ライフサイエンスコーパス: BSP

1 BSP contains numerous substituents which are anionic in

2 BSP expression in mineralized tissues is upregulated at

3 BSP is multifunctional, affecting cell attachment and si

4 BSP is present in cementum, the hard tissue covering the

5 BSP modulation of MMP-2 activity and inhibition may defi

6 BSP, OPN, and DMP1 were invariably co-expressed with the

7 BSP-GSH (2mM), which cis-inhibits sinusoidal GSH uptake

8 g precipitously with an increase in pH >6.0; BSP influx was independent of pH.

9 TGF-beta signaling protein-1 (BSP-1) is rapidly phosphorylated in response to TGF-beta

10 ely diffusable substrate and purified MMP-2, BSP, and natural (tissue inhibitor of matrix metalloprot

11 P-2 alone, MMP-2 and BSP, or preformed MMP-2-BSP complexes and solving a general linear mixed inhibit

12 rates of response and remission than adding BSP or continuing MEDS alone.

13 After organophosphate addition, BSP accumulates within these BAG-75-containing BMF precu

14 bone marker gene (OPN, Cbfa1, Col I alpha1, BSP, ALP) expression in vivo.

15 Native OPN incorporated 1.07 and BSP 2.46 mol of phosphate/mol by factor-independent prot

16 ncentrations added to MMP-2 alone, MMP-2 and BSP, or preformed MMP-2-BSP complexes and solving a gene

17 r the first time that cleavage of BAG-75 and BSP by an AEBSF-sensitive, osteoblast-derived serine pro

18 a hypothetical mechanism in which BAG-75 and BSP function actively in nucleation of apatite within BM

19 Cleavage of BAG-75 and BSP was also inhibited at the minimum dosage of AEBSF su

20 We show here that BAG-75 and BSP, biomarkers for these foci, are specifically enriche

21 finally into osteoblasts expressing Col1 and BSP during postnatal day 7-10, when serum levels of thyr

22 es-such as OPN, DMP1, DMP2, DMP3 (DSPP), and BSP-have been mapped to the same locus.

23 DTT and BSP-GSH affect GSH transport only in cells expressing th

24 ver, the upregulation of MMP9, MMP2, FN, and BSP was observed.

25 expression vectors demonstrated that OC and BSP gene transcription was down-regulated by Cx45 cotran

26 Cx43 in UMR 106-01 cells up-regulated OC and BSP gene transcription.

27 both cell coupling and expression of OC and BSP.

28 ments of in vitro phosphorylation of OPN and BSP by several other known protein kinases were carried

29 Recombinant OPN and BSP can protect murine erythroleukemia cells from attack

30 eptides efficiently, suggesting that OPN and BSP contain sites that are specific for ppGalNAcT-1.

31 uced about 1 mol of phosphate/mol of OPN and BSP molecule.

32 eral synthetic peptides derived from OPN and BSP sequences were designed to include either known or p

33 These data led to calculations that OPN and BSP, respectively, contain 7.83 and 4.14 mol of phosphat

34 ific sites of the bone glycoproteins OPN and BSP.

35 er proteins such as alkaline phosphatase and BSP.

36 resented higher numbers of PCNA-positive and BSP-positive cells than control at 10 and 30 days post-s

37 nions, including biliverdin, bile salts, and BSP, were predominantly excreted by way of the kidney, w

38 peridine/trifluoromethanesulfonic anhydride (BSP), diphenyl sulfoxide/trifluoromethanesulfonic anhydr

39 nk rate (BR) in patients with blepharospasm (BSP) and increased blinking (IB).

40 ng specific peptides and antibodies to block BSP and OPN protective activity.

41 y cementoblasts gave strong signals for both BSP and OCN genes, confirming its nature as cementum or

42 and in vivo phosphorylation sites of bovine BSP by a combination of state-of-the-art techniques and

43 Both the purified bovine BSP and OPN were radiolabeled by [32P]ATP and factor-ind

44 intravenously injected bromosulfophthalein (BSP) was eliminated over a 72-hour period.

45 lial uptake exhibited a strong inhibition by BSP-GSH at 0.05 mM (55%) and 2 mM (64%), whereas cortica

46 ), whereas cortical uptake was unaffected by BSP-GSH.

47 sed as the particle backscatter coefficient (BSP), and PM10 particulate mass concentration-on the occ

48 phosphorylation of native and deglycosylated BSPs by casein kinase II identified seven phosphorylatio

49 ce of a hitherto unreported Na(+)-dependent, BSP-GSH inhibitable GSH transporter in the lens epitheli

50 dioactivity incorporated on dephosphorylated BSP and OPN provided 6.6 and 8.9 mol of phosphate incorp

51 Expression of the endogenous BSP gene in Gallus osteoblasts was similarly downregulat

52 lowest dose of amelogenin slightly enhanced BSP expression, whereas at the highest dose, a dramatic

53 Both controllers used the estimated BSP as feedback.

54 ropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (

55 that undifferentiated cells did not express BSP or osteocalcin.

