ライフサイエンスコーパス: Becker muscular dystrophy

1 orphological changes in a novel pig model of Becker muscular dystrophy.

2 for development as a therapy for Duchenne or Becker muscular dystrophy.

3 individuals versus symptomatic patients with Becker muscular dystrophy.

4 d upon reframing, similar to observations in Becker muscular dystrophy.

5 mice with mdx mice, a model for Duchenne and Becker muscular dystrophy.

6 ex mutants, including patients with Duchenne/Becker muscular dystrophy.

7 n order to detect deletions causing Duchenne/Becker muscular dystrophy.

8 trophin, the protein mutated in Duchenne and Becker muscular dystrophy.

9 g show promise as therapies for Duchenne and Becker muscular dystrophies.

10 Thirteen men with Becker muscular dystrophy, 10 female carriers and 23 con

11 rt failure is characteristic of Duchenne and Becker muscular dystrophies and X-linked dilated cardiom

12 Materials and Methods Eight patients with Becker muscular dystrophy and eight matched control subj

13 ive results for non-DMD disorders, including Becker muscular dystrophy and forms of limb-girdle and c

14 me pseudoexon mutations (one associated with Becker muscular dystrophy and one with DMD), mutation-in

15 ophin, the defective protein in Duchenne and Becker muscular dystrophies, and therapeutic utrophin de

16 cal mechanisms leading to muscle necrosis in Becker muscular dystrophy are still unknown.

17 Patients with Becker muscular dystrophy (BMD) and Duchenne muscular dy

18 Duchenne muscular dystrophy and Becker muscular dystrophy (BMD) are caused by mutations

19 ne muscular dystrophy (DMD) into less severe Becker muscular dystrophy (BMD) by altering pre-mRNA spl

20 Becker muscular dystrophy (BMD) is a progressive X-linke

21 In Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), interventions reducing

22 henne muscular dystrophy (DMD) or the milder Becker muscular dystrophy (BMD), largely depending on wh

23 er disease (GD) type III, Duchenne (DMD) and Becker muscular dystrophy (BMD), Parkinson disease (PD),

24 nclude Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), X-linked dilated cardio

25 in, similar to those expressed in the milder Becker muscular dystrophy (BMD).

26 phies, Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD).

27 functional, dystrophin protein as occurs in Becker muscular dystrophy (BMD).

28 s preserved in calf muscles of patients with Becker muscular dystrophy (BMD, n = 14) and limb-girdle

29 isruption of the reading frame often lead to Becker muscular dystrophy, but a genotype/phenotype corr

30 muscle protein dystrophin triggers Duchenne/Becker muscular dystrophy, but the structure-function re

31 Both DMD and Becker muscular dystrophy can result from out-of-frame p

32 Duchenne and Becker muscular dystrophies (DBMD) are allelic disorders

33 These mutations result in the Duchenne and Becker muscular dystrophies (DMD and BMD).

34 ted progress in gene therapy of Duchenne and Becker muscular dystrophy (DMD and BMD) skeletal muscle

35 dystrophin gene result in both Duchenne and Becker muscular dystrophy (DMD and BMD), as well as X-li

36 ns in about 65% of patients with Duchenne or Becker muscular dystrophy (DMD or BMD).

37 rophin gene are responsible for Duchenne and Becker muscular dystrophy (DMD/BMD).

38 tin, MYO-029, in adult muscular dystrophies (Becker muscular dystrophy, facioscapulohumeral dystrophy

39 n humans [Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, facioscapulohumeral muscular

40 d the clinical phenotype of 17 patients with Becker muscular dystrophy harbouring in-frame deletions

41 were reported in patients with Duchenne and Becker muscular dystrophies; improved understanding of t

42 Mutations in this locus cause Duchenne or Becker muscular dystrophies in human patients and are th

43 Becker muscular dystrophy is an X-linked disease due to

44 Becker muscular dystrophy is an X-linked disorder due to

45 A Becker muscular dystrophy mutation reduces ankyrin bindi

46 patients, missense mutations can cause DMD, Becker muscular dystrophy, or X-linked cardiomyopathy.

47 rial ATP production was similar in muscle of Becker muscular dystrophy patients and controls.

48 later phases of exercise, skeletal muscle in Becker muscular dystrophy patients was less acidic than

49 rate of proton efflux from muscle fibres of Becker muscular dystrophy patients was similar to that o

50 ated with a less severe phenotype in certain Becker muscular dystrophy patients.

51 t and/or slow disease progression in certain Becker muscular dystrophy patients.

52 and glycolytic ATP production in vivo in 14 Becker muscular dystrophy patients.

53 nd of exercise being significantly higher in Becker muscular dystrophy patients.

54 enerative muscle diseases Duchenne (DMD) and Becker muscular dystrophy result from mutations in the D

55 A subset of patients with Duchenne and Becker muscular dystrophy similarly possess a nonsense m

56 Duchenne and Becker muscular dystrophy (the Xp21 dystrophies) are ass

57 hy phenotype to that of the milder disorder, Becker muscular dystrophy, typically caused by in-frame

58 s situation presents a striking analogy with Becker muscular dystrophy, where in-frame deletions in t

59 clinical trial of patients with Duchenne or Becker muscular dystrophy whose LVEF was preserved and M

60 sociated protein expression in patients with Becker muscular dystrophy with deletions relevant for on

61 ping the patients by deletion, patients with Becker muscular dystrophy with deletions with an end-poi