ライフサイエンスコーパス: Babesia

1 aerythrocytic organisms typical of the genus Babesia.

2 lopment of protozoa parasites from the genus Babesia.

3 f the invasion machinery between malaria and Babesia.

4 n the model of acute babesiosis with the WA1 Babesia.

5 eptor interactions must occur for successful Babesia and Plasmodium invasion of the human red cell.

6 urrently known piroplasmida, including other Babesia and Theileria species, in lacking two conserved

7 a new database supporting Piroplasmida (i.e. Babesia and Theileria), the addition of large amounts of

8 es (Stat4KO mice) were infected with the WA1 Babesia, and observations were made on the course of inf

9 rrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombo

10 found in mature erythrocytes that expressed Babesia antigens but not the transferrin receptor CD71.

11 ntained Babesia nuclei and failed to express Babesia antigens.

12 e zoonosis caused by protozoans of the genus Babesia, apicomplexan parasites that replicate within er

13 of cattle, but only in the last 30 years has Babesia been recognized as an important pathogen in huma

14 gondii, responsible for human toxoplasmosis, Babesia belongs to the Apicomplexa family.

15 1 (RAP-1) and which come from the parasites Babesia bigemina and Babesia bovis, is a target for vacc

16 The rhoptry-associated protein 1 (RAP-1) of Babesia bigemina induces partial protective immunity and

17 Babesia bigemina infection of mature bovine erythrocytes

18 rgeted vaccine antigen for Babesia bovis and Babesia bigemina infections of cattle.

19 ction against challenge using the homologous Babesia bigemina strain.

20 iated protein 1 (RAP-1) of Babesia bovis and Babesia bigemina to confer partial protective immunity i

21 dant and previously unrecognized elements of Babesia biology, with evolutionary dynamics consistently

22 ng rhoptry-associated protein 1 (RAP-1) from Babesia bovis and B. bigemina, which have been shown to

23 1 (RAP-1) is a targeted vaccine antigen for Babesia bovis and Babesia bigemina infections of cattle.

24 y of rhoptry-associated protein 1 (RAP-1) of Babesia bovis and Babesia bigemina to confer partial pro

25 ozoite surface antigen 2 (MSA-2) proteins of Babesia bovis are members of the variable merozoite surf

26 The tick-transmitted hemoparasite Babesia bovis causes an acute infection that results in

27 n part attributable to parasite DNA and that Babesia bovis DNA is directly mitogenic for bovine B cel

28 ozoite surface antigen (vmsa) gene family of Babesia bovis encode membrane proteins involved in eryth

29 activity of DNA from the protozoan parasite Babesia bovis for bovine B lymphocytes.

30 Serial blood passage of virulent Babesia bovis in splenectomized cattle results in attenu

31 Babesia bovis is a deadly disease of cattle resulting in

32 Antigenic variation in Babesia bovis is one aspect of a multifunctional virulen

33 The Babesia bovis merozoite surface antigen 1 (MSA-1) is an

34 The Babesia bovis merozoite surface antigen 1 (MSA-1), a mem

35 The Babesia bovis merozoite surface antigen 2 (MSA-2) locus

36 A 225-kDa Babesia bovis protein occurs on the cytoplasmic side of

37 Babesia bovis rhoptry-associated protein 1 (RAP-1), whic

38 Babesia bovis small heat shock protein (Hsp20) is recogn

39 We examined Babesia bovis sporozoites for the expression of two mole

40 believed to play a key role in resistance to Babesia bovis through parasite suppression by macrophage

41 morphism is a defining characteristic of the Babesia bovis variable merozoite surface antigen (VMSA)

42 ied in the carboxy-terminal one-third of the Babesia bovis variable merozoite surface antigen family

43 d on the small-subunit rRNA gene sequence of Babesia bovis were compared in a blind study of experime

44 The protozoan parasite Babesia bovis, a reemerging threat to U.S. cattle, is ac

45 rofolate reductase/thymidylate synthase from Babesia bovis, against 48 different reagents at five dif

46 Babesia bovis, an intraerythrocytic parasite of cattle,

47 come from the parasites Babesia bigemina and Babesia bovis, is a target for vaccine development.

48 Babesia bovis, the causative agent of severe babesiosis

49 Sequestration of Babesia bovis-infected erythrocytes (IRBCs) in the host

50 , Cryptosporidium and Theileria species, and Babesia bovis.

51 rofolate reductase/thymidylate synthase from Babesia bovis.

52 of equine piroplasmosis tested negative for Babesia caballi and Babesia equi in the complement fixat

53 detection of equine antibodies specific for Babesia caballi.

54 f two protozoan parasites, Theileria equi or Babesia caballi.

