ライフサイエンスコーパス: BLIMP1

1 l Z(+) cells in oral hairy leukoplakia being BLIMP1(+).

2 r B lymphocyte-induced maturation protein 1 (Blimp1).

3 r B-lymphocyte-induced maturation protein 1 (BLIMP1).

4 s in B-cell differentiation: LMO2 and PRDM1 (Blimp1).

5 ctional activity of the transcription factor Blimp1.

6 ession of the transcription factors Tbet and Blimp1.

7 of physiological repressors such as BCL6 or BLIMP1.

8 f the microRNA let-7c, which is regulated by BLIMP1.

9 asmacytoid differentiation, notably IRF4 and BLIMP1.

10 essed genes including Chordin, Cerberus, and Blimp1.

11 ied an extended set of promoters occupied by BLIMP1.

12 -7 maturation and consequential induction of BLIMP1.

13 SG and express the transcriptional repressor Blimp1.

14 nd to a region homologous to the location of BLIMP1.

15 ry T cells occurs normally in the absence of Blimp1.

16 tion of the transcription repressor PRD1-BF1/Blimp1.

17 ises results in sustained elevated levels of Blimp1.

18 hen they differentiate and express wild-type BLIMP1.

19 ng electroporation abolished the function of Blimp1.

20 lasma cells due to impaired up-regulation of BLIMP1.

21 BCL6 (26%), CD10 (0%), BCL2 (31%), Blimp1 (0.02%), and Epstein-Barr virus (EBV) (20%) showe

22 B cells had elevated TLR9 and PAX5, but not BLIMP1 (a gene-expression pattern associated with mature

23 show that the cellular transcription factor BLIMP1, a key player in both epithelial and B-cell diffe

24 itiated by signals that induce expression of Blimp1, a key regulator of the germ cell, in a few epibl

25 r cell mass (ICM)-generated cells expressing Blimp1, a key transcriptional repressor of the somatic p

26 Ets-1 negatively regulates the expression of Blimp1, a known suppressor of IL-2 expression, ablation

27 Blimp1, a transcriptional repressor, has a crucial role

28 Blimp1, a zinc-finger containing DNA-binding transcripti

29 Blimp1 ablation in E12.5 mouse dermal fibroblasts delaye

30 ranscription factors such as IRF4, XBP1, and BLIMP1 accompanied by a strong inhibition of proliferati

31 To explore Blimp1 activities at later stages in the embryo proper,

32 BLIMP1 addition was sufficient to induce reactivation in

33 In all cases studied, both BLIMP1 alleles were inactivated by deletions or mutation

34 Furthermore, we show that Blimp1 (also called Prdm1), a let-7 target and a master

35 ma cells expressing the transcription factor Blimp1 (also known as Prdm1).

36 BLIMP1 alterations included gene truncations, nonsense m

37 zinc finger transcriptional repressor Prdm1/Blimp1, an essential regulator of placenta development,

38 s respond to IL-27 and IL-12 by upregulating Blimp1 and adopt a Tr-1-like phenotype characterized by

39 Let-7c reciprocally inhibited Blimp1 and also blocked LPS-induced suppressor of cytoki

40 tes the transcription factors gatae and krox/blimp1 and both of these transcription factors also feed

41 Blimp1 and E2A directly regulated Cxcr5 expression and,

42 confirm and extend the competitive model of BLIMP1 and IRF interaction.

43 transient period of il10 transcription, the blimp1 and irf4 transcription factors were induced in B1

44 At such sites, BLIMP1 and IRFs can antagonistically regulate promoter a

45 with Foxp3(+) Treg-cell specific deletion of Blimp1 and other approaches, here we show that Foxp3(+)

46 to regulate Blimp1 expression via B108, and Blimp1 and Otx2 were shown to form a negative feedback l

47 creting cells by controlling the activity of Blimp1 and Pax5 and may be required for B cell tolerance

48 ession of IRF8 and Bcl6 which are targets of Blimp1 and potent osteoclastogenic transcriptional repre

49 IRF4 promoted the expression and function of Blimp1 and T-bet, two transcription factors required for

50 important for suppressing the expression of Blimp1 and TH1-associated genes and for positively regul

51 fferentiation possibly through repression of Blimp1 and that Fancc(-/-) B cells are hypersensitive to

52 ls, including altered expression of BCL6 and BLIMP1 and unique expression of chemokine receptors that

53 this circuit generates an expanding torus of blimp1 and wnt8 expression.

