ライフサイエンスコーパス: Boc

1 Boc amino acids and carboxylic acids were coupled on fun

2 Boc deprotection was conducted under mild acidic conditi

3 Boc in situ neutralization protocols are used in combina

4 Boc, a component of the hedgehog signaling pathway demon

5 Boc, Fzd8, Mbip, and Zswim5 are apparently expressed in

6 Boc-protected amines can be transformed into nonsymmetri

7 Boc=tert-butoxycarbonyl, LG=leaving group, PMB=para-meth

8 selective route to both enantiomers of cis-1-Boc-3-fluoropiperidin-4-ol, a highly prized building blo

9 ed dendrimer based on melamine displaying 24 Boc-protected amines (Boc is t-butoxycarbonyl) and 12 Dd

10 as Fmoc-protected derivatives Fmoc-m-Abc(2K(Boc))-OH (1a) and Fmoc-o-Abc(2K(Boc))-OH (1b).

11 moc-m-Abc(2K(Boc))-OH (1a) and Fmoc-o-Abc(2K(Boc))-OH (1b).

12 sed alone or in conjunction with Fmoc-Abc(2K(Boc))-OH (1c) as ordinary amino acids in Fmoc-based soli

13 Cholecystokinin-1 receptor agonist A-71623 [Boc-Trp-Lys(epsilon-N-2-methylphenylaminocarbonyl)-Asp-(

14 Demomedin C resulted by coupling a Boc-protected N(4)-chelator to neuromedin C (human GRP(1

15 xidation-cyclization-oxidation reaction of a Boc-protected amino alcohol, prepared from 3-butynol, wh

16 Aldehyde 13 was protected as the N(a)-Boc aldehyde 32 and then converted into the prochiral C(

17 activation and membrane integrity, we added Boc-D-cmk to J774A.1 macrophages at different time point

18 After Boc protection, these products undergo aminolysis and ac

19 erminal aziridines bearing N-alkoxycarbonyl (Boc) protection undergo N- to C-[1,2] migration to give

20 up strategy for linear PAAs to an Fmoc/Alloc/Boc strategy.

21 t are consistent with those between N(alpha)-Boc-protected amino acids and single nucleotides rigorou

22 Reactions between the reactive N(alpha)-Boc-protected amino acids and the trinucleotides d(T(1)B

23 melamine displaying 24 Boc-protected amines (Boc is t-butoxycarbonyl) and 12 Dde-protected (Dde is N-

24 he beta-amino group in the assembly of 3 and Boc-MOM protection of the alpha-amino group in the synth

25 filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway.

26 d beta-amino acid (betaFa) and its Fmoc- and Boc-protected forms were designed and synthesized.

27 logy includes dipeptides Boc-Tyr-Gly-OEt and Boc-Tyr-Phe-Me and provides a pathway for understanding

28 vage of the N-O bond of the oxazepinones and Boc-deprotection provided 2-substituted 2,3-dihydropyrid

29 ing Shh into the developing VTC and Zic2 and Boc into the central retina indicate that Boc expression

30 Several membrane-embedded proteins such as Boc, Cdo, and Gas1 bind Shh and promote signaling.

31 ble with common N-protecting groups, such as Boc, Fmoc, Cbz, and benzyl, as well as various OH protec

32 diate (S)-35 from the commercially available Boc-amino acid 65.

33 Sulfoximines bearing Boc and Cbz groups are stable to further cross coupling

34 anidinomethyl]-3-(trimethylstannyl)benzoate (Boc-SGMTB, 3) was first radio-iodinated to [*I]Boc-SGMIB

35 f three chiral N(alpha)-substituted, N(beta)-Boc protected alpha-hydrazinoacetamide model compounds c

36 ficity and affinity in recognition, N,N'-bis(Boc)-alpha-guanidino acids were synthesized from alpha-a

37 The bis-Boc analog 14 proved useful in peptide chemistry and was

38 N'-bis-(phenylsulfonyl)-, and (2S)-N,N'-bis-(Boc)-3-(2-pyrrolyl)alanines (10, 3, and 14, respectively

39 microcapsules with shell walls bearing both Boc and Fmoc triggering groups.

