ライフサイエンスコーパス: BK

1 BK activation corrected the impaired Ca(2+) release in t

2 BK and TRPML1 forms a positive feedback loop to facilita

3 BK channel upregulation was also sufficient to correct e

4 BK channels localize in the cilia of surface cells.

5 BK K(+) channels undergo N-type inactivation via their b

6 BK polyomavirus (BKPyV) frequently reactivates in kidney

7 BK polyomavirus (BKV)-associated nephropathy is a threat

8 BK polyomavirus is ubiquitous, with a seropositivity rat

9 BK seems to permit the protective effects triggered by c

10 BK virus (BKV) nephropathy remains the main cause of ren

11 BK virus (BKV)-associated nephropathy is the second lead

12 BK virus controllers, defined as those with episodes of

13 BK virus infection remains an important cause of loss of

14 BK virus-associated nephropathy (BKVAN) causes renal all

15 BK/Kv became basally active when cells were depolarized

16 BK/Kv were mostly closed at rest in normoxia.

17 e protein, promotes the trafficking of SLO-1 BK channels from the ER to the plasma membrane by shield

18 calcium-activated potassium channel (KCa1.1; BK, Slo1, MaxiK, KCNMA1) is the predominant potassium ch

19 identified in morbidly obese men carrying a BK gene variant, supporting the hypothesis that K(+) cha

20 We here identify, for the first time, a BK channel-dependent molecular synaptic mechanism leadin

21 r voltage dependence and their response to a BK channel blocker or opener.

22 LS3 suppresses locomotor activity via a BK channel-specific mechanism in wild-type or BK channel

23 flash photolysis of caged Ca(2+) to activate BK channels and determine their intrinsic sensitivity to

24 ia did not directly affect BK, but activated BK via depolarization.

25 Large conductance calcium-activated (BK) channels are broadly expressed in neurons and muscle

26 ction with cytomegalovirus, EBV, adenovirus, BK virus, and/or human herpesvirus 6.

27 This suggests that adipocyte BK activity is at least partially responsible for excess

28 ical weight gain in the absence of adipocyte BKs was beneficial for glucose handling and related to a

29 Anoxia did not directly affect BK, but activated BK via depolarization.

30 affinity is higher than known high affinity BK channel toxins.

31 omavirus-associated nephropathy (PVAN) after BK virus reactivation in kidney transplant recipients (K

32 that are expressed together with the alpha (BK)-subunit in almost every tissue type where they are f

33 ght the importance of not only CFTR but also BK channel function in maintaining ASL homeostasis and e

34 n idiopathic pulmonary fibrosis, ameliorated BK dysfunction and ASL volume loss.

35 , 0.991; P = .012) but not CMV (P = .31) and BK virus (P = .27).

36 actors, and outcomes associated with CMV and BK infections in sensitized patients.

37 f graft-versus-host disease, whereas CMV and BK virus reactivation did not predict clinical outcomes.

38 esvirus 6 (HHV6), cytomegalovirus (CMV), and BK virus screened weekly.

39 One patient developed cytomegalovirus and BK and 2 others EBV and BK viremia.

40 cytomegalovirus and BK and 2 others EBV and BK viremia.

41 cases of DSAEK (423) or PK (405) for FED and BK from the Singapore Cornea Transplant Registry perform

42 DSAEK compared with PK in eyes with FED and BK.

43 g the effects of inhibitors of BK (IBTX) and BK/Kv (TEA/4-AP) on [Ca(2+) ]i responses to a wide range

44 Classic human polyomaviruses (JC and BK viruses) become pathogenic when reactivating from lat

45 close apposition of ryanodine receptors and BK channels.

46 the Ca(2+)-activated K(+) channels, known as BK and SK channels, the physiological importance of Ca(2

47 r in the respiratory tract, but asymptomatic BK virus latency is established in the urothelium.

