ライフサイエンスコーパス: BaP

1 (r = 0.64, 0.72, and 0.74, for PHE, PYR, and BaP).

2 ene (PHE), pyrene (PYR), and benzo[a]pyrene (BaP).

3 d products, and biomass-associated products (BAP).

4 (r = 0.70, 0.68, and 0.70 for PHE, PYR, and BaP).

5 eterocyclic amines (HCA) and benzo(a)pyrene (BaP).

6 etabolites of the carcinogen benzo[a]pyrene (BaP).

7 omatic hydrocarbons, such as benzo(a)pyrene (BaP).

8 e toxin, and the biofilm-associated protein (Bap).

9 ene (PHE), pyrene (PYR), and benzo[a]pyrene (BaP).

10 IDASE2, in the early root growth response to BAP.

11 y to these transplacental ovarian effects of BaP.

12 were reached within only 2 h of exposure to BaP.

13 h from BMHA and 95.9% with induced growth on BAP.

14 absolutely required for detoxication of oral BaP.

15 rasting shoot and root proteome responses to BAP.

16 unosuppression approximately 30 days on oral BaP.

17 as a function of long-term oral exposure to BaP.

18 e transposon disrupts the coding sequence of bap.

19 ML cell lines in the presence and absence of BaP.

20 ity is essential in the detoxication of oral BaP.

21 CD1)] to AML and eBL cell lines treated with BaP.

22 to 4%) and decreases (3%) for particle-bound BaP.

23 characteristic of the syndrome [6-9] and the BAP [10, 11], we examined whether neural sensitivity to

24 The mixture of NNK plus BaP (2 micromol each) was administered by gavage as eigh

25 ties including the broader autism phenotype (BAP) [2, 3].

26 ounds (8.3-, 4.3-, and 8.7-fold increase for BaP, 3-MC, and urethane, respectively).

27 ly induced lung tumors following exposure to BaP, 3-methylcholanthrene (3-MC), and urethane.

28 omatography (HPLC)-fluorescence detection of BaP-7,8,9,10-tetraols released from human DNA upon acid

29 cid hydroperoxides to support epoxidation of BaP-7,8-diol at a much higher rate than with cumene hydr

30 The cytotoxicity of BaP-7,8-diol significantly increased in mammalian cells

31 1A2, and CYP3A4, were also able to epoxidize BaP-7,8-diol using various fatty acid hydroperoxides, al

32 olizes benzo[a]pyrene-trans-7,8-dihydrodiol (BaP-7,8-diol) into the highly mutagenic and carcinogenic

33 orting in vivo CYP2S1-catalyzed oxidation of BaP-7,8-diol, and that fatty acid hydroperoxides and CYP

34 yet been described for the bioactivation of BaP-7,8-diol.

35 romatic hydrocarbons such as benzo[a]pyrene (BaP), a common constituent of tobacco smoke.

36 h a peptide derived from the BCR-ABL fusion (BAp), a key driver mutation, generated a small populatio

37 Benzo[a]pyrene (BaP), a major carcinogen in cigarette smoke, is detected

38 tive organotypic cultures to benzo[a]pyrene (BaP), a major carcinogen in cigarette smoke, resulted in

39 Intakes of benzo(a)pyrene (BaP), a marker of PAHs, and 2-amino-1-methyl-6-phenyl-im

40 integrated at the enhancer level of bagpipe (bap), a NK homeobox gene that serves as an early regulat

41 Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is one of

42 Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, is the major ca

43 We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation

44 t of DNA adducts specific to benzo[a]pyrene (BaP), a representative PAH, in maternal and cord blood.

45 Our results show that BaP accumulates in the lipid bodies of Chlorella sp. and

46 ity, metabolism of BaP, and formation of DNA-BaP adducts.

47 Whereas BaP alone shifted differentiation away from the choliner

48 In cells treated with BaP alone, the transition from cell division to neurodif

49 With the BaP amino tribenzoate, the 6-chloronucleoside provided s

50 no tribenzoate as compared to the bay-region BaP amino tribenzoate.