40 hat the rotation of the tert-butoxycarbonyl (Boc) group is slower in a 2-lithiated pyrrolidine than a

41 cting groups, such as tert-butyloxycarbonyl (Boc), carbobenzyloxy (Cbz), and 9-fluorenylmethyloxycarb

42 esults confirmed that tert-butyloxycarbonyl (Boc), tert-butyl ((t)Bu), and 2,2,4,6,7-pentamethyldihyd

43 indole position of N-tert-butyloxycarbonyl (Boc)-protected (S)-tryptophan ethyl ester is reported.

44 ynthesis (SPPS) using tert-butyloxycarbonyl (Boc)/benzyl (Bzl) chemistry is an indispensable techniqu

45 s such as acetates (Ac, Piv) and carbamates (Boc, Fmoc), respectively.

46 moieties, azetidines, tert-butyl carbamates (Boc-group), cyclobutanes, and spirocycles.

47 monstrate that N-acyl-tert-butyl-carbamates (Boc) and N-acyl-tosylamides (Ts), two classes of acyclic

48 The transmembrane protein Brother of Cdo (Boc) has been implicated in Shh-mediated commissural axo

49 eurons and the Shh receptor, Brother of CDO (Boc), is expressed in local and callosal projection neur

50 and active fragments of heparin, Ihog, Cdo, Boc, Hedgehog-interacting protein (Hhip), Patched (Ptc),

51 of dendritic dipeptides (4-3,4-3,5)12G2-CH2-Boc-L-Tyr-X-OMe where X = Gly, L-Val, L-Leu, L-Ile, L-Ph

52 ystallographic analysis of the corresponding Boc-protected ethyl ester and Cbz-protected ethyl ester,

53 s of the CXCR3 inhibitor starts from (+)-(D)-Boc alanine and 2-chloronicotinic acid and utilizes a Go

54 c alpha/alpha-pseudodipeptide, depsipeptide (Boc-Leu-Lac-OEt).

55 he developed methodology includes dipeptides Boc-Tyr-Gly-OEt and Boc-Tyr-Phe-Me and provides a pathwa

56 Here, we show that the uml locus encodes Boc and that Boc function is cell-autonomously required

57 nt (VTC) of the retina, specifically express Boc, a cell adhesion molecule that acts as a high-affini

58 Five Boc-protected aminooxy and N-alkylaminooxy amines have b

59 l protection schemes (up to five from: Fmoc, Boc Alloc, pNZ, o-NBS, and Troc), together with the righ

60 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2-5 steps.

61 locks for solid-phase synthesis bearing Fmoc/Boc and Fmoc/Alloc protecting groups expanding recently

62 otecting groups expanding recently used Fmoc/Boc protecting group strategy for linear PAAs to an Fmoc

63 ttle is known about in vivo requirements for Boc during vertebrate embryogenesis.

64 This study reveals a role for Boc in ventral CNS cells that receive high levels of Hh

65 Hh and uncovers previously unknown roles for Boc in vertebrate embryogenesis.

66 y of functional groups can be attached, from Boc-protected amines to fluoroalkanes.

67 lization of the silyl carbamate derived from Boc mesylate 27 to produce the key cyclic carbamate 28.

68 beta-Ketosulfonamides derived from Boc or Cbz-protected amino acids bearing hydrophobic sid

69 alogues of pyochelin have been prepared from Boc-pyroglutamic acid-tert-butyl ester in 11 and 13 step

70 repared via an optimized route starting from Boc-dopamine, with paraformaldehyde afforded demethyldeo

71 Starting from Boc-protected tryptamine and (S)-tetrahydro-5-oxo-2-fura

72 Conversely, the loss of functional Boc leads to a reduction in the strength of synaptic con

73 Furthermore, Boc transcript expression decreased in obese EP WAT with

74 la)2-(R)-Aic(NN)-Ala-OMe and the hexapeptide Boc-[Ala-(R)-Aic(NN)-Ala]2-OMe as well.

