ライフサイエンスコーパス: BMP receptor

1 MP9, and only these cells expressed the Alk1 BMP receptor.

2 he added synapse-stabilizing activity of the BMP receptor.

3 as chordin, that sequester ligands from the BMP receptor.

4 account for the stabilizing activity of the BMP receptor.

5 izing effects of Noggin or dominant-negative BMP receptor.

6 ion of wnt inhibitors with dominant-negative BMP receptor.

7 ocopy those induced by the dominant-negative BMP receptor.

8 t on secreted BMP ligands through the type I BMP receptor.

9 ly by forming a plasma membrane complex with BMP receptors.

10 signal through a hetero-oligomer complex of BMP receptors.

11 ecapitulate the effects of dominant negative BMP receptors.

12 ely Smad1, Smad5 and Smad8, are activated by BMP receptors.

13 has overlapping functions with other type I BMP receptors.

14 nd ALK3) and two type II (ActRIIA and BMPR2) BMP receptors.

15 hich expressed low to undetectable levels of BMP receptors.

16 neutralizing antibody or the small molecule BMP receptor 1 inhibitor LDN-193189.

17 Surprisingly, sclerostin, noggin, and human BMP receptor 1A (BMPR1A)-FC fusion proteins blocked Wnt-

18 dy, we overexpressed a constitutively active BMP receptor 1A (caBmpr1a) in chondrocytes by using two

19 ng a heat shock-inducible, dominant-negative BMP receptor 1a [Tg(hs70I:dnBmpr1a-GFP)] to bypass early

20 PTHrP upregulates BMP receptor 1A expression in the mammary mesenchyme, en

21 tro/in vivo hybrid knockout assay, we ablate BMP receptor 1a in purified DP cells.

22 t Cre-mediated mutation of the gene encoding BMP receptor 1A in the surface epithelium and its deriva

23 Moreover, phospho-SMAD1/5 is altered and BMP receptor 1A is reduced in a XMC patient.

24 t BMP4 specifically induces proliferation of BMP receptor 1a-positive MP cells but has no effect on S

25 placeable by that of a constitutively active BMP receptor 1A.

26 ntains inter-myofibre progenitors expressing Bmp-receptor 1a (Bmpr1a) and Myf5 that respond to stimul

27 ural crest-derived human melanocytes express BMP receptor-1A, -1B, and -2.

28 co-express GDF5 and its preferred receptors, BMP receptor 1B and BMP receptor 2, during development.

29 iate into chondrocytes and that signaling of BMP receptor 1B in this context is replaceable by that o

30 of melanogenesis, down-regulated the mRNA of BMP receptor-1B in melanocytes.

31 ought to determine whether disruption of the BMP receptor 2 (BMPR2) would alter mammary tumor progres

32 This effect of BMP7 depended on BMPR2 (BMP receptor 2), and BMPR2 expression inversely correlat

33 its preferred receptors, BMP receptor 1B and BMP receptor 2, during development.

34 rmalities in the bone morphogenetic protein (BMP) receptor 2 (BMP-R2) signaling pathway are important

35 f the BMP type I receptors, we find that the BMP receptors act similarly to BMP4 in the gizzard when

36 entiation inhibitory signals by antagonizing BMP receptor-activated Smad activity while activating cr

37 ecifically increases nuclear localization of BMP receptor-activated SMADs (R-SMADs) confirming a func

38 onstrate that Gata-2 functions downstream of BMP receptor activation in these same cells, and is a di

39 ding to two types of serine/threonine kinase BMP receptors, activation of which leads to phosphorylat

40 Here we show that the BMP receptor activin-like kinase 3 (Alk3) is elevated ea

41 ontribution of EPDCs to the AV junction, the Bmp receptor activin-like kinase 3 (Alk3; or Bmpr1a) was

42 The type I BMP receptors activin-like kinase (ALK)3 and ALK6 share

43 Further reduction of Bmp receptor activity by removing one functional copy of

44 was to analyze the function(s) of the type 1 BMP receptor, Acvr1, in lens development.

