ライフサイエンスコーパス: Bergmann

1 Bergmann glia and retinal Muller cells, nonforebrain ast

2 Bergmann glia-specific expression of mutant ataxin-7 was

3 Bergmann glial cells (BGs), astrocytes of the cerebellar

4 Bergmann glial processes are abnormal and GFAP-positive

5 rya of radial cells in the telencephalon; 2) Bergmann glia in the cerebellum; 3) astrocytes; 4) tanic

6 Using paired recordings of a Bergmann glial cell and a granule cell in the whole cell

7 in Bergmann glia development by utilizing a Bergmann glial culture preparation.

8 ted with the breaches in the BM and abnormal Bergmann glial networks during postnatal cerebellar deve

9 In addition, Bergmann glia were TUNEL positive at P21, and they expre

10 rasynaptic transmission from PFs to adjacent Bergmann glia (BG).

11 tor trafficking to neuronal locomotion along Bergmann glial fibers in the developing cerebellum.

12 process, granule neurons (GNs) migrate along Bergmann glia (BG), which are specialized astroglial cel

13 O mice, possibly as a consequence of altered Bergmann glia orientation or reduced granule cell number

14 pressed in both Purkinje cells (GluR2/3) and Bergmann glia (GluR4) throughout postnatal development.

15 The results demonstrate that astrocytes and Bergmann glia cells are the first cells of the brain par

16 in-1 is found in perivascular astrocytes and Bergmann glia, and is not PSD-enriched.

17 PA receptors expressed by Purkinje cells and Bergmann glia cells are activated predominantly by synap

18 ity traces for up to >100 Purkinje cells and Bergmann glia from single recordings.

19 ved in cerebellar cortex: Purkinje cells and Bergmann glia were positive for both subunits, whereas g

20 elopmental interaction of Purkinje cells and Bergmann glia.

21 involves the generation of granule cells and Bergmann glias (BGs).

22 but is restricted to proliferating GCPs and Bergmann glia.

23 important counterexamples to both James' and Bergmann's temperature-size rules, respectively, undermi

24 vivo results in deficient granule neuron and Bergmann glia differentiation as well as in abnormal Pur

25 ings were obtained from Purkinje neurons and Bergmann glia in mouse cerebellar slices to determine th

26 as also detected in both granule neurons and Bergmann glia.

27 tion of ventricular zone-derived neurons and Bergmann glia.

28 was broadly distributed in both neurons and Bergmann glial radial fibers.

29 ht link between copper homeostasis in PN and Bergmann glia.

30 urkinje cells, Purkinje axonal torpedoes and Bergmann gliosis.

31 As Bergmann glial membranes are excluded from the synaptic

32 c interpretation of empirical clines such as Bergmann's Rule.

33 protein, expressed in astrocytes as well as Bergmann glia.

34 and/or cytoplasmic inclusions in astrocytes, Bergmann glia, and neurons, as well as relationships bet

35 kinje cell synapses during early ages and at Bergmann glia plasma membrane in the adult.

36 es indicates that the glutamate transient at Bergmann glial membranes reaches a lower concentration t

37 s high-concentration glutamate transients at Bergmann glia cell membranes that are necessary to activ

38 is expressed by virtually all astrocytes, by Bergmann glial cells in cerebellum, by Muller cells in r

39 ell dendritic growth and their enwrapping by Bergmann glia.

40 cytosolic Ca(2+) regulates uptake of K(+) by Bergmann glia, thus providing a powerful mechanism for c

41 an alteration of glutamate uptake played by Bergmann glia.

42 ensheathment of CF/Purkinje cell synapses by Bergmann glia.

43 , clearance of glutamate relies on uptake by Bergmann glial cells and Purkinje cells (PCs).

44 e neuronal GABA(A) receptors were wrapped by Bergmann glia processes containing glial GABA(A) recepto

45 stence of radial glia (RG)-like cells called Bergmann glia (BG) are hallmarks of the mammalian cerebe

46 two patients showed loss of Purkinje cells, Bergmann gliosis and deep cerebellar white matter inflam

47 Cerebellar Bergmann glia are radial astrocytes that are implicated

48 is expressed in newborn and adult cerebellar Bergmann glia astrocytes.

