ライフサイエンスコーパス: BMP

1 BMP induces ventral fates, whereas Chordin inhibits BMP

2 BMP lipids have been previously associated with the endo

3 BMP signaling is required in at least three points in DH

4 BMP-9 was associated negatively with Waist hip ratio (WH

5 s that secrete the axon guidance cue UNC-129/BMP, and our data revealed that ncx-9(-/-) mutant animal

6 very of active bone morphogenetic protein-2 (BMP-2) protein to responsive target cells, such as bone

7 -2 (FGF-2) and bone morphogenetic protein-2 (BMP-2) work synergistically to encourage osteogenesis in

8 present study, bone morphogenetic protein-2/BMP-2-directed osteogenic differentiation of bone marrow

9 eptide (PDGFRb), bone morphogenic protein 4 (BMP-4), and stem cell factor (SCF) constituted a common

10 ine circulating Bone morphogenetic protein-9(BMP-9) levels in subjects with Metabolic Syndrome (MetS)

11 d type C domain of Crossveinless 2 (CV-2), a BMP antagonist and member of the chordin family.

12 we identified for the first time TSP-1 as a BMP-2/-4 antagonist and presented a structural basis for

13 Our analysis ruled out a BMP shuttling mechanism and a bmp transcriptionally-info

14 bryonic cells (C3H10T1/2) transfected with a BMP-responsive element, we sought to determine whether p

15 on, enabling the maturation of HSCs within a BMP-negative environment.

16 e cells and show that endogenously activated BMP-SMAD signalling is required for the amnion-like tiss

17 nvestigate the requirement and timing of all BMP signaling in HSC ontogeny, we have used a transgenic

18 r the physical interaction between TSP-1 and BMP-4.

19 ors to target specific genes in TGF-beta and BMP pathways.

20 G) as the binding site for both TGF-beta and BMP-activated Smads and for Smad4.

21 modulate the Wnt/beta-catenin, TGF-beta, and BMP pathways.

22 In addition, TGF-beta1 and BMP-2 antagonized tumor necrosis factor alpha-induced IL

23 This work identifies TGF-beta1 and BMP-2 as potent inhibitors of IL-34 expression in RA syn

24 TGF-beta1 and BMP-2 decreased IL-34 expression in the synovial fibrobl

25 e 1 (ALK1) and ALK5 downstream TGF-beta1 and BMP-2.

26 IL-34, TGF-beta1, and BMP-2 productions were measured in patient synovial flui

27 IL-34, TGF-beta1, and BMP-2 were expressed in synovial fluids from RA patients

28 The Drosophila egg chamber, where EGF and BMP signaling intersect to specify unique cell types tha

29 cells and cardiomyocytes possibly by FGF and BMP signaling, respectively.

30 s identified a fundamental role for GDF6 and BMP signaling in governing an embryonic cell gene signat

31 on in MSCs, and the involvement of Notch and BMP signaling.

32 th a synergy between interleukin 6/STAT3 and BMP/SMAD signaling in regulating hepcidin during inflamm

33 ss-pathway inhibition in between TGFbeta and BMP, despite the fact that both use (or could compete) f

34 he roles of TGFbeta receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cance

35 observed in the complex between CV-2 vWC and BMP-2, revealing an alternative mode of interaction betw

36 action only between the collagen IIa vWC and BMP-2.

37 e complex of crossveinless-2 (CV-2) vWC1 and BMP-2 previously revealed one mode of the vWC/BMP-bindin

38 ointestinal organogenesis and of how Wnt and BMP might coordinate genomic responses in other contexts

39 Modulation of Wnt and BMP signaling directed iPSC differentiation into Mulleri

40 Combinatorial Wnt and BMP signaling was mediated by Smad1 and beta-catenin co-

41 xtraembryonic border, in response to Wnt and BMP signaling.

42 n of SOX17 and BLIMP1 in response to WNT and BMP signalling.