45 not the liver bud, acting through the type I BMP receptor Acvr1l, is required for PE specification.

46 Thus, the type I BMP receptor ALK2 plays an essential cell-autonomous rol

47 FOP-associated mutations in the BMP receptor ALK2 reduce binding of the inhibitor FKBP12

48 FKBP12 preferentially targets the BMP receptor ALK2.

49 basal hepcidin expression, whereas 2 type I BMP receptors, Alk2 and Alk3, are required for regulatio

50 Conditional deletion of the BMP receptor Alk3 from venous pole SHF cells leads to im

51 wild-type mice showed an upregulation of the BMP receptors Alk3 and BMPR-II, and of their ligand BMP4

52 ese observations demonstrate that one type I BMP receptor, Alk3, is critically responsible for basal

53 iac myocyte-specific deletion of the type IA BMP receptor, ALK3.

54 This may represent a novel BMP receptor and is the first to be characterized in pri

55 from the complex and permits it to bind the BMP receptor and signal.

56 bition of Dab2 attenuates internalization of BMP receptors and abrogates the proangiogenic effects of

57 Overall, our results show that BMP receptors and beta3 integrin work together to contro

58 tion by their activation of different type I BMP receptors and distinct modulations of the cell cycle

59 MP) signaling in pulmonary vascular disease, BMP receptors and downstream phospho-Smad1/5/8 were redu

60 The requirement of various BMP receptors and members of the SMAD signal transductio

61 Spict interacts with BMP receptors and promotes their internalization from th

62 However, whereas these BMP receptors and signaling components are required in t

63 re similar to those we observe in mutants of BMP receptors and Smad transcription factors.

64 Flk-1(+) progenitors coexpressed TGFbeta and BMP receptors and target genes.

65 Using siRNAs to type I and II BMP receptors and the signaling intermediaries (Smads),

66 BMPs are mediated by the canonical family of BMP receptors and then regulated by specific inhibitory

67 We show here that several BMP ligands, all BMP receptors, and BMP-associated Smad1/5/8 are expresse

68 nsferrin receptor 2, matriptase-2, neogenin, BMP receptors, and transferrin.

69 s period in vitro or in vivo, using either a BMP receptor antagonist or noggin (Nog).

70 Importantly, blocking BMP activity by BMP receptor antagonist, noggin, reverse the effects of

71 BMP receptor antagonists also decreased clonogenic cell

72 BMP receptor antagonists and silencing of BMP type I rec

73 We find that the BMP receptors are differentially expressed in distinct r

74 The CAF cells express type I and type II BMP receptors as well as the receptor for SDF-1, CXCR4.

75 alk6b, a type IB bone morphogenetic protein (BMP) receptor, as the cause of the zebrafish GCT phenoty

76 BMP receptor association with membrane microdomains, whi

77 overexpressing a dominant-negative form of a Bmp receptor at various embryonic stages, we determined

78 x (Chd-Tsg-BMP) forms relatively quickly and BMP receptor binding is relatively slow.

79 A BMP-receptor binding assay revealed that Tsg has two dis

80 BMP antagonist, noggin, or dominant negative BMP receptors blocked the effects of elevated intracellu

81 arried out to evaluate the potential role of BMP receptor (BMP-R) types IA, IB, and II in bladder tra

82 d-circulating NK cells express type I and II BMP receptors, BMP-2 and BMP-6 ligands, and phosphorylat

83 phogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons.