75 me for the synthesis and purification of [*I]Boc-SGMIB and its subsequent de-protection is approximat

76 Treatment of [*I]Boc-SGMIB with trifluoroacetic acid delivered the final

77 c-SGMTB, 3) was first radio-iodinated to [*I]Boc-SGMIB, a derivative of [*I]SGMIB with the guanidine

78 In Boc(-/-) mutant mice, the ipsilateral projection is sign

79 In Boc(-/-) VTC, the number of Zic2-positive RGCs is reduce

80 sal lateral geniculate nucleus is altered in Boc(-/-) mice.

81 The caspase-1 inhibitor Boc-D-cmk blocked caspase-1 activity and membrane impair

82 by the TG2 catalytic site-specific inhibitor Boc-DON-Gln-Ile-Val-OMe (10 micromol/L).

83 ation mass spectrometry indicates that NH2-K(Boc)LVFF-CONH2 forms a significant population of oligome

84 In contrast, NH2-K(Boc)LVFF-CONH2 undergoes hydrophobic collapse at a low c

85 (R)-enantiomers of tricladins A and B from l-Boc alanine was achieved.

86 The technology uses a modified Boc SPPS strategy that avoids the use of anhydrous HF.

87 N-Boc (S)-proline was converted into (2S)-2-[(phenylselany

88 N-Boc alpha-amino nitriles were deprotonated and alkylated

89 N-Boc- and N-ethoxycarbonyl-4-pyridones and the resulting

90 (18)F-FLT was synthesized from the 3-N-Boc-1-[5-O-(4,4'-dimethoxytrityl)-3-O-nosyl-2-deoxy-beta

91 of diastereomeric (3RS,4RS)- and (3RS,4SR)-N-Boc-3-amino-2-methyldec-5-yn-4-ol (syn-3f and anti-3f, r

92 react with N-Boc 2-lithiopyrrolidine (5a), N-Boc N-methylaminomethyllithium (5b), or 2-lithio-1,3-dit

93 an intramolecular cyclization process of a N-Boc-protected piperidine sulfone.

94 by in situ deprotection of O-Ts activated N-Boc hydroxylamines.

95 a minimally protected vancomycin aglycon (N-Boc-vancomycin aglycon) and provides a direct method for

96 A variety of aryl and aliphatic N-Boc-aldimines are effective substrates for this transfor

97 mines from previously unreported C-alkynyl N-Boc-N,O-acetals, with alpha-substituted beta-keto esters

98 rearrangement of the intermediate allylic N-Boc-sulfimides with a high level of chirality transfer.

99 sing copper-catalyzed amidation of 3-amino-N-Boc-4-chloropyridine.

100 intramolecular reductive cyclization of an N-Boc aniline onto the oxindole moiety to form a pentacycl

101 (e.g., an aryl iodide, a thiophene, and an N-Boc-indole) are compatible with the mild reaction condit

102 c activity from [(18)F]fluoride ion and an N-Boc-protected (phenyl)aryliodonium salt precursor (15).

103 seful chiral building block, from N-Bn and N-Boc 9-azabicyclo[3.3.1]nonane-2,6-diols 2a and 2b was ac

104 groups such as THP, MOMO, N(3), OTBS, and N-Boc are tolerated.

105 ariety of N-acetyl, N-methoxycarbonyl, and N-Boc beta,beta-diaryldehydroamino acids, containing a div

106 wed by a fragmentation, aromatization, and N-Boc deprotection cascade.

107 h-type reaction between various ynones and N-Boc imines, whose stereocontrol presumably derives from

108 ls, ketones, amides, carboxylic acids, and N-Boc protected amines tethered to their 4-position afford

109 of N-Boc-2-lithio-2-phenylpyrrolidine and N-Boc-2-lithio-2-phenylpiperidine have been studied in the

110 yrrolidine (N-Boc-2-lithiopyrrolidine) and N-Boc-2-lithiopiperidine, formed by deprotonation of N-Boc

111 nnich reactions between glycine imines and N-Boc-aldimines with high levels of enantio- and diastereo

112 gically relevant N-Boc-isostatine (2b) and N-Boc-dolaisoleucine (3c).

