descriptions of B-cell epitopes, indicating that increased efforts to fu

114 is currently difficult, because the specific B-cell epitopes involved in toxin neutralization have no

115 Elimination of B-cell epitopes is a promising approach to the productio

116 Accurate prediction of B-cell epitopes is an important goal of computational im

117 T and B cell epitope mapping revealed major and minor T and B

118 Linear B cell epitope mapping showed that serum antibodies reco

119 zing data on more than 900 peptides used for B-cell epitope mapping of immunodominant proteins of Chl

120 n contrast, researchers typically choose for B-cell epitope mapping short peptide antigens in antibod

121 of these studies showed that the B27.29 MUC1 B-cell epitope maps to two separate parts of the glycope

122 Antigenic variation in MSP2 Th cell and B cell epitopes may contribute to immune evasion that al

123 Knowledge of the B-cell epitopes may contribute to the understanding of i

124 el CD4(+) T-cell epitopes as well as a novel B-cell epitope, Meu10, which encodes a glycosylphosphati

125 anti-GBM Ab was not related to the peptidic B cell epitope nested in pCol(28-40); that is, 1) elimin

126 ope vaccine that contains the immunodominant B cell epitope of Abeta in tandem with the synthetic uni

127 laria repeat peptide containing a protective B cell epitope of Plasmodium falciparum, the most lethal

128 eptide (PPPRMPPP) with similarity to a major B cell epitope of the snRNP core protein B were identifi

129 luenza viruses expressing the immunodominant B cell epitope of this CS protein produced high titers o

130 of neutralizing antibodies to conformational B cell epitopes of MSP119 Here, using the PfMSP1/8 const

131 itope vaccines, containing CTL, Th cell, and B cell epitopes of the human papillomavirus type 16.

132 ggests the hybrids to have the discontinuous B cell epitopes of the natural Ag 5 but with an altered

133 h a peptide vaccine containing minimal T and B cell epitopes of the Plasmodium falciparum circumsporo

134 ntibody LA-2 defines an important protective B-cell epitope of OspA against which protective sera hav

135 ts of the sequence Asn-Ala-Asn-Pro (NANP), a B-cell epitope of P.falciparum sporozoites, induced anti

136 ks, and it underlies the cryptic nature of a B-cell epitope of the alpha3.alpha4.alpha5 hexamer, impl

137 The 150HA159 represents a major B-cell epitope of the HA protein.

138 ay peptide libraries in determining dominant B-cell epitopes of allergens, in developing mimotope imm

139 l of the present study is to identify linear B-cell epitopes of EF and to determine the relative cont

140 The primary B-cell epitopes of factor VIII (fVIII) are in the A2 and

141 Additionally, no iSNV enrichment within B-cell epitopes of GP has been observed.

142 he present study were to identify sequential B-cell epitopes of LF and to determine the capacity of t

143 a branched peptide containing minimal T- and B-cell epitopes of Plasmodium falciparum CS protein elic

144 Pol expressed in insect cells, we mapped the B-cell epitopes of Pol recognized by these MAbs to amino

145 rane protein contains important neutralizing B-cell epitopes of relevance for antibody-mediated prote

146 Identification of the most protective B-cell epitopes of TcpA within a particular peptide and

147 Synthetic peptide vaccines targeting B-cell epitopes of the extracellular domain of the HER-2

148 c antibody repertoires to the immunodominant B-cell epitopes of the major peanut allergens Ara h 1 to

149 fective vaccine must target conserved T- and B-cell epitopes of the virus.

150 ctive vaccine should target conserved T- and B-cell epitopes of the virus.

151 In this study, the B cell epitopes on melanin-concentrating hormone recepto

152 Computer prediction of the potential B cell epitopes on melanin-concentrating hormone recepto

153 n by identifying and eliminating most of the B cell epitopes on PE38.