55 cannot be distinguished microscopically, and Babesia can also be confused with the early trophozoite

56 Thus, Babesia can also be transmitted by infected blood, and i

57 The major merozoite surface antigens of Babesia canis have been described as a 28-kDa membrane p

58 Babesia canis is the agent of the canine babesiosis in E

59 were seroreactive to an Ehrlichia sp., 16 to Babesia canis, and 25 to Bartonella vinsonii, and 22 ser

60 mitted pathogens, including Ehrlichia canis, Babesia canis, Babesia gibsonii, or spotted fever group

61 However, even in asymptomatic people, a Babesia carriage state can be established that can last

62 individuals, tick-transmitted infection with Babesia causes no specific clinical manifestations, with

63 Here we identify the RON2 proteins of Babesia divergens (BdRON2) and B. microti (BmRON2) and s

64 we present a detailed characterization of a Babesia divergens homolog of AMA1 (BdAMA1), and taking a

65 n of erythrocytes is an integral part of the Babesia divergens life cycle.

66 and clinically mutant cells, we showed that Babesia divergens uses neuraminidase- and trypsin-sensit

67 7, the major antigenic adhesion protein from Babesia divergens, the agent of bovine babesiosis, was a

68 e patient's serum had strong reactivity with Babesia divergens, which causes babesiosis in cattle and

69 nsfusions acquired babesiosis infection with Babesia divergens-like/MO-1 organisms and not Babesia mi

70 s efficiently acquire the protozoal pathogen Babesia equi during acute and persistent infections and

71 osis tested negative for Babesia caballi and Babesia equi in the complement fixation test before impo

72 zoite antigens 1 and 2 (EMA-1 and EMA-2) are Babesia equi proteins expressed on the parasite surface

73 The protozoan parasite Babesia equi replicates within erythrocytes.

74 a seminested PCR to detect and differentiate Babesia gibsoni (Asian genotype), B. canis subsp. vogeli

75 s, including Ehrlichia canis, Babesia canis, Babesia gibsonii, or spotted fever group rickettsiae, wa

76 Coinfection with other pathogens such as Babesia has been shown to alter the clinical course of L

77 f the relatively understudied zoonotic genus Babesia In humans, babesiosis, particularly transfusion-

78 m a single blood donation by an asymptomatic Babesia-infected donor.

79 Forty-six babesia-infected subjects were identified from 1991 thro

80 a central role in determining the course of Babesia infection in these strains.

81 In this study, we evaluated the course of Babesia infection in three strains of mice, C57BL/6J, BA

82 ated Plasmodium species, the pathogenesis of Babesia infection remains poorly understood.

83 Recognizing that Babesia is an expanding blood safety threat, there shoul

84 e the current gold standard for detection of Babesia is microscopic examination of blood smears, accu

85 d by intraerythrocytic protozoa of the genus babesia, is characterized by nonimmune hemolytic anemia

86 her and with the Missouri and Kentucky human Babesia isolates.

87 n of erythrocytes is an integral part of the Babesia life cycle.

88 A newly identified intraerythrocytic Babesia-like organism, WA1, and its relatives were recen

89 % to Ehrlichia chaffeensis, and 17.8% to the Babesia-like piroplasm WA1.

90 In rare cases, infection with Babesia may be associated with marked pancytopenia.

91 nfections with Borrelia burgdorferi (33.6%), Babesia microti (8.4%), Anaplasma phagocytophila (1.9%),

92 this parasite to be most closely related to Babesia microti (97.9% sequence similarity); sera from i

93 A new strain of Babesia microti (KR-1) was isolated from a Connecticut r

94 rently infected with Borrelia burgdorferi or Babesia microti (or both).

95 Borellia burgdorferi, Babesia microti and Anaplasma phagocytophilum rely almos

96 ly caused by the intraerythrocytic parasite, Babesia microti and transmitted by the same tick as Lyme

97 in indirect fluorescent-antibody tests with Babesia microti antigen, however, suggesting that they r

98 ansplant recipient who survived infection by Babesia microti contracted through blood transfusion.

99 s and fatalities of babesiosis are caused by Babesia microti Current treatment for human babesiosis c

100 Serologic evidence of exposure to Babesia microti did not significantly impact the clinica

101 arasites could be seen on microscopy, and no Babesia microti DNA was detected in the blood of any sub

102 sitive, and accurate method for detection of Babesia microti in patient specimens.

103 testing were used to confirm the presence of Babesia microti in the donor's blood and to establish th

104 aneous infection of Borrelia burgdorferi and Babesia microti in the northeastern and northern midwest

105 of coinfection with Borrelia burgdorferi and Babesia microti in tick vectors, reservoir hosts, and pa

106 y who were suspected of local acquisition of Babesia microti infection.