113 by deprotonation of N-Boc-pyrrolidine and N-Boc-piperidine, respectively.

114 rated beta-hydroxyesters to establish anti,N-Boc-alpha-hydrazino-beta-hydroxyesters.

115 of acid-labile protecting groups, such as N-Boc and O-TBS, were tolerated under these mild condition

116 erted to desirable building blocks such as N-Boc-amines and the parent chiral formamide compounds.

117 n-alkoxycarbonylation of readily available N-Boc-1-amino-3-yn-2-ols.

118 substituted isatins with readily available N-Boc-protected aminoacids followed by an intramolecular a

119 catalyzed carboamination reactions between N-Boc-O-(but-3-enyl)hydroxylamine derivatives and aryl or

120 The effectiveness of utilizing N-Bn-N-Boc-alpha-amino aldehydes in cross-benzoin reactions wit

121 y the gram-scale synthesis of C7-boronated N-Boc-L-tryptophan methyl ester and the rapid synthesis of

122 reaction of in situ generated challenging N-Boc C-alkynyl imines from previously unreported C-alkyny

123 e reaction of sulfenate anions with chiral N-Boc-protected beta-substituted beta-amino iodides was ev

124 Under the same conditions, N-Boc-2-alkynyl-1-amino-3-yn-2-ols were converted into the

125 tterionic compounds from the corresponding N-Boc derivatives has been developed.

126 he in situ generation of the corresponding N-Boc imines and the asymmetric Mannich reaction with exce

127 inyl)ketimines derived from cyclohexanone, N-Boc-piperidin-4-one, and tetrahydropyran-4-one in high y

128 ates at the benzylic position and dimethyl N-Boc alpha-aminophosphonates at the CH3O group to induce

129 However, s-BuLi converted the dimethyl N-Boc-phosphoramidate derived from 1-phenylethylamine to t

130 LiTMP metalated dimethyl N-Boc-phosphoramidates derived from 1-phenylethylamine and

131 which the diazo carbon was disubstituted, N-Boc imines react with both alpha-diazo esters and alpha-

132 A first generation synthesis that employed N-Boc-homopiperazine was improved in a second generation a

133 rimethyl-10-phenyldecadenoic acid (enantio-N-Boc-ADDA) is reported.

134 lithiation-substitution of enantioenriched N-Boc-2-phenylpyrrolidine or -piperidine (prepared by asym

135 In diethyl ether, N-Boc-2-lithio-2-arylpiperidines have been found to be con

136 For N-Boc-2-phenylpyrrolidine and -piperidine, the barriers to

137 idines, can be prepared in four steps from N-Boc beta-lactams.

138 reomeric dipeptide derivatives formed from N-Boc-L-phenylalanine.

139 ynthesis of (+)-saxitoxin in 14 steps from N-Boc-l-serine methyl ester.

140 l auxiliary is prepared in four steps from N-Boc-L-tyrosine on a multigram scale in high yield and at

141 important family of target molecules) from N-Boc-pyrrolidine, a commercially available precursor.

142 on of an alpha-methylbenzyl-functionalized N-Boc piperazine using s-BuLi/(-)-sparteine or (+)-spartei

143 vered a wide range of alpha-functionalized N-Boc piperazines.

144 es followed by alcohol oxidation furnished N-Boc O-TBS-protected beta-aminoynones.

145 oisomeric lactones through hydrogenolysis, N-Boc protection, reduction, methanolysis, and acetate pro

146 Starting from inexpensive N-Boc-O-Bn-L-aspartic acid, gram quantities of L-Aha hydro

147 Interestingly, N-Boc-2-alkynyl-1-amino-3-yn-2-ols 6, bearing an additiona

148 With larger N-Boc, N-Cbz, or N-Troc protecting groups, unrearranged 5-

149 ichiometric dynamic resolution of 2-lithio-N-Boc-piperidine (7) have been investigated.