48 iant culture system, we show that autologous BK virus-specific T cell lines can be reliably generated

49 e functional and spatial interaction between BK and CaV1.3 channels, unique CaV1 channels that activa

50 ound that uncaging Ca(2+) activated biphasic BK currents with fast and slow components (time constant

51 PKC inhibitors GF109203x and Go6983 blocked BK activation by UTP in control epithelia, suggesting th

52 on, abolishing the diurnal variation in both BK current magnitude and SCN firing, and disrupting beha

53 potential clamp experiments showed that both BK and Kv2 current flow during spike repolarization but

54 Bradykinin (BK), at concentrations corresponding to the slightly ele

55 ion by epicardial application of bradykinin (BK) increased heart rate (HR), left ventricular systolic

56 eved to lead to the formation of bradykinin (BK), which increases local vasopermeability and mediates

57 f the N-terminal 1-5 fragment of bradykinin (BK[1-5](2+)) in the gas phase by combining drift tube io

58 d acute contractile responses to bradykinin (BK) in isolated rat bronchioles, and inhibitors of RhoGE

59 increased afterhyperpolarization produced by BK inhibition and likely underlies the very different ef

60 in CD8-positive T- and B-cell proportions by BK, JC, and HPyV9 seropositivity.

61 that APOBEC3B is specifically upregulated by BK polyomavirus (BKPyV) infection in primary kidney cell

62 channels were co-expressed in the same cell, BK channels started activating near -50 mV, 30 mV more

63 odel with global ablation of the BK channel (BK(L1/L1)) and adipocyte-specific BK-deficient (adipoqBK

64 -conductance Ca(2+) -activated K(+) channel (BK) and voltage-dependent K(+) channels (Kv) on [Ca(2+)

65 ctance calcium-activated potassium channels (BK) are composed of pore-forming BKalpha and auxiliary b

66 V), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6).

67 e 5 urines from patients without concomitant BK-viremia.

68 llosterically coupled to each other, control BK channel activity and are potential targets for regula

69 e of the mechanisms responsible for creating BK channel diversity fundamental to the adequate functio

70 -conductance Ca(2+) -activated K(+) current (BK) by purinergic receptor agonists.

71 uantitative PCR to test for cytomegalovirus, BK polyomavirus, human herpesvirus 6B, HHV-6A, adenoviru

72 ed the activity of BK channels by decreasing BK-alpha subunit levels at the plasma membrane.

73 Voltage- and calcium-dependent BK channels regulate calcium-dependent cellular events s

74 ndance is an important factor in determining BK current and thus regulation of calcium-dependent even

75 Specifically, 78 patients (30.7%) developed BK infection, 19 (7.5%) had BKVN, and 33 (12.9%) present

76 d preservation techniques, lower CNI dosing, BK viremia screening) may have had.

77 From the 16 urines collected during BK viremia, 43.8% were PV-Haufen-positive, and 56.2% wer

78 megalovirus (CMV), Epstein-Barr virus (EBV), BK virus (BKV), adenovirus (ADV), and human herpesvirus

79 To establish the role of endogenous BKs in fat cell maturation, storage of excess dietary fa

80 Our data indicate that TGF-beta enhances BK-induced contraction, RhoA translocation and Rho-kinas

81 n of white adipose tissue-derived epididymal BK(L1/L1) preadipocytes and their differentiation to lip

82 negative than for activation of co-expressed BK and high-voltage activated CaV2.2 channels.

83 emains unclear, however, to what extent FMRP-BK channel interactions contribute to synaptic and circu

84 Mean time from transplant to diagnosis for BK and CMV was 4.07 +/- 3.10 and 8.35 +/- 5.20 months, r

85 Identification of risk factors for BK polyoma virus (BKPyV) without confounding by donor fa

86 after minimization of immunosuppression for BK viremia and after no intervention for JC viruria.

87 s undergoing immunosuppression reduction for BK viremia had 10-year outcomes similar to those without

88 alizing serostatus had the greatest risk for BK viremia (odds ratio, 4.9; 95% confidence interval, 1.

89 ralizing activity (D+) had elevated risk for BK viremia, regardless of recipient serostatus (D+ versu

90 supporting a central or peripheral role for BKs in the regulatory system that controls adipose tissu

91 isengagement of the gamma1-F273S mutant from BK channels.

92 Furthermore, BK channels as well as purinergic receptors were shown t

93 activation of the contact system to generate BK and its breakdown products.

94 expansion offers the possibility to generate BK-specific T cell lines for adoptive immunotherapy.

95 terize a clinical-scale protocol to generate BK-specific T cell lines from viremic KTR.

96 Global BK deficiency afforded protection from BW gain and exces

97 Global BK knockouts and CMBK knockouts, in contrast with SMBK k

98 ompared with litter-matched controls, global BK knockout, and wild-type mice.

99 g the pore of heterologously expressed human BK channels.

100 ic evidence that, consistent with this idea, BK polyomavirus genomes are depleted of APOBEC3B-preferr

101 First, we identified BK channels in dopamine neurons by their voltage depende

102 threshold for activation, and alterations in BK support specifically tuned voltage oscillations.

