ライフサイエンスコーパス: Bartonella

1 iales bacteria with affiliation to the genus Bartonella.

2 known about in vivo virulence strategies of Bartonella.

3 ividually tested ticks were PCR positive for Bartonella.

4 ollected at Baird Ranch was PCR positive for Bartonella.

5 y Hill Open Space Reserve were infected with Bartonella.

6 Bacteria of the genus Bartonella, a member of the Alphaproteobacteria, are fas

7 Two species of Bartonella, a novel Bartonella clarridgeiae-like bacteri

8 rom bacteremic Bartonella spp., tested using Bartonella Alphaproteobacteria growth medium (BAPGM), we

9 ntly described clinical isolate, "Candidatus Bartonella ancashi," was obtained from a blood sample of

10 egree of identity with homologues from other Bartonella and alpha-Protebacteria.

11 logenetic analysis reveals a relationship to Bartonella and Brucella, which infect mammals.

12 ding the emerging human and animal pathogens Bartonella and Brucella.

13 argeting a 301-bp region of the ssrA gene of Bartonella and demonstrated specific amplification in ov

14 quences in the ITS region that are common to Bartonella and Mesorhizobium species, the amplification

15 ified that the isolate belonged to the genus Bartonella and that it was genotypically related to B. v

16 association between the exposure of dogs to Bartonella and the exposure of dogs to A. phagocytophilu

17 pneumoniae, Mycobacterium tuberculosis, and Bartonella), and 13 viruses (parechovirus, dengue virus,

18 khoffii genomic expression library with anti-Bartonella antibodies led to the identification of the s

19 odels were used to assess the association of Bartonella antibody titer categories with potential risk

20 te negative blood cultures, the cat had high Bartonella antibody titers and B. henselae type I DNA wa

21 seropositive (titer of 1:4,096) for several Bartonella antigens (B. vinsonii subsp. berkhoffii, B. c

22 Bartonella are ubiquitous gram-negative pathogens that c

23 The mechanisms of Bartonella-associated vascular proliferation remain uncl

24 each other but phylogenetically distant from Bartonella bacilliformis and considerably divergent from

25 Bartonella bacilliformis causes bartonellosis, a potenti

26 Bartonella bacilliformis has caused debilitating illness

27 frame (ORF), showed significant homology to Bartonella bacilliformis IalA (invasion associated locus

28 Recombinant IalA protein from Bartonella bacilliformis is a monomeric adenosine 5'-tet

29 Genotypic diversity among 26 isolates of Bartonella bacilliformis obtained from different areas o

30 Bartonella bacilliformis was continuously internalized i

31 lone expressing an immunoreactive antigen of Bartonella bacilliformis was isolated by screening a gen

32 on-associated locus A and B genes (ialAB) of Bartonella bacilliformis were previously shown to confer

33 The groESL operon of Bartonella bacilliformis, a facultative intracellular, G

34 a clinical syndrome caused by the bacterium Bartonella bacilliformis, and is characterized by the de

35 the sole or principal vectors of Leishmania, Bartonella bacilliformis, and some arboviruses.

36 The causative agent, Bartonella bacilliformis, is endemic in specific regions

37 mpylobacter jejuni, Helicobacter pylori, and Bartonella bacilliformis, require flagellar motility to

38 The results of this study show that Bartonella bacilliformis, the agent of Oroya fever and v

39 d bacteremia from an organism that resembled Bartonella bacilliformis, the causative agent of Oroya f

40 ith the invasion of human red blood cells by Bartonella bacilliformis, the causative agent of several

41 by infection with the alpha-proteobacterium Bartonella bacilliformis.

42 of whom demonstrated previous infection with Bartonella bacilliformis.

43 ned genes by allelic exchange in a wild-type Bartonella background, which had not been achieved previ

44 Six (19%) of 31 Bartonella bacteremic coyotes exhibited the strain profi

45 By PFGE analysis, three Bartonella bacteremic coyotes were infected by a strain

46 Bartonella bacteria adhere to erythrocytes and persisten

47 and genotypes from cattle were identified as Bartonella bovis, both Bartonella species commonly found

48 s revealed a cluster most closely related to Bartonella capreoli, and genotypes from cattle were iden

49 Human exposure to Bartonella clarridgeiae has been reported only on the ba

50 umented case of endocarditis associated with Bartonella clarridgeiae in any species.