150 c dynamic resolution (CDR) of rac-2-lithio-N-Boc-piperidine using chiral ligand 8 or its diastereomer

151 N-tert-butoxycarbonyl-2-lithiopyrrolidine (N-Boc-2-lithiopyrrolidine) and N-Boc-2-lithiopiperidine, f

152 Notably, N-Boc-protected amino acids were successfully coupled in g

153 as well as decarboxylative vinylations of N-Boc alpha-amino acids, proceed in high yield and with ex

154 convergent and demonstrates the utility of N-Boc alpha-amino nitriles as linchpins for alkaloid synth

155 Reductive lithiation of N-Boc alpha-amino nitriles generated alpha-amino alkyllith

156 A new series of N-Boc ketimines derived from pyrazolin-5-ones have been us

157 he selective alpha- and beta- arylation of N-Boc piperazines via lithiation/Negishi coupling is repor

158 res for the racemic lithiation/trapping of N-Boc piperazines.

159 lding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and

160 Both enantiomers of N-Boc protected diol 2b were converted into the correspond

161 11-mediated enantioselective lithiation of N-Boc pyrrolidine (6), followed by reaction of the chiral

162 oselective Pd-catalyzed alpha-arylation of N-Boc pyrrolidine has been carried out.

163 The protocol involves deprotonation of N-Boc pyrrolidine using s-BuLi/(-)-sparteine in TBME or Et

164 outes; and examples of alpha-vinylation of N-Boc pyrrolidine using vinyl bromides exemplified by the

165 tonation reactions (lithiation-trapping of N-Boc pyrrolidine, an O-alkyl carbamate, and a phosphine b

166 ccomplished by asymmetric deprotonation of N-Boc pyrrolidine, followed by the reaction of the in situ

167 n the ruthenium-catalyzed cycloaddition of N-Boc ynamides with azides has been developed to give a pr

168 The convergent synthesis of N-Boc-(2R,3R,8R,9R,4E,6E)-3-amino-9-methoxy-2,6,8-trimethy

169 In the case of N-Boc-1-amino-3-yn-2-ols 3, bearing alkyl or aryl substitu

170 Lithiation of N-Boc-1-phenyltetrahydroisoquinolines was optimized by in

171 The enantiomerization dynamics of N-Boc-2-lithio-2-phenylpyrrolidine and N-Boc-2-lithio-2-ph

172 tion in the presence of a chiral ligand of N-Boc-2-lithiopiperidine followed by the zinc/copper chemi

173 yields for the lithiation-substitution of N-Boc-2-phenylpyrrolidine at -78 degrees C can be ascribed

174 The first features addition of N-Boc-3-bromoindole 26 to the sulfinamide 25, providing a

175 metalation of the SAMP/RAMP hydrazones of N-Boc-azetidin-3-one, reaction with a wide range of electr

176 single-crystal X-ray structure analysis of N-Boc-CbBI (13) revealed their structural origins.

177 The remarkable stability of N-Boc-CbBI (which is stable even at pH 1) relative to N-Bo

178 g Pd-catalyzed carboamination reactions of N-Boc-O-(but-3-enyl)hydroxylamines is significantly higher

179 tion step is mediated by the activation of N-Boc-protected 2-aminopyridine-containing amides by trifl

180 The reactivity of N-Boc-protected 2-benzyl-2-aminoethyl iodide was found to

181 The gold(I)-catalyzed cyclization of N-Boc-protected 6-alkynyl-3,4-dihydro-2H-pyridines, prepar

182 atom transfer (HAT) from the C-H bonds of N-Boc-protected amino acids to the cumyloxyl radical (CumO

183 The scope of Pd-catalyzed synthesis of N-Boc-protected anilines from aryl bromides and commercial

184 ther the (3R,2S) and (3S,2R) enantiomer of N-Boc-protected sphingosine analogues has been synthesized

185 dine ring and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloroimidazopyridine.