56 ed that tubule formation by cells expressing BSP could be inhibited by an activity blocking antibody

57 dothelial cells (HUVECs) were used to follow BSP modulation of MMP-2 inhibition and tubule formation.

58 vascular endothelial cells were positive for BSP, DPP, DMP1, and AP; MEPE was not detected.

59 MethPrimer can design primers for BSP and MSP.

60 the follicle cells expressed transcripts for BSP, OCN, and osteopontin (OPN).

61 t, the high affinity of this transporter for BSP relative to antifolates seems to be intrinsic to its

62 Responsiveness of the 1.2-kb Gallus BSP promoter to Cbfa factors Cbfa1, Cbfa2, and Cbfa3 was

63 nt of Cbfa sites in expression of the Gallus BSP gene.

64 The effect of 2 mM bromosulfophthalein-GSH (BSP-GSH) on GSH uptake in the lens epithelium and cortex

65 the seven Cbfa sites in the Gallus and human BSP promoters, suggest that suppressor activity by Cbfa

66 Three weeks following implantation, human BSP could be identified in RNAs isolated from the retrie

67 study identifies structural domains in human BSP and MMP-2 that contribute to these interactions.

68 For every implant from which human BSP cDNA was amplified, parallel implants harvested at 6

69 assessment of human actin, collagen type I, BSP, and osteocalcin indicated that undifferentiated cel

70 In the Ad/PDGF-1308 treated implants, BSP, OC, and OPN were all downregulated at 3 weeks.

71 BR was increased in patients with IB and in BSP patients with clonic spasms but not in BSP patients

72 BR in BSP and IB patients was compared with that from a group

73 Ex vivo overexpression of RCAS-Dlx5WT in BSP/TVA calvarial cells promoted, whereas that of RCAS-D

74 st dose, a dramatic decrease (three-fold) in BSP expression was observed.

75 accharides, sulfate, and phosphate groups in BSP isolated from human bone.

76 l resorption-stimulating bone matrix high in BSP content.

77 explore the molecular mechanisms involved in BSP regulation, a clonal population of immortalized muri

78 n BSP patients with clonic spasms but not in BSP patients with tonic spasms.

79 n of BSP by Cbfa factors was not observed in BSP promoters in which Cbfa sites were deleted or mutate

80 neralized tissue-associated genes, including BSP and RunX2, between the P-MSCs and the PDL-MSCs.

81 properties of skeletal cell types, including BSP as one component of that phenotype, is the result of

82 emistry indicated that RCAS-Dlx5WT increased BSP and osteopontin (OPN) expression, whereas it decreas

83 Indeed, BSP has been shown to be a positive indicator of the inv

84 The Na(+)-independent, BSP-GSH insensitive RcGshT may function as an apical GSH

85 hrough its importance to cementum integrity, BSP is essential for periodontal function.

86 Thrombin digests of 32P-labeled BSP showed radioactivity to be associated with fragment

87 Furthermore, use of native BSP and matrix-assisted laser desorption ionization time

88 last marker genes, including Runx2, ALP, OC, BSP, OPG, and DMP-1, with concurrent upregulation of RAN

89 d CREB target gene expression, including OC, BSP, cyclin A, cyclin D1, and vascular endothelial growt

90 he 26 amino acid domain encoded by exon 4 of BSP is shown by a series of binding and activity assays

91 resence of inhibitors, while the addition of BSP restored vessel formation.

92 significant reduction in the total amount of BSP synthesized and secreted.

93 MP analog treatment blocks the deposition of BSP in the extracellular matrix without a significant re

94 ralizing cultures, with matrix deposition of BSP temporally preceding that of apatite.

95 both amino- and carboxy-terminal domains of BSP contribute to restoration of activity to TIMP2-inhib

96 ssibly due to the observed downregulation of BSP and OC and a persistence of stimulation of MNGCs.

97 The effect of BSP on MMP-2 modulation by inhibitors was determined wit

98 e of a greater than 500-fold molar excess of BSP.

99 wn to reduce melatonin-induced expression of BSP and ALP.

100 The expression of BSP and OPN in tumor cells provides a selective advantag

101 ouse model was used to examine expression of BSP and other markers, including Type I collagen, in tis

102 Melatonin increased gene expression of BSP and the other bone marker proteins, including alkali

103 y contribute to spatiotemporal expression of BSP during bone development.