107 Babesia microti is a tick-borne red blood cell parasite

108 Human babesiosis caused by Babesia microti is an emerging tick-borne zoonosis of in

109 long-term carriers of the zoonotic parasite Babesia microti is evidenced by numerous reported cases

110 Although infection by the protozoan Babesia microti is rarely symptomatic in immunocompetent

111 Tickborne transmission of Babesia microti mainly occurs in 7 states in the Northea

112 atment of babesiosis, including clearance of Babesia microti parasitemia.

113 acted from whole-blood specimens and detects Babesia microti with a limit of detection of approximate

114 the United States is caused predominantly by Babesia microti, a tick-transmitted blood parasite.

115 Babesia microti, a tick-transmitted, intraerythrocytic p

116 Babesia microti, a tickborne intraerythrocytic parasite

117 Babesia microti, a zoonotic intraerythrocytic parasite,

118 agent of human monocytic ehrlichiosis (HME), Babesia microti, and Borrelia burgdorferi.

119 burgdorferi, babesiosis, which is caused by Babesia microti, and human granulocytic ehrlichiosis (HG

120 babesiosis, which is caused by the piroplasm Babesia microti, is made by microscopic identification o

121 besiosis, a zoonosis caused by the protozoan Babesia microti, is usually not treated when the symptom

122 gainst a panel of 24 organisms consisting of Babesia microti, other Babesia species, Plasmodium speci

123 abesia divergens-like/MO-1 organisms and not Babesia microti, the common United States species.

124 ime PCR assay targeting the 18S rRNA gene of Babesia microti, the dominant babesiosis pathogen in the

125 ted States have been tickborne and caused by Babesia microti, the etiologic agent of all previously d

126 The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human ba

127 and molecular tests for the causative agent, Babesia microti.

128 gnosed by peripheral red blood cell smear as Babesia microti.

129 tic Ehrlichia sp., Borrelia burgdorferi, and Babesia microti.

130 ere coinfected with Borrelia burgdorferi and Babesia microti.

131 ic cycle, including Borrelia burgdorferi and Babesia microti.

132 burgdorferi, Anaplasma phagocytophilum, and Babesia microti.

133 CD71-positive reticulocytes rarely contained Babesia nuclei and failed to express Babesia antigens.

134 ection with the recently identified WA1-type Babesia parasite is described.

135 ich develops through cyclical replication of Babesia parasites in host erythrocytes.

136 methods do not identify infected donors, and Babesia parasites survive blood-banking procedures and s

137 s the identification of novel stage-specific Babesia proteins for testing transmission-blocking immun

138 s four cysteine residues conserved among all Babesia RAP-1 family members and a C-terminal (CT) regio

139 ever, there are no exoerythrocytic stages in Babesia, so targeting of the blood stage and associated

140 A Babesia sp. found in eastern cottontail rabbits (Sylvila

141 of an underrecognized, but highly enzootic, Babesia sp. in baboons may result in substantial, unanti

142 irst identification of antigens expressed in Babesia sp. sporozoites and establishes that, at least i

143 of severe combined immunodeficient mice with Babesia sp. strain WA1 was studied to assess the contrib

144 Two continuous lines of the zoonotic Babesia sp. were established and confirmed to share iden

145 ing of 130 slides positive for Plasmodium or Babesia species and 151 negative controls.

146 c characteristics; MO1 probably represents a Babesia species not previously recognized to have infect

147 s a tick-borne multisystem disease caused by Babesia species of the apicomplexan phylum.

148 mpared the detection rates of Plasmodium and Babesia species on peripheral blood smears utilizing the

149 omparative analysis within and between three Babesia species, (B. bigemina, B. divergens and B. bovis

150 ganisms consisting of Babesia microti, other Babesia species, Plasmodium species, tick-borne and othe

151 rious Ehrlichia, Bartonella, Rickettsia, and Babesia species.

152 nalysis was done to compare MO1 with various Babesia species.

153 on for reactivity with antigens from various Babesia species.

154 Plasmodium, Toxoplasma, Cryptosporidium and Babesia species.

155 has been identified and characterized in any Babesia spp.

156 extension of the geographic range of various Babesia spp. and the movement of donors and blood produc

157 Babesia spp. are tick-borne, intraerythrocytic hemoparas

158 ion at 56% (5 of 9); Plasmodium malariae and Babesia spp. had the highest rate of detection at 100% (

159 phic range of B. microti is expanding, other Babesia spp. have been implicated in transfusion transmi

160 id diagnostic technique for the detection of Babesia spp. that has not yet been systematically evalua

161 er 1933 is synonymous with that of the genus Babesia Starcovici 1893 and that the morphological varia

162 No Babesia test for screening blood donors has been license

163 e response that protects from the pathogenic Babesia WA1 is mediated by macrophages and NK cells, pro