ライフサイエンスコーパス: BAT

1 BAT also secreted several adipokines, including adiponec

2 BAT and beige fat oxidized fatty acids to fuel Ucp1-medi

3 BAT and the measurement of nasal sIgE can also contribut

4 BAT can also be used to monitor resolution of food aller

5 BAT dysfunction resulting from p62 deficiency is manifes

6 BAT functions as hepatoprotective machinery to counterac

7 BAT product was US-licensed in 2013.

8 BAT product was well tolerated in patients.

9 BAT results were assessed against confirmed allergic sta

10 BAT rPru p 3 and rMal d 3 were performed and sIgG4 antib

11 BAT using %CD63(+) basophils (SSClow/CCR3pos) as outcome

12 BAT volume and 18F-FDG uptake were not associated with q

13 BAT volume, BAT 18F-FDG uptake, and skeletal muscle 18F-

14 BAT was positive in 12 out of 15 patients and negative i

15 BAT was safe and significantly improved QOL, 6MHW, and N

16 BAT was safe and significantly improved QOL, exercise ca

17 BAT-specific deletion of Sirt5, a mitochondrial desuccin

18 BATs confirmed that, comparable to the anti-IgE monoclon

19 BATs to measure upregulation of basophil CD203c and indu

20 Thirty-one (19.1%) patients had 41 BAT product-related adverse events.

21 rotein 1 (Ucp1) expression and activity in a BAT sympathetic nerve-dependent manner.

22 direct activation of MnPO neurons induced a BAT thermogenic response in warm rats.

23 In turn, a BAT-specific defect in BCAA catabolism attenuates system

24 rmogenesis in humans; how to safely activate BAT and other organ thermogenesis; and how to sustain a

25 might be thermogenic lipokines that activate BAT in response to cold.

26 After a cooling procedure to activate BAT, volunteers underwent (18)F-FDG imaging.

27 ance correlated with the extent of activated BAT in a given scan.

28 Active BAT was segmented using the BARCIST 1.0 methods.

29 Expanding the volume of active BAT via transplantation holds promise as a therapeutic s

30 cle, white adipose (WAT), and brown adipose (BAT) tissues.

31 s tissue-cholesterol homeostasis and affects BAT metabolism, suggesting beneficial LAL activation in

32 Although BAT has been implicated to be protective in cardiovascul

33 be detected by SPT, PHMB ImmunoCAP, and ALX-BAT in 15%-33% of CHX-allergic patients.

34 lexaFFA uptake in the heart (58 +/- 12%) and BAT (278 +/- 19%) compared to warm/fed animals.

35 lexaFFA uptake in the heart (48 +/- 20%) and BAT (40 +/- 10%) compared to saline-injected/fed mice.

36 BCN, only ratios of sIgG4/sIgE rMal d 3 and BAT rMal d 3 (0.001 ug/mL) can identify clinically relev

37 reased 3-hydroxybutyrate levels in blood and BAT in response to the cold, suggesting that ketogenesis

38 , as exhibited by target gene expression and BAT-gal staining.

39 crease FFA uptake in the heart (fasting) and BAT [cold exposure and injection with the beta(3) adrene

40 In vivo imaging of the heart and BAT after exposure to CL and fasting showed a significan

41 that dissipates energy via UCP1 as heat, and BAT mass is correlated negatively with obesity.

42 ession of thermogenic genes in both iWAT and BAT of C57BL6/J mice.

43 ransferase 1B (CPT1B) in striated muscle and BAT.

44 Our study showed that SBPCDPT and BAT are both useful diagnostic tools for IHRs due to 5-n

45 y, along with increased body temperature and BAT gene expression, specifically Cox8b.

46 nificant alterations in body temperature and BAT thermogenic gene expression, perhaps contributing to

47 oprotective effects, can also impact WAT and BAT function.

48 revealed that BMAT is distinct from WAT and BAT, with altered glucose metabolism and decreased insul

49 , BMAT is functionally distinct from WAT and BAT.

50 ong skeletal muscle and subcutaneous WAT and BAT.

51 ting the prominent contribution of brown AT (BAT) thermogenesis.

52 ditional Kiss1r knockout exclusively in BAT (BAT-Kiss1r KO).