186 tivity by sparteine-mediated lithiation of N-Boc-pyrrolidine and addition to silyl fluoride electroph

187 thiopiperidine, formed by deprotonation of N-Boc-pyrrolidine and N-Boc-piperidine, respectively.

188 Asymmetric deprotonation of N-Boc-pyrrolidine or dynamic resolution in the presence of

189 ne-mediated enantioselective lithiation of N-Boc-pyrrolidine was followed by in situ transmetalation

190 In this paper, N-Boc and N-Cbz protected alpha-branched amines are synthe

191 Deprotection of the poly(N-Boc-morpholin-2-one) yields a water-soluble, cationic po

192 The synthesis of the enantiomerically pure N-Boc 9-azabicyclo[3.3.1]nonane-2,6-dione (4b), a potentia

193 carbon center (C8), and an azide reduction/N-Boc-lactam-opening cascade leading to the northern amina

194 facile synthesis of biologically relevant N-Boc-isostatine (2b) and N-Boc-dolaisoleucine (3c).

195 Reduction of the resulting N-Boc amino alcohols furnished hygrolines and pseudohygrol

196 2]octane (DABO, 1) and its two selectively N-Boc monoprotected derivatives 15 and 16 is described.

197 he synthesis of oxazolidinones from simple N-Boc amines is reported.

198 clization, hydroxyl group-assisted in situ N-Boc-deprotection, selective deoxygenation of the xanthat

199 ing the southern aminal, a stereoselective N-Boc-lactam enolate C-allylation to introduce the second

200 A method to prepare 1-substituted N-Boc-tetrahydro-beta-carbolines was developed by lithiati

201 ate derived from 1-phenylethylamine to the N-Boc alpha-aminophosphonate preferentially.

202 During preparation of the N-Boc compounds from trifluoroacetamides, a competing intr

203 highly diastereoselective synthesis of the N-Boc derivative of (2S,3S)-3-hydroxypipecolic acid.

204 duction, and an orthogonal cleavage of the N-Boc protecting group in piperidone derivatives was carri

205 Our approach was based on the N-Boc-directed metalation of enantiopure 4-piperidone (-)-

206 tion of branched allylic sulfides with the N-Boc-oxaziridine 1 results in [2,3]-sigmatropic rearrange

207 beta3-amino esters, and unexpectedly, the N-Boc-protected aziridine-2-carboxylate 16b with a phenyl

208 Thus, N-Boc anilines (I) are sequentially converted to heterocyc

209 tioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions.

210 nucleophilic addition of acetylacetone to N-Boc protected aldimines Type I E and Type II E are activ

211 synthons for enantioselective additions to N-Boc-aldimines.

212 (which is stable even at pH 1) relative to N-Boc-CBI containing a cyclopropane (t(1/2) = 133 h at pH

213 An effective route to N-Boc-protected aromatic sphingosine analogues is accompli

214 Preparative scale peptide couplings of two N-Boc amino acids were achieved with this method.

215 ridin-3-ol derivatives, e.g., 43) by using N-Boc-protected piperidin-3-one (40).

216 ationally stable at -80 degrees C, whereas N-Boc-2-lithio-2-arylpyrrolidines are configurationally st

217 n occurs with complete regiocontrol, while N-Boc-alkyl ynamides yield a mixture of regioisomers.

218 boalkoxy phenols, respectively, react with N-Boc 2-lithiopyrrolidine (5a), N-Boc N-methylaminomethyll

219 ssful cycloaddition of the parent TMM with N-Boc imines, and has further permitted the reaction of su

220 aCl(3).2LiCl metal exchange, reaction with N-Boc pyrrolidin-3-one (5), and subsequent decarboxylative

221 nich reaction of silyl ketene acetals with N-Boc-amino sulfones has been developed.

222 When aryl or alkyl azides are reacted with N-Boc-aminopropiolates or arylynamides, the cycloaddition

223 ted in one post-modification reaction with N-Boc-ethylenediamine via reductive amination.