103 erization of the two prolyl-peptide bonds in BK[1-5](2+).

104 ild-type mice but are profoundly impaired in BK channel-null mice.

105 We induced C-type inactivation in BK channels and studied the relationship between activat

106 ominent slow C-type inactivation/recovery in BK channels by an extreme low concentration of extracell

107 rface beta1 subunits leads to a reduction in BK channel calcium-sensitivity, inhibition of transient

108 firing rate potentiation, and reductions in BK currents in vestibular nucleus neurons.

109 trinsic plasticity mediated by reductions in BK-type calcium-activated potassium currents in spontane

110 .001-.026) in FED, but only over 3 years in BK (P < .001-.031).

111 Here, we report that inactivating BK currents predominate during the day in the suprachias

112 a broad range of viral infections including BK virus, cytomegalovirus, adenovirus, human herpesvirus

113 Ethanol also increased BK channel open probability measured in single-channel r

114 nt ex vivo studies implicated that increased BK activity favors the survival of the myocardium at isc

115 rect upregulation of ENaC, whereas increased BK channel expression has a less significant role.

116 d BK channel open probability via increasing BK channel open frequency, but not through prolonging it

117 a-catenin directly regulates alcohol-induced BK internalization via glycogen synthase kinase phosphor

118 Hypoxia did not inhibit BK in inside-out patches.

119 Test the hypothesis that ET-1 inhibits BK channels by altering BKalpha and beta1 surface traffi

120 ownregulates CFTR activity but also inhibits BK channel function, thereby causing ASL depletion.

121 o not support the view that hypoxia inhibits BK/Kv to initiate or maintain the hypoxic response.

122 echanism by which a vasoconstrictor inhibits BK channels and identify Rab11A serine 177 as a modulato

123 Interestingly, BK application in CHF rats increased cardiac systolic an

124 molecular events downstream of cGMP involve BK channels present in cardiomyocytes or in other cardia

125 cited by ischemia/reperfusion do not involve BK in vascular smooth muscle cells.

126 nductance voltage and Ca(2+)-activated K(+) (BK) channel have a key role in the ethanol effect on GPe

127 a-specific subtype of Ca(2+)-activated K(+) (BK) channel is responsible for generation of MIH and ant

128 at large-conductance calcium-activated K(+) (BK) channel open probability was reduced by loss of frag

129 n of the Ca(2+)- and voltage-activated K(+) (BK) channel was identified in morbidly obese men carryin

130 ductance Ca(2+)- and voltage-activated K(+) (BK) channels are involved in a large variety of physiolo

131 uctance voltage- and calcium-activated K(+) (BK) channels are key physiological players in muscle, ne

132 th large-conductance calcium-activated K(+) (BK) channels, specifically their auxiliary beta4 subunit

133 uctance, voltage- and Ca(2+)-activated K(+) (BK) channels.

134 ve large-conductance Ca(2+) -activated K(+) (BK) current was demonstrated in control epithelia but wa

135 Large-conductance calcium-activated K(+) (BK-type) channels, abundantly distribute in excitable ce

136 a(2+)-activated, and voltage dependent K(+) (BK) channels.

137 Ca(2+)- and voltage-dependent K(+) (BK) currents and the expression of the pore-forming BKal

138 uctance, calcium- and voltage-activated K(+)(BK) channel consists of the pore-forming alpha subunits

139 ABSTRACT: Large-conductance KCa (BK) and other voltage-dependent K(+) channels (Kv) are h

140 lial dystrophy (FED) or bullous keratopathy (BK) in Asian eyes.

141 ctivation is diminished, resulting in larger BK currents.

142 Patients with only low level BK viremia expressed low frequencies of polyfunctional T

143 angement allows tight tracking between local BK channel activation and the gating of CaV1.3 channels

144 s leads to the sole activation of microglial BK channels in the spinal cord.

145 n pharmaceutical applications for modulating BK channel function.

146 Mallotoxin is a potent small-molecule BK channel activator.

147 ntly Chinese (76.6%) Asian cohort, with more BK compared with FED (68.1% vs. 31.9%; P < 0.001).

148 cluding endothelin-1 (ET-1), inhibit myocyte BK channels, leading to contraction, but mechanisms invo

149 ine of a kidney transplant patient and named BK virus.

