ライフサイエンスコーパス: Breg cell

1 ween plasmacytoid dendritic cells (pDCs) and Breg cells.

2 mablast differentiation but failed to induce Breg cells.

3 onditions reduces the number and function of Breg cells.

4 e the functional properties and phenotype of Breg cells?

5 p35 may be utilized for in vivo expansion of Breg cells and autologous Breg cell immunotherapy.

6 B cells into IL-10-producing CD24(+)CD38(hi) Breg cells and plasmablasts, via the release of IFN-alph

7 Here we show that IL-35 induces Breg cells and promotes their conversion to a Breg subse

8 used to induce autologous Breg and IL-35(+) Breg cells and treat autoimmune and inflammatory disease

9 Taken together, Breg cells appear to be involved in mediating allergen t

10 This work describes how Breg cells are critical in humoral homoeostasis and may

11 Regulatory B (Breg) cells are characterized by their immunosuppressive

12 Regulatory B (Breg) cells are immunosuppressive cells that support imm

13 Can a Breg cell arise at every stage in B cell development?

14 cells, they also raise other questions about Breg cell biology and phenotype.

15 ons to discuss the advances in understanding Breg cell biology, with a particular emphasis on their o

16 in vivo existence of allergen-specific human Breg cells comes from direct detection of their increase

17 Human Breg cells control TFH cell maturation, expand follicula

18 CD24(+)CD38(hi) Breg cells conversely restrained IFN-alpha production by

19 The majority of Breg cells described in mouse and man have been identifi

20 Regulatory B cells (Breg cells) differentiate in response to inflammation an

21 sed mice and both cytokines directly promote Breg cell differentiation and IL-10 production.

22 Is inflammation the primary requisite for Breg cell differentiation?

23 ignaling (IL-12Rbeta2 KO mice) produced less Breg cells endogenously or after treatment with IL-35 an

24 G subtypes and Ab avidity; and regulatory B (Breg) cell frequency and function.

25 Several types of murine and human Breg cells have been described, such as mouse CD5(+)CD1d

26 vivo expansion of Breg cells and autologous Breg cell immunotherapy.

27 ovel observations demonstrate a role for the Breg cell in germinal center reactions and suggest that

28 t microbiota promotes the differentiation of Breg cells in the spleen as well as in the mesenteric ly

29 induced by both the gut flora and arthritis, Breg cells increase in number and restrain excessive inf

30 Adoptive transfer of Breg cells induced by recombinant IL-35 suppressed EAU w

31 opose that alteration in pDC-CD24(+)CD38(hi) Breg cell interaction contributes to the pathogenesis of

32 Both altered pDC-CD24(+)CD38(hi) Breg cell interactions and STAT1-STAT3 activation were n

33 However, Breg cell mediated immune suppression, independent of IL

34 Human regulatory B (Breg) cells modulate cellular responses, but their contr

35 Breg cells modulated IL-21 receptor expressions on TFH c

36 ve pDC-mediated expansion of CD24(+)CD38(hi) Breg cell numbers in SLE was associated with altered STA

37 Breg cells obtained by Toll-like receptor 9 and CD40 act

38 We sought to assess the role of Breg cells on TFH cell development and function.

39 Allergen-specific regulatory T and Breg cells orchestrate a general immunoregulatory activi

40 Here we show that Breg cells play a critical role in regulating humoral im

41 nt inflammatory environments induce distinct Breg cell populations.

42 autoimmune disease, and increased numbers of Breg cells prevent host defense to infection and promote

43 s mediating the induction and development of Breg cells remain unclear.

44 controlling the generation of regulatory B (Breg) cells remain ill-defined.

45 generation of regulatory T and regulatory B (Breg) cell responses; regulation of IgE and IgG4; decrea

46 on their ontogeny; we propose that multiple Breg cell subsets can be induced in response to inflamma

47 ssion of TIM1 or TIM4 on these Breg or other Breg cell subsets.

48 transforming growth factor beta (TGF-beta), Breg cells suppress immunopathology by prohibiting the e

49 terleukin-10 (IL-10)-producing regulatory B (Breg) cells suppress autoimmune disease, and increased n

50 Peripheral blood CD19(+)CD25(+) Breg cells suppressed T cell proliferation compared with

51 induced the conversion of human B cells into Breg cells, these findings suggest that IL-35 may be use

52 flammatory signals in the differentiation of Breg cells, they also raise other questions about Breg c

53 Human Breg cell types include CD27(+)CD24(high) B10 cells, CD2

54 Recently, inducible IL-10-secreting Breg cells were also demonstrated to contribute to aller

55 Breg cells were included in these cultures, and their ef