224 thodology was developed and optimized with N-Boc-indole-2-boronic acid giving access to alpha-indole-

225 With N-Boc-protected 4-(allylaminomethyl)-2(5H)furanones as sta

226 nce of NaBH4 as the hydride donor to yield N-Boc-1-alkyl-THIQs (+)-10a-g in up to 97:3 er's after rem

227 cross-couplings of racemic alpha-zincated N-Boc-pyrrolidine with unactivated secondary halides, thus

228 N-(Boc)-Ynamides are converted to oxazolones via a cyclizat

229 (2S)-N-(Boc)-N'-(Phenylsulfonyl)-, (2S)-N,N'-bis-(phenylsulfonyl

230 ve Ni-mediated cyclization of an N4-aryl,N4-(Boc)cytosine intermediate as a key step.

231 rfuryl alcohol, can be transformed via its O-Boc derivative to 4-acyloxy, 4-aryloxy-, 4-amino-, or 4-

232 bonded complex with the carboxylate anion of Boc-d-proline.

233 In the case of Boc-L-Phe-L-Oxd-OBn, VCD spectra in CCl(4) and detailed

234 organic dye, eosin Y, catalyzes coupling of Boc-protected potassium alpha-aminomethyltrifluoroborate

235 s multistep process involves deprotection of Boc-amino ynones and subsequent treatment with methanoli

236 Deprotection of Boc-protected products proceeded readily to provide amin

237 Expression of Boc and Mup transcript was further assessed in murine ti

238 data together, we propose that expression of Boc in cells from the VTC is required to sustain Zic2 ex

239 that EP WAT is a major site of expression of Boc transcript.

240 e carbonylation reaction led to a mixture of Boc-protected and N-unsubstituted pyrrole-3-carboxylic e

241 Avoiding HF extends the scope of Boc SPPS to post-translational modifications that are co

242 The crystal structure of Boc-l-4-thiolphenylalanine tert-butyl ester revealed cry

243 Direct synthesis of Boc- or Cbz-D-Hyv lactone proceeded in low yield; additi

244 se EP WAT with a concomitant upregulation of Boc transcript in the obese SC WAT depot.

245 hat the structural behavior of the oligomers Boc-(L-Phe-L-Oxd)(n)-OBn is similar from n = 2 to n = 6;

246 Here we focus on Boc-diphenylalanine, an archetypical example of a peptid

247 rganocatalytic Mannich reaction performed on Boc-imines of o-(azidomethyl)benzaldehydes, followed by

248 f aryl bromides and CH(2)=C(NHP)CO(2)Me (P = Boc or CBz) to form ArCH=C(NHP)CO(2)Me, which are then u

249 d at positions i and i+3 of the pentapeptide Boc-(R)-Aic(NN)-(Ala)2-(R)-Aic(NN)-Ala-OMe and the hexap

250 ates, based on variation of the pentapeptide Boc-l-Ala-gamma-d-Glu-l-Lys-d-Ala-d-Ala, were synthesize

251 ) protocol and Amyloid beta (39-42) peptide (Boc-Val-Val-IIe-Ala-OMe), following solution-phase strat

252 protected C-terminal-free carboxyl peptide, Boc-Tyr( tBu)- d-Ala-Gly Phe-Pro-Leu-Trp(Boc)-OH, was sy

253 and N-t-butoxycarbonyl-Phe-Leu-Phe-Leu-Phe (Boc-2), an antagonist of formyl peptide receptors (FPR/F

254 /downregulated by oncogenes binding protein (Boc), Frizzled homolog 8 (Fzd8), Ankrd43 (ankyrin repeat

255 r the secreted molecule Shh and its receptor Boc in synapse formation.

