ライフサイエンスコーパス: BK virus

1 nd in the polyomaviruses simian virus 40 and BK virus.

2 ine of a kidney transplant patient and named BK virus.

3 ation is believed to be primarily due to the BK virus.

4 s to investigate the immunologic response to BK virus.

5 und to exhibit elevated titers to the JC and BK viruses.

6 ed for replication of mouse polyomavirus and BK virus, a human polyomavirus associated with allograft

7 n blood and urine for JC virus reactivation; BK virus, a JC virus-related polyomavirus, was used as a

8 (early UTI; <3 months after transplant) and BK virus allograft nephropathy (BKVAN).

9 Published data for BK virus allograft nephropathy, a recently emerged graft

10 BK virus-allograft nephropathy (BKVAN) is an increasingl

11 Rates of BK virus and acute rejection were comparable, but a high

12 also inhibited large T antigen expression by BK virus and JC virus, two important, pathogenic human p

13 Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of so

14 gens, including cytomegalovirus, adenovirus, BK virus, and Epstein-Barr virus in the absence of acute

15 cidence of viral infection (cytomegalovirus, BK virus, and Epstein-Barr virus) and posttransplant lym

16 cussed in relation to human cytomegalovirus, BK virus, and Epstein-Barr virus, while the importance o

17 s of cytomegalovirus disease, herpes zoster, BK virus, and nephropathy, which led to the discontinuat

18 ction with cytomegalovirus, EBV, adenovirus, BK virus, and/or human herpesvirus 6.

19 stimulation by overlapping peptide pools of BK virus antigen to determine frequency of CD8+ and CD4+

20 lantation after losing their renal grafts to BK virus-associated nephropathy (BKAN) are described.

21 BK virus-associated nephropathy (BKVAN) causes renal all

22 BK virus-associated nephropathy (BKVN) is associated wit

23 BK virus-associated nephropathy is an increasingly recog

24 The differentiation of BK virus-associated renal allograft nephropathy (BKVAN)

25 d 369 renal transplant recipients tested for BK virus at serial time points after transplantation.

26 Classic human polyomaviruses (JC and BK viruses) become pathogenic when reactivating from lat

27 BK virus (BKV) allograft nephropathy (BKVAN) is a compli

28 ey, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed

29 iously had only two disease-causing members (BK virus (BKV) and JC virus (JCV)) identified.

30 s of SV40 as well as of human polyomaviruses BK virus (BKV) and JC virus (JCV).

31 polyomavirus infect humans: JC virus (JCV), BK virus (BKV) and Simian Vacuolating virus-40.

32 immunofluorescence indicated the presence of BK virus (BKV) antigen.

33 PCR showed BK virus (BKV) DNA in all these and in an additional 18%

34 erassay variability in the quantification of BK virus (BKV) DNA precludes establishing broadly applic

35 Quantitative BK virus (BKV) DNA surveillance in plasma/urine was perf

36 was assayed in urine, and JC virus (JCV) and BK virus (BKV) DNAs were assayed in urine and PBMCs.

37 Infection with BK virus (BKV) generally occurs early during life, but i

38 BK virus (BKV) genotyping has been historically based on

39 id organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients.

40 ated human polyomaviruses JC virus (JCV) and BK virus (BKV) in mesothelioma remained unclear.

41 tology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carci

42 Posttransplant reactivation of BK virus (BKV) in the renal allograft progresses to poly

43 here are limited data on the epidemiology of BK virus (BKV) infection after alemtuzumab induction.

44 BK virus (BKV) infection causing end-organ disease remai

45 Treatment of BK virus (BKV) infection in renal transplant recipients

46 BK virus (BKV) infection of kidney transplant patients i

47 ssion is a widely recognized risk factor for BK virus (BKV) infection, particularly with the combinat

48 Cytomegalovirus (CMV) and BK virus (BKV) infections can cause significant morbidit

49 alogous viral genetic changes occur in human BK virus (BKV) interstitial nephritis (ISN).

50 BK virus (BKV) is a common human polyomavirus infecting

51 The human polyomavirus BK virus (BKV) is a common virus for which 80 to 90% of

52 BK virus (BKV) is a nonenveloped, ubiquitous human polyo

53 BK virus (BKV) is a polyomavirus that establishes a life

54 BK virus (BKV) is a polyomavirus which infects a large p

55 BK virus (BKV) is a ubiquitous pathogen that establishes

56 BK virus (BKV) is the infectious cause of polyomavirus-a

57 BK virus (BKV) is ubiquitous in the human population and

58 BK virus (BKV) is widely accepted to be the causative ag

59 In patients with PVAN, a high BK virus (BKV) load is detectable in plasma.

60 In recent years, BK virus (BKV) nephritis after renal transplantation has

61 Because the occurrence of BK virus (BKV) nephritis is far less frequent than BK vi

62 BK virus (BKV) nephropathy remains the main cause of ren

63 pathy has been attributed to reactivation of BK virus (BKV) or more rarely JC virus (JCV).

