ライフサイエンスコーパス: BAFF

1 BAFF (TNF superfamily [TNFSF] 13B/Blys) and APRIL (TNFSF

2 BAFF also contributed to the maintenance and/or expansio

3 BAFF and a proliferation-inducing ligand (APRIL), which

4 BAFF and APRIL enhanced the immune reaction, improved an

5 BAFF expression was significantly increased in lungs of

6 BAFF is a B cell survival and maturation factor implicat

7 BAFF is a crucial cytokine that affects the activity of

8 BAFF is a cytokine critical for development and proper s

9 BAFF is a key cytokine in B cell homeostasis, but its po

10 BAFF is an ideal molecule to improve early pathways of B

11 BAFF is critical for the survival and maturation of matu

12 BAFF is significantly increased in lungs of patients wit

13 BAFF levels were also higher in blood and bronchoalveola

14 BAFF reactivity correlated with the severity of disease-

15 BAFF staining in lymphoid follicles was observed around

16 BAFF stimulation, in contrast to CD40 activation, was un

17 BAFF, via BAFFR, activates multiple signaling pathways i

18 BAFF-mediated atheroprotection required B cells and was

19 D20, CD22, etc.) and cytokines (IL-6, IL-21, BAFF and APRIL) with key effects on B cell/plasma cell s

20 A BAFF/APRIL-like relative called BAFF- and APRIL-like mol

21 d bony fishes, and we report in this study a BAFF-like gene in lampreys.

22 This corresponded to a BAFF-R-dependent defect in GC colonization.

23 OLD stage IV COPD, characterized by abundant BAFF-positive cells but few apoptotic cells (mostly B ce

24 The N and C termini of adjacent BAFF or APRIL monomers are spatially close and can be li

25 accine incorporating the molecular adjuvants BAFF (B cell activating factor) and APRIL (a proliferati

26 red survival of ERK5-deficient B cells after BAFF stimulation.

27 However, ERK5 deficiency did not alter BAFF activation of the PI3-kinase-Akt or NF-kappaB signa

28 The HIV-infected children had an altered BAFF profile that could have affected their B cell compa

29 Although BAFF-depleting therapy with belimumab achieved approval

30 h chronic gastritis is enriched in IL-17 and BAFF, whereas the two cytokines are weakly expressed in

31 IL-4 and BAFF strongly synergized to promote B cell maturation, a

32 compared the maturation effects of IL-4 and BAFF.

33 mplement-coated antigen surrogate, IL-4, and BAFF +/- exogenous PGE2 (50 nM) or an analog specific fo

34 previously unknown synergy between AngII and BAFF in inducing IL-10 production by B cells, resulting

35 e increased, the expression of the APRIL and BAFF receptor transmembrane activator and calcium-modula

36 Serum levels of TNF-alpha, APRIL, and BAFF and saliva levels of BAFF were significantly higher

37 ted salivary and serum TNF-alpha, APRIL, and BAFF in patients with periodontitis may contribute to th

38 Proportion of Bm2 and BAFF levels were positively associated with the diversit

39 o cGVHD: CXCL9, IL2Ralpha, elafin, CD13, and BAFF.

40 G1 and IgA production upon in vitro CD40 and BAFF, but not BCR and LPS stimulation, indicating that D

41 r IgG-immune complexes (ICs), FcgammaRs, and BAFF during the formation of memory B cells in mice.

42 rmation of B cell memory through IgG-ICs and BAFF.

43 smembrane activator and CAML interactor, and BAFF receptor, in sorted human immune cell subsets, we f

44 We analyzed serum BAFF levels and BAFF expression in B cells in blood and bronchoalveolar

45 reduces Aiolos and Ikaros protein levels and BAFF- and CD40L-induced proliferation, plasmablast diffe

46 ion mainly in neutrophils and monocytes, and BAFF expression in neutrophils from pSS patients strongl

47 proliferation, such as BCL6, MYC, PIK3CA and BAFF-R.

