ライフサイエンスコーパス: B7 molecule

1 act epithelial cells express a wide range of B7 molecules.

2 of CTLA-4 can also function independently of B7 molecules.

3 purified CD8+ cells, even in the absence of B7 molecules.

4 ) mice with mice lacking B7-1, B7-2, or both B7 molecules.

5 assuming the absence of trans-stimulation by B7 molecules.

6 action of CD28 or CTLA-4 on the T cells with B7 molecules.

7 g CTLA-4, the inhibitory T cell receptor for B7 molecules.

8 ized in mouse strains lacking either or both B7 molecules.

9 press MHC class II proteins or costimulatory B7 molecules and fail to induce proliferation of T cells

10 blood monocytes (which express low levels of B7 molecules and FcgammaRs) compared with control mAb, b

11 umbilical vein endothelial cells (which lack B7 molecules and FcgammaRs) or by blood monocytes (which

12 The ligand, which has homology to B7 molecules and is called B7-related protein-1 (B7RP-1)

13 The effect of ribavirin on the expression of B7 molecules and on CHS responses was neutralized by IL-

14 llows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of

15 ase, but essentially unaltered expression of B7 molecules and T cell cytokine transcripts (interleuki

16 The intragraft transcript expression of the B7 molecules and their counterreceptors was defined usin

17 provides an important tool for examining how B7 molecules and their effects on CTLA-4 modulate T cell

18 eports of differential signaling through the B7 molecules and their ligands CD28 and CTLA-4.

19 e immune responses requires costimulation by B7 molecules, and Ag recognition without B7 is thought t

20 lls, were less dependent on costimulation by B7 molecules, and independent of costimulation by CD40.

21 ssional APCs, recent evidence shows that the B7 molecules are also expressed on T cells.

22 The transgene-derived B7 molecules are functional, because B7-1 transgenic B c

23 er than PBAMCs, which use both the LFA-3 and B7 molecules, at costimulating IL-2 and IL-4 production.

24 mice that lack expression of the endogenous B7 molecules (B7 double knock-out mice), because of the

25 A comparison of the level of expression of B7 molecules by APC and CD4 T cells, under different con

26 o determine whether Ts inhibit expression of B7 molecules by blocking transcription, we cloned and ch

27 , but as a result of specific recognition of B7 molecules by CTLA-4.

28 g stimulation of T cells, the recognition of B7 molecules by the CD28 costimulatory receptor increase

29 T cell upregulation of B7 molecules CD80 and CD86 limits T cell expansion in im

30 ets, we investigated the contribution of the B7 molecules CD80 and CD86 to the Th2 cytokine profile a

31 iltrating neutrophils sharply upregulate the B7 molecules CD80 and CD86, but they do not express CD40

32 nized homeostatic role for the costimulatory B7 molecules (CD80 and CD86) in preventing adipose infla

33 own to mediate costimulation, including CD28/B7 molecules (CD80 and CD86), CD40/CD40 ligand (CD40L, C

34 owed macrophage, recipient MHC class II, and B7 molecule co-localization by immunohistochemistry to G

35 The expression of costimulatory B7 molecules correlated with macrophage numbers.

36 Since the B7 molecules could be costimulating CD8+ and/or CD4+ T c

37 B7 molecules could directly costimulate CD8+ cells, as p

38 h peak induction of HLA-DR and costimulatory B7 molecule (especially CD86) expression on B cells.

39 regulatory cells requires engagement of the B7 molecule expressed on target T cells.

40 In mammals, the classical B7 molecules expressed on antigen-presenting cells, B7-1

41 Our results indicate that MRP-14 regulates B7 molecule expression and reduces antigen presentation

42 a deficiency in costimulation due to lack of B7 molecule expression does not fully explain the inabil

43 rotective role for C5a through regulation of B7 molecule expression on plasmacytoid DCs.