49 tical basal radial glia (bRG) and cerebellar Bergmann glia (BG) are basal progenitors derived from ve

50 ncephalic radial glia, as well as cerebellar Bergmann glia.

51 utamate transporters expressed by cerebellar Bergmann glial cells are activated by neurotransmitter r

52 amate to outside-out patches from cerebellar Bergmann glia activates anion-potentiated glutamate tran

53 beta2 and beta3, are expressed in cerebellar Bergmann glia as well as granule neurons.

54 prenatally but became enriched in cerebellar Bergmann glia early postnatally and then was also presen

55 ocytes, microglia, and subsets of cerebellar Bergmann glia, spinal motor neurons, macrophages, and de

56 Focusing on cerebellar Bergmann glia (BG) cells, which exhibit the highest rate

57 r, quantal events recorded in rat cerebellar Bergmann glial cells (BGs) have fast kinetics, comparabl

58 Recent studies have shown that cerebellar Bergmann glia display coordinated Ca(2+) transients in l

59 nd was particularly strong in the cerebellar Bergmann glia.

60 In the cerebellum, Bergmann glia cells (BGs) are intimately associated with

61 The second is to establish the correct Bergmann glia morphology, which is crucial for granule c

62 ith impaired glutamate transport in cultured Bergmann glia, cerebellar slices and cerebellar synaptos

63 The first morphologically definable Bergmann glia, astrocytes, and oligodendrocytes were als

64 as well as the importance of time-dependent Bergmann glia differentiation during cerebellar developm

65 nted folia, profound granule cell depletion, Bergmann gliosis, and signs of Purkinje cell deafferenta

66 n marker, but was present in differentiating Bergmann glia that expressed brain lipid binding protein

67 and decreased the number of differentiating Bergmann glia, without significantly altering the non-gl

68 -8a mutation in mice results in disorganized Bergmann glial scaffolding, defective granule cell migra

69 owed severe ataxia associated with disrupted Bergmann fiber scaffold formation, impaired granule neur

70 ts that Ric-8a is essential for the enhanced Bergmann glia-basement membrane adhesion required for fi

71 change because modern coyotes do not follow Bergmann's rule, which states body size increases with d

72 times on the Rotarod, suggesting a role for Bergmann glia-expressed Punc in the cerebellar control o

73 Critical correlative support for Bergmann's ecogeographic rule is provided by symmetrical

74 ic neurons and defects in fissure formation, Bergmann glia organization and basement membrane integri

75 r release sites located directly across from Bergmann glial membranes.

76 ll patch-clamp recordings were obtained from Bergmann glia in mice cerebellar slices to determine whe

77 NBC mRNA was present in glial cells (e.g., Bergmann glia of cerebellum and hippocampal astrocytes)

78 ease may provide a geographical cue to guide Bergmann glia cell membranes to surround active synapses

79 lar K(+) evoked by agonist-induced Ca(2+) in Bergmann glia transiently increased spike activity of Pu

80 study addresses the function of caspase-3 in Bergmann glia development by utilizing a Bergmann glial

81 hat directed expression of polyQ-ataxin-7 in Bergmann glia (BG) in transgenic mice leads to ataxia an

82 and generated mice that express ataxin-7 in Bergmann glia of the cerebellum with the Gfa2 promoter.

83 e glomerular layer of olfactory bulbs and in Bergmann glia in the cerebellum.

84 y glutamate transporter-mediated currents in Bergmann glia cells follow the rules of synaptic release

85 ceptor and glutamate transporter currents in Bergmann glia that have a rapid onset, suggesting that g

86 abnormalities result from primary defects in Bergmann glia since mutations in granule cells do not sh

87 e transporter currents were also elicited in Bergmann glial cells and Purkinje neurons of the cerebel

88 receptor subunit is expressed exclusively in Bergmann glia in the adult rodent.