48 enotype status affects HIV-1 replication and BAFF induction, as both were abrogated in MDMs displayin

49 ate the role of BAFF in COPD, we antagonized BAFF by prophylactic or therapeutic administration of a

50 Antagonizing BAFF in CS-exposed mice attenuates pulmonary inflammatio

51 Moreover, antagonizing BAFF altered the phenotype of alveolar and interstitial

52 APRIL, BAFF, TNF-alpha, IL-6, and IL-10 levels in serum and sal

53 Serum and saliva levels of TNF-alpha, APRIL, BAFF, IL-6, and IL-10 were similar in CP and AgP groups.

54 our results support the notion that an axis BAFF/Th17 exists in chronic gastritis of Helicobacter(+)

55 Mice with transgenic expression of BAFF (BAFF-Tg) harbor increased numbers of Helios+ Foxp3+ thym

56 hich nonetheless display a very strong basal BAFF production.

57 We report also that basal BAFF secretion was higher in monocytes obtained from fem

58 Finally, baseline BAFF-R levels before CHMI were predictive of subsequent

59 Because BAFF promotes B cell class-switch recombination and humo

60 roles for NIK in additional pathways beyond BAFF signaling.

61 to BAFF-R on the surface of B-cells, blocked BAFF-mediated B-cell proliferation and were internalized

62 g B cells in patients with lupus by blocking BAFF, type I interferon, or TLR7 to TLR9.

63 ase at 18 months of age had lower cord blood BAFF levels than nonallergic children.

64 Both BAFF and APRIL assemble as homotrimers that bind and act

65 gastritis; moreover, the expression of both BAFF and IL-17 decreases after bacteria eradication.

66 body, neutralizes soluble and membrane-bound BAFF.

67 A BAFF/APRIL-like relative called BAFF- and APRIL-like molecule (BALM) has also been ident

68 ough B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a

69 mulation, indicating that DBC1 inhibits CD40/BAFF-mediated B cell activation in a cell-intrinsic mann

70 gnaling pathway and the receptors for CD40L, BAFF and TLR ligands.

71 garette smoke extract (CSE) increases B-cell BAFF expression and (2) recombinant BAFF (rBAFF) rescues

72 Our data support the hypothesis that B-cell BAFF expression creates a self-perpetuating loop contrib

73 Single-chain BAFF (BBB) and to a lesser extent single-chain ABB, but

74 Circulating BAFF levels were maximal at birth, and farmers' children

75 ensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay.

76 In conclusion, BAFF-APRIL heteromers of different stoichiometries have

77 In contrast, BAFF overexpression markedly reduced hypercholesterolemi

78 We correlated BAFF immunostaining in LFs in lung explants or biopsies

79 eatment of wild-type cells with the cytokine BAFF, a known attenuator of p18(INK4c) function in B lym

80 B lymphocytes via production of the cytokine BAFF.

81 ment was diminished in both B cell-deficient BAFF-Tg chimeras, but also B cell-deficient wild-type ch

82 Loss of CD16, hematopoietic cell-derived BAFF, or blocking IC:FcgammaR regions in vivo diminished

83 mportance of pDC/monocyte crosstalk to drive BAFF secretion.

84 We demonstrate here that HIV-1 drives BAFF production in MDMs in a type-I IFN- and TLR-indepen

85 vision rate that correlates with an elevated BAFF/CD19(+) B-cell ratio, supporting a B-cell hyperacti

86 IL-2, whereas SLE patients exhibit elevated BAFF and DN B cells and reduced IL-21.

87 cating IFN induction as a factor in elevated BAFF levels in CGVHD.

88 B cells chronically stimulated with elevated BAFF, however, rapidly increased glycolysis and Ab produ

89 nization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12

90 ow that DNA or DNA-protein vaccines encoding BAFF or APRIL multitrimers, IL-12p70, and membrane-bound

91 ing recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detec

92 is usually limited to mature B cells, excess BAFF promotes the expansion of TACI-expressing transitio

93 I-dependent activation in settings of excess BAFF remain unclear.

94 al autoimmunity, we hypothesized that excess BAFF would accelerate atherosclerosis.

95 Exogenous BAFF confers a state of immediate responsiveness to anti

96 G-ICs prior to significant B cell expansion, BAFF secretion, and lupus nephritis.

97 eased and correlated with membrane-expressed BAFF on monocytes and dendritic cells, as well as blood-

98 ells still respond to the prosurvival factor BAFF in culture and require BAFF-R signaling for their i

99 expressing murine B cell activating factor (BAFF) (rRABV-mBAFF).