43 The inductive roles of FGF, Wnt, and BMP at the neural plate border are well established, but

44 mode of interaction between vWC domains and BMPs.

45 th factors and cytokines including RANKL and BMPs, in osteoclastogenesis and bone resorption by ablat

46 Furthermore, we observe asymmetric BMP-SMAD signaling concurrent with PASE development, and

47 In addition, inhibition of TGF-beta, BMP, or Wnt pathways does not impede reactionary dentine

48 to loss-of-function mutation of the TGF-beta/BMP receptor complex and the second to increased signali

49 ions are related to deregulation of TGF-beta/BMP signaling.

50 that are induced by deregulation of TGF-beta/BMP signaling: hereditary hemorrhagic telangiectasia (HH

51 increased signaling sensitivity to TGF-beta/BMP.

52 hibited changes in genes regulating TGF-beta/BMP/FGF signaling, as well as in genes controlling ECM s

53 (MetS) and examine the relationship between BMP-9 and conventional markers for MetS and insulin resi

54 firmed that recombinant human TSP-1 can bind BMP-2 and -4 and antagonize their effects on C3H10T1/2 c

55 nd ALK3) and two type II (ActRIIA and BMPR2) BMP receptors.

56 Mechanistically, T63 activated both BMPs and WNT/beta-catenin signaling pathways.

57 MP production in enterocytes is inhibited by BMP signaling itself, and that BMP autoinhibition is req

58 cription factors activated by TGF-beta or by BMP receptors form trimeric complexes with Smad4 to targ

59 ation marker of odontoblasts is regulated by BMP-2.

60 Fibrinogen effects are rescued by BMP type I receptor inhibition using dorsomorphin homolo

61 Circulating BMP-9 levels were associated with the key components of

62 Circulating BMP-9 levels were measured by ELISA.

63 Circulating BMP-9 levels were significantly lower in MetS patients c

64 In addition, circulating BMP-9 levels reduced progressively with an increasing nu

65 The best cutoff values for circulating BMP-9 to predict MetS was 56.6 ng/L.

66 s uterine receptivity by preserving critical BMP signaling.

67 rove clinical efficacy and safety of current BMP therapeutics.

68 herapeutic depletion of fibrinogen decreases BMP signaling and enhances remyelination in vivo.

69 tes depressive behavior, and that decreasing BMP signaling may be required for the effects of some an

70 ial therapeutic target to increase defective BMP signaling in disorders of low hepcidin.

71 e with butylmethylpyrrolidinium-dicyanamide (BMP-DCA) IL shows high sensitivity toward ascorbic acid

72 ignaling and principally induced a different BMP ligand.

73 Targeting fibrinogen or its downstream BMP signaling pathway may help with CNS repair.

74 st distribution acting as a sink that drives BMP flux dorsally and gradient formation.

75 cell and nTB implants, but not in dTB or dTB-BMP implants.

76 with bone morphogenetic protein (BMP)-2 (dTB-BMPs); and 4) freshly isolated nondecellularized natural

77 Our study suggests that dynamic BMP signaling controls ISC population size during midgut

78 zed two kinds of plasmid DNA encoding either BMP-2 or FGF-2 formulated into polyethylenimine (PEI) co

79 ndothelial cells failed to align when either BMPs were inhibited or SMAD4 was depleted.

80 of endosomal compartments leads to elevated BMP signaling within nerve terminals, driving excessive

81 ding sequence near the gremlin 1, DAN family BMP antagonist gene (GREM1) originally described in Ashk

82 By precisely varying FGF, BMP, WNT, and TGFbeta pathway activity in a minimal, che

83 xperimental evidence for a specific role for BMP signaling during endomesoderm specification in the e

84 ht on this problem by identifying a role for BMP signaling in development of the cerebral venous syst

85 attering (SRS) microscopy, define a role for BMP signaling in lipid metabolism in C. elegans.