53 we determined that transplantation of BAT (+BAT) improves cardiac function via the release of the li

54 Because BAT is a specialized metabolic tissue that takes up and

55 However, the link between BAT and appetite regulation needs to be more rigorously

56 We found ANKO mice, which lack NAMPT in both BAT and WAT, had impaired gene programs involved in ther

57 tabolism attenuates systemic BCAA clearance, BAT fuel oxidation and thermogenesis, leading to diet-in

58 Ectopic engraftment of BAPC-derived BAT in skeletal muscle augmented the EE of recipient mic

59 bjects were randomized 1:1 to receive either BAT plus optimal medical management (BAT group) or optim

60 rgy expenditure was correlated with elevated BAT activity and inguinal WAT thermogenic program.

61 itoxin Heptavalent (A,B,C,D,E,F,G)-(Equine) (BAT) manufactured by Emergent BioSolutions Canada Inc is

62 sufficiency of UCP1 to account for eutherian BAT, these data support a mechanism for the emergence of

63 is the first, to our knowledge, to evaluate BAT in patients with melatonin deficiency (radiotherapy

64 , blocked cold-evoked or NMDA in MnPO-evoked BAT thermogenesis.

65 Among 162 patients, 7 (4.3%) experienced BAT product-related serious adverse events, including 1

66 After overnight fasting, BAT lacking ALK7 showed increased expression of genes re

67 nscriptional silencing, which impaired fetal BAT development.

68 mits an important fuel source fatty acid for BAT thermogenesis.

69 The optimal concentration of both drugs for BAT was determined as 5 mg/mL.

70 The requirement for BAT fatty acid synthesis has broad implications for adap

71 Our results identify an endocrine role for BAT to enhance cardiac function that is mediated by regu

72 e no studies that identify a direct role for BAT to mediate cardiac function.

73 a promising approach to deriving functional BAT engraftment, which may be applied to therapeutic BAT

74 ANKO mice, which lack NAMPT in BAT only, had BAT cellular alterations similar to the ANKO mice, BANKO

75 esis has been well addressed in rodents, how BAT grows after birth remains unknown.

76 Surprisingly, however, BAT-Kiss1r KOs of both sexes displayed significantly low

77 weight-loss effects of cold-activated human BAT exists to date.

78 CONCLUSIONThese findings indicate that human BAT metabolic activity can be increased after chronic ph

79 supraclavicular adipose tissue (where human BAT is localized) obtained from human subjects increased

80 With a holistic view on hypothalamic-BAT interactions, we aim to raise ideas and provide a ne

81 ase, and recent studies have also identified BAT as an endocrine organ.

82 ted sympathetic nerve activation and impairs BAT thermogenic programs, leading to reduced core body t

83 rgc1a promoter, which epigenetically impairs BAT thermogenesis and energy expenditure, predisposing o

84 Loss of FGF9 impairs BAT thermogenesis.

85 GF with the BAPC transplant further improved BAT formation in muscle.

86 In BAT of DEX offspring, Ppargc1a expression was suppressed

87 In BAT, the induction of thermogenic markers following cold

88 Aifm2 in BAT and subcutaneous white adipose tissue (WAT) promotes

89 fic deletion of the activin receptor ALK7 in BAT resulted in fasting-induced hypothermia due to exagg

90 ntrast, deletion of REV-ERBalpha and beta in BAT allowed mice to maintain their body temperature in c

91 abolism and body temperature and lower BW in BAT-Kiss1r KOs reveal a previously unidentified role for

92 Mechanistically, active BCAA catabolism in BAT is mediated by SLC25A44, which transports BCAAs into

93 The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2

94 still continues to be a matter of debate in BAT.

95 t (LD)-associated protein highly enriched in BAT.

96 e conditional Kiss1r knockout exclusively in BAT (BAT-Kiss1r KO).

97 thermogenesis and mitochondrial function in BAT and a blunted thermogenic (rectal temperature, BAT t

98 ring showed promoted thermogenic function in BAT and inguinal WAT through the upregulation of UCP1 an

99 th higher expression of thermogenic genes in BAT, and are protected from high-fat diet-induced obesit

100 n succinylation and malonylation are high in BAT and subject to physiological and genetic regulation.

101 abolism, and increase thermogenic markers in BAT.