51 ded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx.

52 liminated the distance-dependent decrease in bAP amplitude and its associated Ca(2+) signal.

53 dritic A-type K(+) current and increased the bAP amplitude in distal dendrites.

54 was generated and was not due to a change in bAP amplitude or shape.

55 Voltage imaging in the branches showed that bAP amplitude was initially constant and then steadily d

56 1 PCs) is responsible for the attenuation of bAP amplitude with distance from the soma.

57 Benzo[a]pyrene (BaP), an archetypical polycyclic aromatic hydrocarbon, i

58 dence is presented here that benzo(a)pyrene (BaP), an environmental hydrocarbon metabolized by mammal

59 ha,9 beta-trisbenzoyloxy-7,8,9,10-tetrahydro BaP and (+/-)-1 beta-amino-2 alpha,3 alpha,4 beta-trisbe

60 to the dA adducts, the C-N reactions of both BaP and BcPh amino tribenzoates with the 2-bromo-2'-deox

61 The dual roles of BAP and BON genes in repressing defense responses mediat

62 All abnormal BAP and CTX concentrations fell within the elevated ( ge

63 Age- and sex-specific BAP and CTX concentrations of at least the 97th percenti

64 rmined the mutagenic response to mixtures of BaP and PhIP at concentrations relevant to human exposur

65 Mixtures of BaP and PhIP produced dose responses different from thos

66 mechanisms related to the cooking compounds BaP and PhIP.

67 is Forster resonance energy transfer between BaP and photosystems of Chlorella sp., indicating the cl

68 BaP and TCDD enhanced osteoclast formation in bone marro

69 oking questionnaire linked to a database for BaP and the heterocyclic amines 2-amino-3,8-dimethylimid

70 e show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inte

71 Chemical carcinogens such as benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

72 iated with action potential backpropagation (bAP) and a supralinear increase in dendritic Ca(2+).

73 drogen peroxide (H2O2), 6-benzylaminopurine (BAP) and calcium chloride (CaCl2) could induce tolerance

74 city to the aromatic CK 6-benzylaminopurine (BAP) and that fast posttranscriptional and/or posttransl

75 We also identified the basophil progenitor (BaP) and the MCP in the bone marrow and the gastrointest

76 id hormone (PTH), bone alkaline phosphatase (BAP), and C-telopeptide (CTX) in youth infected with hum

77 Outcomes included change in TRP, PTH, BAP, and CTX from baseline to week 12 by TDF/noTDF; and

78 sorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts.

79 higher molecular weight PAHs (BaA, BkF, BbF, BaP, and IcdP), most of which did not undergo significan

80 gest that the critical anticancer actions of BaP are decreases in SCD1 levels and monounsaturated fat

81 The patterns of polymorphism in tin and bap are not compatible with an equilibrium model of sele

82 c hydrocarbons (PAH) such as benzo[a]pyrene (BaP) are ubiquitous environmental pollutants found in to

83 high (> or = 100 nmol/mmol creatinine), and BAP as low (< 146 U/L) or high (> or = 146 U/L).

84 We have described Bap as the surface structure involved in adherence of A.

85 om contaminated sites, using benzo[a]pyrene (BaP) as an example.

86 stral basolateral (BLA) and basal posterior (BAP)- as they provide a major source of glutamatergic in

87 DMPC-NP-SLBs and DMPC-SUVs, with and without BaP, as their sole carbon source.

88 The spatial profile of the bAP-associated Ca(2+) influx was biphasic, with an initi

89 d) received a single gavage dose of 50 mg/kg BaP at either noon or midnight, and mammary tissues were

90 In TC neurons, bAP attenuation strength varies according to firing mode

91 We suggest that modulations in the bAP baseline-to-peak amplitude by local EPSPs act as a m

92 the quercetin metabolites at 10muM inhibited BaP+BC-induced cell death.