54 Thus even-skipped and hox11/13b, along with blimp1 and wnt8, are members of a cohort of torus genes

55 ring the long isoform had significantly less BLIMP1 and XBP1 mRNA and, for human pre-B cells, remaine

56 and CD138 positive, demonstrated upregulated BLIMP1 and XBP1 mRNA, and acquired the morphology of pla

57 , TBX21 (T-bet), NFIL3 (E4BP4), ZEB2, PRDM1 (BLIMP1), and RORA mRNA levels are higher in CD56(dim) ce

58 rectly bound to the promoter region of IRF4, BLIMP1, and BCL2.

59 tion of key osteoclastogenic factors NFATc1, BLIMP1, and c-FOS by inhibiting ITAM-mediated expression

60 ss the zinc finger transcriptional repressor Blimp1, and demonstrate that this subset of highly clono

61 n-regulates the expression of IRF4 and PRDM1/BLIMP1, and memory B cell-enriched hsa-miR-223 down-regu

62 ion factors IFN regulatory factor (IRF)4 and Blimp1, and paradoxically also activation-induced deamin

63 n MHC II and plasma cell markers MUM1, PRDM1/Blimp1, and XBP1s.

64 Blimp1 appears to govern cellular input into the gland s

65 RDI-BF1 or BLIMP1 gene and its mouse homolog Blimp1 are members of the recently realized PR domain fa

66 analyzed in transgenic embryos, establishing Blimp1 as a direct Gli target and identifying Gli activa

67 These findings point to a role for BLIMP1 as a tumor suppressor gene, whose inactivation ma

68 re we identify the transcriptional regulator Blimp1 as crucial to induce IL-10 in inflammatory T help

69 colleagues have identified FOXO3 and PRDM1 (Blimp1) as tumor suppressor genes with a potentially cri

70 tory reconstruction experiment revealed that blimp1 autorepression accounts for progressive extinctio

71 ression of the zinc finger repressor protein Blimp1 (B-lymphocyte-induced maturation protein), the cr

72 tiple motif variants are required to capture BLIMP1 binding specificity.

73 in I-binding factor 1 (PRDI-BF1, also called BLIMP1) binds the ISRE sites and competes with ISGF3 bin

74 s, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) spontaneously develop severe int

75 trikingly, Zbtb20 induction does not require Blimp1 but depends directly on Irf4, acting at a newly i

76 more about functional contributions made by Blimp1+ cell lineages here we perform the first single-c

77 Prdm1.Cre-LacZ allele demonstrate that these Blimp1(+) cells give rise to the mature SpA-TGCs, canal

78 We observed that Blimp1+ cells gave rise to all photoreceptors, but also

79 Transcriptome analysis of Blimp1 CKO macrophages identified the murine chemokine (

80 the precociously generated bipolar cells in Blimp1 CKO mice co-expressed GFP, suggesting that rods b

81 ed elevated levels of Ccl8, and consequently Blimp1 CKO mice had higher levels of circulating CCL8, r

82 Birthdating analyses in control and Blimp1 CKO mice showed that bipolar cells were birthdate

83 O) of Blimp1 in myeloid cells and found that Blimp1 CKO mice were protected from lethal infection ind

84 r cells were birthdated as early as E13.5 in Blimp1 CKO mice, five days before this cell type was gen

85 oked for transitioning rod photoreceptors in Blimp1 conditional knock-out (CKO) mice carrying the NRL

86 In addition, we show that Blimp1 controls common and unique aspects of Treg and Te

87 We demonstrate that KLF4 and BLIMP1 cooperatively induce the expression of LMP1, even

88 Alternatively, Blimp1 could be expressed broadly in Otx2+ cells and sil

89 In principle, Blimp1 could be expressed only in Otx2+ cells that are c

90 Using a Blimp1-Cre germline conditional knockout, we discovered

91 ed the fate of Blimp1 expressing cells using Blimp1-Cre mice and Lox-Stop-Lox reporter strains.

92 A Blimp1-Cre transgenic strain was also exploited to gener

93 Blimp1 deficient embryos die at mid-gestation, but surpr

94 Blimp1-deficient DCs exhibited elevated expression of MH

95 re we explored further phenotypic changes in Blimp1-deficient DCs, the molecular mechanism underlying

96 ributing to the proinflammatory phenotype of Blimp1-deficient DCs.

97 Accordingly, Blimp1-deficient effector T cells fail to produce IL-10,

98 BLIMP1-deficient macrophages expressed elevated levels o

99 Blimp1 deletion results in excess bipolar cell formation

100 quisition of pluripotency does not require a Blimp1-dependent PGC intermediate state.