44 B7 molecule expression was detected on the surface of ce

45 Therefore, the two B7 molecules have overlapping functions, since either B7

46 o residues 75-84 of the alpha1 domain of HLA-B7 molecule (HLA-B7.75-84 [Allotrap]) inhibits cytotoxic

47 r both B7 molecules to determine the role of B7 molecules in activation of primary alloreactive CTL.

48 However, the role of B7 molecules in inducing tumor immunity is controversial

49 We measured levels of soluble B7 molecules in supernatants of isolated primary hepatoc

50 To study the role of B7 molecules in the effector phase of the disease, MOG 3

51 s in the presence of strong costimulation by B7 molecules in vitro and can reduce T cell-mediated ski

52 rformed antibody (Ab)-mediated inhibition of B7 molecules in wild-type mice in DIO.

53 s, while B7-1 appeared to be the predominant B7 molecule involved in the ability of LT (E112K) to aug

54 indicates that B7-2 represents the dominant B7 molecule involved in the generation of an immune resp

55 These studies revealed that blockade of both B7 molecules is required for decreased production of IFN

56 in proteins share sequence homology with the B7 molecules, it is unclear whether they have any functi

57 In vivo, constitutive expression of B7 molecules leads to the elimination of immature B cell

58 Culture with APC expressing MHC II plus B7 molecules led to strong proliferation and T cell prim

59 e induced by blocking the interaction of the B7 molecule on the surface of antigen-presenting cells w

60 of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an import

61 T cells is critical for the upregulation of B7 molecules on antigen-presenting B cells that subseque

62 in which activation-induced up-regulation of B7 molecules on APC leads to increased CD28 signaling an

63 Up-regulation of B7 molecules on PEC was evaluated by FACS after exposure

64 o mouse heterotopic cardiac transplantation, B7 molecules on recipient cells rather than donor cells

65 To study the functions of B7 molecules on T cells, we transfected murine B7.1 (CD8

66 ion of CTLA4Ig, a fusion protein which binds B7 molecules on the surface of antigen-presenting cells,

67 The expression of B7 molecules on thymocytes results in the down-regulatio

68 the absence of MHC class I and II, CD40, or B7 molecules on transfused cells.

69 Thus, the obligatory role of B7 molecules paradoxically is to promote effective T cel

70 T cell costimulation by B7 molecules plays an important role in the regulation o

71 d to determine whether costimulation through B7 molecules plays any role in the unusual form of splen

72 The absence of both B7 molecules profoundly reduced generation of both prima

73 a 10-amino-acid peptide derived from the HLA-B7 molecule, prolongs rat heterotopic cardiac allograft

74 The B7 molecules provide critical costimulation, as in their

75 B7 molecules provide important costimulatory signals to

76 T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in an

77 uced the IgG2a response in mice lacking both B7 molecules, suggesting that CD4(-) cells may supply he

78 ity requires induction of tumor cell-encoded B7 molecules that are mediated by the cytoplasmic region

79 i differentially associates with variant HLA-B7 molecules that have peptide-binding groove mutations,

80 the existence of an additional receptor for B7 molecules that is neither CD28 nor CTLA4.

81 piratory tract epithelial cells up-regulates B7 molecules that regulate memory immune responses and t

82 made genetically deficient in either or both B7 molecules to determine the role of B7 molecules in ac

83 om neonatally induced T cell anergy requires B7 molecules to serve double functions, namely, costimul

84 ECs, which lack B7 molecules, use predominantly leukocyte-function assoc

85 These data suggest that HLA-A2 and HLA-B7 molecules utilize distinct TAP-independent peptide su

86 tor (pHEBo) containing cDNA encoding the HLA-B7 molecule was transfected into lymphoblastoid cell lin

87 The expression of B7 molecules was observed for up to 3 days, which corres

88 tion by naive T cells is highly dependent on B7 molecules, whereas IL-4 production by previously acti

89 Blocking the interaction of the CD28 and B7 molecules with a CTLA4Ig fusion protein abrogates the