154 We have previously mapped the T and B cell epitopes on the alpha-subunit of acetylcholine re

155 Computer analysis of the potential B cell epitopes on tyrosinase revealed that the epitope

156 In this study we have determined the B cell epitopes on tyrosinase which are recognized by th

157 -CSF is driving the autoantibodies and not a B-cell epitope on a pathogen cross-reacting with GM-CSF.

158 with plague, suggesting that this protective B-cell epitope on rV is conserved between these three sp

159 including the fact that the key neutralizing B-cell epitopes on RTA have not been fully defined.

160 ever, in the absence of cross-reactive T and B cell epitopes, one lung infection can modify immunity

161 than mice receiving the gene coding for the B-cell epitope only.

162 substitution of the critical residues of the B cell epitope or by truncation, failed to abrogate anti

163 ied autoantibodies (amAb) against linear ZP3 B cell epitopes outside the peptide immunogen.

164 Conserved B-cell epitopes overlapping the CD81 receptor-binding si

165 adjuvant by noncovalently assembling a T and B cell epitope peptide into nanofibers using a short C-t

166 determinant that enhances the response to a B-cell epitope peptide of Plasmodium falciparum expresse

167 ore, the results suggest that conformational B cell epitopes play a more significant role in ovomucoi

168 bly several freely available structure-based B cell epitope prediction programs can identify already

169 ts that are commonly used for development of B-cell epitope prediction approaches from protein antige

170 comes the well known inaccuracy of in silico B-cell epitope prediction from primary protein sequences

171 In addition, a new B-cell epitope prediction tool was added, and the homolo

172 of eight new tools were added, including two B-cell epitope prediction tools, four T-cell epitope pre

173 For B-cell epitope prediction, the most effective approach i

174 mproved datasets for evaluation of in silico B-cell epitope prediction.

175 We developed SEPIa, a B-cell epitope predictor from the protein sequence, whic

176 ng the limitations of SEPIa and of all other B-cell epitope predictors are discussed.

177 exhibit immunogenicity, whereby a variety of B-cell epitopes, predominantly in the amino terminus of

178 This study identifies a major B cell epitope present on the apoptotic but not the inta

179 e Database, we found that only 31% (8/26) of B-cell epitopes present in recently circulating H1N1 str

180 The identified immunodominant B cell epitopes provide a better understanding of immune

181 that, inasmuch as contiguity between T- and B-cell epitopes provides enough signaling capacity to tr

182 against hybrid ubiquitin presenting the HIV B cell epitope reacted specifically with the foreign epi

183 specific T cell help by cross-linking of the B cell epitope receptor.

184 ng homology between the pathogenic human MPO B cell epitope recognized by ANCA in patients with acute

185 d envelope protein containing several linear B cell epitopes recognized by neutralizing antibody.

186 d to T cell determinants located outside the B cell epitope region, because processing/presentation o

187 n disorder tendency is the best indicator of B-cell epitope regions for chlamydial and published data

188 gen is available, the accurate prediction of B-cell epitopes remains challenging.

189 Reliable prediction of antibody, or B-cell, epitopes remains challenging yet highly desirabl

190 eluted anti-GBM Ab recognized conformational B cell epitope(s) of multiple native GBM proteins.

191 on of Ag 5 was found to contain its dominant B cell epitope(s).

192 ith antibiotic-resistant organisms, and some B-cell epitopes should be included in a subunit vaccine.

193 th the peptide vaccine or treatment with the B cell epitopes significantly reduced tumor growth in bo

194 Ag, in addition to within a known protective B-cell epitope (so-called group a determinant of HBsAg 1

195 These results present a new murine model of B cell epitope spreading and lupus autoimmunity induced

196 des harboring T cell epitopes can initiate a B cell epitope spreading cascade within the snRNP comple

197 These data implicate B cell epitope spreading in antibody-mediated pathogenes

198 rabbits develop anti-Sm autoantibodies with B cell epitope spreading of the autoimmune response as w

199 cipitation assays showed that intermolecular B cell epitope spreading to U1RNA-associated A ribonucle

200 on SmD, indicating a lack of intramolecular B cell epitope spreading within SmD.