86 s, leading to the discovery of new roles for BMP signaling in linking mitochondrial homeostasis and l

87 sitol 3-kinase/Akt, and Ca(2+) signaling for BMP-2-induced NFATc1 expression through an autoregulator

88 The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of

89 ing a potential endocrine/paracrine role for BMPs, but some of the mechanisms are unclear.

90 lture, compared to the GFP group, cells from BMP group showed >1,000-fold higher BMP-2 release, and t

91 ceptors, DMH1, and described the inputs from BMP signaling into the DH GRN and the HE, as well as int

92 -2 and green fluorescent protein (GFP) gene (BMP group); or (2) Lv-GFP, containing GFP gene (GFP grou

93 t not for patients whose tumors did not have BMP signaling (adjusted RR, 0.81; 95% CI, 0.55-1.21; P =

94 d for quantitative analysis of mouse hepatic BMP and PG species and their changes induced by long-ter

95 e display a dramatic accumulation of hepatic BMP compared to chow-fed littermates.

96 lls from BMP group showed >1,000-fold higher BMP-2 release, and the majority of them stained intensel

97 studies validated the important role of HJV-BMP interaction for Hjv stimulation of BMP signaling and

98 uring root development and shed light on how BMP signaling can achieve functional specificity in regu

99 However, BMP/Smad signaling in unchallenged animals is determinan

100 and cellular differentiation, including HOX, BMP and WNT.

101 onstructs - (1) Lv-BMP/GFP, containing human BMP-2 and green fluorescent protein (GFP) gene (BMP grou

102 nic pain, these findings indicate that human BMP pathway components may represent targets for novel p

103 tion by their activation of different type I BMP receptors and distinct modulations of the cell cycle

104 In this report, we investigated if BMP-2 and FGF-2 together can synergistically promote bon

105 that are involved in WNT, HGF, TGFbeta, IGF, BMP, FGF and estrogen signaling.

106 Using siRNAs to type I and II BMP receptors and the signaling intermediaries (Smads),

107 conditional genetic deletion of the type II BMP receptor in Ascl1-expressing cells promoted neurogen

108 lidinium-bis(trifluoromethanesulfonyl)imide (BMP-TFSI) IL is beneficial for glucose detection, wherea

109 olidinium bis(trifluoromethylsulfonyl)imide (BMP TFSI) and dimethylformamide.

110 epressant treatment, and that the changes in BMP signaling mediate effects of antidepressant treatmen

111 modulated by a Chordin-mediated increase in BMP diffusivity have gained recent prominence.

112 al knockdown of Zeb2 leads to an increase in BMP-Smad-dependent axon growth.

113 trols multiple molecular pathways, including BMP and Sema3 signaling, in palate development.

114 Increasing BMP signaling in the hippocampus via viral overexpressio

115 Individual BMPs promote progenitor patterning or neuronal different

116 GDF6-induced BMP signaling maintained a trunk neural crest gene signa

117 Conversely, inhibiting BMP signaling via viral overexpression of noggin in the

118 uces ventral fates, whereas Chordin inhibits BMP signaling on the dorsal side.

119 cancer for patients whose tumors had intact BMP signaling (adjusted RR, 0.39; 95% CI, 0.22-0.68; P =

120 Tumor tissues were considered to have intact BMP signaling if they contained SMAD4 plus BMPR1A, BMPR1

121 reater for patients whose tumors have intact BMP signaling, independent of KRAS mutation status.

122 y from that in CV-2 vWC, which comprises its BMP-2-binding site.

123 truncated or deglycosylated Cripto-1 lacked BMP-4 binding activity.

124 ical analyses, we identified a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression directly

125 e mechanical properties to promote localized BMP-2 signaling.

