ライフサイエンスコーパス: Brucella abortus

1 cterium tumefaciens, and the animal pathogen Brucella abortus.

2 mefaciens, and the bovine and human pathogen Brucella abortus.

3 Lon protease homologue has been cloned from Brucella abortus.

4 nd we show here that it is also essential in Brucella abortus.

5 lar survival of the global zoonotic pathogen Brucella abortus.

6 li and the glucose/galactose:H+ symporter of Brucella abortus.

7 ion (AI) induced by injection of heat-killed Brucella abortus.

8 n zinc transport has been found to attenuate Brucella abortus.

9 proteobacteria Agrobacterium tumefaciens and Brucella abortus.

10 important factor for growth and virulence of Brucella abortus.

11 th the Gram-negative intracellular bacterium Brucella abortus.

12 such as trinitrophenyl (TNP)-Ficoll and TNP-Brucella abortus.

13 s (Brucella cell surface proteins [BCSP]) of Brucella abortus 19 and later challenge exposed with B.

14 e responses and resistance to infection with Brucella abortus 2308 (S2308) were measured in mice foll

15 s, the intracellular trafficking of virulent Brucella abortus 2308 and attenuated hfq and bacA mutant

16 lectrophoretic analysis of cell lysates from Brucella abortus 2308 and the isogenic hfq mutant Hfq3 r

17 ent (IRF-1(-/-)) mice infected with virulent Brucella abortus 2308 at 5 x 10(5) CFU developed acute h

18 -responsive regulation of mntH expression in Brucella abortus 2308 but also identify the cis-acting e

19 coding gene, galE or exoB, was isolated from Brucella abortus 2308 by complementation of an exoB muta

20 We constructed a rough mutant of Brucella abortus 2308 by transposon (Tn5) mutagenesis.

21 Brucella abortus 2308 derivatives with mini-Tn5 insertio

22 nsporter BhuA exhibits maximum expression in Brucella abortus 2308 during growth under iron-deprived

23 nt (designated CAM220) derived from virulent Brucella abortus 2308 exhibited increased sensitivity to

24 The genes designated BAB2_0837-0840 in the Brucella abortus 2308 genome sequence are predicted to e

25 annotated as BAB2_0350 and BAB2_0351 in the Brucella abortus 2308 genome sequence are predicted to e

26 The gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is predicted to en

27 The gene annotated BAB2_1150 in the Brucella abortus 2308 genome sequence is predicted to en

28 H is required for the wild-type virulence of Brucella abortus 2308 in mice and indicated that the mnt

29 evaluation of isogenic mutants derived from Brucella abortus 2308 indicates that the AlcR homolog Dh

30 redox-responsive two-component regulator in Brucella abortus 2308 that responds to decreasing levels

31 this protein plays a role in the ability of Brucella abortus 2308 to use heme as an iron source, an

32 ding region was removed from virulent strain Brucella abortus 2308 via allelic exchange.

33 -mediated immune response, a gene library of Brucella abortus 2308 was screened for the expression of

34 mutant (DeltaentC) constructed from virulent Brucella abortus 2308, however, we found that production

35 Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 sho

36 sogenic hfq mutant constructed from virulent Brucella abortus 2308.

37 erone Hfq to wild-type expression of virB in Brucella abortus 2308.

38 ic differences between B. melitensis 16M and Brucella abortus 2308.

39 n) with the HtrA stress-response proteins of Brucella abortus (59%), Ec (37%) and Salmonella typhimur

40 Brucella abortus, a mammalian pathogen, and Rhizobium me

41 overy from the anemia induced by heat-killed Brucella abortus, a model of inflammatory anemia.

42 inorhizobium meliloti, a legume symbiont and Brucella abortus, a phylogenetically related mammalian p

43 norhizobium meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian p

44 Two small RNAs in Brucella abortus, AbcR1 and AbcR2, are required for wild

45 hese bacteria, including Rhizobium meliloti, Brucella abortus, Agrobacterium tumefaciens, and Rhodoba

46 RIV and MRIV), USDA standard tube tests with Brucella abortus and Brucella melitensis antigens (SATA

47 ntified an OPS epitope equally common to all Brucella abortus and Brucella melitensis strains but uni

48 candidates, manBA, virB2, and asp24, in both Brucella abortus and Brucella melitensis.

49 d Fz phages that are predominantly lytic for Brucella abortus and Brucella neotomae; Group II include

50 nemia induced by an injection of heat-killed Brucella abortus and examined the contribution of hepcid

51 own about the role of DNA repair networks in Brucella abortus and its role in pathogenesis.

52 role of O antigen in the interaction between Brucella abortus and macrophages, we have monitored the

53 ely related bacteria Sinorhizobium meliloti, Brucella abortus, and Ochrobactrum anthropi.

54 Burkholderia mallei, Francisella tularensis, Brucella abortus, and ricin.

55 responses to intracellular pathogens such as Brucella abortus are characteristically Th1-like.

56 Brucella abortus, B. melitensis, and B. suis are pathoge

57 broth microdilution susceptibility tests of Brucella abortus, B. melitensis, and B. suis.

58 was identical to the homologous sequences of Brucella abortus, B. melitensis, B. canis, and B. suis.