101 We propose that Blimp1-dependent recruitment of Tle4 to the Ifng locus c

102 ew insights into the chromatin landscape and Blimp1-dependent regulatory networks governing trophobla

103 trophoblast stem cells allow us to identify Blimp1-dependent transcripts enriched in SpA-TGCs.

104 ng domain was required for reactivation, but BLIMP1 did not directly bind the nucleotide (nt) -660 Rp

105 y, we identify a population of proliferating Blimp1(+) diploid cells present within the spongiotropho

106 Loss of Blimp1 disrupts epithelial architecture and lumen format

107 CpG content, leading to the observation that BLIMP1 DNA-binding is methylation sensitive.

108 The mechanism by which BLIMP1 does so involves strongly turning on expression o

109 f B lymphocyte-induced maturation protein 1 (Blimp1) does not rescue the expression of IL-2 by Ets-1-

110 regulatory network, established by SOX17 and BLIMP1, drives comprehensive germline DNA demethylation

111 d the secretion of IgM without up-regulating Blimp1, driving the cells towards an intermediate activa

112 e polarization between Bcl6(+) Tfh cells and Blimp1(+) effector Th cell populations developed by 72 h

113 Finally, we used IgM1:eGFP and cd45DsRed;blimp1:eGFP zebrafish to characterize plasma B cells and

114 cers of Prdm1 and Prdm14 in EpiLCs in vitro; BLIMP1 (encoded by Prdm1) then directly induces Tfap2c.

115 t induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell d

116 r B lymphocyte-induced maturation protein-1 (Blimp1) exhibit a lupus-like phenotype, secondary to enh

117 these alternatives, we followed the fate of Blimp1 expressing cells using Blimp1-Cre mice and Lox-St

118 genetic lineage tracing, we demonstrate that Blimp1-expressing cells are upstream from other cells of

119 was also exploited to generate a fate map of Blimp1-expressing cells.

120 On the molecular level, Fra1 represses Blimp1 expression and interferes with binding of the act

121 ation domains, we propose that Fra1 inhibits Blimp1 expression and negatively controls plasma cell di

122 in culture significantly increased CD138 and Blimp1 expression and PC-specific IgM, but did not affec

123 n of activated B cells is required to foster Blimp1 expression but needs to be terminated to avoid ov

124 Thus, Blimp1 expression defines a mammary stem cell subpopulat

125 east cancer models, shows that the increased Blimp1 expression depends on both MAPK activation and mi

126 Rather, loss of Blimp1 expression disrupts morphogenesis of the caudal b

127 asm that is inherited from the egg; in mice, Blimp1 expression in the epiblast mediates the commitmen

128 ession of VEGF signaling diminishes PRD1-BF1/Blimp1 expression in tumor vasculature and inhibits intr

129 Previous reports showed that ectopic BLIMP1 expression induces reactivation in some EBV-posit

130 Thus, we conclude that BLIMP1 expression is both necessary and sufficient to in

131 c germ cells that are derived from PGCs when Blimp1 expression is lost.

132 Indeed, high Blimp1 expression levels are detected in invasive p130Ca

133 Blimp1 expression marks a rare subpopulation of unipoten

134 Our results suggest that Blimp1 expression stabilizes immature photoreceptors by

135 whereas IL2Ralpha(hi) cells exhibited strong Blimp1 expression that repressed Bcl6 (effector Th cell

136 Otx2 and RORbeta were found to regulate Blimp1 expression via B108, and Blimp1 and Otx2 were sho

137 Thus, the association of Blimp1 expression with ESC development furthers understa

138 SOX11 silencing downregulates PAX5, induces BLIMP1 expression, and promotes the shift from a mature

139 gous phenotypic changes, including decreased BLIMP1 expression, increased let-7c expression, and incr

140 nt BACH2 and IRF8 downregulation, sustaining BLIMP1 expression, the master regulator for PC different

141 nerate a beta-catenin/Tcf input required for blimp1 expression, while the wnt8 gene in turn requires

142 s-regulatory module (CRM), B108, that mimics Blimp1 expression.

143 ls plasma cell differentiation by repressing Blimp1 expression.

144 RBPJ expression, resulting in a decrease of Blimp1 expression.

145 ivates a feed-forward loop in which KLF4 and BLIMP1 first activate LMP1 expression and then cooperate

146 ory conditions, the intrinsic requirement of Blimp1 for homeostatic maintenance of these T cell subse

147 the first time the defects caused by loss of Blimp1 function in the mouse.