256 Remarkably, Boc-D-cmk rescued LT-treated macrophages, even when adde

257 Representative Boc-protected and acetyl-protected peptide methyl esters

258 Selectivities that previously required Boc protection can be achieved; furthermore, the NBpin d

259 ECT), such as 5-[(123)I]-A85380 (see scheme, Boc = tert-butyloxycarbonyl, cod = 1,5-cyclooctadiene, T

260 ment with AnxA1Ac2-26 plus FPR antagonists t-Boc-FLFLF (250 ng/kg) or WRW4 (FPR2/ALX selective, 1.4 m

261 Blockade of FPRs by an antagonist, Boc2 (t-Boc-Phe-d-Leu-Phe-d-Leu-Phe), abrogates CXCL2 release, w

262 ies to block the AnxA1 pathway (by using N-t-Boc-Met-Leu-Phe, a nonselective AnxA1 receptor antagonis

263 the P1 to P3 side chains and the N-terminal Boc were sequentially truncated, revealed a correlation

264 show that the uml locus encodes Boc and that Boc function is cell-autonomously required for Hh-mediat

265 , pituitary, somites and upper jaw, but that Boc might negatively regulate Hh signals in the lower ja

266 nd Boc into the central retina indicate that Boc expression alone is insufficient to fully activate t

267 Our phenotypic analysis suggests that Boc is required as a positive regulator of Hh signaling

268 The Boc group can be removed on thermolysis or left intact d

269 The Boc/Bzl strategy has several advantages, including relia

270 similar to Boc; suggestive of a role for the Boc-Cdon axis in WAT depot function.

271 esymmetrizing, cascade process involving the Boc protecting group.

272 ed upon the addition of MG132, mirroring the Boc-D-cmk response.

273 Assessment of the Boc binding partner Cdon in adipose tissue and cell frac

274 coordination from the carbonyl group of the Boc group to zinc.

275 , the half-life (t(1/2)) for rotation of the Boc group was found to be approximately 10 h at -78 degr

276 -piperidine, the barriers to rotation of the Boc group were determined using density functional theor

277 ompounds 61 and 64 and, after removal of the Boc groups, the desired IBR2 analogues 15 and 16.

278 The use of the Boc-protected aniline 10b was crucial to the success of

279 N-Hydroxylation occurs in the case of the Boc-protected peptides, and side chain hydroxylation tak

280 in situ IR spectroscopy and showed that the Boc group rotates slowly at low temperature.

281 , as we had previously demonstrated that the Boc-(L-Ala-D-Oxd)(n)-OBn series folds in a beta-band rib

282 e DNA binding profile of 4 is similar to the Boc derivative, confirming the central influence of char

283 Using the Boc protectng group in 18 allowed preparation of 1 in an

284 clization via transition states in which the Boc group is placed in a perpendicular orientation relat

285 lied for simultaneous deprotections with the Boc and (t)Bu groups.

286 ble oxazole-5-trifluoroacetamides into their Boc-protected 5-aminooxazole derivatives provides interm

287 f, revealed transcript expression similar to Boc; suggestive of a role for the Boc-Cdon axis in WAT d

288 de, Boc-Tyr( tBu)- d-Ala-Gly Phe-Pro-Leu-Trp(Boc)-OH, was synthesized as a shared intermediate using

289 urthermore, it was shown that one of the two Boc-groups of the disubstituted derivatives was selectiv

290 in which the amino group was masked with two Boc substituents, a Cu(I) carboxylate complex and the we

291 well as cyclization of the free amine, under Boc- or ArSO- deprotection conditions have been examined

292 prohibits on-resin thioester synthesis using Boc chemistry, we devised a method for the synthesis of

293 d under simple reaction conditions utilizing Boc(2)O as the reagent at room temperature.

294 erse gelators, employing structures in which Boc-protected amino acids are attached to either end of

295 expressed in postsynaptic target cells while Boc is expressed in a complementary population of presyn

296 tion of the N-H-aziridines was achieved with Boc, tosyl, and Fmoc groups.

297 -H borylation is found to be compatible with Boc protecting groups.

298 f single racemic naphthylglycidyl ether with Boc-protected isoproylamine with 100% epoxide utilizatio

299 roxy group and treatment of the product with Boc anhydride provided the activated cyclic sulfamates 1

300 B with the guanidine function protected with Boc groups.

301 l 4-[ (18)F]fluorobenzoate ([(18)F]SFB) with Boc-Dmt-Tic--Lys(Z)-OH under slightly basic conditions a