126 s prepattern's condition of high FGF and low BMP activity across the entire skin reveals a latent der

127 udy, two lentiviral gene constructs - (1) Lv-BMP/GFP, containing human BMP-2 and green fluorescent pr

128 Our studies support an alternative model: BMPs have signal-specific activities directing particula

129 mp1 gene, which encodes variants of the mTLD/BMP-1 metalloproteases, as a critical regulator of alpha

130 h reduced laminin-gamma2 processing via mTLD/BMP-1.

131 the developing dorsal spinal cord, multiple BMPs are required to specify sensory interneurons (INs).

132 However, it remains unresolved how multiple BMPs would cooperate to establish a unified morphogen gr

133 verses disease progression, restoring normal BMP/NOTCH signalling.

134 um contains a factor that inhibits action of BMP-2 and -4.

135 bition of TGFbeta and CXCR7 or activation of BMP and CXCR4 signalling enhanced generation of rEC-HSCs

136 Brief activation of BMP signaling is sufficient to activate a posterior HOX

137 novel strategy for quantitative analysis of BMP and PG species was developed after one-step methylat

138 s study shows that a 'mix and match' code of BMP signaling results in distinct classes of sensory INs

139 BMPER contributes to the precise control of BMP activity within the AGM region, enabling the maturat

140 heories can explain how the distributions of BMP and Chordin are regulated to achieve patterning, but

141 Spatiotemporally regulated domains of BMP, FGF, and other signaling molecules in late gastrula

142 her Olig1 function is required downstream of BMP antagonism for response to injury in the neonatal br

143 Klf4, Satb2 and Lhx8 as being downstream of BMP signaling and expressed in a spatially restricted pa

144 ese data show a role of NFATc1 downstream of BMP-2 in mouse bone development and provide novel eviden

145 rogenitor cells contribute to the effects of BMP signaling on affective behavior.

146 The effects of BMP signaling were shown to be largely specific to the s

147 t formation is through a counter-gradient of BMP antagonists, often along with ligand shuttling to ge

148 In spiders, a group of BMP secreting mesenchymal cells (the cumulus) functions

149 n a manner consistent with the inhibition of BMP signaling.

150 , Noggin, as well as a chemical inhibitor of BMP receptors, DMH1, and described the inputs from BMP s

151 e, which inducibly expresses an inhibitor of BMP signaling, Noggin, as well as a chemical inhibitor o

152 is not required to establish peak levels of BMP signaling.

153 eased or decreased directly by modulation of BMP activity in the small intestine.

154 In summary, we reveal that persistence of BMP alterations and existence of an autocrine loop promo

155 e explored the physiological presentation of BMP-2 by using a biomaterial that harbors tunable mechan

156 Furthermore, alternative processing of BMP proproteins produces ligands that signal through dif

157 t in ECs both Hh and Yki limit production of BMP ligands to allow germline differentiation.

158 pentagone (pent), is expanding the range of BMP signaling during wing patterning.

159 finity to BMP2 and could expand the range of BMP signaling in an in vitro assay by competition for HS

160 Regulation of BMP signaling involves binding to a variety of extracell

161 of the inactive state through regulation of BMP/TGF-beta signaling.

162 eso-endoderm fate, owing to de-repression of BMP signalling.

163 facilitate our understanding of the role of BMP in biological systems.

164 s demonstrate the functional significance of BMP signaling in regulating MSC fate during root develop

165 f HJV-BMP interaction for Hjv stimulation of BMP signaling and hepcidin expression.

166 sition and servers as a downstream target of BMP signaling, was significantly induced by OA.

167 that TSP-1 could regulate bioavailability of BMPs, either produced locally or reaching the pituitary

168 tion, although inhibition of TGF-beta and/or BMP signaling does result in more disorganized, nontubul

169 mine whether pituitary cells secrete BMPs or BMP antagonists.