100 B-cell activating factor (BAFF) is an important cytokine for B-cell maturation.

101 The B cell-activating factor (BAFF) is critical for B cell development and humoral imm

102 ficantly increased B cell-activating factor (BAFF) levels and that their B cells are activated and re

103 elevated levels of B-cell-activating factor (BAFF) receptor (BAFF-R) and as a result proliferate more

104 ls provided by the B cell-activating factor (BAFF) receptor (BAFF-R).

105 ptor (BCR) and the B cell-activating factor (BAFF) receptor.

106 B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essen

107 oprotegerin (OPG), B-cell activating factor (BAFF), and a proliferation-inducing ligand (APRIL) were

108 ng ligand (APRIL), B-cell activating factor (BAFF), interleukin (IL)-6, and IL-8 in biofluids of pati

109 -inducing ligand), B-cell activating factor (BAFF), tumor necrosis factor-alpha (TNF-alpha), interleu

110 ne and drug target B-cell activating factor (BAFF), was associated with multiple sclerosis as well as

111 ne of these is the B cell-activating factor (BAFF).

112 TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve

113 ted MZ B cells via B cell-activation factor (BAFF), the ligand of the costimulatory receptor CD40 (CD

114 The observation that the soluble factors BAFF, IL-2, and IL-21 induce memory and DN B cell activa

115 in renal expression for PC survival factors (BAFF, a proliferation-inducing ligand, and IL-6) and PC

116 factor of the tumor necrosis factor family (BAFF) is an essential survival factor for B cells and ha

117 ting factor of tumor necrosis factor family (BAFF) regulates B cells in health, but its role in COPD

118 longing to the tumor necrosis factor family (BAFF; also known as BLyS) is a cytokine that enhances B-

119 tivating factor belonging to the TNF family (BAFF) and a proliferation inducing ligand (APRIL) signal

120 B cell activating factor of the TNF family (BAFF) develop systemic autoimmunity characterized by cla

121 B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligan

122 B-cell activating factor of the TNF family (BAFF), nucleic acid-sensing Toll-like receptors (TLRs),

123 onging to the tumor necrosis factor family" [BAFF]).

124 characterized by abundant apoptotic but few BAFF-positive cells (mostly B cells); and (2) type B, th

125 Correspondingly, we find BAFF orthologs in all of the jawed vertebrate representa

126 occurred normally in infected mice following BAFF neutralization.

127 L interactor (TACI) signals are critical for BAFF-mediated autoimmunity, but the B cell developmental

128 aling pathways, which are also important for BAFF to promote mature B cell survival.

129 Median GCF, serum, and saliva levels for BAFF (P <0.001) and IL-6 and IL-8 (P <0.005) were higher

130 n of ERK 1 and 2 MAP kinases is required for BAFF-R to promote B cell survival.

131 TACI(+) transitional cells from BAFF-transgenic mice are characterized by an activated,

132 oimmunity, TACI(+) transitional B cells from BAFF-transgenic mice spontaneously produce class-switche

133 Serum and GCF BAFF (P <0.0001), serum, saliva, and GCF APRIL (P <0.000

134 Higher BAFF levels at birth were positively associated with pro

135 At birth, girls had higher BAFF levels and lower proportions of CD5(+) B cells than

136 l at birth, and farmers' children had higher BAFF levels than nonfarmers' children.

137 IV-1 Nef accessory protein is dispensable in BAFF upregulation as a nef-deleted HIV-1 strain is still

138 nges strongly correlated with an increase in BAFF and APRIL expression in the IFN-high BM.

139 erum levels of BAFF/BLyS and by increases in BAFF-producing Ly6C(hi) inflammatory monocytes and monoc

140 B cells could be infected in BAFF-R(-/-) mice, but virus loads remained low.

141 rescued BAFFR-dependent B cell maturation in BAFF-deficient mice.

142 s, down to levels close to those observed in BAFF-deficient mice.

143 to this, expansion of Tregs did not occur in BAFF-Tg/Ig hen egg lysozyme BCR chimeras, demonstrating

144 he MEK5-ERK5 MAP kinase signaling pathway in BAFF-induced mature B cell survival and homeostatic main

145 pathway, in addition to its critical role in BAFF-mediated cell survival, may control the expression

146 factor (TNF) superfamily ligands, including BAFF and APRIL, can be multitrimerized using the lung pr

147 leted HIV-1 strain is still able to increase BAFF at levels similar to the wild type strain.

