ライフサイエンスコーパス: BMP-6

1 kinase-2 are necessary for IL-6 induction by BMP-6.

2 ing ability to a level comparable to that of BMP-6.

3 and a hypertrophic phenotype in response to BMP-6.

4 ed by both the BMP inhibitor noggin and anti-BMP-6.

5 cancer produces a variety of BMPs, including BMP-6.

6 mRNA levels of FGF-2, TGFbeta-1, BMP-2, and BMP-6.

7 Using BMP-6/7 chimeras, we identified lysine 60 as a key resid

8 eas ACVR2A was more critical to signaling by BMP-6/7 than BMP-2/4.

9 Signaling by both BMP-2/4 and BMP-6/7 was mediated by homodimers of ACVR1A or BMPR1A.

10 n BMPR2 was observed for BMP-2/4 relative to BMP-6/7, whereas ACVR2A was more critical to signaling b

11 uggest different mechanisms for BMP-2/4- and BMP-6/7-induced osteoblastic differentiation in primary

12 n differed significantly between BMP-2/4 and BMP-6/7.

13 ACVR1A was the preferred type I receptor for BMP-6/7.

14 ta (TGF-beta), bone morphogenetic protein-6 (BMP-6) activates macrophages.

15 This BMP-6 activity resembles BMP-15 but differs from GDF-9 a

16 BMP-6 also decreased FSH- and forskolin-stimulated cAMP

17 BMP-6 also exhibited similar action to BMP-15 by attenua

18 ancer promotes osteoblastic activity through BMP-6 and that, in addition to its bone effects, suggest

19 owth factor 1, bone morphogenetic protein 6 (BMP-6), and dexamethasone, in various combinations, on t

20 We found that BMP-2, BMP-4, BMP-6, and BMP-7 had no direct effect on prostate cancer

21 aluate receptor utilization by BMP-2, BMP-4, BMP-6, and BMP-7 in primary human mesenchymal stem cells

22 bited the TGF-beta family ligands Activin B, BMP-6, and BMP-7, but not the frog Cerberus ligand BMP-2

23 We have found that BMP-2, BMP-6, and BMP-9 induce the most potent osteogenic diffe

24 ion of Smad1/5, mRNA synthesis for BMP-2 and BMP-6, and cell growth in MCF10AT1 cells.

25 BMP-4, BMP-6, and TGF-beta1 increased noggin mRNA in Ob cells,

26 , and phosphorylation was diminished by anti-BMP-6 antibody.

27 resent study, we show that BMP-2, BMP-4, and BMP-6 are endogenous ligands for HJV in hepatoma-derived

28 9), bone morphogenetic protein (BMP)-15, and BMP-6 are oocyte-derived members of the transforming gro

29 l metastases; differential expression favors BMP-6 as a potential new marker and mediator of osteoscl

30 of basal cell hyperplasia were positive for BMP-6 by immunohistochemistry.

31 ntagonist, was significantly up-regulated by BMP-6 by microarray analysis and was confirmed by quanti

32 e may be mediated by increased production of BMP-6 by osteoblasts.

33 We tested the hypothesis that BMP-6 contributes to prostate cancer-induced osteosclero

34 ctive morphogens, and elevated expression of BMP-6 correlates with skeletal metastases of prostate ca

35 As assumed, BMP-6 did not alter basal FSH-R mRNA levels, whereas it

36 results suggest a close association between BMP-6 expression in primary malignant prostatic tissue a

37 tor alpha and bone morphogenetic protein-6B (BMP-6) genes are specifically repressed by Tel-2 indicat

38 phogenetic protein-7 (BMP-7) and its related BMP-6 have recently emerged as key regulators of kidney

39 an RCC specimens, the three-marker signature BMP-6/IL-10/CD68 was associated with a poor prognosis.

40 irst insight into the biological function of BMP-6 in the ovary and demonstrate its unique mechanism

41 ng is known about the biological function of BMP-6 in the ovary.

