ライフサイエンスコーパス: BHV-5

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1 xpression of the full virulence potential of BHV-5.

2 with the gE5 epitope-reverted and wild-type BHV-5.

3 with the gE5 epitope-reverted and wild-type BHV-5.

4 similar to that of the Us9 rescue mutant of BHV-5.

5 differential neuropathogenesis of BHV-1 and BHV-5.

6 te genomic sequence of bovine herpesvirus 5 (BHV-5), an alphaherpesvirus responsible for fatal mening

7 ted BHV-1 and BHV-5 recombinants: gE-deleted BHV-5 (BHV-5gEDelta), BHV-5 expressing BHV-1 gE (BHV-5gE

8 nfected intranasally with gE epitope-deleted BHV-5 did not develop seizures, and only 20% of the infe

9 tranasal infection, the Us9 rescue mutant of BHV-5 displayed a wild-type level of neurovirulence and

10 combinants: gE-deleted BHV-5 (BHV-5gEDelta), BHV-5 expressing BHV-1 gE (BHV-5gE1), and BHV-1 expressi

11 Rabbits infected with BHV-5 expressing BHV-1 Us9 showed severe neurological si

12 In a rabbit seizure model, Us9-deleted BHV-5 failed to invade the central nervous system (CNS)

13 The gE epitope-deleted BHV-5 formed wild-type-sized plaques in MDBK cells, and

14 ng BHV-1 gE (BHV-5gE1), and BHV-1 expressing BHV-5 gE (BHV-1gE5).

15 tion, and immunohistochemistry indicate that BHV-5 gE is important for efficient neural spread and ne

16 However, BHV-5 gE is not required for initial viral entry into ol

17 predicted amino acid sequences of BHV-1 and BHV-5 gE open reading frames showed that they had 72% id

18 ificantly less efficiently in the brain than BHV-5 gE revertant or wild-type BHV-5, which produced se

19 The bovine herpesvirus 5 (BHV-5) gE ectodomain contains a glycine-rich epitope cod

20 Intranasal inoculation of BHV-5 gEDelta and BHV-5gE1 produced significantly reduce

21 ompared with those of a Us9 rescue mutant of BHV-5 in a rabbit model.

22 significantly reduced the neurovirulence of BHV-5 in rabbits.

23 a doublet of 17- and 19-kDa protein bands in BHV-5-infected cell lysates and in purified virions.

24 anterograde spread of bovine herpesvirus 5 (BHV-5) infection from the olfactory receptor neurons to

25 BHV-5 is very similar to BHV-1, the etiological agent of

26 Bovine herpesvirus 5 (BHV-5) is a neurovirulent alphaherpesvirus that causes f

27 The structure of the BHV-5 latency-related (LR) region departs markedly from

28 determine the role of the BHV-5 Us9 gene in BHV-5 neuropathogenesis, a BHV-5 Us9 deletion recombinan

29 it is likely these differences contribute to BHV-5 neuropathogenicity.

30 V-1 and BHV-5, we have constructed BHV-1 and BHV-5 recombinants: gE-deleted BHV-5 (BHV-5gEDelta), BHV

31 d BICP22, the three proteins being longer in BHV-5 than in BHV-1.

32 erences, BHV-1 Us9 not only complemented for BHV-5 Us9 and rescued the anterograde-spread defect of t

33 BHV-5 Us9 gene in BHV-5 neuropathogenesis, a BHV-5 Us9 deletion recombinant was generated and its neu

34 To determine the role of the BHV-5 Us9 gene in BHV-5 neuropathogenesis, a BHV-5 Us9 d

35 The BHV-5 Us9 gene sequence was determined, and the predicte

36 9 is a 30- to 32-kDa protein, whereas mature BHV-5 Us9 is an 18- to 20-kDa protein.

37 xpressed at 3 h postinfection (hpi), whereas BHV-5 Us9 is expressed at 6 hpi.

38 BHV-5 Us9 peptide-specific antibody recognized a doublet

39 ed, and the predicted amino acid sequence of BHV-5 Us9 was compared with the corresponding Us9 sequen

40 rescued the anterograde-spread defect of the BHV-5 Us9-deleted virus but conferred increased neurovir

41 earlier than BHV-5 wild-type or Us9-reverted BHV-5 virus.

42 tory pathway, but the Us9 deletion mutant of BHV-5 was virtually avirulent and failed to invade the C

43 e of the neurovirulent bovine herpesvirus 5 (BHV-5) was determined and compared with that of the nonn

44 differential neuropathogenesis of BHV-1 and BHV-5, we have constructed BHV-1 and BHV-5 recombinants:

45 e brain than BHV-5 gE revertant or wild-type BHV-5, which produced severe neurological signs in 70 to

46 nfection, which was 1 to 2 days earlier than BHV-5 wild-type or Us9-reverted BHV-5 virus.

47 In contrast to BHV-5, wild-type BHV-1 failed to invade the CNS followin

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