148 el mechanistic explanation for the increased BAFF levels observed during HIV-1 infection and highligh

149 fully competent (R5-tropic) HIV-1 to induce BAFF production by monocyte-derived macrophages (MDMs).

150 exposure during pregnancy appears to induce BAFF production in the newborn child, and high neonatal

151 IFN-beta injections induced BAFF expression mainly in neutrophils and monocytes, and

152 els and promoted lupus nephritis by inducing BAFF production in the kidneys, and the formation of ren

153 It functioned as a decoy receptor inhibiting BAFF- and APRIL-mediated B cell survival and NF-kappaB a

154 (DCs), suggesting that NO normally inhibits BAFF expression.

155 igger B cell activation, and one of these is BAFF.

156 Like mammalian BAFF and APRIL, the lamprey BAFF-like gene is expressed in T-like, B-like, and innat

157 l, including a proliferation-induced ligand, BAFF, insulin-like growth factor 1, vascular endothelial

158 We quantified and localized BAFF expression in lungs of never-smokers, smokers witho

159 Mechanistically, lowering BAFF levels also diminished the number of T cells positi

160 Like mammalian BAFF and APRIL, the lamprey BAFF-like gene is expressed

161 ts higher sequence similarity with mammalian BAFF than APRIL.

162 farming and nonfarming families, we measured BAFF levels in plasma from mothers and their children at

163 tion of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circul

164 d, we found that NOS2(-/-) DCs produced more BAFF than did wild-type DCs, and addition of a NO donor

165 Moreover, BAFF directly promotes the differentiation of Th17 cells

166 ies to recognize, inhibit, or activate mouse BAFF was investigated.

167 functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF

168 ometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and ant

169 tion in the newborn child, and high neonatal BAFF levels were associated with more accelerated postna

170 Notably, BAFF and APRIL did not cause indiscriminate B cell expan

171 s; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administ

172 RNA-sequencing analysis of BAFF-stimulated nfkb2-deleted versus normal B cells sugg

173 Application of BAFF on monocytes triggers the accumulation of reactive

174 IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembra

175 similar to what is observed upon blockade of BAFF.

176 decoy receptor for the specific depletion of BAFF in mice.

177 pSS patients will lead to downregulation of BAFF and a consequential reduction of autoreactive B cel

178 hway, which plays a vital role downstream of BAFF, CD40L, lymphotoxin, and other inflammatory mediato

179 teers, we therefore examined the dynamics of BAFF induction and B cell subset activation and composit

180 MHC class II expression, thymic expansion of BAFF-Tg Tregs was lost.

181 Mice with transgenic expression of BAFF (BAFF-Tg) harbor increased numbers of Helios+ Foxp3

182 , activation of ERbeta reduced expression of BAFF and GRB7, 2 important molecules involved in B-cell

183 correlating with the unaltered expression of BAFF receptor, BAFF stimulation induced the activation o

184 ined plasma levels of BAFF and expression of BAFF receptors on B cells.

185 ory factors (IRFs) control the expression of BAFF.

186 However, heteromers of BAFF and APRIL that occur in patients with autoimmune di

187 uggest that, whereas an ancestral homolog of BAFF and APRIL was already present in a common ancestor

188 activation and, in particular, induction of BAFF.

189 The interaction of BAFF, also known as BLyS, with its receptors BAFFR and T

190 e treatment of SLE, where elevated levels of BAFF and Aiolos may prime CD27(+) memory and DN memory-l

191 We also determined plasma levels of BAFF and expression of BAFF receptors on B cells.

192 ul information about the increased levels of BAFF observed during HIV-1 infection and highlights the

193 -alpha, APRIL, and BAFF and saliva levels of BAFF were significantly higher in periodontitis groups t

194 eripheral B-cell subsets and serum levels of BAFF, the main homeostatic cytokine for peripheral B cel

195 by significant increases in serum levels of BAFF/BLyS and by increases in BAFF-producing Ly6C(hi) in

196 NA plasmids encoding soluble multitrimers of BAFF and APRIL using surfactant protein D as a scaffold,

197 with disease severity, and overexpression of BAFF has been demonstrated within lymphoid follicles of

198 Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.

199 enic transitional B cells in the presence of BAFF.

200 e show that the virus-mediated production of BAFF by monocytes relies on a type I IFN response by a s

201 eas IRF4 and IRF8 are negative regulators of BAFF expression.