93 a similar order, these compounds suppressed BaP+BC-induced cytochrome P450 (CYP)1A1/1A2 expression b

94 reactive oxygen species formation induced by BaP+BC; however, Q3G had the best effect on decreasing t

95 nd isorhamnetin also significantly decreased BaP+/-BC-induced DNA damage by 64%, 60% and 24%, respect

96 hich incorporates a biotin acceptor peptide (BAP) between an N-terminal signal sequence and a transme

97 BAP but not BLA increased unconditioned port-entries, wh

98 death due to absent metabolic activation of BaP by CYP1B1 in immune cells.

99 Pt-oxidizing enzyme, which was proven to be BAP by N terminus protein sequencing.

100 Our results indicate that, although BaP can act directly as a developmental neurotoxicant, i

101 BaP carcinogenicity is believed to occur mainly through

102 a photooxidation reaction of benzo(a)pyrene (BaP) carried out in controlled conditions using a 6 W UV

103 Highly purified BAP catalyzed Pt oxidation with specific activities of 6

104 ts show that prenatal exposure of females to BaP causes premature ovarian failure and ovarian tumorig

105 Prenatal exposure to BaP causes premature reproductive senescence in mice, an

106 uct, oleate, rescued AML and e-BL cells from BaP cell killing and decreased levels of BaP-induced rea

107 We also identified that the BAP chromatin-remodeling complex probably functions coop

108 f urine plated onto blood (blood agar plate [BAP]), colistin-nalidixic acid (CNA), and MacConkey agar

109 mplex associates either with Osa to form the BAP complex or with Bap170 and Bap180 to form the PBAP c

110 o which (3)H-benzo(a)pyrene ((3)H-BaP; total BaP concentrations of 1, 10, and 100 ppm) was added in a

111 tions, the baseline-to-peak amplitude of the bAP could be either increased, decreased or unaltered at

112 This "oral BaP Cyp1" mouse paradigm represents a powerful teaching

113 Thus, for oral BaP, CYP1A1 is more important in detoxication than in me

114 g agents in transforming PAHs to NPAHs, with BaP-d12 being the most readily nitrated.

115 terogeneous reactions of benzo[a]pyrene-d12 (BaP-d12), benzo[k]fluoranthene-d12 (BkF-d12), benzo[ghi]

116 Reaction of BaP-d12, BkF-d12, and BghiP-d12 with NO2 and NO3/N2O5 re

117 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced t

118 ST occurred in the presence of bulky BaP DE DNA adducts attached to the end of the viral DNA

119 Position-specific effects of these BaP DE DNA adducts were found for inhibition of integras

120 everal benzo[a]pyrene 7,8-diol 9,10-epoxide (BaP DE) adducts tested, only the adduct in the minor gro

121 ,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP DE) isomer with (+)-7R,8S,9S,10R configuration ((+)-

122 of the four isomeric dA adducts derived from BaP DE-2 and two adducts derived from 9,10-epoxy-7,8,9,1

123 t dA formed by cis ring opening of these two BaP DE-2 isomers exhibit a 2-3-fold preference for A ove

124 ommon mutations in animal cells treated with BaP DE-2 isomers.

125 reoselective synthesis of the cis adducts of BaP DE-2 with 2'-deoxyguanosine as well as the first syn

126 pha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP DE-2) by 2'-deoxyadenosine and 2'-deoxyguanosine is

127 mer with (+)-7R,8S,9S,10R configuration ((+)-BaP DE-2), misincorporation of A or G and incorporation

128 Partial unwinding of the DNA helix at BaP DE-dA adduct sites may make such adducted DNAs more

129 ity is only mildly affected by intercalating BaP DE-dA adducts that locally perturb DNA double helica

130 me inhibition by either the trans-R or cis-R BaP DE-dG adduct, suggesting that WRN and RPA may functi

131 is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand.

132 particle changes alone accounting for 15% of BaP decline under 2050 emissions.