51 inoculated with Bartonella henselae- and/or Bartonella clarridgeiae-infected cat blood and monitored

52 Two species of Bartonella, a novel Bartonella clarridgeiae-like bacterium and B. vinsonii s

53 ed primers that were designed to amplify the Bartonella consensus ITS region.

54 All Bartonella cultures were found to be negative.

55 In this study we compared some common Bartonella culturing methodologies using four diverse sp

56 sion in specific-pathogen-free cats and that Bartonella DNA can be detected in blood, brain, lymph no

57 Using this assay, we identified Bartonella DNA in 29% and 47% of blood specimens from el

58 repeats not found in any other bacterial or Bartonella DNA sequences.

59 in some Warthin-Starry stained sections, and Bartonella DNA was amplified from the lymph node (from 6

60 udy of the adaptation mechanisms employed by Bartonella during the transition between human host and

61 Bartonella effector protein A (BepA) of vasculotumorigen

62 Bartonella henselae or Bartonella elizabethae DNA from EDTA-anticoagulated bloo

63 tis E virus in this population was 13.6%; to Bartonella elizabethae, 12.5%; to B. quintana, 9.5%; to

64 ates from R. norvegicus were most similar to Bartonella elizabethae, isolated previously from a patie

65 eiae, and B. henselae), highly suggestive of Bartonella endocarditis.

66 o infection by undergoing apoptosis and that Bartonella evolved the antiapoptotic activity to enhance

67 nce analyses of gltA amplicons obtained from Bartonella from the rodents demonstrated considerable he

68 The most notable difference between Bartonella Fur and other Fur proteins was a substantiall

69 204 nucleotides immediately upstream of the Bartonella fur gene.

70 racterize antigens recognized by the host, a Bartonella genomic expression library was screened with

71 tA, a commonly used gene for differentiating Bartonella genotypes.

72 ted to each other and secondarily related to Bartonella grahamii and Bartonella vinsonii.

73 (93%-100% sequence similarity), followed by Bartonella grahamii and other Bartonella species isolate

74 In this model, Bartonella grows in extracellular aggregates, embedded w

75 Four species of Bartonella have been reported to infect cats and dogs, a

76 Five species of Bartonella have been reported to infect humans and cause

77 Members of the genus Bartonella have historically been connected with human d

78 on at a sequence that is highly conserved in Bartonella hbp genes, which we designated the hbp family

79 oronary artery disease and seropositivity to Bartonella henselae (odds ratio [OR], 0.852; 95% confide

80 Bartonella henselae and B. koehlerae bacteremia was docu

81 Bartonella henselae and B. quintana induce an unusual va

82 ter membrane protein family of proteins from Bartonella henselae and Bartonella quintana, respectivel

83 ichia, and Rickettsia species, as well as on Bartonella henselae and Escherichia coli, and the assay

84 Sixty-five (24%) cats had Bartonella henselae bacteremia, and 138 (51%) cats were

85 Herein, we report a case of Bartonella henselae endocarditis involving prosthetic mi

86 We report the first feline case of Bartonella henselae endocarditis.

87 and it facilitated the primary isolation of Bartonella henselae from blood and aqueous fluid of natu

88 Bartonella henselae fur gene expression complemented a V

89 rovide molecular microbiological evidence of Bartonella henselae genotype San Antonio 2 (SA2) infecti

90 Bartonella henselae has only recently been isolated, cha

91 mechanism contributes to the persistence of Bartonella henselae in the chronically infected vascular

92 We report the first case of HLH due to Bartonella henselae infection in a patient with human im

93 alignancies, high-dose androgen therapy, and Bartonella henselae infection.