170 Release of latent TGF-beta or BMPs from dentine is not required for the deposition of

171 from primary or secondary loss of paracrine BMP signaling from preosteoblasts and dura, highlighting

172 metabolism of bis(monoacylglycero)phosphate (BMP), an important but low-abundance class of phospholip

173 ipid class, bis(monoacylgylercoro)phosphate (BMP) lipids, and to distinguish them from isobaric speci

174 In the adult pituitary, BMPs participate in the control of hormone secretion and

175 inary logistic regression showed that plasma BMP-9 concentrations were significantly associated with

176 lastoma (DAN), a bone morphogenetic protein (BMP) antagonist we detected by analysis of the chick cra

177 The Bone Morphogenetic Protein (BMP) family reiteratively signals to direct disparate ce

178 roduction of two bone morphogenetic protein (BMP) ligands, Dpp and Gbb, which drive an expansion of i

179 egulation of the bone morphogenetic protein (BMP) pathway is involved in LSC and progenitor expansion

180 actor (TGF)-beta/bone morphogenetic protein (BMP) pathway, which is one of the most important and com

181 ta (TGFbeta) and bone morphogenetic protein (BMP) pathways.

182 and the TGF-beta bone morphogenetic protein (BMP) provide critical molecular signaling inputs during

183 which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcri

184 at SMOC inhibits bone morphogenetic protein (BMP) signaling downstream of its receptor via activation

185 re, we show that bone morphogenetic protein (BMP) signaling is essential for the initiation of this G

186 that hippocampal bone morphogenetic protein (BMP) signaling is modulated by antidepressant treatment,

187 The bone morphogenetic protein (BMP) signaling pathway comprises multiple ligands and re

188 lso activate the bone morphogenetic protein (BMP) signaling pathway in colorectal cancer cells.

189 en activates the bone morphogenetic protein (BMP) signaling pathway in oligodendrocyte progenitor cel

190 induced via the bone morphogenetic protein (BMP) signaling pathway that preferentially uses two type

191 a member of the Bone Morphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp), specifica

192 omponents of the Bone Morphogenetic Protein (BMP) signaling pathway, revealing that BMP signaling ina

193 ogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis

194 of TGF-beta and bone morphogenetic protein (BMP) signaling proteins has numerous developmental and p

195 h antagonists of bone morphogenetic protein (BMP) signaling, such as Noggin, promote oligodendrocyte

196 while enhancing bone morphogenetic protein (BMP) signaling.

197 site (WNT), and bone morphogenetic protein (BMP) signalling interactions capable of spontaneously pr

198 p-regulated, and bone morphogenetic protein (BMP) signals are impaired.

199 are (TGFbeta and bone morphogenetic protein (BMP)) core signaling components.

200 ling of the Wnt, bone morphogenetic protein (BMP), or Ras/ERK pathways, converging on shared nuclear

201 dTBs seeded with bone morphogenetic protein (BMP)-2 (dTB-BMPs); and 4) freshly isolated nondecellular

202 y, TGF-beta1 and bone morphogenetic protein (BMP)-2, in synovial fibroblasts from RA patients.

203 The bone morphogenetic protein (BMP)-SMAD signaling pathway has a central role in hepcid

204 of the parallel bone morphogenetic protein (BMP)/Smad1/5 axis (recently identified as a positive reg

205 in expression of bone morphogenetic protein (BMP)/sons of mothers against decapentaplegic (SMAD) path

206 e members of the bone morphogenetic protein (BMP)/TGF-beta pathway.

207 eta [TGF-beta] and bone morphogenic protein [BMP]) in the dentine that are believed to stimulate odon

208 Bone morphogenetic proteins (BMPs) are secreted growth factors that promote different

209 Bone morphogenetic proteins (BMPs) regulate diverse cellular responses during embryog

210 involving Wnt, bone morphogenetic proteins (BMPs), Notch, and Hedgehog (Hh).

211 ts that produce bone morphogenetic proteins (BMPs).

212 eptors from signaling endosomes or to reduce BMP signaling reduce pathology in this HD model.