64 We compared the utility of BK virus (BKV) polymerase chain reaction (PCR) and urine

65 Identification of risk factors for BK virus (BKV) replication may improve transplant outcom

66 In the case of the human polyomaviruses, BK virus (BKV) replication occurs in the tubular epithel

67 In situ hybridization showed BK virus (BKV) to be the predominant species, but polyme

68 JC virus (JCV) viruria is more common than BK virus (BKV) viruria in healthy individuals but in kid

69 ison of antibody titers to JC virus (JCV) or BK virus (BKV) was made by hemagglutination inhibition (

70 BK virus (BKV), a human polyomavirus, causes BKV nephrit

71 comparisons, SA12 is most closely related to BK virus (BKV), a human polyomavirus.

72 megalovirus (CMV), Epstein-Barr virus (EBV), BK virus (BKV), adenovirus (ADV), and human herpesvirus

73 V), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6).

74 Samples were analyzed for BK virus (BKV), JC virus (JCV), and simian virus 40 (SV4

75 Samples were analyzed for BK virus (BKV), JC virus (JCV), and simian virus 40 (SV4

76 the human polyomaviruses JC virus (JCV) and BK virus (BKV), the first step to a successful infection

77 the membrane receptor and entry pathway for BK virus (BKV), which can cause severe disease in immuno

78 to the hypothesis that a human virus such as BK virus (BKV), which establishes a persistent subclinic

79 BK virus (BKV), which infects a large percentage of the

80 The LAMP assay was developed for BK virus (BKV), which is a leading cause of morbidity in

81 the VP1 polypeptide of a human polyomavirus, BK virus (BKV), which is associated with polyomavirus-as

82 BK virus (BKV)-associated nephropathy (BKVAN) has been i

83 BK virus (BKV)-associated nephropathy is the second lead

84 uated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus t

85 y (PML) and cross-recognize the polyomavirus BK virus (BKV).

86 lovirus (CMV), Epstein-Barr virus (EBV), and BK virus (BKV).

87 Epstein-Barr virus (EBV), and 64 (34.6%) for BK virus (BKV).

88 ed the frequent detection of polyomaviruses (BK virus [BKV] or simian virus 40 [SV40]) in 46% of stoo

89 ntibiotics have antiviral properties against BK virus but efficacy at preventing this infection has n

90 ly mimics the binding characteristics of the BK virus coat protein to cells.

91 BK virus controllers, defined as those with episodes of

92 a broad range of viral infections including BK virus, cytomegalovirus, adenovirus, human herpesvirus

93 5 urine specimens submitted for polyomavirus BK virus detection were used.

94 f BK DNA in plasma appears to be a marker of BK virus disease in HCT recipients.

95 Weekly plasma samples were tested for BK virus DNA by polymerase chain reaction (PCR).

96 It is concluded that quantitative PCR for BK virus DNA in serum is useful both for identifying tra

97 BK virus DNA was detected in serum samples from all 4 ca

98 me polymerase chain reaction (PCR) assay for BK virus DNA, a retrospective analysis was done of seque

99 an herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.

100 by progressive decrease in the median plasma BK virus-DNA load, and undetectable levels at the last f

101 o develop more effective and less toxic anti-BK virus drugs for clinical use.

102 immunocompromised individuals, JC virus and BK virus, encode miRNAs with the same function as that o

103 s known to have potent inhibitory effects on BK virus gene expression, both at the level of transcrip

104 ATG was associated with an increased risk of BK virus in low-PRA patients.

105 s with kidney transplantion and is caused by BK virus in more than 95% of cases.

106 ith clinical course and with the presence of BK virus in renal biopsy specimens.

107 avenous bolus steroids to five patients with BK virus in the plasma (BKP) (group 1) and also tried ot

108 antirejection therapies in 13 patients with BK virus in the urine (BKU) but no BKP (group 2).

109 BK virus incidence was 29.2%, with no graft losses due t

110 blood and urine (by PCR) remain negative for BK virus, indicating the absence of virus reactivation.

111 ctors significantly associated with PML were BK virus infection (22.2% vs. 1.1%), pretransplant trans

112 with clinical consequences quite similar to BK virus infection in humans, including renal dysfunctio

113 tion must be paid to the higher incidence of BK virus infection in recipients of ABO-incompatible gra

114 BK virus infection is a significant complication of mode

115 BK virus infection remains an important cause of loss of

116 s of cytomegalovirus infection, two cases of BK virus infection, and one case of Epstein-Barr virus i

117 is a useful tool in monitoring the course of BK virus infection.

118 utors to susceptibility to the activation of BK virus infection.

119 e currently no therapies to prevent or treat BK virus infection.

120 se of levofloxacin to prevent posttransplant BK virus infection.