102 Loss of MPC1 in BAT increased 3-hydroxybutyrate levels in blood and BAT

103 Although BANKO mice, which lack NAMPT in BAT only, had BAT cellular alterations similar to the AN

104 ing the functional relevance of PHOPSPHO1 in BAT thermogenesis and energy metabolism, we show that PH

105 rt5 regulates the key thermogenic protein in BAT, UCP1.

106 SREBP was required in BAT for the thermogenic response to norepinephrine, and

107 hondrial proteins plays an important role in BAT and in regulation of energy homeostasis.

108 role for endogenous kisspeptin signaling in BAT in modulating metabolic and thermogenic physiology.

109 whether kisspeptin signaling specifically in BAT influences BW, metabolism, or body temperature, we u

110 and beta as rhythmic regulators of Srebp1 in BAT.

111 tion of SREBP1 that drives fuel synthesis in BAT and is necessary to maintain circadian body temperat

112 eased markers of mitochondrial uncoupling in BAT suggest that BD-AcAc(2) initiates a transcriptional

113 innervating BAT, and dramatically increased BAT uncoupling protein 1 (Ucp1) expression and activity

114 ll four studied patients presented increased BAT volume and activity measured by positron emission to

115 .RESULTSChronic mirabegron therapy increased BAT metabolic activity.

116 ow that oral melatonin replacement increases BAT volume and activity and improves blood lipid levels

117 he first direct evidence of UCP1-independent BAT thermogenesis in knockout mice.

118 circuits and sympathetic nerves innervating BAT, and dramatically increased BAT uncoupling protein 1

119 A mixed effect model integrating BAT results for 10 and 100 ng/mL of peanut and individua

120 Neither the interaction BAT volume x time elapsed after meal consumption nor tha

121 Interestingly, BAT is regulated by multiple interactions with the hypot

122 ocnemius, subcutaneous WAT and interscapular BAT, coupled with neurochemical characterization of spec

123 2) silencing of the Pnpla2 in interscapular BAT causes a brown-to-white phenotypic shift accompanied

124 Using mouse interscapular BAT (iBAT) as an example, we studied the cellular and mo

125 KOs, BAT-Kiss1r KOs (lacking Kiss1r in just BAT) were not hypogonadal, as expected.

126 Unlike global Kiss1r KOs, BAT-Kiss1r KOs (lacking Kiss1r in just BAT) were not hyp

127 during cold stress in large mammals lacking BAT, strengthening the hypothesis that muscle NST has li

128 role in thermoregulation in species lacking BAT, we investigated the thermogenic capacities of newbo

129 ely test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance

130 se findings indicate that a thermogenic-like BAT phenotype is not linked to heightened glucose tolera

131 either BAT plus optimal medical management (BAT group) or optimal medical management alone (control

132 in stimulates a hypothalamus-adrenal medulla-BAT axis, which is necessary and sufficient to induce li

133 ually projected to muscle + WAT and muscle + BAT.

134 d dual projections to muscle + WAT, muscle + BAT, and WAT + BAT.

135 ed KLF15 and POX expression levels in mutant BAT, suggesting that loss of BAT ALK7 results in excessi

136 Neither BAT volume, nor BAT 18F-FDG uptake after cold stimulatio

137 NA methylation was also detected in neonatal BAT and brown progenitors.

138 ized brain alcohol-sensing/sympathetic nerve/BAT/liver axis that counteracts liver steatosis and inju

139 reflect impaired kisspeptin signaling in non-BAT tissues.

140 Neither BAT volume, nor BAT 18F-FDG uptake after cold stimulation, are related t

141 This novel BAT-Kiss1r KO phenotype was of greater magnitude in fema

142 duced by adrenergic stimulation of NCLX-null BAT, triggers the mitochondrial permeability transition

143 rial function and thermogenesis in NCLX-null BAT, while calcium overload persists.

144 Conversely, activation of BAT and beige fat through cold exposure suppressed alcoh

145 at thermoneutrality, enhanced activation of BAT and its thermogenic phenotype via chronic mild cold

146 Physiological activation of BAT and other organ thermogenesis occurs through beta-ad

147 am of ALK7 which regulates the adaptation of BAT to nutrient availability by limiting nutrient stress

148 We aimed to investigate the associations of BAT volume and 18F-fluordeoxyglucose (18F-FDG) uptake af

149 plored as quantitative imaging biomarkers of BAT activity in future studies.