133 BaP decreased SCD1 protein levels in each cell line (0.4

134 iction of developmental potential by the Erm-BAP-dependent mechanism functionally distinguishes inter

135 , these data led us to conclude that the Erm-BAP-dependent mechanism stably restricts the development

136 uire either boosting or the reduction of the bAP, depending on the initial size of both signals.

137 iver CYP1A1, is critically important in oral BaP detoxication.

138 pe, the addition of dexamethasone along with BaP did the opposite.

139 ckout mice treated by oral administration of BaP die at 28 to 32 days with immunosuppression, whereas

140 individuals with autism and parents with the BAP differed from controls on measures of social cogniti

141 acid and EGF were required to promote hiPSCs-BAP differentiation at a level similar to adult-BAP diff

142 differentiation at a level similar to adult-BAP differentiation.

143 onary cytosol to catalyze conjugation of the BaP diol epoxide was significantly reduced.

144 ced cyclobutane pyrimidine dimers (CPDs) and BaP diol epoxide-deoxyguanosine (BPDE-dG), which are rem

145 n mammalian cells overexpressing CYP2S1, and BaP-diol-t-epoxide formation in these cells also increas

146 a]pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide (BaP-diol-t-epoxide), using cumene hydroperoxide in lieu

147 this, a significant increase in the level of BaP DNA adducts was measured in the lungs of null animal

148 Number and brightness analysis suggests that BaP does not aggregate inside Chlorella sp. (average bri

149 effects in Cyp1a1(-/-) mice were noted at a BaP dose as low as 1.25 mg/kg/day.

150 At an oral BaP dose of 125 mg/kg/day, Cyp1a1(-/-) mice died within

151 Similarly, we observed significant BaP dose x Gclm genotype interactions on ovarian follicl

152 deleted in hepatocytes can ingest large oral BaP doses (125 mg/kg/d) without apparent toxicity.

153 -type mice remain healthy for 1 year on high BaP doses (125 mg/kg/day).

154 Ten-fold lower oral BaP doses result in adenocarcinoma of the proximal small

155 to low, noncytotoxic doses (0.1 and 1 nM) of BaP elicited increased promoter hypermethylation and red

156 re essential to prevent the induction of the bap enhancer by Dpp in the dorsal ectoderm.

157 We show that an evolutionarily conserved bap enhancer element requires combinatorial binding site

158 Additionally, the PEF-determined BaP-equivalent concentrations were compared to those det

159 d the PEF-method provided lower estimates of BaP-equivalents than the BDM.

160 the PEF-method provided higher estimates of BaP-equivalents than the BDM.

161 Experimental measurements show that a BAP evoked by current injection at the soma causes calci

162 After DA depletion, bAP-evoked Ca(2+) transients were enhanced in distal den

163 Local application of DA depressed dendritic bAP-evoked Ca(2+) transients, whereas application of ACh

164 ffect lipid metabolism, we hypothesized that BaP exerts anticancer effects by disrupting lipogenesis.

165 BaP exposure also increased HPV16 and HPV18 viral titers

166 d ovarian tumorigenesis after transplacental BaP exposure compared with Gclm(+/+) females.

167 ion: the same oral, but not intraperitoneal, BaP exposure leads to dramatic differences in target-org

168 more ovarian tumors in response to prenatal BaP exposure than Gclm(+/+) females.

169 The lifetime of BaP fluorescence was measured to be 14 ns in N,N-dimethy

170 BaP forms covalent DNA adducts after metabolic activatio

171 Relative oral bioavailability (RBA) of the BaP from soil was estimated by comparing the area under

172 Thus, the BAP genes function as general negative regulators of PCD

173 BaP has been shown to accumulate in phytoplankton and zo

174 and medroxyprogesterone acetate (designated BaP) has potent in vivo anticancer activity in acute mye

175 bezafibrate and medroxyprogesterone acetate (BaP) has shown anti-leukaemic activity in vitro and in v