213 berrant signaling from endosomes or reducing BMP activity ameliorates the severity of HD pathology an

214 In a multiple linear regression, BMP-9 was independently associated with type 2 diabetes

215 a crosstalk whereby Wnt negatively regulates BMP ligand expression in the foregut.

216 sink mechanism, which relies on a restricted BMP antagonist distribution acting as a sink that drives

217 The same BMP lipids were also detected in the RPE of healthy huma

218 to determine whether pituitary cells secrete BMPs or BMP antagonists.

219 oreover, TSP-1 inhibited the action of serum BMPs.

220 k model, suggesting a new mechanism to shape BMP gradients during development.

221 onical Wnt/planar cell polarity pathway, Shh/BMP signalling, and the transcription factors Grhl2/3, P

222 Together these data show BMP-dependent patterning of human hindgut into HCOs, whi

223 n Gbb produces Gbb15, the conventional small BMP ligand, whereas NS site cleavage produces a larger G

224 ralisation beyond the current gold-standard, BMP-2.

225 pha-mediated suppression of BMPR-II subverts BMP signalling, leading to BMP6-mediated PASMC prolifera

226 nin reuptake inhibitor fluoxetine suppressed BMP signaling in the adult mouse hippocampus both by dec

227 dimensional culture system, we modulate TGF, BMP, FGF, and WNT signaling to generate multiple otic-ve

228 se analyses reveal the complexity of TGFbeta-BMP signaling and illuminate potential therapeutic targe

229 ts important in organogenesis (Wnt, TGFbeta/ BMP, FGF, Notch, SHH, Erbb) were differentially expresse

230 inhibited by BMP signaling itself, and that BMP autoinhibition is required for resetting ISC pool si

231 Our findings demonstrate that BMP prodomain cleavage ensures that the mature ligand is

232 nt with PASE development, and establish that BMP-SMAD activation/inhibition modulates stable PASE dev

233 ults provide the first in vivo evidence that BMP signaling activity is required for the odontogenic d

234 We find that BMP production in enterocytes is inhibited by BMP signal

235 We found that BMP signaling is required to establish a posterior SATB2

236 In the present investigation, we found that BMP-2 stimulated expression and nuclear translocation of

237 We hypothesized that BMP-2 regulation of Dspp transcription was mediated by D

238 These observations indicate that BMP signaling in the hippocampus regulates depressive be

239 ngs are consistent with the observation that BMP receptor hyperactivation correlates with bone abnorm

240 Here, we report that BMP pathway alterations persist in TKI-resistant patient

241 tein (BMP) signaling pathway, revealing that BMP signaling inactivation causes exhaustion of lipid re

242 Here, we show that BMP signaling plays a critical role in looping morphogen

243 Using RNA-seq and ChIP-seq we show that BMP/Smad1 regulates dorsal-ventral gene expression in bo

244 in the regulation of cell migration and the BMP and TGFbeta signaling pathways.

245 Additionally, we observed that Olig1 and the BMP signaling effector, phosphorylated SMADs (Sma- and M

246 Fibrinogen and the BMP target Id2 are increased in demyelinated multiple sc

247 Because the BMP family is so strongly conserved between vertebrates

248 nt of ECM accumulation was unaffected by the BMP antagonist Gremlin-1 but a pronounced effect on matr

249 ron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation an

250 rsal-ventral patterning is controlled by the BMP/Chordin activator/inhibitor system.

251 factor 6 (GDF6), which is the ligand for the BMP family, is recurrently amplified and transcriptional

252 as a model with which to investigate how the BMP signaling pathway regulates transcriptional complexe

253 d zebra finch gut morphology to identify the BMP pathway as a promising candidate to regulate differe

254 wed detectable mineralized areas only in the BMP group, which was restricted within the scaffolds.

255 ion of osteogenesis marker genes only in the BMP group.

256 nsights into the involvement of TSP-1 in the BMP-2/-4 mechanisms of action.