150 gnificantly enhanced thermogenic capacity of BAT, and this effect was diminished in Opn3-KO animals.

151 Although the development of BAT during embryogenesis has been well addressed in rode

152 s is currently impeded by poor efficiency of BAT tissue formation in vivo and undesirably short engra

153 lutionary events underlying the emergence of BAT are unknown.

154 ata support a mechanism for the emergence of BAT based on the acquisition of a novel capacity for adi

155 g of this event relative to the emergence of BAT, the phylogeny of CHKB-CPT1B synteny, and the insuff

156 Therefore, in the further exploration of BAT as a potential source of novel drug targets, we disc

157 LAL overexpression increased levels of BAT free cholesterol, decreased SREBP targets, and induc

158 evels in mutant BAT, suggesting that loss of BAT ALK7 results in excessive activation of glucocortico

159 on cardiac function, we utilized a model of BAT transplantation.

160 ndrial biogenesis, together with a number of BAT selective and beige gene markers.

161 we discuss the hypothalamic orchestration of BAT activity and the relatively unexplored BAT feedback

162 of ALD, implying a therapeutic potential of BAT activity modulation for the treatment of ALD.

163 The presence of BAT/BAT-like tissue in humans renders BAT as an attracti

164 gion, which co-locates to the main region of BAT in adult humans, and is indicative of thermogenesis.

165 r data identify p62 as a master regulator of BAT function in that it controls the Ucp1 pathway throug

166 role of PHOSPHO1 as a negative regulator of BAT thermogenesis, and inhibition of PHOSPHO1 or enhance

167 To determine the role of BAT on cardiac function, we utilized a model of BAT tran

168 Here, we show that adrenergic stimulation of BAT activates a PKA-dependent mitochondrial Ca(2+) extru

169 e elapsed after meal consumption nor that of BAT 18F-FDG uptake x time elapsed after meal consumption

170 Here, we determined that transplantation of BAT (+BAT) improves cardiac function via the release of

171 uced by cold and isoproterenol treatments of BAT and primary brown adipocytes.

172 brown progenitor cells sorted from offspring BAT demonstrated attenuated brown adipogenic capacity.

173 his study examined the effect of caffeine on BAT thermogenesis in vitro and in vivo.

174 tures that may provide useful information on BAT, the impact of reconstruction methods and imaging mo

175 Inclusion of BHRA or BAT in the diagnostic workup of CSU patients may aid ide

176 nlike white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear.

177 onally activates the Ucp1 promoter and other BAT genes.

178 Recent discoveries of other BAT futile cycles based on creatine and succinate have p

179 Opn5-null mice show overactive BAT, increased body temperature, and exaggerated thermog

180 Seven of 37 patients showed a positive BAT with ALX, but only under optimized conditions.

181 Of biomarkers, positive BAT and BHRA tests were 69% and 88% predictive of aiCSU,

182 ncy, suggesting that melatonin is a possible BAT activator.

183 molecular mechanisms that regulate postnatal BAT growth.

184 esults demonstrate that caffeine can promote BAT function at thermoneutrality and may have the potent

185 T/CT appear to provide information regarding BAT activity distinct from SUV(max) These features might

186 nce of BAT/BAT-like tissue in humans renders BAT as an attractive target against obesity and insulin

187 usion: Several clusters of highly repeatable BAT radiomic features derived from (18)F-FDG PET/CT appe

188 nction of UCP1 and other proteins in Sirt5KO BAT results in impaired mitochondria respiration, defect

189 nravel an unrecognized LepR neuron Sh2b1/SNS/BAT/thermogenesis axis that combats obesity and metaboli

190 mediobasal hypothalamus also impairs the SNS/BAT/thermogenesis axis; conversely, hypothalamic overexp

191 Eighteen of the 27 volunteers had sufficient BAT activity for radiomic analysis.

192 tion during cold exposure acutely suppresses BAT temperature in wild-type mice but not in Opn5-null m

193 Id1 suppresses BAT thermogenesis by binding to and suppressing PGC1alph

194 brain photoreceptor that normally suppresses BAT thermogenesis.

195 ey are engaged in a boundary-avoidance task (BAT).