94 Bartonella henselae is a gram-negative pathogen that cau

95 Bartonella henselae is a recently recognized pathogenic

96 The gram-negative bacterium Bartonella henselae is capable of causing angiogenic les

97 Bartonella henselae is increasingly associated with a va

98 Bartonella henselae is known to cause central nervous sy

99 Bartonella henselae is one of the most common zoonotic a

100 A hallmark of Bartonella henselae is persistent bacteremia in cats des

101 Bartonella henselae is responsible for various disease s

102 Bartonella henselae is the causative agent of human cat

103 Using Bartonella henselae isolates from cats and a human, the

104 Bartonella henselae or Bartonella elizabethae DNA from E

105 egative pathogens were identified, including Bartonella henselae Pap31, Brucella Omp31, Agrobacterium

106 hat the closest homologs to HbpA include the Bartonella henselae phage-associated membrane protein, P

107 ector protein A (BepA) of vasculotumorigenic Bartonella henselae protects the infected human endothel

108 s is usually made on the basis of increasing Bartonella henselae serum antibody titers.

109 ittens born to antibody-positive queens with Bartonella henselae to determine the contribution of ant

110 We observed a CAMP-like reaction when Bartonella henselae was grown in close proximity to S. a

111 Bartonella henselae wound-associated infections suggest

112 rium tumefaciens and similar pathogens (e.g. Bartonella henselae) may also be able to transform human

113 In Bartonella henselae, 8 of the 10 virB operon genes share

114 at-scratch disease is an infection caused by Bartonella henselae, a fastidious gram-negative bacillus

115 etect and differentiate Bartonella quintana, Bartonella henselae, and Coxiella burnetii from surgical

116 ogens Brucella abortus, Brucella melitensis, Bartonella henselae, and Legionella pneumophila, which a

117 chronic infections, e.g., Brucella abortus, Bartonella henselae, and Legionella pneumophila.

118 rom animals known to be infected with either Bartonella henselae, B. clarridgeiae, or B. vinsonii sub

119 athogenic Bartonella species and subspecies: Bartonella henselae, B. quintana, B. washoensis, and B.

120 patient's blood and serum were negative for Bartonella henselae, Bartonella quintana, and B. bacilli

121 aciens, Bordetella pertussis, Brucella spp., Bartonella henselae, Helicobacter pylori and Legionella

122 with the facultative intracellular bacterium Bartonella henselae, is characterized by angiogenic lesi

123 ophils with intracellular pathogens, such as Bartonella henselae, Listeria monocytogenes, Legionella

124 ng was conducted, eight were seroreactive to Bartonella henselae, one to E. chaffeensis, and one to R

125 Bartonella vinsonii subsp. berkhoffii, Bartonella henselae, or DNA of both organisms was amplif

126 human pathogens have emerged recently (e.g., Bartonella henselae, Rickettsia felis), and their mechan

127 Sera from patients who had a high titer for Bartonella henselae, the causative agent of bacillary an

128 ific-pathogen-free cats were inoculated with Bartonella henselae- and/or Bartonella clarridgeiae-infe

129 chia chaffeensis, Rickettsia rickettsii, and Bartonella henselae.

130 ilar to the VirB type IV secretion system of Bartonella henselae.

131 been identified upstream of the htrA gene of Bartonella henselae.

132 The veterinarian was coinfected with Bartonella henselae.

133 e an important new tool for investigation of Bartonella-host interaction.

134 of 273 bp of the gltA gene were applied for Bartonella identification.

135 es shared major characteristics of the genus Bartonella in terms of most biochemical features and cel

136 The genus Bartonella includes numerous species with varied host as

137 Here, I establish in vitro models to study Bartonella-induced blood vessel formation.

138 thelioma, these results suggest that chronic Bartonella infection could have a role in the developmen

139 wildlife removal on per capita prevalence of Bartonella infection in either rodents or fleas.

140 who developed clinical signs compatible with Bartonella infection in Santa Clara County, Calif., this

141 the diagnostic and therapeutic management of Bartonella infection.

142 opod exposure as a potential risk factor for Bartonella infection.

143 tive diagnostic method for identification of Bartonella infections in humans and have utility in Bart

144 Diagnosis of Bartonella infections is hampered by the slow, fastidiou

145 Human Bartonella infections result in diverse medical presenta

146 at elicit antibody production in response to Bartonella infections, this project was undertaken to id

147 ues are increasingly important in diagnosing Bartonella infections.

