1                                              BFNC has been linked to mutations in two putative K+ cha

2 0q13.3 that co-segregates with seizures in a BFNC family.

3 mapped to the same region of chromosome 8 as BFNC.

4 ome of benign familial neonatal convulsions (BFNC) exhibits the remarkable feature of clinical remiss

5        Benign familial neonatal convulsions (BFNC) is a rare autosomal dominant generalized epilepsy

6        Benign familial neonatal convulsions (BFNC), a class of idiopathic generalized epilepsy, is an

7 ype is benign familial neonatal convulsions (BFNC), a dominantly inherited disorder of newborns.

8 lepsy, benign familial neonatal convulsions (BFNC), has also been localized to chromosome 8.

9 sorder benign familial neonatal convulsions (BFNC), presumably by reducing IK(M) function.

10 e: the benign familial neonatal convulsions (BFNC; refs 2,3).

11  of 8q24, distal to the interval defined for BFNC.

12 duced missense mutations that underlie human BFNC into the orthologous murine Kcnq2 (Kv7.2) and Kcnq3

13                              This finding in BFNC provides additional evidence that defects in potass

14 We screened KCNQ3 for mutations in the large BFNC family previously linked to chromosome 8q24 in the

15                     Genetic heterogeneity of BFNC has been observed.

16 gnitive profile exhibited by the majority of BFNC patients.

17                                   Five other BFNC probands were shown to have KCNQ2 mutations, includ

18 re region in perfect co-segregation with the BFNC phenotype.

19  have been identified in human families with BFNC, and truncation of the C terminus prevents proper K

20 howed that they are mutated in patients with BFNC.