150 Here we report a novel BK channel-targeted peptide with functional activity in

151 e significantly attenuated in the absence of BK, together supporting a central or peripheral role for

152 CaV-channel dependent activation of BK channels is critical for feedback control of both cal

153 udy supports a scheme in which activation of BK/Kv strongly limits the magnitude of hypoxia-induced [

154 gest METH exposure decreased the activity of BK channels by decreasing BK-alpha subunit levels at the

155 We found that METH decreased the activity of BK channels by stimulating BK-alpha subunit trafficking.

156 While METH suppressed the amplitude of BK channel-mediated unitary currents, the BK channel ope

157 effect on GPe neurons, as the application of BK channel inhibitors blocked the ethanol-induced firing

158 s of CaV1.3 channels surrounding clusters of BK channels and forming a multi-channel complex both in

159 Our study thus indicates that the control of BK channel trafficking is a critical regulatory mechanis

160 ide insight into the mechanism of control of BK virus replication and may allow for future patient ri

161 m repositories for having varying degrees of BK viremia (range, 0-1.0 x 10 copies/mL), hemorrhagic cy

162 resent the external architectural details of BK channels using lanthanide-based resonance energy tran

163 Here, we demonstrate the detection of BK Polyomavirus (BKPyV), an emerging indicator of microb

164 Recent case series describe detection of BK polyomavirus (BKV) in urinary tract cancers in kidney

165 -recipient serostatus and the development of BK viremia, specific risk factors for BKV-related compli

166 The ion-mobility distribution of BK[1-5](2+) consists of two well-separated peaks.

167 In this study, we assessed the effect of BK agonist, NS1619 and NS11021 in a number of LSDs inclu

168 ll interfering RNA suppressed the effects of BK and TGF-beta on RhoA-GTP content, RhoA translocation

169 -beta pre-treatment amplified the effects of BK on RhoA translocation and MYPT1/MLC20 phosphorylation

170 osphorylation, but suppressed the effects of BK on RhoA-GTP content, SrcFK auto-phosphorylation and c

171 nonuclear cells collected during episodes of BK viral replication were evaluated by multiparameter fl

172 ntrollers, defined as those with episodes of BK viremia of 3 months or less, had an 11-fold increase

173 red with patients with prolonged episodes of BK viremia.

174 s critical in mediating a persistent form of BK molecular alcohol tolerance establishing a commonalit

175 ts was then correlated with the incidence of BK viremia during the first year posttransplantation.

176 tion must be paid to the higher incidence of BK virus infection in recipients of ABO-incompatible gra

177 5) were associated with increase incident of BK/CMV, whereas rituximab (HR, 0.47; 95% CI, 0.24-0.91;

178 sue by studying the effects of inhibitors of BK (IBTX) and BK/Kv (TEA/4-AP) on [Ca(2+) ]i responses t

179 i was enhanced 2- to 3-fold by inhibitors of BK/Kv.

180 Furthermore, positive modulation of BK channels in vivo can enhance short-term habituation.

181 MP pathway and by using direct modulators of BK.

182 zation of immune suppression at the onset of BK viremia.

183 stimulation by overlapping peptide pools of BK virus antigen to determine frequency of CD8+ and CD4+

184 The open probability of BK channels is regulated by the intracellular concentrat

185 erassay variability in the quantification of BK virus (BKV) DNA precludes establishing broadly applic

186 tilized the sensitivity and dynamic range of BK to explore non-uniform Ca(2+) local transients in the

187 osophorylation site within the S10 region of BK blocks internalization, suggesting that Wnt/beta-cate

188 onses is, in part, due to METH regulation of BK channel activity.

189 ed role for glucocorticoids in regulation of BK channels in airway epithelial cells.

190 de convincing evidence for a crucial role of BK channel phosphorylation in synaptic depression underl

191 trol, could be detected early after start of BK viremia, which would provide insight into the mechani

192 ur studies thus suggest that upregulation of BK channel activity normalizes multi-level deficits caus

193 Genetic upregulation of BK channel activity via deletion of BKbeta4 normalized a

194 Genetic upregulation of BK channel activity via deletion of BKbeta4 was sufficie

195 rdation protein (FMRP) and that FMRP acts on BK channels by modulating the channel's gating kinetics.

196 it effectively interferes with mallotoxin on BK channel modulation via either a direct steric competi

197 111 patients (43%) developed CMV disease or BK infection or nephropathy (BKVN).