148 The human PRDI-BF1 or BLIMP1 gene and its mouse homolog Blimp1 are members of

149 ic program and regulated by a balanced SOX17-BLIMP1 gene dosage.

150 We report here that the BLIMP1 gene is inactivated by structural alterations in

151 The blimp1 gene is itself linked into a feedback circuit tha

152 BLIMP1 gene transcription was activated by TGF-beta1 via

153 able fraction of ABC-DLBCL carry an inactive BLIMP1 gene, and suggest that the same gene is inactivat

154 ork subcircuit comprising the otx, wnt8, and blimp1 genes accounts for a moving torus of gene express

155 subcircuit that includes the otx, wnt8, and blimp1 genes, the cis-regulatory control systems of whic

156 tal abnormalities, whereas transheterozygous Blimp1(gfp/-) embryos with further reduced expression le

157 Here, we show that Blimp1 has a novel interaction with Prmt5, an arginine-s

158 Blimp1 has been shown to function as a direct activator

159 functional annotation analysis revealed that Blimp1 has broadly shared as well as cell type-specific

160 The transcriptional repressor Blimp1 has now been shown to be required in embryonic sl

161 PGC allocation around 7.25 days post coitum, Blimp1 heterozygous embryos exhibit decreased numbers of

162 akage and tissue apoptosis, and, strikingly, Blimp1 homozygous mutants entirely lack PGCs.

163 inhibited by the transcriptional regulators Blimp1, Id2 and Id3.

164 To examine the role of BLIMP1 in innate immunity, we used a conditional knockou

165 The specific high-level expression of Blimp1 in late B and plasma cells, its induction during

166 s DC phenotype and confirm the importance of BLIMP1 in maintaining tolerogenic DCs in both mice and h

167 ely, these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expres

168 ity, we used a conditional knockout (CKO) of Blimp1 in myeloid cells and found that Blimp1 CKO mice w

169 ll, our study reveals the functional role of Blimp1 in promoting the dermal papilla inductive signali

170 last by sequential upregulation of SOX17 and BLIMP1 in response to WNT and BMP signalling.

171 inflammation, indicating a crucial role for Blimp1 in T cell homeostasis regulation.

172 We analyzed the function of Blimp1 in the mouse retina using a conditional deletion

173 The DNA motif bound by BLIMP1 in vitro overlaps with that of interferon regulat

174 anscription factor Prdm1 (also called Ubo or Blimp1) in response to Hedgehog (Hh) signalling, express

175 dent cellular transcription factors KLF4 and BLIMP1 induce lytic EBV reactivation in epithelial cells

176 siRNA knockdown of BLIMP1 inhibited 12-O-tetradecanoyl-phorbol-13-acetate (

177 consistent with the latter alternative: that Blimp1 inhibits bipolar competence in Otx2+ cells and mu

178 sion, while the wnt8 gene in turn requires a Blimp1 input.

179 to occupied promoters containing overlapping BLIMP1/IRF motifs (e.g. AIM2, SP110, BTN3A3) are shown t

180 The transcription factor BLIMP1 is a master regulator of primordial germ cell (PG

181 rst time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated inv

182 Notably, Blimp1 is also dispensable for reprogramming epiSCs to E

183 experimental validation we demonstrated that Blimp1 is both a target and a mediator of key dermal pap

184 sing a genetic approach, we demonstrate that Blimp1 is dispensable for the derivation and maintenance

185 Blimp1 is dynamically expressed at diverse tissue sites

186 Here we show that Blimp1 is dynamically regulated in dermal papilla cells

187 zinc finger transcriptional repressor Prdm1/Blimp1 is essential for specification of spiral artery t

188 In T cells, Blimp1 is expressed in both effector (Teff) and regulato

189 Later in development Prdm1/Blimp1 is expressed in many other tissues, including pha

190 Although in the epidermis Blimp1 is important for keratinocyte and sebocyte differ

191 Our study demonstrates that Blimp1 is involved in a novel transcriptional regulatory

192 Thus, although Blimp1 is obligatory for PGC specification, it is not re

193 Considerable evidence suggests that Blimp1 is required for the establishment of anteroposter

194 t Foxp3(+) Treg cell-intrinsic expression of Blimp1 is required to control Treg and Teff cells homeos

195 Collectively, these results demonstrate that Blimp1 is required to maintain a highly proliferative lu

196 e pluripotent state, it is not known whether Blimp1 is similarly involved.

