ライフサイエンスコーパス: B. thetaiotaomicron

1 B. thetaiotaomicron adapts to E. rectale by up-regulatin

2 B. thetaiotaomicron contains a large number of glycoside

3 B. thetaiotaomicron had larger first order rate constant

4 B. thetaiotaomicron produces TLR4-stimulatory lipid A be

5 B. thetaiotaomicron was then harvested from the ceca of

6 B. thetaiotaomicron-M. smithii cocolonization produces a

7 is the first molecular characterization of a B. thetaiotaomicron outer membrane protein involved in m

8 The products afforded by chondroitinase ABC (B. thetaiotaomicron) and chondroitinase ACII (A. auresce

9 s H2 O2 formation was much higher in aerated B. thetaiotaomicron than in Escherichia coli.

10 domas disclosed that this IgA did not affect B. thetaiotaomicron population density or suppress 260.8

11 suggesting that the identified strategy aids B. thetaiotaomicron in the competitive gut environment.

12 E. coli and B. thetaiotaomicron were routinely detected in sampled r

13 nical isolates, Bacteroides fragilis ERL and B. thetaiotaomicron DOT.

14 Comparisons of germ-free and B. thetaiotaomicron-colonized transgenic mice lacking Pa

15 the separateness of the unknown species and B. thetaiotaomicron.

16 secreted by mucin-foraging bacteria such as B. thetaiotaomicron, inhabiting the same niche, may affe

17 teins that are the primary interface between B. thetaiotaomicron and its environment.

18 Although both B. thetaiotaomicron and P. gingivalis synthesize lipopol

19 of approximately 1.6 kb was produced in both B. thetaiotaomicron and E. coli gdhA+ transformants.

20 The different strategies employed by B. thetaiotaomicron when faced with multiple polysacchar

21 es showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model for the c

22 tained at these two time points using custom B. thetaiotaomicron GeneChips.

23 ed that, unlike D. piger, M. smithii directs B. thetaiotaomicron to focus on fermentation of dietary

24 genic B. fragilis isolates or B. distasonis, B. thetaiotaomicron, B. uniformis, B. ovatus, Escherichi

25 lular beta2-6 endo-fructanase, distinguishes B. thetaiotaomicron genetically and functionally, and en

26 rsified sensor domains may be one reason for B. thetaiotaomicron's success in our intestinal ecosyste

27 body that recognizes an epitope specific for B. thetaiotaomicron isolates in a large panel of hospita

28 and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with

29 , but they can be differentiated easily from B. thetaiotaomicron by virtue of not utilizing trehalose

30 a pullulanase, and an alpha-glucosidase from B. thetaiotaomicron had been purified and characterized

31 micron, if the primary integration site from B. thetaiotaomicron, BT1-1, was provided on a plasmid in

32 properties and crystal structure of the GH2 B. thetaiotaomicron enzyme BtMan2A.

33 n in vivo indicated that in the suckling gut B. thetaiotaomicron prefers host-derived polysaccharides

34 fatases than anticipated and establishes how B. thetaiotaomicron, and other major human commensal bac

35 NrtR family transcription factor (BT0354 in B. thetaiotaomicron, BtAraR) as a novel regulator contro

36 These changes in B. thetaiotaomicron gene expression were only evident in

37 of the starch-degrading activity detected in B. thetaiotaomicron cell extracts.

38 Only one of these genes was expressed in B. thetaiotaomicron, the homolog of linA, a lincomycin r

39 s lower than the frequency of integration in B. thetaiotaomicron.

40 Whereas integration of NBU1 in B. thetaiotaomicron is site specific, integration of NBU

41 microbiome likely exceeds those observed in B. thetaiotaomicron by an order of magnitude.

42 egrates preferentially into a single site in B. thetaiotaomicron 5482.

43 Integration occurred in two primary sites in B. thetaiotaomicron.

44 t increasing the number of copies of susR in B. thetaiotaomicron increased the rate of growth on star

45 egration was much less site specific than in B. thetaiotaomicron.

46 and regulator compete for the intermediate, B. thetaiotaomicron tunes transcription of CS utilizatio

47 described species closest to both of them is B. thetaiotaomicron (approximately 94% sequence similari

48 During growth in mucin, B. thetaiotaomicron contributes to EHEC virulence by cle

49 aride synthesis and conserved among multiple B. thetaiotaomicron isolates, that is required for 260.8

50 iduals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate con

51 f RelA and the anti-inflammatory activity of B. thetaiotaomicron.

52 r of DNA contributes to the aerotolerance of B. thetaiotaomicron.

53 bited significantly higher concentrations of B. thetaiotaomicron.

54 leting bt3312, which prevented the growth of B. thetaiotaomicron on 1,6-beta-glucan.

55 Whole-genome transcriptional profiling of B. thetaiotaomicron, combined with mass spectrometry, re

56 starch-associated outer membrane proteins of B. thetaiotaomicron that have no starch-degrading activi

57 strate that the starch utilization system of B. thetaiotaomicron is controlled on at least two levels

58 s show that the starch utilization system of B. thetaiotaomicron is quite complex and contains a numb

59 t adiposity compared with monoassociated, or B. thetaiotaomicron-D. piger biassociated, animals.

60 by polysaccharides, and its absence reduces B. thetaiotaomicron fitness in polysaccharide-rich diet-

61 to the current paradigm, we discovered that B. thetaiotaomicron possesses an authentic GAG endosulfa

62 lipid A phosphate positions observed for the B. thetaiotaomicron and P. gingivalis LPS contributes to

63 Within Fut2(-) mice, the B. thetaiotaomicron fucose catabolic pathway was markedl

64 port the sequencing of a 7-kbp region of the B. thetaiotaomicron chromosome that lies immediately dow

65 ween these mechanisms, the components of the B. thetaiotaomicron Hep/HS degrading apparatus were anal

66 resented here is the atomic structure of the B. thetaiotaomicron protein BT1043, an outer membrane li

67 ity, BT1043 is a structural homologue of the B. thetaiotaomicron starch-binding protein SusD.

68 ch led to disruption of the gdhA gene on the B. thetaiotaomicron chromosome indicated that gdhA mutan

69 emonstrate that the binding of starch to the B. thetaiotaomicron surface involves at least four outer

70 E. rectale adapts to B. thetaiotaomicron by decreasing production of its glyc

71 leocytoplasmic redistribution in response to B. thetaiotaomicron.

72 he role of HTCS in nutrient sensing, we used B. thetaiotaomicron GeneChips to characterize their expr

73 After weaning, B. thetaiotaomicron expands its metabolism to exploit ab

74 yR stress response to H2 O2 was induced when B. thetaiotaomicron was aerated, and in that circumstanc

75 e HTCS BT0366 is phosphorylated in vivo when B. thetaiotaomicron experiences the BT0366 inducer arabi

76 tion of dietary fructans to acetate, whereas B. thetaiotaomicron-derived formate is used by M. smithi

77 M. loti GmhB prefer the beta-anomer, whereas B. thetaiotaomicron GmhB is selective for the alpha-anom

78 only evident in mice fed a PD diet, wherein B. thetaiotaomicron relies on host mucus consumption.

79 lactosidase from family GH43; however, while B. thetaiotaomicron grows on larch wood arabinogalactan,

80 Genomic comparison with B. thetaiotaomicron in conjunction with cell culture stu

81 Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentrati

82 Colonization of germ-free mice with B. thetaiotaomicron has shown how this anaerobe modifies

83 70-fold, to a value close to that seen with B. thetaiotaomicron, if the primary integration site fro