198 Inhibiting Kv2 or BK channels had very different effects on spike shape an

199 K channel-specific mechanism in wild-type or BK channel-humanized Caenorhabditis elegans.

200 In particular, BK receptor 1, which is induced on the endothelium by in

201 nosuppression in kidney transplant patients, BK polyomavirus (BKV) has been shown to induce nephropat

202 peutic effect of an ADAM8 inhibitor peptide (BK-1361) that specifically blocks cellular ADAM8 activit

203 orresponding to the slightly elevated plasma BK levels that have been shown to occur in the auto-dige

204 flu-like syndrome (11.6% vs 14.1%), polyoma (BK) viremia (8.2% vs 11.1%), and herpes simplex infectio

205 opoietic cell transplantation (HCT), polyoma-BK virus is associated with hemorrhagic cystitis and als

206 ecoy" cells, and/or significant polyomavirus BK viremia.

207 Reactivation of the polyomavirus BK has been associated with de novo antibodies against m

208 hty-five recipients (40%) had posttransplant BK viruria including 61 with additional viremia and 22 w

209 gnificantly with incidence of posttransplant BK viremia.

210 big conductance calcium-activated potassium (BK) channel are preferentially expressed by electrosenso

211 big conductance Ca(2+)-activated potassium (BK) channel forms a physical and functional coupling wit

212 rge-conductance calcium-activated potassium (BK) channel lacks a classic intracellular bundle-crossin

213 subunit of the calcium-activated potassium (BK) channel; this interaction increases calcium-dependen

214 rge-conductance calcium-activated potassium (BK) channels and Kv3.3 voltage-gated potassium channels

215 ), voltage- and calcium-activated potassium (BK) channels and their modulatory beta-subunits are able

216 the activity of Ca(2+)-activated potassium (BK) channels.

217 the activity of Ca(2+)-activated potassium (BK) channels.

218 Thus, a potent BK channel peptide modulator is open to neurological app

219 2+)]i Constitutively open mutation prevented BK channels from C-type inactivation.

220 ermined the seroprevalence of 10 human PyVs (BK, JC, KI, WU, MCV, HPyV6, HPyV7, TSV, HPyV9, and HPyV1

221 The effect of polyomavirus reactivation (BK viremia or JC viruria) on antibodies to kidney-specif

222 on of the BKbeta4 subunit alleviated reduced BK channel open probability via increasing BK channel op

223 nel analyses revealed that FMRP loss reduced BK channel open probability, and this defect was compens

224 ke repolarization and a persistently reduced BK channel mediated afterhyperpolarization (AHP), repeti

225 sely, activation of Wnt/beta-catenin reduces BK current density.

226 canonical Wnt/beta-catenin pathway regulates BK channel surface expression in a protein synthesis-dep

227 2 N-terminal 'ball-and-chain' domain rescues BK current levels and firing rate, unexpectedly contribu

228 alysis of lung tissues from Berkeley sickle (BK-SS) mice showed increased levels of ATF3 and increase

229 Silencing BK channel auxiliary beta3 subunit significantly attenua

230 ET-1 inhibited single BK channels and transient BK currents in myocytes and st

231 e-conductance Ca(2+)- and voltage-gated Slo1 BK channels are directly activated by nanomolar levels o

232 K channel (BK(L1/L1)) and adipocyte-specific BK-deficient (adipoqBK(L1/L2)) mice.

233 Therefore, microglia-specific BK channels contribute to the generation of MIH and anti

234 a permissive role in purinoceptor-stimulated BK activation.

235 d the activity of BK channels by stimulating BK-alpha subunit trafficking.

236 tion, surface trafficking of beta1 subunits, BK channel and transient BK current activation, and vaso

237 late the multisubunit composition of surface BK channels to stimulate contraction is unclear.

238 Drugs targeting BK channel represent a potential therapeutic approach fo

239 l outcomes of DSAEK for FED were better than BK.

240 e, with Kv having a much greater effect than BK.

241 We concluded that BK channel C-type inactivation is closed state-dependent

242 We found that BK-1361 (25 mug/g body weight) attenuated airway respons

243 idence from previous studies indicating that BK channels might play a critical role in habituation.