202 tify IRF1 and IRF2 as positive regulators of BAFF transcription and IRF4 and IRF8 as potent repressor

203 While the role of BAFF in B cells has been widely described, its role in i

204 Next, to investigate the role of BAFF in COPD, we antagonized BAFF by prophylactic or the

205 esent findings suggest a significant role of BAFF in driving disease flare after B cell repopulation

206 These findings suggest an important role of BAFF in facilitating B cell subset proliferation and red

207 the last decade, insights into the roles of BAFF (BLyS) and APRIL in lymphoma development have helpe

208 the importance of macrophages as a source of BAFF, a phenomenon that might contribute to B cell dysfu

209 r selection of B cells, and the targeting of BAFF has emerged as a successful treatment strategy of S

210 nesis, of particular relevance to the use of BAFF-targeted therapies in systemic lupus erythematosus.

211 milar to APRIL, heteromers consisting of one BAFF and two APRILs (BAA) bind to the receptors B cell m

212 and serum levels of IL-6, IL-8, sRANKL, OPG, BAFF, and APRIL were determined by enzyme-linked immunos

213 ERK5 was required for optimal BAFF up-regulation of Mcl1 and Bcl2a1, which are prosurv

214 0L, anti-IgM, IL-21, CpG, IFN-alpha, IL-6 or BAFF induces miR-155 and decreases PU.1 expression.

215 ression and impaired TACI function, APRIL or BAFF did not activate the classical NF-kappaB pathway in

216 nable to secrete Igs in response to APRIL or BAFF.

217 f a proliferation-inducing ligand (APRIL) or BAFF and their receptors in the unresponsiveness of XID

218 estored TACI-mediated signaling in APRIL- or BAFF-stimulated XID B cells.

219 ermsii infection, mice deficient in BAFFR or BAFF exhibit impairment in B. hermsii-specific IgM respo

220 ransplant proportion of any B-cell subset or BAFF serum levels.

221 Bm2 cells but not of other B-cell subsets or BAFF levels was independently associated with the presen

222 belimumab achieved approval for lupus, other BAFF inhibitors were much less beneficial in clinical tr

223 Concomitantly, plasma BAFF levels during CHMI were increased and correlated wi

224 Correlating with increased plasma BAFF and IFN-gamma levels, IgD(-)CD38(low)CD21(-)CD27(-)

225 tor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mat

226 of B-cell-activating factor (BAFF) receptor (BAFF-R) and as a result proliferate more robustly in res

227 he B cell-activating factor (BAFF) receptor (BAFF-R).

228 tes CD40, B cell activating factor receptor (BAFF-R), and TLR4 signaling in B cells.

229 activator of the TNF-alpha family receptor (BAFF-R) or caspase recruitment domain-containing protein

230 h the unaltered expression of BAFF receptor, BAFF stimulation induced the activation of the alternati

231 the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modul

232 s B-cell BAFF expression and (2) recombinant BAFF (rBAFF) rescues B cells from CSE-induced apoptosis

233 o that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools wi

234 ition of a NO donor to NOS2(-/-) DCs reduced BAFF production.

235 Reducing BAFF in vivo prevented the formation of TLSs and lupus n

236 physiological role might be to down-regulate BAFF activity.

237 ubsets plays an important role in regulating BAFF production and TI-2 Ab responses.

238 osurvival factor BAFF in culture and require BAFF-R signaling for their in vivo maintenance.

239 ents show that Syk-deficient B cells require BAFF receptor and CD19/PI3K signaling for their long-ter

240 iferation driven by a murid gammaHV requires BAFF-R.

241 tions that induce dendritic cells to secrete BAFF, which acts at or upstream of Bcl-6 in activated B

242 Serum BAFF was measured sequentially by enzyme-linked immunoso

243 We analyzed serum BAFF levels and BAFF expression in B cells in blood and

244 The correlations between serum BAFF levels and levels of IgG and IgA were lost followin

245 ndergoing Ai transplantation, elevated serum BAFF levels at baseline (before both antibody removal/de

246 re lost following BCDT, but changes in serum BAFF levels correlated positively with changes in anti-d

247 Clinical periodontal recordings, serum BAFF, IL-8, and saliva sRANKL levels were higher in the

248 We discovered that whereas serum BAFF levels were increased, the expression of the APRIL

249 Any single BAFF receptor, including BR3, is dispensable for the dev

250 immunity through increased levels of soluble BAFF, B lymphocytes, and immunoglobulins.