84 ermore, a dynamic expression profile for the BMP receptor (BMPR) isoform IB was observed, with dramat

85 udies, we have demonstrated that the type IB BMP receptor (BMPR-IB) plays an essential and specific r

86 ncer, we examined the expression of BMPs and BMP receptors (BMPR) as well as the responsiveness to re

87 on by examining whether either of the type I BMP receptors (Bmpr), BmprIa and BmprIb, have a role con

88 s of function of bone morphogenetic protein (BMP) receptor (BMPR)II, observed in pulmonary arterial h

89 We revealed the presence of mRNA of Type I BMP receptors, BMPR-1A (ALK3), BMPR-1B (ALK6) and ALK2 i

90 analyzed the expression and function of two BMP receptors, BMPR-IA and BMPR-IB, in neural precursor

91 n and regulation of the mRNAs for the type I BMP receptors, BMPR-IA and BMPR-IB, in quail embryos in

92 ing, we conditionally inactivated the type 1 Bmp receptor Bmpr1a in the facial primordia, using the N

93 expressed type I bone morphogenetic protein (BMP) receptor Bmpr1a (also known as Alk3) in the mesench

94 Genetic ablation of the type 1A BMP receptor (Bmpr1a) in brown adipogenic progenitor cel

95 xpressing progenitors, we ablated the Type I Bmp receptor, Bmpr1a utilizing Isl1Cre/+.

96 ns, we deleted the genes encoding the type I BMP receptors, Bmpr1a and Acvr1, and the canonical trans

97 eviously found that disruption of two type I BMP receptors, Bmpr1a and Acvr1, respectively, in an ost

98 trathymic progenitors expressing the type IA BMP receptor (BMPRIA) and provide evidence that CD34(+)C

99 A role for the type I BMP receptor BmprIB as a regulator of ovulation rates in

100 NIPA1 physically interacts with the type II BMP receptor (BMPRII) and we demonstrate that this inter

101 We show that the type II BMP receptor (BMPRII) is a novel target of miR-302.

102 The type II BMP receptor (BMPRII) is expressed as two alternatively

103 s in the Type II Bone morphogenetic protein (Bmp) receptor, BmpRII, in families with PAH has implicat

104 Signaling is transduced by BMP receptors (BMPRs) of type I and type II that are ser

105 demonstrated that the loss of expression of BMP receptors (BMPRs) type IA, -IB, and -II (BMP-RIA, -R

106 ts of the BMP signalling pathway, the type I BMP receptors (BMPRs), are both necessary and sufficient

107 P signaling loops, we first localized Type I BMP receptors (BMPRs), BMPR-1A (ALK3), -1B (ALK6) and AL

108 ssociation is dependent on the expression of BMP receptors but not transforming growth factor beta re

109 of beta1-integrin reduced overall levels of BMP receptors but significantly increased partitioning o

110 Therefore, potentiation of the BMP receptor by H11K promotes an activation of the PI3K/

111 ts BMP signalling involves downregulation of BMP receptors by promoting their endocytosis and lysosom

112 Activation of BMP receptors by their ligands leads to induction of sev

113 Further, ectopic BMP receptors cause an upregulation of Nkx2.5, the pylor

114 ted and constitutively active type IA and IB BMP receptor cDNAs were stably expressed in these cells.

115 r alone or together with a dominant-negative BMP receptor, Chordin and/or Noggin in competent epiblas

116 to loss-of-function mutation of the TGF-beta/BMP receptor complex and the second to increased signali

117 This paper visualizes time-resolved BMP receptor complex formation and demonstrates that the

118 affold to facilitate assembly of the HJV.BMP.BMP receptor complex to induce hepcidin expression.

119 est the specific roles of the type IA and IB BMP receptor components, truncated and constitutively ac

120 ecycling endosomes and increased mobility of BMP receptor-containing compartments at the NMJ.

121 However, how postendocytic trafficking of BMP receptors contributes to the regulation of signal tr

122 Surprisingly, we find that the type II BMP receptor, DAF-4 (dauer formation-defective-4), is re

123 n of BMP signaling using a dominant negative BMP receptor (DeltaBMPR) leads to the ectopic activation

124 BMP receptors determine the intensity of BMP signals via

125 lopment, yet mice lacking type II or type IA BMP receptors die at gastrulation and cannot be used to

126 , Noggin, as well as a chemical inhibitor of BMP receptors, DMH1, and described the inputs from BMP s

127 ggin and, independently, a dominant negative Bmp receptor (dnAlk6), were overexpressed using the surf

128 Importantly, a specific kinase inhibitor of BMP receptors drastically attenuated chondrogenesis in r

129 the avian embryo with constitutively active Bmp receptors driven by promoters of varying strengths.