148 Here we show that Bartonella inhibits apoptosis of endothelial cells in vi

149 No evidence of infection was seen in Bartonella-inoculated astrocyte cultures.

150 Bartonella is a Gram-negative pathogen that is unique am

151 owed that the novel Bartonella species and a Bartonella isolate from a mouse captured on Martha's Vin

152 ltA, 16S rRNA gene, and groEL sequences of a Bartonella isolate obtained from a California ground squ

153 Bartonella isolates associated with human disease and re

154 rphism, sequence, and phylogenetic analyses, Bartonella isolates from a dog with endocarditis, 22 gra

155 ed from the human patient in question and of Bartonella isolates obtained from the following Nevada r

156 However, a specific blood culture for Bartonella isolation grew a fastidious, gram-negative or

157 nsation, and hallucinations was persistently Bartonella koehlerae seroreactive and bacteremic.

158 Bartonella koehlerae, a recently described feline Barton

159 er Blattabacterium-like, Solitalea-like, and Bartonella-like symbionts.

160 Undetected coinfection with Bartonella may also complicate the evaluation of treatme

161 The Bartonella mitogen was found in bacterial culture supern

162 These data suggest that Bartonella modulation of host or target cell cytokines a

163 intracellular organisms with characteristic Bartonella morphology but identified no ultrastructural

164 species within Methanosarcina, Pseudomonas, Bartonella, Nitrosomonas, Thermotoga, and Aquifex showed

165 sponse, and ELISA testing using other feline Bartonella OMP antigens showed statistically lower optic

166 Very recently, Bartonella organisms have been isolated from large rumin

167 We identified the flea-borne Bartonella parasites infecting sympatric populations of

168 Bartonella proteins that elicit an antibody response dur

169 95% confidence interval [CI], 0.293-2.476), Bartonella quintana (OR, 0.425; 95% CI, 0.127-1.479), C.

170 previously identified four highly conserved Bartonella quintana adhesin genes that undergo phase var

171 Here, we report latent infections with Bartonella quintana and a hemotropic Mycoplasma sp. in a

172 Of all bacteria, Bartonella quintana has the highest reported in vitro he

173 saccharide (LPS) and Pap31, a homolog of the Bartonella quintana heme-binding protein A (HbpA), defin

174 necessary to characterize the risk of human Bartonella quintana infection following cat bites.

175 Bartonella quintana is a fastidious, gram-negative, rod-

176 Bartonella quintana is a gram-negative agent of trench f

177 Bartonella quintana is a vector-borne bacterial pathogen

178 The bacterial pathogen Bartonella quintana is passed between humans by body lic

179 family of hemin-binding proteins (Hbp's) of Bartonella quintana that bind hemin on the outer surface

180 We report here the detection of Bartonella quintana, after putative bite transmission, i

181 serum were negative for Bartonella henselae, Bartonella quintana, and B. bacilliformis.

182 DNA amplification of biopsy tissue revealed Bartonella quintana, and Bartonella serologies were subs

183 d to simultaneously detect and differentiate Bartonella quintana, Bartonella henselae, and Coxiella b

184 ily of proteins from Bartonella henselae and Bartonella quintana, respectively.

185 Bartonella quintana, the agent of trench fever and a cau

186 Bartonella quintana, the agent of trench fever and an et

187 as cultured in the 1960s and reclassified as Bartonella quintana; it was also found to cause endocard

188 The genes were termed brpA to -C (bartonella repeat protein) and bore significant similari

189 characteristic retinal white spot syndrome, Bartonella retinitis, branch retinal arteriolar or venul

190 ns can be coinfected with various Ehrlichia, Bartonella, Rickettsia, and Babesia species.

191 This study reports the occurrence of "Bartonella rochalimae" in Europe and the presence of Bar

192 first case of canine endocarditis caused by "Bartonella rochalimae" is reported.

193 We propose that Bartonella's antiapoptotic mechanism accounts at least i

194 ree strains and placed them within the genus Bartonella separately from previously described species.

195 psy tissue revealed Bartonella quintana, and Bartonella serologies were subsequently noted to be posi

196 Indirect immunofluorescence assay for Bartonella serology was positive, and B henselae DNA was

197 serological testing (i.e., Q fever serology, Bartonella serology) in culture-negative cases.