176 d survival did not correlate with numbers of BAp:I-A(b)-specific T cells, but rather with increased e

177 835/2011 were exceeded for BaP in 12%, and for total 4 PAHs in 28%, with a greater

178 ead to a better understanding of the role of Bap in biofilm formation on medical surfaces and in colo

179 studied the localization and aggregation of BaP in Chlorella sp., a microalga that is one of the pri

180 might reflect efficient detoxication of oral BaP in proximal small intestine such that significant am

181 when added to saturated BaP solutions, sorb BaP in ratios of up to 10/1 to 5/1 lipid/BaP, over a 2-w

182 d dams were treated with 0, 2, or 10 mg/kg/d BaP in sesame oil by gavage from gestational days 7 to 1

183 thickness and volume, suggesting a role for Bap in supporting the development of the mature biofilm

184 acterize the location and the aggregation of BaP in the cell.

185 e staphylococcal biofilm-associated protein (Bap) in a bloodstream isolate of Acinetobacter baumannii

186 yridyl)-1-butanone (NNK) and benzo[a]pyrene (BaP) in A/J mice.

187 In Chlorella grown in sediments spiked with BaP, in 12 h the BaP uptake could be visualized using fl

188 Interestingly, BLA and BAP inactivation produced dissociable effects.

189 ning viral titer that high concentrations of BaP increase HPV31b titers within the context of organot

190 rements of hormone metabolites, showing that BAP increases ABA levels in the shoot and 1-aminocyclopr

191 rmore, this study shows that the presence of Bap increases the bacterial cell surface hydrophobicity.

192 benzo[k]fluoranthene (BkP), benzo[a]pyrene (BaP), indeno[123-cd]pyrene (IP) and benzo[ghi]perylene (

193 s including smoking compound benzo[a]pyrene (BaP) induced E6/E7 and IL-6 expression.

194 Nicotine had no effect on BaP-induced changes in cell number or growth, but it syn

195 expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene e

196 BaP-induced Cyp1a1 and Cyp1b1 mRNA levels were higher 4

197 we identified the role of proteins mediating BAP-induced ethylene production, METHIONINE SYNTHASE1 an

198 ates that quercetin metabolites decrease the BaP-induced harmful effect of beta-carotene in A549 cell

199 tigate the effects of these compounds on the BaP-induced harmful effects of BC.

200 ature proteins are increased during NNK plus BaP-induced lung carcinogenesis, and I3C inhibits this e

201 rom BaP cell killing and decreased levels of BaP-induced reactive oxygen species, whereas supplementa

202 P inhibition of cell growth and enhanced the BaP-induced shift in phenotype toward a higher proportio

203 I3C reduced NNK plus BaP-induced tumor multiplicity by 78% in experiment 1 an

204 al and electrophysiological model to measure BAP-induced voltage and calcium signals in spines after

205 c activity of Tin and activated Smads during bap induction.

206 Chlorpyrifos coexposure augmented BaP inhibition of cell growth and enhanced the BaP-induc

207 by these DE adducts is consistent with known BaP inhibition of mitochondrial (mt)DNA synthesis and su

208 The concentration of BkP, BaP, IP and BghiP in smoked, grilled and boiled meat sam

209 0.5, 1.0, 1.5mug/kg, respectively, for BkP, BaP, IP and BghiP.

210 formation by A. baumannii and suggests that Bap is involved in intercellular adhesion within the mat

211 Since BaP is known to deregulate multiple pathways of cellular

212 However, Bap is not involved in internalization of the bacterium

213 on microscopy analyses of biofilms show that Bap is required for three-dimensional tower structure an

214 ycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) is a major component of cigarette smoke condensate

215 Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (

216 The backpropagating action potential (BAP) is hypothesised to provide distance-dependent infor

217 the A. baumannii biofilm-associated protein (Bap) is necessary for mature biofilm formation on medica

218 Benzo(a)pyrene (BaP) is present at less than 1%, and therefore is not a

219 that the step sizes of both M10(Full)LZ and BAP-M10(1-979)HMM are widely distributed on single actin

220 sin-X without artificial dimerization motif (BAP-M10(1-979)HMM).