196 d a blunted thermogenic (rectal temperature, BAT temperature, and whole-body oxygen consumption) resp

197 though UCP1 expression declined in long-term BAT grafts, this deterioration can be reversed by swimmi

198 y (BASO) using the basophil activation test (BAT) and basophil histamine release assay (BHRA).

199 c performance of a basophil activation test (BAT) and sIgG4 in nsLTP-sensitized patients from Antwerp

200 administering the basophil activation test (BAT) and the skin prick test (SPT) and measuring the lev

201 in vivo tests and basophil activation test (BAT) for the diagnosis of IHRs due to metronidazole and

202 A basophil activation test (BAT) with seasonal and/or perennial allergens was perfor

203 itive responses in basophil activation test (BAT).

204 (according to the basophil activation test [BAT]) might meet this requirement for different IgE-depe

205 P (n = 32) and by basophil activation tests (BAT) with CHX and ALX (n = 37).

206 assays and human basophil activation tests (BATs) were used to study IgE-dependent activation.

207 Our results suggest that BAT serves as a key metabolic filter that controls BCAA

208 The BAT diagnosed PA with high specificity and identified se

209 The BAT identified severe reactions with 97% specificity and

210 The BAT is a demanding sensory-motor task paradigm that we i

211 The BAT outperformed sIgE testing for peanut or hazelnut and

212 The BAT was the best biomarker for severity, surpassed only

213 The BAT with seasonal allergens was positive in 100% of SAR

214 The SPT and the BAT were the best individual predictors of threshold.

215 : a mononucleotide (A) microsatellite at the BAT-26 locus and a dinucleotide (CA) microsatellite in t

216 ian preoptic area (MnPO) neurons blocked the BAT thermogenic responses during both PGE(2)-induced fev

217 Finally, the BAT of IIA+ mice had increased UCP1 and other proteins i

218 NAR and HC subjects tested negative for the BAT.

219 atients followed-up for 6 months (120 in the BAT group and 125 in the control group).

220 In the BAT group versus the control group, QOL score decreased

221 so-called nondiagnostic applications of the BAT involve therapeutic monitoring, follow-up of natural

222 Determination of whether modulation of the BAT morphology/function drives changes in glucoregulatio

223 lso become clear that appropriate use of the BAT necessitates knowledge about degranulation metrics a

224 cell cycle, and the further expansion of the BAT was mainly due to lipogenesis-mediated BAs volume in

225 relevant applications and limitations of the BAT.

226 that, following adrenergic stimulation, the BAT temperature of knockout mice increases more and fast

227 viously defined optimal cutoff was used, the BAT diagnosed PA with 98% specificity and 75% sensitivit

228 n 100% of SAR and group A cases, whereas the BAT with perennial allergens was positive in 37.5% and 6

229 aftment, which may be applied to therapeutic BAT transplantation and tissue engineering.

230 ectiveness of baroreflex activation therapy (BAT) in patients with heart failure with reduced ejectio

231 ruxolitinib (RUX) to best available therapy (BAT) in HC-RES/INT ET, which showed no difference betwee

232 hese effects do not track with a thermogenic BAT phenotype.

233 h-amplitude circadian rhythms in thermogenic BAT.

234 mportance of brown and white adipose tissue (BAT and WAT) NAD(+) metabolism in regulating whole-body

235 hat, on cold exposure, brown adipose tissue (BAT) actively utilizes BCAA in the mitochondria for ther

236 hly enriched in mature brown adipose tissue (BAT) and is further induced by cold and isoproterenol tr

237 ipose tissue (WAT) and brown adipose tissue (BAT) are involved in whole-body energy homeostasis and m

238 n (placental) mammals, brown adipose tissue (BAT) can also dissipate this proton gradient through unc

239 Brown adipose tissue (BAT) contains mitochondria-enriched thermogenic fat cell

240 ma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis

241 rticoids (GC) on fetal brown adipose tissue (BAT) development and its long-term thermogenesis and ene

242 Promoting brown adipose tissue (BAT) function or browning of white adipose tissue (WAT)

243 abolism in thermogenic brown adipose tissue (BAT) has not been studied.

244 tent, energy-consuming brown adipose tissue (BAT) in adult humans, much effort has been devoted to ex

245 ored the role of human brown adipose tissue (BAT) in energy expenditure.