130 emonstrating functional redundancy of type I BMP receptors during cerebellar development.

131 has broadly overlapping functions with other BMP receptors during skeletal development.

132 partially rescued TDP-43-induced defects in BMP receptor dynamics and distribution and suppressed BM

133 tive manner to prevent binding to the type I BMP receptor ectodomain, and inhibited BMP-dependent ind

134 Based on the BMP receptor expression pattern, we examined the functio

135 Increasing bone morphogenetic protein (BMP) receptor expression in mesenchymal cells decreased

136 endothelial-specific member of the TGF-beta/BMP receptor family that is inactivated in patients with

137 oprecipitated with ALK3, an essential type-I BMP receptor for hepatic hepcidin expression.

138 pe I and type II bone morphogenetic protein (BMP) receptors for binding to BMPs, decreased BMP signal

139 cription factors activated by TGF-beta or by BMP receptors form trimeric complexes with Smad4 to targ

140 nd Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocat

141 Further, we observed a shift of BMP receptors from early to recycling endosomes and incr

142 , we have used a Cre-loxP strategy to delete Bmp receptor function specifically within the developing

143 e studies show the effects of alterations in BMP receptor function targeted to the osteoblast lineage

144 However, the mechanisms by which BMP receptors function in vertebrate development are inc

145 e find that mutation of the zebrafish type I BMP receptor gene alk8 causes reduction of atrial size w

146 Here, we inactivated the mouse BMP receptor gene Bmpr1a specifically in the limb bud ap

147 sexpression or inactivating mutations of the BMP receptor gene can lead to dedifferentiation of vSMC

148 xpression and up-regulated HOXB4, BMP-4, and BMP receptor gene expressions.

149 A transcribed from the only type II TGF-beta/BMP receptor gene in Caenorhabditis elegans.

150 In mutants containing either single BMP receptor gene mutation alone, cerebellar histogenesi

151 In the present study, deletion of the BMP receptor genes, Bmpr1b and Bmpr1a, in the mouse tele

152 ning a heatshock-inducible dominant-negative Bmp receptor-GFP fusion.

153 ngs are consistent with the observation that BMP receptor hyperactivation correlates with bone abnorm

154 Similarly, BMP receptor I expression is increased and its downstrea

155 Finally, c-Abl associates with BMP receptor IA and regulates phosphorylation of Smad in

156 itional gene targeting in mice, we show that BMP receptor IA is essential for the differentiation of

157 in in the epithelium and mesenchyme, and the BMP receptor IA is prominently expressed in the follicul

158 us requirement of SNS development, the Alk3 (BMP receptor IA) was deleted in the NC lineage.

159 BMP receptor IA, IB, and II mRNAs were also detected in

160 xpression of a constitutively active form of BMP receptor-Ia (caBmprIa) in CNC lineage did not produc

161 en shown that constitutive activation of the BMP receptor-IA blocks chondrocyte differentiation in a

162 nt of G8neg cells with a soluble form of the BMP receptor-IA or Noggin promoted N-cadherin synthesis

163 al wall progenitors with a dominant-negative BMP receptor Ib (dnBMPIb) virus increased their producti

164 encoding a dominant negative mutant form of BMP receptor IB inhibits expression of the visceral endo

165 he exposure of immature cells overexpressing BMP receptor Ib to BMP2 and BMP4.

166 negative and constitutively active forms of BMP receptors IB (BMPRIB), we show that BMPs, possibly a

167 hh expression by BMP4 may not be mediated by BMP receptor-IB.