257 ues among orthologous domains, we mapped the BMP-binding epitope on the subdomain 1 of the vWC domain

258 Overexpression of the BMP antagonist Noggin in hair follicles or deletion of t

259 Localization of the BMP co-receptor hemojuvelin was visualized by immunofluo

260 Dpp, a member of the BMP family, is a morphogen that specifies positional inf

261 BMP4 ligand and increasing production of the BMP inhibitor noggin.

262 that the identity, not concentration, of the BMP ligand directs distinct dorsal identities.

263 Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte forma

264 uced in levels of specific components of the BMP signaling pathway, were injured and then tested for

265 therefore investigated known agonists of the BMP/SMAD pathway and found that Bmp gene expression was

266 r bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a simi

267 were associated with changes in KRAS or the BMP signaling pathways.

268 sm in zebrafish, we precisely quantified the BMP activity gradient in wild-type and mutant embryos an

269 FKBP12 preferentially targets the BMP receptor ALK2.

270 Here, we show that the BMP pathway processes multi-ligand inputs using a specif

271 hesis and mobilization, we discover that the BMP signaling mutants have increased rates of lipid mobi

272 In conclusion, we present evidence that the BMP/SMAD signaling pathway is perturbed in malaria infec

273 ast, activin B, which can signal through the BMP/SMAD pathway and has been associated with increased

274 At the same time, the BMP signal transducers SMAD1/5/8 were activated in devel

275 Notably, 'shuttling' models in which the BMP distribution is modulated by a Chordin-mediated incr

276 Previous studies suggested that the BMPs act as concentration-dependent morphogens to direct

277 main of TSP-1 is likely responsible for this BMP-2/4-binding activity, an assertion based on sequence

278 sion in a ligand-independent manner, through BMP-SMAD signaling.

279 Thus BMP signaling is a new and powerful potential target for

280 ing mechanism, other vWC domains may bind to BMP differently.

281 ity of these vWC domains to directly bind to BMP-2 and detected an interaction only between the colla

282 mal identities and functions, in response to BMP signaling, required neoblasts.

283 Concomitantly, two BMP ligands activate their receptor, Thickveins, and the

284 The requirement of various BMP receptors and members of the SMAD signal transductio

285 y minimal signaling pathways (Wnt+BMP versus BMP+FGF) that regulate distinct lung- versus thyroid-lin

286 nd concurrently attenuated Runx2 and Osx via BMP-mediated SMAD1/5 phosphorylation.

287 MP-2 previously revealed one mode of the vWC/BMP-binding mechanism, other vWC domains may bind to BMP

288 the period of dopaminergic axon growth, when BMP pathway components are upregulated.

289 t/beta-catenin and Nodal signalling, whereas BMP signalling is dispensable.

290 these findings identify mechanisms by which BMP and TNFalpha signalling contribute to disease, and s

291 we found a novel signaling pathway in which BMP-2 activates Dspp gene transcription via Dlx3/Osx pat

292 We demonstrate that BMPER is associated with BMP signaling inhibition, but is transcriptionally induc

293 es for quantitatively controlling cells with BMP ligands.

294 ly by forming a plasma membrane complex with BMP receptors.

295 ins of two proteins thought to interact with BMP-2: collagen IIA and matricellular protein CCN3.

296 FKBP12 interacts with BMP type I receptors to avoid uncontrolled signaling.

297 Cripto-1 interacts with BMP-4 in addition to its known partner Nodal, whereas Cr

298 keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro.

299 tify the key minimal signaling pathways (Wnt+BMP versus BMP+FGF) that regulate distinct lung- versus

300 mutations in 12 negative regulators of Wnt, BMP, and Ras/ERK signaling (10.9-fold enrichment, P = 2.

301 gical manipulation, we demonstrate that Wnt, BMPs, Notch, and Hh signaling pathways are necessary for