121 tely, however, the majority of patients with BK virus infections are asymptomatic.

122 BK virus is a human polyomavirus associated with a range

123 opoietic cell transplantation (HCT), polyoma-BK virus is associated with hemorrhagic cystitis and als

124 A monoclonal antibody directed against the BK virus large T-antigen (clone BK.T-1) has previously b

125 r in the respiratory tract, but asymptomatic BK virus latency is established in the urothelium.

126 BK virus load decreased in 3 of 3 patients after the red

127 renal transplantation, and we correlated the BK virus load with clinical course and with the presence

128 eveloped a real-time PCR assay to quantitate BK virus loads in the setting of renal transplantation,

129 BK virus loads were measured in urine, plasma, and kidne

130 BK virus nephritis (BKN) in recipients of renal allograf

131 immunosuppressive agents as risk factors for BK virus nephropathy (BKN) has not been well studied.

132 BK virus nephropathy (BKVAN) causes about 10% of late ki

133 BK virus nephropathy (BKVN) is a recognized cause of gra

134 BK virus nephropathy (BKVN) is a significant cause of re

135 BK virus nephropathy (BKVN) is an important cause of ren

136 The course of BK virus nephropathy (BKVN) is difficult to predict.

137 BK virus nephropathy (BKVN) may cause renal allograft dy

138 Clinical outcome in BK virus nephropathy (BKVN) was examined in relation to

139 BK viremia, a prerequisite for BK virus nephropathy (BKVN), affects 5% to 16% of pediat

140 2.4 +/- 2.4; P=0.001) but no different from BK virus nephropathy (BKVN; 20.3+/-15.7; P=0.98).

141 dentifying transplant recipients at risk for BK virus nephropathy and for monitoring the response to

142 cipients with histopathologically documented BK virus nephropathy and from samples (n=76) from 16 tra

143 However, technical complications and BK virus nephropathy continue to be important causes of

144 BK virus nephropathy is one of the most common viral inf

145 Kidney transplant recipients with BK virus nephropathy or viremia are generally treated wi

146 ection (ACR), cytomegalovirus (CMV) disease, BK virus nephropathy, and kidney graft function.

147 toxicity, chronic allograft nephropathy, and BK virus nephropathy, as well as donor and recipient fac

148 iciency was not associated with CMV disease, BK virus nephropathy, or kidney allograft function at 1

149 ide are used empirically in the treatment of BK virus nephropathy.

150 (range, 17-61 weeks) before the diagnosis of BK virus nephropathy.

151 a, and 29% (two of seven) patients developed BK virus nephropathy.

152 by addition of SV40 VLPs but not by VLPs for BK virus or JC virus, which are related human polyomavir

153 aft function, 1-year acute rejection, 1-year BK virus or patient death.

154 e incorporated site-specifically into a SV40/BK virus origin-based shuttle vector and replicated in x

155 , 0.991; P = .012) but not CMV (P = .31) and BK virus (P = .27).

156 ntrols and viremic KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-de

157 gimens and with other cohorts not undergoing BK virus polymerase chain reaction surveillance.

158 Polyoma BK virus produces an aggressively destructive nephropath

159 centage of renal transplant recipients, with BK virus reactivation as the main causative agent.

160 f graft-versus-host disease, whereas CMV and BK virus reactivation did not predict clinical outcomes.

161 omavirus-associated nephropathy (PVAN) after BK virus reactivation in kidney transplant recipients (K

162 Conversely, BK virus remained stable in urine and was undetectable i

163 BK virus renal allograft nephropathy (BKVAN) in the sett

164 kidney recipients had a higher incidence of BK virus replication (P = 0.04) and nephropathy (P = 0.0

165 ide insight into the mechanism of control of BK virus replication and may allow for future patient ri

166 of BKVN and (2) to identify risk factors for BK virus replication in the retransplant.

167 esvirus 6 (HHV6), cytomegalovirus (CMV), and BK virus screened weekly.

168 Posttransplant BK virus screening and treatment are essential tools to

169 BK virus seems to play a role in the development of HC a

170 iant culture system, we show that autologous BK virus-specific T cell lines can be reliably generated

171 Nevertheless, the recovery of BK virus-specific T-cell immunity may require prolonged

172 ding to MPtV, bovine polyomavirus, Sa12, and BK virus, suggesting a combination of vertical and horiz

173 ates started collecting data on treatment of BK virus (TBKV) on the kidney follow-up forms.

174 l load in the urine was 400 times higher for BK virus than JC virus.

175 as defined by surrogate markers (i.e., high BK virus viremia).

176 ts were screened for T-cell immunity to this BK virus VP1 epitope by in vitro stimulation of their pe

177 BK virus was detected by in situ hybridization in bladde

178 BK virus was grown in a cell-culture system.

179 While the BK virus was predominant in the BKV+ group, it was also

180 eings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma.

181 tervention is the initial association of the BK virus with the host cell.