89 rotein gamma-5, which is highly expressed in Bergmann glia, a cell type possessing only CP-AMPARs.

90 ar glutamate transporter GLAST, expressed in Bergmann glia, only fall progressively from 3 months onw

91 nt with positive immunostaining for GlyT1 in Bergmann glia while inhibitors of glycine transport thro

92 Furthermore, loss of Huwe1 in Bergmann glia leads to extensive disorganization of this

93 In addition, the protein was induced in Bergmann glia and scattered microglia/macrophages in the

94 HO-1 was induced in Bergmann glia in the vermis of cerebellum.

95 nd gamma1 immunoreactivity were localized in Bergmann glia processes that wrapped Purkinje cell somat

96 from climbing fiber release are observed in Bergmann glial cells in the cerebellar cortex.

97 erebellar cortex, APOE mRNA was seen only in Bergmann glial cells and scattered astrocytes but not in

98 We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this

99 eceptor pathway, is specifically required in Bergmann glia during cerebellar foliation.

100 mma-5 acts as a TARP and serves this role in Bergmann glia.

101 we observe parallel ontogeny of D-serine in Bergmann glia and NR2A/B in Purkinje cells, suggesting a

102 Specific assays show that in Bergmann glia cells Gpr37l1 is associated with primary c

103 nd Na+/Cl--dependent taurine transporters in Bergmann glia in slices.

104 resent in protoplasmic astrocytes, including Bergmann glia in the cerebellum.

105 n of glutamate transporters in an individual Bergmann glial cell enhanced mIPSC frequency recorded in

106 lgi cells, and molecular layer interneurons; Bergmann glia, astrocytes, and resting microglia also ex

107 0 dpi, most labeled cells had developed into Bergmann glia, astrocytes, oligodendrocytes, and interne

108 n addition, the differentiation of RGCs into Bergmann glias was suppressed in KO mice.

109 reveal a novel role of Ric-8a in modulating Bergmann glia-basement membrane adhesion during foliatio

110 t the onset of foliation, when ric-8a mutant Bergmann glia fail to maintain adhesion to the basement

111 In this issue of Neuron, Bergmann et al. propose that adult human olfactory bulb

112 luding astrocytes, large projection neurons, Bergmann glia, Schwann cells, and ganglionic satellite c

113 d developmental failure of Purkinje neurons, Bergmann glia and granule neurons.

114 mate concentrations or by using nonsaturated Bergmann glial AMPA receptors to monitor presynaptic rel

115 granule and Purkinje cells, the alignment of Bergmann glia, and the integrity of the basement membran

116 ty, Purkinje cells (Pcs), an early cohort of Bergmann glia, and four classes of GABAergic interneuron

117 -out modes, respectively, depolarizations of Bergmann glia to +20 mV induced a 73% increase in the op

118 ursors and it induces the differentiation of Bergmann glia.

119 , suggested a role in the differentiation of Bergmann glia.

120 this enzyme in promoting differentiation of Bergmann glia.

121 ll migration secondary to disorganization of Bergmann glial cell fibers cause cerebellar developmenta

122 filled approximately ellipsoidal domains of Bergmann glia processes.

123 n arises in networks of at least hundreds of Bergmann glia extending across several hundred microns o

124 GFAP immunostaining of Bergmann glial fibers shows no parasagittally localized

125 as they resume rapid movement independent of Bergmann glial fibers.

126 uron precursors and precocious maturation of Bergmann glia and Purkinje neurons.

127 Thus, large networks of Bergmann glia can be activated by specific animal behavi

128 In the cerebellar cortex the processes of Bergmann glia cells encase synapses between presynaptic

129 D-Serine in the radial processes of Bergmann glia is also well positioned to regulate NMDA r

130 However, the functional significance of Bergmann glial Ca(2+) signaling remains poorly understoo

131 transformation in the developmental state of Bergmann glia occurring after suppression of caspase-3 a

132 ter granule cells detach from the surface of Bergmann glia and the somata become transiently round, w

133 geographically separated modern populations (Bergmann's Rule).