251 hibition and increased production of soluble BAFF, which in turn up-regulated humoral immunity.

252 his in vitro study, we describe that soluble BAFF in combination with IL-2 and IL-21 is a T cell cont

253 identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interact

254 rvation that heteromers are less active than BAFF, we speculate that their physiological role might b

255 We demonstrate that BAFF accumulates in macrophages in vivo and that it is p

256 In this article, we demonstrate that BAFF is a bona fide ISG and that IFN regulatory factors

257 Moreover, we demonstrated that BAFF is able to drive Th17 responses both indirectly, by

258 In the present study, we demonstrated that BAFF-induced B cell survival was actually independent of

259 cient and wild-type mice, demonstrating that BAFF modulated immunity through the extrafollicular and

260 We propose that BAFF and APRIL multitrimers are promising molecular adju

261 In summary, we show that BAFF expression is directly induced by type I IFNs via I

262 In this manuscript, we show that BAFF promotes events leading to lupus nephritis.

263 Previous reports have suggested that BAFF expression is directly induced by type I IFNs, but

264 the B-cell expansion defect, suggesting that BAFF-R is a bona fide miR-142 target through which it co

265 The BAFF-APRIL system is best known for its control of B cel

266 Furthermore, chimeric molecules between the BAFF-R aptamer and small interfering RNAs (siRNAs) were

267 recise binding site for these factors in the BAFF promoter.

268 With this study, we investigated the BAFF/Th17 responses in Helicobacter pylori-induced gastr

269 Lowering the BAFF-R gene dose in miR-142(-/-) mice rescues the B-cell

270 activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic

271 n containing the extracellular domain of the BAFF-APRIL receptor TACI, was applied in clinical trials

272 ases with established hyperactivation of the BAFF-APRIL system.

273 istration of a soluble fusion protein of the BAFF-receptor, BAFFR-Fc, in mice exposed to air or CS fo

274 ic strategies based on the inhibition of the BAFF/IL-17 response.

275 reduced atherosclerosis was dependent on the BAFF family receptor transmembrane activator and CAML in

276 or and CAML interactor (TACI) but not to the BAFF receptor (BAFFR).

277 These BAFF and APRIL effects coincided with an enhanced germin

278 The predicted protein encoded by this BAFF-like gene in lampreys exhibits higher sequence simi

279 Thus, BAFF plays a previously unappreciated role in lupus neph

280 the IFN-inducible genes CXCL10 and TNFSF13B (BAFF) were correlated at both the gene and the plasma le

281 The aptamers efficiently bound to BAFF-R on the surface of B-cells, blocked BAFF-mediated

282 ) B cells, and this effect was comparable to BAFF.

283 Consistent with a potential contribution to BAFF-mediated humoral autoimmunity, TACI(+) transitional

284 RNAs (siRNAs) were specifically delivered to BAFF-R expressing cells with a similar efficiency as the

285 ch NIK is acutely deleted fail to respond to BAFF stimulation in vitro and in vivo.

286 ult proliferate more robustly in response to BAFF stimulation.

287 NOD mice receiving transient BAFF blockade were characterized by an enrichment of reg

288 HIV-1-induced type I IFN by pDCs triggers BAFF production in both classical and intermediate monoc

289 Heteromers consisting of one APRIL and two BAFF (ABB) bind to TACI and BCMA and weakly to BAFFR in

290 y that HIV-1 (X4- and R5-tropic) upregulates BAFF expression and secretion by human monocytes.

291 nd provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depleti

292 Using BAFF receptor (BAFFR)-deficient mice, we characterized B

293 8) at the expense of memory B cells, as were BAFF serum levels (1,651 +/- 1,297 vs. 1,139 +/- 693 pg/

294 ng pregnancy and early childhood and whether BAFF levels are associated with postnatal B-cell maturat

295 We sought to investigate whether BAFF levels are related to environmental exposures durin

296 gs highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI-depe

297 pathways and suggests that interfering with BAFF-R could more generally reduce gammaHV-associated B

298 Moreover, treatment of Muvarphis with BAFF or APRIL enhanced the clearance of Leishmania from

299 itional B cell checkpoint, not observed with BAFF.

300 with the in vivo data, AngII synergized with BAFF to induce IL-10 production by B cells in vitro via