168 he roles of TGFbeta receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cance

169 sults showed that type II receptors, such as BMP receptor II, activin receptor IIA, and activin recep

170 Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary

171 Activation of bone morphogenetic protein (BMP) receptor II (BMPRII) promotes pulmonary artery endo

172 d pathway by dorsomorphin, which targets the BMP receptors, improves the hepcidin responsiveness to E

173 conditional genetic deletion of the type II BMP receptor in Ascl1-expressing cells promoted neurogen

174 ies show enhanced activity downstream of the Bmp receptor in cells where Fmn1 is perturbed, suggestin

175 Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte forma

176 BMP antagonist noggin or a dominant-negative BMP receptor in normal EBs leads to increased apoptosis.

177 ion experiments, conditional deletion of the BMP receptor in Shh-Cre;Bmpr1a(flox/flox) embryos allows

178 Knockdown of the BMP receptor in SMAD4-negative cells reduced their invas

179 ntagonist Noggin or an activated form of the BMP receptor in the chick limb, we demonstrate that BMP

180 quired for the EMT and the activation of the BMP receptor in the endocardium can promote AV EMT in th

181 protein, alphaA-crystallin were regulated by BMP receptors in a Smad-independent manner.

182 teins (BMPs) is suggested by the presence of BMP receptors in chicken embryo lenses.

183 appear to mediate neogenin interaction with BMP receptors in chondrocytes.

184 rrent loss of SMAD4 and normal expression of BMP receptors in colorectal tumors was associated with r

185 negative Type I (tALK3) or Type II (tBMPRII) BMP receptors in developing Xenopus embryos results in r

186 ng the expression of BMP7 or the activity of BMP receptors in muscles induced hypertrophy that was de

187 Moreover, blocking endogenous BMP receptors in progenitors with a virus transducing dn

188 ts did not induce differential expression of BMP receptors in RPE.

189 lecular mechanism consistent with a role for BMP receptors in the establishment of early morphogen gr

190 re, we describe the pattern of expression of BMP receptors, including Bmpr-Ia, Bmpr-Ib, Bmpr-II, Actr

191 cur via a distinct subset of BMP ligands and BMP receptors, independently of neogenin.

192 or by overexpression of a dominant-negative BMP receptor, indicates that BMPs regulate cell cleavage

193 y in the presence of a constitutively active BMP receptor, indicating a mechanism of action downstrea

194 , or visualization of the spatial pattern of BMP-receptor interactions reveals a spatially bistable p

195 lar feedback to produce two stable states of BMP-receptor interactions, a spatial bistability in whic

196 sitive feedback circuit that promotes future BMP-receptor interactions.

197 Signaling by Bmp receptors is mediated mainly by Smad proteins.

198 TGF-beta signaling acting through the BMP receptors is necessary for the generation of several

199 li is still required by a ligand-independent BMP receptor, its function likely occurs between recepto

200 ation reduces Smad interaction with TGF-beta/BMP receptor kinase and affects all receptor-activated S

201 ssion patterns of BMP-2, -4, -5, -6, and -7, BMP receptor kinases (BRKs) -1, -2, and -3, and BMP bind

202 TGF-beta and BMP receptor kinases activate Smad transcription factors

203 phorylation, which is mediated by the type I BMP receptor kinases in response to BMP stimulation, is

204 Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control d

205 The effect of bone morphogenetic protein (BMP) receptor knockdown on BMP-6-stimulated hepcidin pro

206 1 of the type II bone morphogenetic protein (BMP) receptor ligands, BMP4, is widely expressed in the

207 regulation of the relative concentrations of BMP receptors, ligands and antagonists.

208 of a transgenic inducible dominant-negative Bmp receptor line to examine the temporal roles of Bmp s

209 ted SMAD1, an indicator of signaling through BMP receptors, localizes to the nuclei of elongating len

210 al. and Marques et al. present evidence that BMP receptors may also influence the development of syna

211 is required both upstream and downstream of Bmp receptor-mediated Smad1 phosphorylation for inductio

212 Neither noggin nor dominant negative BMP receptor misexpression causes similar vascular pheno

213 duced by the thymic stroma and the requisite BMP receptor molecules (BMPR-1A, BMPR-1B, BMPR-II), and

214 d lamina cribrosa (LC) cells express BMP and BMP receptor mRNA and proteins.