198 We challenged cats transfused with anti-Bartonella serum and kittens born to antibody-positive q

199 DNA sequencing evidence of a potentially new Bartonella sp. infecting dogs in Greece and Italy.

200 After a 1-month incubation period, a Bartonella sp. was isolated on a 5% rabbit blood agar pl

201 r bacterial, viral and parasitic agents like Bartonella sp., Phleboviruses and Leishmania spp., respe

202 We detected infection with a Bartonella species (B. henselae or B. vinsonii subsp. be

203 Three strains of a novel Bartonella species (Bartonella tamiae) were isolated fro

204 . elizabethae should be added to the list of Bartonella species (i.e., B. vinsonii subsp. berkhoffii,

205 citrate synthase genes showed that the novel Bartonella species and a Bartonella isolate from a mouse

206 species are a reservoir host for pathogenic Bartonella species and are consistent with a hypothesize

207 ergoing coronary angiography for evidence of Bartonella species and Coxiella burnetii infection.

208 srA sequences was sufficient to discriminate Bartonella species and provided phylogenetic data consis

209 strain and to several known human-pathogenic Bartonella species and subspecies: Bartonella henselae,

210 t advance in the genetic manipulation of all Bartonella species and, combined with the animal model t

211 Most known Bartonella species are arthropod borne.

212 Bartonella species are gram-negative, emerging bacterial

213 Bartonella species cause serious human infections global

214 le were identified as Bartonella bovis, both Bartonella species commonly found in wild and domestic r

215 Bartonella species constitute emerging, vector-borne, in

216 pid and reliable method for the detection of Bartonella species DNA in clinical samples.

217 , we investigated the potential use of other Bartonella species for their ability to recapitulate hum

218 pecific enough to detect a diverse number of Bartonella species in a wide range of environmental samp

219 cular findings related to the isolation of a Bartonella species in North Carolina beef cattle and the

220 s associated with the molecular detection of Bartonella species in patient samples and indicate that

221 cats supports a potential etiologic role for Bartonella species in several idiopathic disease process

222 al results support perinatal transmission of Bartonella species in this family.

223 voles) in the UK and confirmed that several Bartonella species infect both rodent species.

224 ), followed by Bartonella grahamii and other Bartonella species isolated from Old World rodents (Clet

225 ent with a hypothesized Old World origin for Bartonella species recovered from Rattus species introdu

226 ed strains, the activity is produced only by Bartonella species that are significant human pathogens

227 ngle-step PCR assay to differentiate between Bartonella species was determined with characterized iso

228 Infection with a Bartonella species was implicated in three cases of epis

229 Bartonella species were isolated from the blood of 63 of

230 pable of detecting the diverse repertoire of Bartonella species while maintaining genus specificity h

231 ed by an organism identified as the proposed Bartonella species, "B. washoensis." The organism was is

232 Because of variation in ITS sequences among Bartonella species, a single PCR amplification can be us

233 tys, 20 with a Rickettsia species, 16 with a Bartonella species, and 7 with B. canis.

234 o support cocultures consisting of different Bartonella species, and it facilitated the primary isola

235 resented a previously uncultured and unnamed bartonella species, closely related to B. clarridgeiae a

236 and considerably divergent from other known Bartonella species, confirming their novelty.

237 monstrated specific amplification in over 30 Bartonella species, subspecies, and strains.

238 ulted in a product of a unique size for each Bartonella species, thereby allowing differentiation wit

239 nella koehlerae, a recently described feline Bartonella species, was isolated from two naturally infe

240 refore, it is important to determine if some Bartonella species, which are emerging pathogens, could

241 an uncommon manifestation of infection with Bartonella species.

242 m that supports the growth of at least seven Bartonella species.

243 used as a diagnostic target for detection of Bartonella species.

244 to achieve molecular diagnostic detection of Bartonella species.

245 tration of molecular Koch's postulates for a Bartonella species.

246 d the fur gene and flanking regions of three Bartonella species.

247 es to the identification of human-pathogenic Bartonella species.

248 on and differentiation of medically relevant Bartonella species.

249 on and differentiation of medically relevant Bartonella species.

250 e slow, fastidious growth characteristics of Bartonella species.

251 dogs were more likely to be seroreactive to Bartonella spp.

252 ty was observed with antiserum against other Bartonella spp.

253 (8.4%), Anaplasma phagocytophila (1.9%), and Bartonella spp. (34.5%).