246 However, the role of brown adipose tissue (BAT) in regulating gestational metabolism is unknown.

247 ences thermogenesis of brown adipose tissue (BAT) independent of ambient temperature conditions.

248 Brown adipose tissue (BAT) is a type of fat specialized in non-shivering therm

249 Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise mac

250 Brown adipose tissue (BAT) is an important tissue for thermogenesis, making it

251 Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemi

252 Brown adipose tissue (BAT) is highly metabolically active tissue that dissipat

253 Brown adipose tissue (BAT) is rich in mitochondria and plays important roles i

254 Brown adipose tissue (BAT) is the primary non-shivering thermogenesis organ in

255 t photoperiod increase brown adipose tissue (BAT) mass.

256 igher in interscapular brown adipose tissue (BAT) of mice receiving the KE diet.

257 atability of activated brown adipose tissue (BAT) radiomic features.

258 Brown adipose tissue (BAT) thermogenesis increases energy expenditure (EE).

259 es muscle hypertrophy, brown adipose tissue (BAT) thermogenesis, and white adipose tissue (WAT) lipol

260 cused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of whi

261 disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis

262 arks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca(2+)

263 level of activation of brown adipose tissue (BAT) thermogenesis.

264 pact of PLA2G2A on the brown adipose tissue (BAT) thermogenic gene expression was explored.

265 ances thermogenesis of brown adipose tissue (BAT) through sympathetic nerve activation.

266 WAT) and interscapular brown adipose tissue (BAT) to an acute (48 h) cold stress or challenge with th

267 ly, direct exposure of brown adipose tissue (BAT) to light in living mice significantly enhanced ther

268 late the adaptation of brown adipose tissue (BAT), a key organ for non-shivering thermogenesis, to va

269 lic tissues, including brown adipose tissue (BAT), but it is unknown which specific tissue is respons

270 energic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription fa

271 such as the heart and brown adipose tissue (BAT), where substrate preference changes in pathophysiol

272 ulate thermogenesis in brown adipose tissue (BAT).

273 ent in mitochondria of brown adipose tissue (BAT).

274 renergic activation of brown adipose tissue (BAT).

275 energy dissipation in brown adipose tissue (BAT).

276 ng accumulation in the brown adipose tissue (BAT).

277 ion of species lacking brown adipose tissue (BAT).

278 s of muscle origin and brown adipose tissue (BAT).

279 ot induced in liver or brown adipose tissue (BAT).

280 hepatoprotective brain/brown adipose tissue (BAT)/liver axis.

281 cal component of a SNS/brown adipose tissue (BAT)/thermogenesis axis.

282 eries relative to the glutamatergic drive to BAT sympathoexcitatory neurons in DMH augment our unders

283 urther show that Opn5 POA neurons project to BAT and decrease its activity under chemogenetic stimula

284 ess and were assessed as unlikely related to BAT product.

285 erforation following blunt abdominal trauma (BAT) is an uncommon situation with high morbidity and mo

286 f BAT activity and the relatively unexplored BAT feedback mechanisms on neuronal regulation.

287 As a unique BAT-specific first mammalian NDE (external NADH dehydrog

288 BAT volume, BAT 18F-FDG uptake, and skeletal muscle 18F-FDG uptake w

289 ons to muscle + WAT, muscle + BAT, and WAT + BAT.

290 31-68% of CGRP cells projected both to WAT + BAT.

291 We hypothesized that WAT, BAT, and skeletal muscle may share an integrated regulat

292 GC, in the last trimester of gestation, when BAT development is the most active.

293 DPTs) were performed with both drugs whereas BAT was applied only with the culprit drug.

294 To determine whether BAT radiomic feature repeatability correlates with BAT S

295 treated with ruxolitinib vs 23 (44.2%) with BAT (P = .40).

296 sepsis (2 [2%]), and dyspnoea (2 [2%]) with BAT.

297 a transcriptional signature consistent with BAT thermogenesis in the context of HFD-induced obesity.

298 diomic feature repeatability correlates with BAT SUV(max) repeatability, participants were stratified

299 d under a registry for patients treated with BAT product.

300 Treatment with BAT product at <=2 days of symptom onset was associated