215 In addition, type I and type II BMP receptor mRNA levels were also increased in P19 cell

216 ted after the identification of heterozygous BMP receptor mutations as the underlying defect in the r

217 gnaling by expression of a dominant-negative BMP receptor or Noggin allows other animal blastomeres t

218 a expression of constitutively active type I BMP receptors or by reducing retrograde transport in mot

219 Constitutively active BMP receptors or constitutively active Smad1 mimicked th

220 ee cell lines that underexpressed either the BMP receptors or Smad1.

221 forms of either bone morphogenetic protein (BMP) receptor or fibroblast growth factor (FGF) receptor

222 ndings of a modulating effect of ROR2 on the BMP-receptor pathway through the formation of a heterome

223 itutively active bone morphogenetic protein (BMP) receptors prevents pdfr mutants misrouting phenotyp

224 1), and 8-fold (P < 0.01) increase of BMP-2, BMP receptor (R)-IA, and BMPR-II messenger RNA levels, r

225 Vegfa is transcriptionally regulated by the Bmp receptor-regulated Smad.

226 , and suppressed activation of intracellular BMP receptor-regulated Smads (R-Smads) and Erk1/2 was id

227 urf1), which results in the stabilization of BMP receptor-regulated Smads and potentiation of the Sma

228 ly supports the role of Laf/Alk8 as a type I BMP receptor required for the specification of ventral c

229 ly, the causative amino acid mutation of the BMP receptor responds to activin, thereby turning soft t

230 ansmitted through HFE, TfR2, and HJV augment BMP receptor sensitivity to BMPs.

231 rovide the first evidence that activation of BMP receptor serine/threonine kinase stimulates the PI 3

232 tion results from the combined inhibition of BMP receptor serine/threonine kinases and activation of

233 nalysis of compound mutants of Alk3/6 type I BMP receptors shows that BMP signaling is necessary for

234 BMP receptors signal through C-terminal phosphorylation

235 Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which th

236 B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression.

237 Studies on BMP receptor signaling during organogenesis have been ha

238 To determine the role of BMP receptor signaling in bone formation in vivo, we gen

239 lineage and demonstrate a necessary role of BMP receptor signaling in postnatal bone growth and bone

240 d by cadherin-6B was found to be mediated by BMP receptor signaling independent of BMP.

241 A key function of Smad-independent BMP receptor signaling may be reorganization of actin cy

242 We present evidence that BMP receptor signaling regulates vascular remodeling dur

243 ase (TAK)1, a "noncanonical" mediator of the BMP receptor signaling.

244 using dorsomorphin, a chemical inhibitor of Bmp receptors, significantly increased beta-cell neogene

245 Upon phosphorylation by the BMP receptors, Smad1 interacts with Smad4 and translocat

246 c-Abl contributed to BMP receptor-specific Smad-dependent transcription of CS

247 ized and secreted BMP-4 as well as expressed BMP receptor subtypes BMPRI and BMPRII.

248 Expression of BMP-2 and BMP-4, BMPR-IA (BMP receptor subunit), BMPR-IB, and BMPR-II, and the BMP

249 When coinjected with dominant-negative BMP receptor (tBR) in the ventral side of the embryo, XR

250 BmprIa and BmprIb encode two type I BMP receptors that are primarily responsible for BMP sig

251 e examined the effects of loss of one of the BMP receptors, the BmprIb, on the development of the eye

252 Genes encoding two type I BMP receptors, the type II TGFbeta receptor, two BMP- or

253 We investigated the roles of the BMP receptor Thickveins (Tkv) and the BMP inhibitor Shor

254 Germline-specific expression of an activated BMP receptor thickveins (Tkv) or E-cadherin can partiall

255 Cv-2 binds the type I BMP receptor Thickveins (Tkv), and we demonstrate how th

256 nges in the expression pattern of the type I BMP receptor thickveins (tkv).

257 correlate with the expression of the type I BMP receptor thickveins (tkv).

258 naling through a direct interaction with the BMP receptor, thickveins.

259 tagonists that prevent BMP interactions with BMP receptors thus modulating BMP effects in tissues.