244 Cox regression analysis revealed that BK was a significant factor associated with graft failur

245 We show that BK channel activation and subsequent phosphorylation of

246 Rather, our results show that BK/Kv are activated as glomus cells depolarize in respon

247 These findings suggest that BK-1361 blocks ADAM8-dependent asthma effects in vivo by

248 der high-calorie conditions, suggesting that BK channels are promising drug targets for pharmacothera

249 Our study suggests that BK channel activation stimulates the TRPML1-BK positive

250 We further verified that BK-1361 specifically targets ADAM8 in vivo as the peptid

251 The BK-induced Ca(2+) signals were mediated by B2 receptors

252 The BK-type potassium channels are exclusively linked to the

253 of BK channel-mediated unitary currents, the BK channel opener NS1619 attenuated the effects of METH

254 does not alter the expression of either the BK channel SLO-1 or the Shaker type potassium channel SH

255 t cations sensed by a large structure in the BK channel called the "gating ring," which is formed by

256 iary gamma1-3 subunits potently modulate the BK channel by shifting its voltage-dependence of channel

257 smooth muscle cell-specific deletion of the BK (CMBK or SMBK knockouts) were subjected to the open-c

258 sine was not observed in the presence of the BK antagonist, iberiotoxin, but persisted in the presenc

259 eted mouse model with global ablation of the BK channel (BK(L1/L1)) and adipocyte-specific BK-deficie

260 Addition of the BK channel opener NS11021 directly activated channels in

261 ermined (i) a basic extracellular map of the BK channel, (ii) beta1-subunit-induced rearrangements of

262 to a well-characterized pore blocker of the BK channel.

263 ncreases calcium-dependent activation of the BK channel.

264 ge and Ca(2+)-activated K(+) channels of the BK type are stimulated by cGMP/cGMP-dependent protein ki

265 However, we found that the BK channel C-type inactivation occurred during hyperpola

266 We hypothesized that the BK channel's activation gate may spatially overlap or co

267 the selectivity filter, we propose that the BK channel's normal closing may represent an early confo

268 to evoke the observed voltage waveform, the BK channel is functionally redundant whereas hERG is ess

269 While the BK virus was predominant in the BKV+ group, it was also

270 tor for measurements of distances within the BK channel structure in a living cell.

271 n mallotoxin and the gamma subunits in their BK channel-activating effects in membrane patches excise

272 on via a fast afterhyperpolarization through BK channel activation.

273 alling pathways such as K(+) release through BK channels, and the production and release of arachidon

274 Thus, BK and Kv were mostly closed at rest and activated by de

275 s had significantly better BSCVA compared to BK eyes (P = .006 at 4-year follow-up).

276 ls, which in turn are specifically linked to BK channels.

277 ope of the ESPVR and dp/dtmax in response to BK, indicating a poor contractile response to CSAR activ

278 Delivery of tubacin to BK-SS mice significantly attenuated plasma ET-1 and PlGF

279 of beta1 subunits, BK channel and transient BK current activation, and vasodilation did not involve

280 1 inhibited single BK channels and transient BK currents in myocytes and stimulated vasoconstriction

281 calcium-sensitivity, inhibition of transient BK currents, and vasoconstriction.

282 ess of minimizing immunosuppression to treat BK viremia.

283 BK channel activation stimulates the TRPML1-BK positive reinforcing loop to correct abnormal lysosom

284 nockout (dKO) mice to genetically upregulate BK channel activity in the absence of FMRP and determine

285 ice were generated to genetically upregulate BK channel activity in the absence of FMRP.

286 ntrols and viremic KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-de

287 We found that when BK and CaV1.3 channels were co-expressed in the same cel

288 cortical/medullary collecting duct, whereas BK channel abundance increased in principal cells of the

289 s downregulated via Smad3 signalling whereas BK activity is decreased via the p38 cascade.

290 ysosomal storage diseases (LSDs) and whether BK channel agonists rescue abnormal lysosomal storage in

291 Regardless of whether BK/Kv were closed or basally open, hypoxia-induced eleva

292 mSlo1 and further developed a model in which BK channels act as a calcium sensor capable of quantitat

293 Here we report that CaCCs coexist with BK and SK channels in inferior olivary (IO) neurons that

294 and mediates angioedema on interaction with BK receptor 2 on the endothelium.

295 fen test was only seen in some patients with BK viremia and was not associated with hemorrhagic cysti

296 a positive virtual crossmatch presented with BK infection/CMV disease, high PRA greater than 80% seem

297 centage of renal transplant recipients, with BK virus reactivation as the main causative agent.

298 y infiltrates in renal biopsy specimens with BK polyomavirus-associated nephropathy (BKPyVAN) and spe

299 In hASMCs, acute treatment with BK triggered subcellular translocation of ARHGEF1 and Rh

300 s of cytomegalovirus disease, herpes zoster, BK virus, and nephropathy, which led to the discontinuat