ライフサイエンスコーパス: BRCA2 gene

1 s can occur through genetic reversion in the BRCA2 gene.

2 with protein truncating mutations within the BRCA2 gene.

3 genotyping 50 SNPs spanning 109.4 kb of the BRCA2 gene.

4 rca2-null mice carrying a human BAC with the BRCA2 gene.

5 due to mutations in either the BRCA1 or the BRCA2 gene.

6 ial breast cancers have mutations within the BRCA2 gene.

7 romosome 13 q12.3, in close proximity to the BRCA2 gene.

8 ole in the transcriptional regulation of the BRCA2 gene.

9 ibuted in part to inherited mutations in the BRCA2 gene.

10 by mutations in either the BRCA1 gene or the BRCA2 gene.

11 d to carry novel truncating mutations in the BRCA2 gene.

12 ng women who carry mutations in the BRCA1 or BRCA2 gene.

13 Here we describe the mouse Brca2 gene.

14 the inheritance of mutations in the BRCA1 or BRCA2 genes.

15 er is a result of a mutation in the BRCA1 or BRCA2 genes.

16 ely, in the p53, VHL, K-ras, APC, BRCA1, and BRCA2 genes.

17 ot be explained by mutations in the BRCA1 or BRCA2 genes.

18 o cancer unrelated to mutations within BRCA1/BRCA2 genes.

19 otentially harmful mutations in the BRCA1 or BRCA2 genes.

20 ng a 1-bp deletion at nucleotide 6174 of the BRCA2 gene (6174delT).

21 identify mutations anywhere in the BRCA1 and BRCA2 genes (7,461 analyses) or for three specific Ashke

22 Mutations within the high penetrance BRCA1/BRCA2 genes account for approximately 20% of familial br

23 erature review among women with the BRCA1 or BRCA2 gene and mortality rates were determined from Surv

24 -ABL1 and PML-RAR, mutations in BRCA1 and/or BRCA2 genes, and gene expression profiles identifying le

25 Carriers of mutations in the BRCA2 gene are at a highly elevated risk of breast and o

26 herited mutations in the recently discovered BRCA2 gene are believed to be responsible for a signific

27 Mutations in the BRCA2 gene are dominantly inherited but cause cancers wh

28 Mutations in the human BRCA2 gene are responsible for about 45% of hereditary e

29 People carrying a mutant BRCA2 gene are susceptible to breast, ovarian, pancreati

30 linically significant mutations of BRCA1 and BRCA2 genes are associated with increased susceptibility

31 Cells carrying mutated BRCA1 or BRCA2 genes are defective in DNA repair by homologous re

32 ponding increased transcription of XRCC1 and BRCA2 genes, both of which are required for repair of DN

33 The gene is organized similarly to the human BRCA2 gene, but is more compact and is localized to the

34 e second allele upon screening of the entire BRCA2 gene by in vitro synthesized protein assay.

35 Germline mutation of the BRCA2 gene carries a high risk of developing breast canc

36 Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset

37 eate a single missense mutation in the human BRCA2 gene cloned in a BAC without the use of any select

38 or three specific mutations in the BRCA1 and BRCA2 genes common among Ashkenazi Jews for the first oc

39 Mutations in the BRCA2 gene confer a high risk of breast cancer and are r

40 Inherited mutations of the human BRCA2 gene confer increased risks for developing breast,

41 Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer.

42 Germ-line mutations in the human BRCA2 gene confer susceptibility to breast cancer.

43 Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast can

44 Deleterious mutations of the BRCA1 and BRCA2 genes confer susceptibility to breast and ovarian

45 The BRCA1 and BRCA2 genes contain unusually high densities of repetiti

46 Mutant forms of the BRCA2 gene contribute significantly to hereditary breast

47 lines, V-C8 (BRCA2 deficient) and V-C8 with BRCA2 gene correction were used.

48 A networks are considered interconnected, as BRCA2 gene defects have been discovered in individuals w

49 The chicken BRCA2 gene encodes a protein of 3399 amino acids, which

50 The BRCA2 gene encodes a very large protein thought to play

51 Mutations of the human BRCA1 and BRCA2 genes encoding tumor suppressors have been implica

52 s significantly different for both BRCA1 and BRCA2 gene expression (P < 0.02 and P < 0.02, respective

53 conditions and kinetics of the induction of BRCA2 gene expression may implicate roles for the functi

54 ppears that SLUG is a negative regulator for BRCA2 gene expression.