221 Studies of this broad autism phenotype (BAP) may provide a potentially important complementary a

222 Elucidation of the BaP mechanism of action is required in order to understa

223 puts, and is nearly invariant to the rate of bAP-mediated "cross-talk" from other dendrites over a 10

224 zed in the presence of BaP were dependent on BaP-mediated alteration in CDK1 kinase activity for main

225 portance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by E

226 Here, we report that BaP-mediated upregulation of virus synthesis is correlat

227 ies indicate time-of-day exposure influences BaP metabolism in mouse mammary glands and describe an i

228 in vitro model for investigating changes in BaP metabolism resulting from cross-talk between the mol

229 on receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp

230 pact of circadian rhythms on benzo-a-pyrene (BaP) metabolism in the mouse mammary gland and develop a

231 ment, as evident by the measurable levels of BaP metabolites in virtually all human urine samples exa

232 BaP-metabolizing CYP1B1 in the PSI and CYP3A59 in the PG

233 Overall, BaP modulation of the HPV life cycle could potentially e

234 such that significant amounts of the inducer BaP no longer reach the liver.

235 Dexamethasone enhanced the effect of BaP on cell numbers and altered the impact on neurotrans

236 We explored the effects of benzo[a]pyrene (BaP) on neurodifferentiation in PC12 cells, in combinati

237 ls (metabolically competent) were exposed to BaP or PhIP individually or in mixtures.

238 The osteoclastogenesis triggered by BaP or RANK-L was reduced in Ahr(-/-) cells, consistent

239 ase from a backpropagating action potential (bAP) or subthreshold depolarization was reduced if it wa

240 orb BaP in ratios of up to 10/1 to 5/1 lipid/BaP, over a 2-week period at 33 degrees C.

241 We demonstrate that BAP predominantly regulates proteins involved in carbohy

242 s and the ABA response, whereas in the root, BAP rapidly and strongly up-regulates the majority of pr

243 The extent to which BaP RBA was diminished in soil versus food varied among

244 esis and suggests that continued exposure to BaP reduces mtDNA copy number, increasing the opportunit

245 of cervical cells to high concentrations of BaP resulted in a 10-fold increase in HPV type 31 (HPV31

246 whereas treatment with low concentrations of BaP resulted in an increased number of HPV genome copies

247 of death in Cyp1a1(-/-) mice receiving oral BaP seemed to be immunotoxicity, including toxic chemica

248 On BAP, sensitivity was 96.0% with induced growth.

249 Low molecular mass BAP sequences are less likely to be broken down by diges

250 oxyguanosine (dG) adducts of benzo[a]pyrene (BaP) series 1 (syn) and benzo[c]phenanthrene (BcPh) seri

251 nd calcium signals, the spatial influence of bAP signaling in TC and TRN neurons is more restricted,

252 colloidal stability, when added to saturated BaP solutions, sorb BaP in ratios of up to 10/1 to 5/1 l

253 -SLBs and DMPC-SUVs, indicating preferential BaP sorption into the hydrophobic lipids.

254 Bap-specific monoclonal antibody (MAb) 6E3 was generated

255 in bone marrow cell cultures and gavage with BaP stimulated bone resorption and osteoclastogenesis in

256 growth, but it synergistically enhanced the BaP suppression of differentiation into both dopaminergi

257 nduced in HPV-containing Caski, HOK-16B, and BaP-T cells during growth in methylcellulose-containing

258 BaP targeting of CDK1 occurred independently of HPV stat

259 [2,3-b]indole (AalphaC), and benzo[a]pyrene (BaP); the cooked-meat carcinogens MeIQx, AalphaC, and 2-