104 n could similarly modulate the expression of BSP in two cell lines, the MC3T3-E1(MC3T3) pre-osteoblas

105 vealed a dramatic reduction in expression of BSP mRNA and protein in cementoblasts and surrounding os

106 gain of function by tumor cell expression of BSP or OPN has been defined using specific peptides and

107 d displayed an increase in the expression of BSP, ALP, and osteocalcin genes within 1 h of exposure t

108 is for further understanding the function of BSP in bone nucleation.

109 probability of observing NPF as functions of BSP and PM10.

110 These data demonstrate the importance of BSP in maintaining proper periodontal function and alveo

111 Loss of BSP caused progressively disorganized PDL and significan

112 resent study the state of phosphorylation of BSP and OPN was evaluated by in vitro 32P labeling using

113 The presence of BSP increased the competitive K I values between 15- and

114 Thus, the proposed role of BSP in hydroxyapatite nucleation and growth may depend o

115 RGD of DMP1 with corresponding sequences of BSP did not enhance the ability of DMP1 to bind alphaVbe

116 Suppression of BSP by Cbfa factors was not observed in BSP promoters in

117 ctrometry with selective enzyme treatment of BSP to provide new information on the precise distributi

118 ipts for OCN and OPN with an upregulation of BSP mRNA noted at 72 hours.

119 nvolvement of covalently bound phosphates on BSP in receptor mediated "outside-in" signaling via tran

120 However, HSG cells could not migrate onto BSP in a modified Boyden chamber assay.

121 we found that PDL cells did not express OPN, BSP, OCN, or ALP under any of the conditions used in thi

122 y were randomized to receive either CBASP or BSP stratified by phase 1 response, ie, as nonresponders

123 ostn/Osf2, and the bone sialoprotein gene or BSP), genes that are expressed in the developing brain (

124 n kinase showed no phosphorylation of OPN or BSP, while protein kinase C and cGMP-dependent protein k

125 R methods, such as bisulfite sequencing PCR (BSP) and methylation specific PCR (MSP), remain the most

126 DIP-Seq results by bisulfite sequencing PCR (BSP) in some of the differentially methylated promoters.

127 nophore 4-(trifluoromethoxy)phenylhydrazone; BSP influx was also suppressed at pH 7.4.

128 se (SVP) or bovine spleen phosphodiesterase (BSP), clearly slows as the digestion approaches the abas

129 combination of 1-benzenesulfinyl piperidine (BSP) and trifluoromethanesulfonic anhydride (Tf(2)O) for

130 These results indicate that although poplar BSP is encoded by a multigene family, transcriptional ac

131 of poplar share some similarities to poplar BSP, the observed developmental expression patterns in t

132 Poplar BSPs are encoded by a multigene family and one member, b

133 oral dynamics of the body surface potential (BSP) during atrial excitation.

134 atients with a clinical diagnosis of primary BSP (19 patients had tonic orbicularis oculi (OO) spasms

135 ol signal the burst suppression probability (BSP), the brain's instantaneous probability of being in

136 cumulation of a 32 kDa bark storage protein (BSP) in the inner bark parenchyma and xylem rays.

137 nd the presence of the bone matrix proteins, BSP and BAG-75.

138 2 (200 received CBASP and MEDS, 195 received BSP and MEDS, and 96 received MEDS only).

139 distal bsp promoter sequences act to repress BSP expression in cancer cells and that most of the prom

140 Bone sialoprotein (BSP) and apatite co-localize in the extracellular matrix

141 omoted gene expression of bone sialoprotein (BSP) and OPN.

142 Bone sialoprotein (BSP) and osteocalcein (OCN) markers were upregulated 3-f

143 resulted in a decrease in bone sialoprotein (BSP) and osteocalcin (OCN) mRNAs while PDGF-BB also incr

144 n, for gene expression of bone sialoprotein (BSP) and osteocalcin (OCN), and histomorphometric analys

145 pressed the expression of bone sialoprotein (BSP) and osteonectin in both femurs and bone marrow oste

146 with mineralized tissues, bone sialoprotein (BSP) and osteopontin (OPN), and a cell-surface receptor

147 Bone sialoprotein (BSP) and osteopontin (OPN, ETA-1) are expressed by troph

148 between the expression of bone sialoprotein (BSP) and skeletal metastasis of breast cancers.