55 y a germline mutation in either the BRCA1 or BRCA2 gene face a lifetime risk of breast cancer of up t

56 tability associated with brh2 means that the BRCA2 gene family is more widespread than previously tho

57 Mutations in the BRCA1 and BRCA2 genes give rise to a dramatically increased risk o

58 The BRCA2 gene has recently been identified.

59 The recent cloning of the human BRCA2 gene has revealed that it encodes a large protein

60 Heterozygous carriers of mutations in the BRCA2 gene have a high risk of developing breast and oth

61 Carriers of mutations in the BRCA2 gene have a high risk of developing breast and oth

62 Mutations of the BRCA2 gene have been extensively characterized and are p

63 Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-s

64 who carry deleterious mutations of BRCA1 or BRCA2 genes have up to a 54% lifetime risk of developing

65 a 1-megabase 13q12.3 locus, encompassing the BRCA2 gene, in 80% of 35 CLL cases studied.

66 Loss-of-function mutations in the BRCA1 and BRCA2 genes increase the risk of cancer.

67 s suggest that biallelic inactivation of the BRCA2 gene is a relatively late event in pancreatic tumo

68 The BRCA2 gene is involved in recombinational DNA repair and

69 The BRCA2 gene is mutated in familial breast and ovarian can

70 he embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified

71 To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an incre

72 s, suggesting that altered expression of the BRCA2 gene may contribute to breast tumorigenesis.

73 erlying genetic mutation (such as a BRCA1 or BRCA2 gene mutation or other familial breast cancer synd

74 Among women who test positive for a BRCA1 or BRCA2 gene mutation, prophylactic surgery at a young age

75 significant changes in women with BRCA1 and BRCA2 gene mutations when compared with control subjects

76 nhibitors in patients with germline BRCA1 or BRCA2 gene mutations, that this approach could be benefi

77 , and the inactivation of the p53, DPC4, and BRCA2 genes occur late in the neoplastic progression.

78 iated deletion of exons 3 and 4 of the mouse Brca2 gene occurring specifically in mammary epithelial

79 The penetrance of the BRCA2 gene on chromosome 13q12-13 has been estimated in

80 ers using markers spanning the region of the BRCA2 gene on chromosome 13ql2-ql3 suggest that only two

81 Germ line mutations in BRCA2 gene predispose women to early-onset familial brea

82 Mutations in the BRCA1 or BRCA2 genes predispose to a wide spectrum of familial ca

83 Germ-line mutations in the BRCA1 and BRCA2 genes predispose women to breast cancer.

84 Here we show that the BRCA2 gene product is a 460-kDa nuclear phosphoprotein,

85 ntify novel proteins that associate with the BRCA2 gene product, we found that a deubiquitinating enz

86 Functional analyses of the BRCA1 and BRCA2 gene products have established their dual particip

87 Recent studies suggest that the BRCA1 and BRCA2 gene products may function in the sensing and/or r

88 ing for inherited mutations in the BRCA1 and BRCA2 genes provides potentially valuable information to

89 alysis of the upstream sequence of the human BRCA2 gene revealed an E2-box-containing silencer at the

90 BRCA2 gene sequencing identified five mutations (5 of 29

91 er suggesting the involvement of SLUG in the BRCA2 gene silencing.

92 recommend in-person counseling before BRCA1/BRCA2 gene testing, genetic counseling is increasingly o

93 we have cloned and characterized the chicken BRCA2 gene, the first non-mammalian BRCA2 gene to be des

94 chicken BRCA2 gene, the first non-mammalian BRCA2 gene to be described.

95 The original localization of the BRCA2 gene was aided by its homozygous deletion in a pan

96 Recently, the human BRCA2 gene was cloned, and several germline mutations we

97 The BRCA2 gene was identified based on its involvement in fa

98 Mutation analysis in the BRCA1 and BRCA2 genes was also undertaken in all families.

99 In an effort to isolate the BRCA2 gene, we have cloned 73 non overlapping cDNAs from

100 R, IGFIIR, BAX, E2F4, MSH3, MSH6, BRCA1, and BRCA2 genes were generally rare.

101 genetic predisposition, the TP53, BRCA1, and BRCA2 genes were not frequently mutated in this cohort o

102 riants that have been described in the human BRCA2 gene which are of unknown significance in disease

103 Unlike other mutations in the Brca2 gene, which are lethal early in embryogenesis when

104 The BRCA2 gene, which is located on human chromosome 13, enc

105 Inherited mutations of the BRCA1 and BRCA2 genes, whose protein products are necessary for th

106 n who carry mutations in either the BRCA1 or BRCA2 gene will also experience reduced incidence of bre

107 lation of the normal and mutant forms of the BRCA2 gene with its natural promoter would greatly facil