260 gnals synergistically through the two type I BMP receptors Tkv and Sax.

261 The bone morphogenetic protein (BMP) receptor Tkv localizes to microtubule-based nanotub

262 itogenesis, by targeting a dominant-negative BMP receptor to Lmo2+ cells in developing zebrafish embr

263 onformational change, which denies access of BMP receptors to the growth factor.

264 that it inhibits BMP signaling by regulating BMP receptor traffic.

265 tly elevated, possibly due to alterations in BMP receptor trafficking.

266 ed BMP-2 expression, and showed no effect on BMP receptor transcripts.

267 hese results demonstrate that type IB and IA BMP receptors transmit different signals to bone-derived

268 Overexpression of truncated type IB BMP receptor (trBMPR-IB) in 2T3 cells completely blocked

269 differentiation, and that signaling through BMP receptors triggers neuronal precursors to differenti

270 ation action of the constitutively activated BMP receptor type 1A, ca-ALK-3.

271 ciprocal feedback loop, miR-21 downregulates BMP receptor type 2 expression.

272 predictions, we have found that hypoxia and BMP receptor type 2 signaling independently upregulate m

273 lammation, and genetic haploinsufficiency of BMP receptor type 2.

274 cle tracking microscopy, we demonstrate that BMP receptor type I and II (BMPRI and BMPRII) have disti

275 epithelium, we have exploited the fact that Bmp receptor type Ia (Alk3) is expressed in the epitheli

276 mutant mice with conditional inactivation of BMP receptor type IA (BMPRIA).

277 e protein kinase casein kinase II (CK2) as a BMP receptor type Ia (BRIa) interacting protein.

278 scle cells, BMP2 and BMP4 signaling required BMP receptor type II (BMPRII), but not activin receptor

279 d knockdown experiments, we demonstrate that BMP receptor type II and activin-like kinase-2 are neces

280 y co-immunoprecipitates with BMP-15, whereas BMP receptor type II extracellular domain was most effec

281 structure-function analysis of the BMP-Alk3-BMP receptor, type 2 (BMPR2) ligand-receptor complex, al

282 BMP receptor-type 2 (BMPR2) knockdown in HepG2 cells inc

283 ic day 7.5 (E7.5), phenotypes that mimic the Bmp receptor type1a (Bmpr1a) null mutant.

284 ling for BMP-4 and -7 in the theca cells and BMP receptor types IA, IB, and II in the granulosa cells

285 to suggest that SMOC acts downstream of the BMP receptor via MAPK-mediated phosphorylation of the Sm

286 2, alk3, and alk6 and inhibition of a single BMP receptor was not sufficient to decrease signaling.

287 mRNA for the type II BMP receptor was observed in freshly isolated and cultur

288 The expression of both type I BMP receptors was inhibited by exogenous TGF-beta1.

289 The effect of IL-1beta on BMP receptors was studied by reverse transcription-polym

290 m injection of noggin or a dominant negative BMP receptor, was transplanted into the non-neural ectod

291 the functional redundancies among the Type I BMP receptors, we applied dominant-negative (dn) BMPR-1B

292 ring RNAs to inhibit the expression of other BMP receptors, we found that wild-type cells transduce B

293 Finally, expression of a dominant-negative BMP receptor (which induces a P-to-O fate change in the

294 bb) in muscle, and alternatively the type II BMP receptor Wishful Thinking (Wit) in the motoneuron.

295 Here, we demonstrate that the BMP receptor Wishful Thinking (Wit) is required for syna

296 Furthermore, we demonstrate that presynaptic BMP receptor wishful thinking is required for the retrog

297 Here, we demonstrate that the BMP receptor (Wit) and ligand (Gbb) are necessary for th

298 ion of cells with BMPR1A and ligation of the BMP receptor with BMP-2 also activated GTP-Rho A of thes

299 neous misexpression of constitutively active BMP receptors with Smad7 suppresses the Smad7-induced ph

300 The distribution of BMP receptors within large neurons in adult dorsal root