254 Bartonella spp. are known to induce vasoproliferative tu

255 e performed to clarify the potential role of Bartonella spp. as a cause of chronic neurological and n

256 lished reports, support a potential role for Bartonella spp. as a cause of epistaxis in dogs and pote

257 h as PCR may help to implicate a spectrum of Bartonella spp. as a cause of or a cofactor in chronic c

258 evalence of bacteremia and seroreactivity to Bartonella spp. in gray foxes suggests that they may act

259 orting concurrent infection with one or more Bartonella spp. in more than one family member; however,

260 ining changes in prevalence and abundance of Bartonella spp. infection in rodents and their flea vect

261 It is of clinical relevance that Bartonella spp. may adversely influence human reproducti

262 had reciprocal titers of antibodies against Bartonella spp. of > or =64.

263 hern blots indicate that all five pathogenic Bartonella spp. possess hbpA homologs.

264 ts (20.8%) were PCR positive for one or more Bartonella spp. using the BAPGM platform.

265 virus, and yellow fever virus), 8 bacteria (Bartonella spp., Brucella spp., Coxiella burnetii, Lepto

266 Infections caused by several bacteria (e.g. Bartonella spp., Lawsonia intracellularis and Citrobacte

267 Patients with infection from bacteremic Bartonella spp., tested using Bartonella Alphaproteobact

268 ains, which were closely related to a cattle Bartonella strain and to several known human-pathogenic

269 icks, molecular analysis showed a variety of Bartonella strains, which were closely related to a catt

270 tsia typhi also reacted with our recombinant Bartonella SucB.

271 Bartonella suppresses both early and late events in apop

272 lla infections in humans and have utility in Bartonella surveillance studies.

273 Although heme is essential for Bartonella survival, little is known about genes involve

274 Our data showed that Bartonella tamiae demonstrated temperature-dependent gro

275 Three strains of a novel Bartonella species (Bartonella tamiae) were isolated from human patients fro

276 Here, we demonstrate the ability of Bartonella taylorii to cause chronic infection in SCID/B

277 e ticks were more likely to be infected with Bartonella than female ticks (26 versus 12%, P = 0.05).

278 acificus ticks may play an important role in Bartonella transmission among animals and humans.

279 , defaunation represents an elevated risk in Bartonella transmission to humans (bartonellosis).

280 monella, Escherichia, Shigella, Listeria and Bartonella, using published literature.

281 es associated with each rodent host, and the Bartonella variants carried by individual fleas.

282 were host-generalists but the assemblage of Bartonella variants in fleas tended to reflect the assem

283 in fleas tended to reflect the assemblage of Bartonella variants in the host species they were collec

284 This process led to the discovery of a Bartonella vinsonii subsp. arupensis gene encoding a 382

285 We propose the name Bartonella vinsonii subsp. arupensis subsp. nov. as the

286 Immunologic screening of a Bartonella vinsonii subsp. berkhoffii genomic expression

287 In this report, we describe isolation of Bartonella vinsonii subsp. berkhoffii genotype II from a

288 The molecular characterization of a Bartonella vinsonii subsp. berkhoffii genotype III strai

289 la rochalimae" in Europe and the presence of Bartonella vinsonii subsp. berkhoffii genotypes II and I

290 Bartonella vinsonii subsp. berkhoffii was originally iso

291 Bartonella vinsonii subsp. berkhoffii, Bartonella hensel

292 in 12 dogs, of which 11 were seroreactive to Bartonella vinsonii subspecies berkhoffii antigens.

293 emia with fever due to a novel subspecies of Bartonella vinsonii was found in a cattle rancher.

294 hrlichia sp., 16 to Babesia canis, and 25 to Bartonella vinsonii, and 22 seroconverted to Rickettsia

295 condarily related to Bartonella grahamii and Bartonella vinsonii.

296 om a mouse experimentally infected with live Bartonella was reactive against recombinant SucB, indica

297 We report the first documented case of Bartonella washoensis bacteremia in a dog with mitral va

298 ck protein gene groEL, and 16S rRNA gene) of Bartonella washoensis cultured from the human patient in

299 of 38 cattle had antibodies (> or =1:64) to Bartonella weissii (bovine origin) antigens.

300 Structures suggestive of Bartonella were visualized in some Warthin-Starry staine

301 fecal-oral transmission pathway, but not in Bartonella, which use blood-borne transmission pathways.