42 n prostate cancer cell growth, but BMP-2 and BMP-6 increased the in vitro invasive ability of prostat

43 oteins blocked Wnt-3A-induced ALP as well as BMP-6-induced ALP activity.

44 negative feedback regulator of BMP-7 but not BMP-6-induced biological responses.

45 Here, we report that BMP-6 induces the expression of IL-6 in macrophages.

46 However, unlike BMP-15, BMP-6 inhibited forskolin- but not 8-bromo-cAMP-induced

47 sting that the underlying mechanism by which BMP-6 inhibits FSH action most likely involves the down-

48 These findings suggest that BMP-6 is a potent inducer of chondrogenesis in ADAS cell

49 Here we show that BMP-6 is more resistant to noggin inhibition and more po

50 Here we show that, unlike BMP-15 and GDF-9, BMP-6 lacks mitogenic activity on rat granulosa cells (G

51 press type I and II BMP receptors, BMP-2 and BMP-6 ligands, and phosphorylated isoforms of Smad-1/-5/

52 Together, our results suggest that BMP-6/macrophage/IL-10 regulates M2 polarization of TAMs

53 BMP-6 may be responsible, in part, for the osteoblastic

54 Combinations of growth factors containing BMP-6 may provide a novel means of regulating the differ

55 BMP-6-mediated IL-10 expression in macrophages required

56 We investigated BMP-6 mRNA and protein expression by in situ hybridizati

57 - 10(-)7 M) increased steady-state levels of BMP-6 mRNA dose dependently by twofold in the hFOB/ER3 c

58 e compounds increased BMP-2 but not BMP-4 or BMP-6 mRNA expression in osteoblastic cells, suggesting

59 BMP-6 mRNA expression was detected exclusively in malign

60 present the crystal structures of BMP-3 and BMP-6, of which BMP-3 has remained poorly understood wit

61 Anti-BMP-6 or isotype antibody administration was then initia

62 significantly up-regulated genes upon BMP-2, BMP-6, or BMP-9 stimulation.

63 Herein, we report that BMP-6 promotes the growth of RCC by interleukin (IL)-10-

64 17beta-estradiol increased BMP-6 protein production sixfold by Western analysis.

65 idue conferring noggin resistance within the BMP-6 protein.

66 we show that in C3H10T1/2 cells, Wnt-3A and BMP-6 proteins were inducers of osteoblast differentiati

67 addition to decreased bone production, anti-BMP-6 reduced intraosseous, but not s.c., tumor size.

68 Anti-BMP-6 reduced LuCaP 23.1-induced osteoblastic activity,

69 results, taken together, demonstrate a novel BMP-6 signaling mechanism in which both the Smad and non

70 2 (BMPR2) knockdown in HepG2 cells increased BMP-6-stimulated hepcidin expression.

71 ogenetic protein (BMP) receptor knockdown on BMP-6-stimulated hepcidin production was assessed in hum

72 Recombinant noggin inhibited the function of BMP-6, suggesting a negative feedback regulation of BMP

73 not only the first identification of GCs as BMP-6 targets in the ovary but also its selective modula

74 e cancer cells and clinical tissues produced BMP-6 that increased with aggressiveness of the tumor.

75 Addition of exogenous BMP-6 to DU-145 prostate cancer cell cultures inhibited

76 f bone morphogenetic protein (BMP)-2, BMP-4, BMP-6, transforming growth factor (TGF) beta 1, TGF-beta

77 Most notably, BMP-6 up-regulated AGC1 and COL2A1 expression by an aver

78 Immunostaining for BMP-6 was predominantly cytoplasmic and was present in a

79 ), bone morphogenetic protein-2 (BMP-2), and BMP-6 were measured by real-time RT-PCR, and histologica

80 region on chromosome 6 contains the gene for BMP-6, which is expressed in vascular calcific lesions.