260 This BAP-TM allows noninvasive real-time imaging of any cell

261 Tumors expressing the BAP-TM have high sensitivity for magnetic resonance and

262 signal sequence and a transmembrane domain, (BAP-TM) was efficiently biotinylated by endogenous bioti

263 ivation of L1 is dependent on the ability of BaP to cause DNA damage because it is absent in HeLa cel

264 followed by incubation with benzo[a]pyrene (BaP), to investigate the effects of these compounds on t

265 fuel oil-to which (3)H-benzo(a)pyrene ((3)H-BaP; total BaP concentrations of 1, 10, and 100 ppm) was

266 Our results confirm that BAP treated hESC (ESCd) lack a mesoderm signature and ar

267 l A, a specific inhibitor of CDK1 kinase, to BaP-treated cultures, resulted in the production of noni

268 Oral BaP-treated Cyp1a1/1a2/1b1(-/-) mice showed the same "re

269 s of the same genotype, Gclm(-/-) prenatally BaP-treated females had significantly greater decrements

270 ments in offspring production than Gclm(+/+) BaP-treated females.

271 y (LC-MS)-based detection of BPDE-N(2)-dG in BaP-treated rodents, and indirectly through high-perform

272 hifts in urinary metabolite patterns in oral BaP-treated triple-knockout and wild-type mice were also

273 Finally, BaP treatment activated p90RSK and its downstream target

274 Here, we show that BaP treatment activates the Ras-Raf-Mek1/2-Erk1/2 signal

275 Furthermore, we found that BAP treatment affects endogenous hormonal homeostasis, a

276 occurred independently of HPV status, since BaP treatment also increased CDK1 activity in tissues de

277 BaP treatment decreased fatty acid and phospholipid bios

278 Specifically, BaP treatment increased accumulation of hyperphosphoryla

279 important role in mediating the response to BaP treatment that ultimately leads to increased viral t

280 A and fibroblast growth factor-2 signaling (BAP treatment).

281 Benzo[a]pyrene (BaP) treatment induced oxidative stress, mitochondrial r

282 In the shoot, BAP up-regulates the abundance of proteins involved in a

283 bF (up to 0.39 ng/g), BkF (up to 0.90 ng/g), BaP (up to 0.29 ng/g) and Bghip (up to 0.43 ng/g) were d

284 wn in sediments spiked with BaP, in 12 h the BaP uptake could be visualized using fluorescence micros

285 of soil organic matter, does not affect the BaP uptake rate by DMPC-NP-SLBs and DMPC-SUVs, indicatin

286 d electron microscopy (EM) structures of the BAP variant of ClpB that binds the protease ClpP, clearl

287 d to the bacterial biotin acceptor peptides (BAP) varies among different mammalian cell types and can

288 limit of detection (LOD) of 5.2 x 10(-11) M BaP was achieved, and highly accurate, that is, a repeat

289 backpropagating dendritic action potential (bAP) was not critical in this process.

290 After several days of oral BaP, we found surprisingly low CYP1A1 levels in liver, c

291 studied prototype of PAHs is benzo[a]pyrene (BaP), well known to be toxic, mutagenic, and carcinogeni

292 PV31b virions synthesized in the presence of BaP were dependent on BaP-mediated alteration in CDK1 ki

293 reticulum (ER)-associated co-chaperone SIL1/BAP were identified to be the major cause of MSS.

294 HCAs and BaP were significantly associated with increased risk of

295 e (Ntx) and serum bone alkaline phosphatase (BAP) were obtained in 1,824 bisphosphonate-treated patie

296 Bronchial allergen provocations (BAP) were repeated at weeks 1, 2, 4, and 8.

297 zo[b]fluoranthene (BbF), and benzo[a]pyrene (BaP), were detected in 96% of the samples at individual

298 ferase induction relative to benzo[a]pyrene (BaP), which is used as a positive reference PAH congener

299 d from growth on BMHA and blood agar plates (BAP), with and without cefoxitin disk induction.

300 xyguanosine and a diol epoxide metabolite of BaP, with subsequent mutation of critical growth control