197 In mouse embryos, Blimp1 is strongly expressed in axial mesendoderm, the t

198 Blimp1 is transiently expressed in Otx2+ cells.

199 r B lymphocyte-induced maturation protein 1 (BLIMP1) is a master regulator of B and T cell differenti

200 )/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor expressed in a su

201 B-lymphocyte-induced maturation protein 1 (Blimp1) is a transcriptional repressor that regulates ce

202 get set which is preferentially activated by BLIMP1 knock-down.

203 ly, and shown to respond to blockade of both Blimp1/Krox and Tcf1/beta-catenin inputs just as does th

204 We confirmed previously published data that blimp1/krox autoregulates its own expression, but discov

205 During cleavage stages the blimp1/krox gene is expressed in the large micromeres an

206 The blimp1/krox gene of Strongylocentrotus purpuratus, forme

207 analysis to be activated by inputs from the blimp1/krox gene, itself expressed zygotically in the en

208 The Tcf1/beta-catenin and Blimp1/Krox inputs are both necessary for normal endomes

209 The MASO perturbation analysis also revealed blimp1/krox inputs into other genes of the endomesoderm

210 The expression of blimp1/krox is dynamic, and involves several distinct sp

211 A different splice variant, blimp1/krox1a, is expressed only from gastrula stage onw

212 This construct closely mimics blimp1/krox1b expression during early stages of sea urch

213 that the SG defects associated with loss of Blimp1 lead to enhanced bulge stem cell activity, sugges

214 Functional studies indicate that Blimp1, like BCL-6, can block IRF-4-transactivating abil

215 Blimp1 likely forms a cross-repressive network with pro-

216 ially dependent on the transcription factor, BLIMP1, linking plasma cell commitment and cessation of

217 The BLIMP1 locus lies on chromosome 6q21-q22.1, a region fre

218 enhancers and a distal element at the Prdm1 (Blimp1) locus, E-proteins contributed to Igk, Igh, and P

219 Blimp1(+) luminal stem cells give rise to Blimp1(-) prog

220 Blimp1 may also have a role in the maintenance of early

221 The data led us to suggest that BLIMP1 may be a candidate B-NHL tumor suppressor gene.

222 death into T cell-independent proliferation, Blimp1-mediated plasmablast differentiation, and autoant

223 motif) ligand 8, CCL8, as a direct target of Blimp1-mediated transcriptional repression in these cell

224 nhancer-targeted IRF2 protected LCLs against Blimp1-mediated tumor suppression.

225 In occupied promoters, only a subset of BLIMP1 motifs overlap with IRF motifs.

226 protein expression, despite the presence of BLIMP1 mRNA.

227 Blimp1 mutant embryos also show widespread blood leakage

228 its functional role remains unknown because Blimp1 mutant embryos arrest at E10.5 due to placental i

229 tenin was able to override the HF defects in Blimp1 mutant mice, underlining the close reciprocal rel

230 We have now mapped the physical location of BLIMP1 near the marker D6S447 on human chromosome 6q21-q

231 Importantly, Blimp1 not only silences TSC gene expression but also pr

232 is unknown, since an unbiased assessment of BLIMP1 occupancy in vivo is lacking.

233 The GRN centers on Blimp1, one of the transcription factors (TFs) that regu

234 TG resulted in sustained BCL6 but not BLIMP1 or CD138 expression, which is consistent with mai

235 tif selection predicts that only a subset of BLIMP1 or IRF sites is subject to antagonistic regulatio

236 The transcriptional regulator Blimp1 plays crucial roles in controlling terminal diffe

237 Blimp1 plays essential roles in multipotent progenitor c

238 entified role that transcriptional repressor Blimp1 plays in the control of breast cancer invasivenes

239 ssion profiling indicated that many of these Blimp1-positive cells coexpress other genes typically as

240 may not entail an obligatory route through a Blimp1-positive PGC-like state.

241 ments revealed that ESCs commonly arise from Blimp1-positive precursors; indeed, prospective sorting

242 ells can become ESCs without first acquiring Blimp1 positivity.