134 hat the formation of this Sox2/Sox9 positive Bergmann glia population does not require the presence o

135 ebellar molecular layer thickness or prevent Bergmann glia degeneration.

136 er an unexpected role for PTEN in regulating Bergmann glia differentiation, as well as the importance

137 of Purkinje cells (PC) in regions of robust Bergmann glia activation in Cln3(-/-) mice and human JNC

138 expressed glutamate transporters can shield Bergmann glial AMPA receptors and presynaptic metabotrop

139 estingly, despite the apparent death of some Bergmann glia, there was up-regulation of glial fibrilla

140 in neuronal migration, glutamate stimulates Bergmann glia to form and release D-serine, which, toget

141 Using two-photon microscopy we found that Bergmann glia exhibit three forms of Ca(2+) excitation i

142 results demonstrate for the first time that Bergmann glia express functional GlyT1 that can work in

143 e vermis, the densities of microglia and the Bergmann glial expression of metallothionein I/II and th

144 gration of immature granule neurons down the Bergmann glial fibers into the internal granule cell lay

145 f MMP-2 was mainly localized in the EGL, the Bergmann glial fibers, and the Purkinje cell layer (PCL)

146 se Bergmann glia processes as well as in the Bergmann fibers, it was more pronounced in the Purkinje

147 plitude of the AMPA receptor response in the Bergmann glia (840 +/- 240%; n = 8) with the shift in th

148 lar distribution of GABA(A) receptors in the Bergmann glia and Purkinje cells in the molecular layer

149 rters (homologous to the transporters in the Bergmann glia ensheathing the Purkinje cells), nor did i

150 o neuronal cells but also was located in the Bergmann glia of the postnatal cerebellum.

151 t cerebellum, Sox 1 is only expressed in the Bergmann glia, a population of radial glia present in th

152 he SoxB1 subgroup), is also expressed in the Bergmann glia.

153 Moreover, the Bergmann glia GABA(A) receptors were often located in cl

154 ons secrete FGF9 to control formation of the Bergmann fiber scaffold, which in turn, guides their own

155 ion of glia and subsequent disruption of the Bergmann glia (BG) scaffold.

156 We used the change in the EC50 of the Bergmann glia AMPA receptors produced by cyclothiazide (

157 entrated principally in the processes of the Bergmann glia located in the vicinity of the Purkinje ce

158 Expression of the Bergmann glia-specific glutamate transporter GLAST was r

159 release may account for the majority of the Bergmann glial AMPA response evoked by climbing fiber st

160 se results are consistent with a role of the Bergmann glial GABA(A) receptors in sensing GABAergic sy

161 transmission activates AMPA receptors on the Bergmann glial cell processes that envelop parallel fibr

162 ell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, exp

163 luR2/3 immunolabeling also occurred in these Bergmann glia processes as well as in the Bergmann fiber

164 Thus, Bergmann glia play a previously unappreciated role in co

165 ny neuronal population, but was localized to Bergmann glial in the cerebellum and a subset of the oli

166 ever, its expression changed from neurons to Bergmann glia once these glial cells had completed their

167 ATP7A switches during development from PN to Bergmann glia, the cells supporting PN function in adult

168 7B target protein, ceruloplasmin, from PN to Bergmann glia, where ATP7A (Menkes disease protein) is p

169 ) channels inhibited ectopic transmission to Bergmann glia and decreased EPSC decay time.

170 We also find that weakening Bergmann glia-basement membrane interaction by beta1 int

171 To determine whether Bergmann glia express functional transporters that can m

172 long the Purkinje cell layer (PCL), in which Bergmann glia are generated up to first the postnatal we

173 osphacan immunoreactivity is associated with Bergmann glial fibers in the molecular layer and their c

174 ading processes remain in close contact with Bergmann glial fibers.