201 ersified anti-GBM antibody response through "B cell epitope spreading." In this study, an expansion o

202 In DR2, DR3, and DQ8 mice, the B cell epitopes subsequently spread to the amino and car

203 peptides containing the same minimal T- and B-cell epitopes, T1BT*, comprised of a CS-derived univer

204 h a truncated form of OspA that contains the B cell epitope targeted by protective OspA mAb.

205 lapped with regions in histones that contain B cell epitopes targeted by autoantibodies, as well as t

206 In recent years, identification of B-cell epitopes targeted by neutralizing antibodies has

207 ls from B. bovis-immune cattle and that like B-cell epitopes, Th-cell epitopes are conserved in diffe

208 une oophoritis-inducing T cell epitope and a B cell epitope that induces autoantibody to ZP.

209 caques recognized a limited number of linear B cell epitopes that are highly conserved among orthopox

210 The apoptotic form of U1-70 kd displays B cell epitopes that are not displayed on the intact for

211 out 100 amino acids that encodes immunogenic B-cell epitopes that induce variant-specific antibodies

212 g M5 peptides revealed myosin-cross-reactive B-cell epitopes throughout the A and C repeat regions an

213 cell help was provided by coupling an Abeta B cell epitope to BSA.

214 enic RITs by identifying and removing T- and B-cell epitopes to hide the RIT from the immune system.

215 apsid is an efficient vehicle for presenting B-cell epitopes to the immune system, making this a usef

216 iously reported that we could eliminate most B-cell epitopes using a combination of point mutations a

217 The B cell epitope was created by inserting a 12-residue loo

218 from the GAS M protein (J14) representing a B cell epitope was incorporated alongside a universal T

219 The 418-435 B cell epitope was the best candidate both as a vaccine

220 c envelope containing only T-helper (TH) and B-cell epitopes was dependent on CD8+ T cells as well as

221 cell epitopes located within the autoimmune B cell epitope were suppressed in a dominant fashion.

222 The dominant B cell epitopes were conformational and common to both r

223 elop a multiepitope vaccine, 12 high ranking B cell epitopes were identified from the extracellular d

224 Multiple T and B cell epitopes were identified in Ro60.

225 Ten immunodominant B cell epitopes were identified: CbpD-pep4 (amino acids

226 In contrast, the early dominant B cell epitopes were located in the middle and carboxy p

227 genes of HCV, encoding cytotoxic (CTL), and B cell epitopes were sequenced at 2 time points, 2 years

228 The B cell epitopes were synthesized alone and also linked w

229 Four novel HER-2 B cell epitopes were synthesized as chimeras with a prom

230 In contrast, linear B-cell epitopes were concentrated in the HVR, residing w

231 The peptide B-cell epitopes were grafted onto the epsilon side chain

232 Several HER-2 B-cell epitopes were identified by computer-aided analys

233 onse against HVR epitopes, T-cell and linear B-cell epitopes were localized by measuring peripheral b

234 Three major linear immunodominant B-cell epitopes were mapped to residues Leu(156) to Ser(

235 alysis of protein antigenicity, and selected B-cell epitopes were synthesized colinearly with a promi

236 Immunization with EGFR B cell epitopes will train the immune system to produce

237 is a promising vaccine candidate and various B cell epitopes within OprF have been identified.

238 The identification of immunodominant B cell epitopes within surface pneumococcal virulence pr

239 In this study, dominant B-cell epitopes within the acidic (pI 5.35) ankyrin repe

240 Several linear B-cell epitopes within the three proteins were recognize

241 gE Ab responses can be boosted by repetitive B cell epitopes without allergen-specific T cell help by

242 ctor VIII can be reduced by mutagenesis of a B-cell epitope without apparent loss of function, sugges