243 zinc finger transcriptional repressor Prdm1/Blimp1 (PR domain containing 1, with ZNF domain; previou

244 sitive regulatory domain I-binding factor 1 (Blimp1/PRD1-BF1), a Kruppel-type zinc finger protein who

245 The zinc-finger transcriptional repressor Blimp1 (Prdm1) controls gene expression patterns during

246 toreceptor fate determination, we found that Blimp1 (Prdm1) is expressed transiently in developing ph

247 Blimp1 (Prdm1), the key determinant of primordial germ c

248 Commensurately higher Blimp1/PRDM1 expression was detected in ERalpha-negative

249 of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the establishment of epith

250 In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of

251 Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5

252 Here we investigate Blimp1/Prdm1 requirements in the trophoblast cell lineag

253 Blimp1-Prmt5 colocalization results in high levels of H2

254 ubsequently, Dhx38, a putative target of the Blimp1-Prmt5 complex, is upregulated.

255 However, at E11.5, Blimp1-Prmt5 translocates from the nucleus to the cytopl

256 Thus Blimp1 probably acts to turn off the default pathway tha

257 Blimp1(+) luminal stem cells give rise to Blimp1(-) progeny that are invariably Elf5(+)ERalpha(-)P

258 cell differentiation through binding to the Blimp1 promoter.

259 g of the activating AP-1 member c-Fos to the Blimp1 promoter.

260 on-GC type DLBCL cases (n = 20/26, 77%) lack BLIMP1 protein expression, despite the presence of BLIMP

261 Blimp1 protein repressed ERalpha (ESR1) gene transcripti

262 rate aberrant transcripts encoding truncated BLIMP1 proteins.

263 Thus, Blimp1 regulates proliferation, apoptosis and alveolar c

264 We conclude that Blimp1 regulates the decision between photoreceptor and

265 r B lymphocyte-induced maturation protein-1 (BLIMP1) regulates gene expression and cell fate.

266 Thus, the induction of Blimp1 represents a novel mechanism whereby the RelB NF-

267 the key regulator of hPGC-like fate, whereas BLIMP1 represses endodermal and other somatic genes duri

268 Blimp1 represses the incipient somatic program in these

269 of the hesC gene, however, is controlled by Blimp1 repression.

270 of c-Fos in Fra1 transgenic B cells releases Blimp1 repression.

271 e include activation by beta-catenin/Tcf and Blimp1, repression within the torus by Hox11/13b, and re

272 ly, the present experiments demonstrate that Blimp1 requirements in diverse cell types are exquisitel

273 e being three or more synergistically acting BLIMP1-responsive elements (BRE) within Rp.

274 TGFB1 and BLIMP1 RNA levels were correlated in patient breast tumo

275 BLIMP1's DNA-binding domain was required for reactivatio

276 Here, we examined BLIMP1's role in inducing EBV lytic gene expression in n

277 document previously unappreciated aspects of Blimp1's role in T cell biology and shed light on the in

278 DCs from Blimp1 SLE-risk allele carriers exhibited analogous phen

279 BLIMP1 strongly induced transcription from Rp as well as

280 ore, cellular transcription factors, such as BLIMP1, that are key mediators of differentiation likely

281 n repressor/differentiation factor, PRDI-BF1/BLIMP1, through a conserved amino-terminal motif, the PR

282 Blimp1 thus represses the repressor of delta, thereby pe

283 n chromosome 6q21-q22.1; we have also mapped Blimp1 to mouse Chromosome 10 at 14 cM distal to the Myb

284 nctions with the master germline determinant BLIMP1 to promote primordial germ cell (PGC) specificati

285 r B lymphocyte-induced maturation protein 1 (BLIMP1) to promote MHC-II expression.

286 B, increased IgM secretion, up-regulation of Blimp1 transcription and decreased MHC-II surface expres

287 nactivated in myeloid leukemia, the PRDI-BF1/BLIMP1 transcription repressor of c-myc involved in driv

288 Moreover, we demonstrate that Blimp1 triggers cell invasion and metastasis formation v

289 We identified Hrd1-mediated BLIMP1 ubiquitination as a previously unknown mechanism

290 ression and dominant-negative studies, Prdm1/Blimp1 was proposed to promote anterior endomesoderm and

291 The latter gene, coding for BLIMP1, was inactivated by multiple mechanisms, more fre

292 two cellular transcription factors (KLF4 and BLIMP1) which cooperatively activate the two LMP1 promot

293 EZH2 inhibition in NHL cells induced BLIMP1, which impaired tumor growth.

294 Cell Stem Cell, Bao et al. demonstrate that Blimp1, which is required for primordial germ cell (PGC)

295 master regulator of plasma cell development, Blimp1 will in turn suppress AID expression and drive th

296 ontrolled at the cis-regulatory level by the blimp1-wnt8 torus-generating subcircuit now explains the

297 xpression of multiple key factors, including Blimp1, Xbp1, and CXCR4, and is therefore critical for e