149 thods were used to detect bone sialoprotein (BSP) distribution in Hyp and WT mouse molar tissues, and

150 the relationship between bone sialoprotein (BSP) expression and osteocalcin expression with subseque

151 nced osteocalcin (OC) and bone sialoprotein (BSP) gene expression in human prostate cancer cells by a

152 Expression of the bone sialoprotein (BSP) gene, a marker of bone formation, is largely restri

153 Bone sialoprotein (BSP) has been shown to induce limited gelatinase activit

154 ins osteopontin (OPN) and bone sialoprotein (BSP) have been implicated in biological functions such a

155 s), osteopontin (OPN) and bone sialoprotein (BSP) in the Galnt1-null mice relative to those of the wi

156 Bone sialoprotein (BSP) is a multifunctional, highly phosphorylated, and gl

157 Bone sialoprotein (BSP) is a secreted glycophosphoprotein normally restrict

158 Bone sialoprotein (BSP) is an acidic 301 amino acid protein expressed by os

159 Bone sialoprotein (BSP) is an acidic phosphoprotein with collagen-binding,

160 Bone sialoprotein (BSP) is an extracellular matrix protein found in mineral

161 ot cultures of UMR-106-01 Bone Sialoprotein (BSP) osteoblast cells.

162 i.e., osteopontin (OPN), bone sialoprotein (BSP), alkaline phosphatase (ALP), osteocalcin (OCN), alp

163 glycoprotein-75 (BAG-75), bone sialoprotein (BSP), and alkaline phosphatase that are the exclusive si

164 ription factor 2 (RunX2), bone sialoprotein (BSP), and osteocalcin (OCN) messenger RNA (mRNA), was ev

165 matrix protein-1 (DMP1), bone sialoprotein (BSP), and osteopontin (OPN) are three SIBLINGs (small in

166 length osteopontin (OPN), bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin phosphoprot

167 n of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix formation and calcifi

168 d tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate t

169 ssociated genes including bone sialoprotein (BSP), OC, and osteopontin (OPN) in the cell-implant spec

170 l nuclear antigen (PCNA), bone sialoprotein (BSP), osteocalcin (OCN), and tartrate-resistant acid pho

171 ulation (OC/CM) expressed bone sialoprotein (BSP), osteopontin (OPN), and OC, markers selective to ce

172 .g., osteocalcin (OCN) or bone sialoprotein (BSP).

173 e response element of rat bone sialoprotein (BSP).

174 is, we infected 5-day-old bone sialoprotein (BSP)/avian retroviral receptor gene (TVA) transgenic mic

175 g factor alpha-1 [Cbfa1], bone sialoprotein [BSP], osteocalcin [OCN], and osteopontin [OPN], markers

176 nchymal stem cell, BMMSC; bone sialoprotein, BSP; hydroxyapatite/tricalcium phosphate, HA/TCP; Hertwi

177 ing phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1

178 Simulated BSP maps during normal atrial excitation (i.e. sinoatria

179 ce uptake of bilirubin, sulfobromophthalein (BSP), and taurocholate, had any influence on 55Fe-heme u

180 s property with that of sulfobromophthalein (BSP), a preferred OATP2B1 substrate.

181 ed osteoblast differentiation and suppressed BSP gene expression.

182 To test our hypothesis that BSP plays an important role in cementogenesis, we analyz

183 In this report, we show that BSP and OPN form rapid and tight complexes with compleme

184 Previous work has shown that BSP can bind to matrix metalloproteinase-2 (MMP-2).

185 Results collected here suggest that BSP plays a non-redundant role in acellular cementum for

186 These data suggest that BSP-1 is the prototype of a new class of signaling molec

187 The BSP and Ph(2)SO methods give comparable results in all t

188 esian binary filter algorithm to compute the BSP from the EEG and controllers using a linear-quadrati

189 undary element method is used to compute the BSP resulting from atrial excitation.

190 ur data indicate that Cbfa repression of the BSP promoter does not involve the transducin-like enhanc

191 cids 362 to 513) relieved suppression of the BSP promoter.

192 We show that the BSP at 08 h on a given day is a reliable indicator of an

193 PF event was greater than 0.5 (95%) when the BSP at 08 h was less than 6.8 Mm(-1).

194 electron microscopy, which included thinner BSP-positive staining within the cementum, discontinuous

195 alphaVbeta5 integrin, HSG cells attached to BSP but not to DMP1 or OPN.

196 ic migration-enhancing properties of DMP1 to BSP and OPN were performed using human skeletal (MG63 an

197 factors mediated repression of the wild-type BSP promoter, in contrast to their well known activation

198 yl 4-DP donors with glycosyl acceptors using BSP/Tf2O activation, whereas beta-linked 4'-DP disacchar

199 We have investigated whether BSP and OPN may play a similar role in tumor cell comple

200 activates a mineralization program in which BSP localizes to extracellular matrix sites where hydrox

201 resorption fronts and reversal lines, while BSP was localized to reversal lines.

202 differentially modulates BR in patients with BSP and IB depending on the baseline BR.

203 significantly reduced BSDI in patients with BSP and IB.