ライフサイエンスコーパス: BMP type I receptor

1 y canonical Smad dependent signaling through BMP Type I receptor.

2 inhibited with selective antagonists of the BMP type I receptors.

3 s Smad1 phosphorylation independently of the BMP type I receptors.

4 n mutation, C118W, is able to associate with BMP type I receptors.

5 e domain-binding protein that prevents leaky BMP type I receptor activation in the absence of ligand.

6 to proteasome for degradation in response to BMP type I receptor activation.

7 We therefore assessed the role of BMP Type I receptor AcvR1 in anterior second heart field

8 This study tests the role of the BMP type I receptor ACVRI in establishing left-right asy

9 nhibitors of BMP signaling by binding to the BMP type I receptors ALK1/2/3/6.

10 ollectively, these results indicate that the BMP type I receptor ALK2 in endothelial cells plays a cr

11 Instead, we determine that the BMP type I receptor ALK2 is a novel target of miR-130a a

12 ACVR1, encoding bone morphogenetic protein (BMP) type I receptor ALK2, which lead to inappropriate s

13 The bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 play key, nonredunda

14 While HJV can use all 3 BMP type I receptors (ALK2, ALK3, and ALK6) in vitro, on

15 Two BMP type I receptors, Alk2 (Acvr1) and Alk3 (Bmpr1a), ar

16 We found that BMP type I receptor Alk3 is expressed predominantly in a

17 erum iron concentrations is dependent on the BMP type I receptor Alk3.

18 ntiation and proliferation by activating the BMP type-I receptor ALK3 in the absence of canonical TGF

19 PV(+) interneurons in the cortex express BMP type I receptors and a subpopulation displays activa

20 d to human Fc (RGMa.Fc) forms a complex with BMP type I receptors and binds directly and selectively

21 SANE binds to Smad1/5 and to BMP type I receptors and regulates BMP signaling.

22 overexpression of bmp4, bmp2b, an activated BMP type I receptor, and the downstream functioning Smad

23 sequence of the bone morphogenetic protein (BMP) type I receptor (BMPR-I) specifies Smad1 interactio

24 recruitment of type II receptor subunits to BMP-type I receptor complexes.

25 The formation of follistatin:BMP:type I receptor complexes can be explained by the st

26 Pharmacologic blockade of BMP type I receptor function within 24 h after BMP stimu

27 Disruption of a Bmp type I receptor gene, Bmpr1a, leads to no detectable

28 y by removing one functional copy of another Bmp type I receptor gene, Bmpr1b, in the retina-specific

29 re, we show that conditional inactivation of BMP type I receptor genes Bmpr1a and Bmpr1b (Bmpr1a;b) i

30 examined mice with targeted mutations in the BMP type I receptor genes Bmpr1a and Bmpr1b, to genetica

31 r stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiqui

32 se residues are phosphorylated directly by a BMP type I receptor in vitro.

33 Conditional mutation of BMP type I receptors in interneuron precursors significa

34 ne-serine (GS) activation domain of ACVR1, a BMP type I receptor, in all affected individuals examine

35 ion of the activin receptor-like kinase 1, a BMP type I receptor, in cerebrovascular endothelium.

36 Fibrinogen effects are rescued by BMP type I receptor inhibition using dorsomorphin homolo

37 red new protein synthesis and was blocked by BMP type I receptor inhibition.

38 ional Bmpr1a mutation nor treatment with the BMP type I receptor inhibitor dorsomorphin expands scler

39 ffect that was inhibited by treatment with a BMP type I receptor inhibitor, LDN-193189, or BMP ligand

40 Addition of dorsomorphin, a Bmp type I receptor inhibitor, prolonged spermatogonial

41 Furthermore, truncated, dominant-negative, BMP type I receptor, introduced into neocortical precurs

42 BMPR1B, another BMP type I receptor, is also capable of binding to BMP l

43 y activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2.

44 ith LDN193189, a small-molecule inhibitor of BMP type I receptor kinases, represses clonogenicity and

45 ng, and that the small-molecule inhibitor of BMP type I receptors, LDN193189, was able to replace Nog

46 Constitutively active BMP type I receptor or the downstream pathway components

47 Selective antagonists of the BMP type I receptors represents a potential means to pha

48 ted by two Bmp ligands, Gbb and Dpp, and two Bmp type I receptors, Sax and Tkv.

49 tracellular domain of Caenorhabditis elegans BMP type I receptor SMA-6 (small-6) binds to the retrome

50 y of Alk2 or Alk3, we sought to identify the BMP type I receptor that participates in IL-6-mediated i

51 and Gbb, Sax exhibits a novel function for a Bmp type I receptor: the ability to both promote and ant

52 roles of patterning and morphogenesis by the BMP type I receptor thickveins (tkv) have been studied e

53 vertebrates and interacts with BMPs and the BMP type I receptor to promote receptor-ligand interacti

54 FKBP12 interacts with BMP type I receptors to avoid uncontrolled signaling.

55 ing constitutively activated versions of the BMP type I receptors, we find that the BMP receptors act

56 betaRIII also enhances ligand binding to the BMP type I receptors, whereas short hairpin RNA-mediated

57 BMP receptor antagonists and silencing of BMP type I receptors with siRNA induced cell death, inhi