59 olates of human and animal origin, including Brucella abortus, B. melitensis, B. ovis, B. neotomae, m

60 onary relationships of five Brucella species-Brucella abortus, B. melitensis, B. suis, B. canis, and

61 We determined whether heat-killed Brucella abortus (BA), an inducer of Th1 responses, coul

62 AI was induced with heat-killed Brucella abortus (BA).

63 ndent (TI) response to insulin conjugated to Brucella abortus (BA-ins).

64 athogens that form chronic infections, e.g., Brucella abortus, Bartonella henselae, and Legionella pn

65 Although the Brucella abortus bhuQ mutant DCO1 did not exhibit a defe

66 lipid A of the medically relevant pathogens Brucella abortus, Brucella melitensis, Bartonella hensel

67 react with several other bacteria including Brucella abortus, Brucella melitensis, Yersinia enteroco

68 Clostridium botulinum, Brucella melitensis, Brucella abortus, Brucella suis, and Brucella canis were

69 s pathogenic in humans (Brucella melitensis, Brucella abortus, Brucella suis, and Brucella canis) is

70 adiations, producing four clades as follows: Brucella abortus-Brucella melitensis, Brucella suis-Bruc

71 1 and the control of in vitro replication of Brucella abortus but not Salmonella enterica serovar Dub

72 the heat-inactivated gram-negative bacterium Brucella abortus can induce IFN-gamma secretion by T cel

73 Brucella abortus Cu,Zn superoxide dismutase (SOD), a pro

74 Several intracellular pathogens, such as Brucella abortus, display a biphasic infection process s

75 Signaling pathways triggered by Brucella abortus DNA involves TLR9, AIM2, and stimulator

76 e report the x-ray crystal structures of the Brucella abortus DRL enzyme in its apo form and in compl

77 The intracellular bacterium Brucella abortus ensures its survival by forming the Bru

78 ed that the prokaryotes Brucella melitensis, Brucella abortus, Erythrobacter litoralis, and Pseudomon

79 The intracellular, gram-negative pathogen Brucella abortus establishes chronic infections in host

80 Here we use a genomic approach to examine Brucella abortus evolution, cross-species transmission a

81 We report the complete genome sequence of Brucella abortus field isolate 9-941 and compare it to t

82 wine, B. melitensis for sheep and goats, and Brucella abortus for cattle).

83 The Brucella abortus general stress response (GSR) system is

84 at was 43% similar to a previously described Brucella abortus group 3 Ag, Omp25.

85 The O antigen of Brucella abortus has been described as a major virulence

86 Heat-killed Brucella abortus (HBa) has been proposed as a carrier fo

87 These findings suggest that the Brucella abortus hfq gene product makes an essential con

88 and BAB2_0612 are highly over-produced in a Brucella abortus hfq mutant compared with the parental s

89 se sigma factor RpoS in many bacteria, and a Brucella abortus hfq mutant displays a phenotype in vitr

90 As expected, the Brucella abortus hfq mutant, designated Hfq3, showed inc

91 The Brucella abortus hfq mutant, unlike its parental strain

92 bacterial DNA in the context of heat-killed Brucella abortus (HKBA) engages TLR9 in dendritic cells

93 rototypic Th1-inducing adjuvant, heat-killed Brucella abortus (HKBA) to assess stimulation of DC subs

94 been identified in the previously described Brucella abortus htrA mutant PHE1.

95 ) is required for the wild-type virulence of Brucella abortus in cattle.

96 The genetic basis for chronic persistence of Brucella abortus in lymphoid organs of mice, cows, and h

97 Here, we show that a Brucella abortus in-frame mucR deletion strain exhibits

98 the description of cell-cycle progression of Brucella abortus, including unipolar growth and the orde

99 t in vitro and in vivo evidence showing that Brucella abortus-induced inflammatory response leads to

100 oteins or peptides conjugated to inactivated Brucella abortus induces the secretion of virus-neutrali

101 The chronicity of Brucella abortus infection in humans and animals depends

102 The present study demonstrates that Brucella abortus infection induces the activation of the

103 We demonstrate that Brucella abortus infection inhibits matrix metalloprotei

104 cells (HBMEC) in response to infection with Brucella abortus Infection of HBMEC with B. abortus indu

105 for the diagnosis of Mycobacterium bovis and Brucella abortus infection simultaneously in bovine milk

106 Bronner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum str

107 lved in the TLR-initiated immune response to Brucella abortus infection.

108 at immunoglobulin M and complement-opsonized Brucella abortus infects and survives inside primary mur

109 to determine its accuracy in differentiating Brucella abortus into three categories: field strains, v

110 Brucella abortus is a facultative intracellular pathogen

111 Brucella abortus is a facultative intracellular pathogen

112 Brucella abortus is a facultative intracellular pathogen

113 Brucella abortus is a facultative, intracellular zoonoti

114 Brucella abortus is an intracellular bacterial pathogen

115 Brucella abortus is an intracellular pathogen that persi

116 Brucella abortus-killed S19 was inoculated into the Brug

117 -lysine, in a manner that paralleled that of Brucella abortus lipopolysaccharide mutants.

118 These findings suggest that the Brucella abortus Lon homologue functions as a stress res

119 To evaluate the capacity of the Brucella abortus Lon homologue to function as a stress r

120 is revealed that transcription of the native Brucella abortus lon increases in response to heat shock

121 In contrast to the parent strain, the Brucella abortus lon mutant, designated GR106, was impai

122 The putative Brucella abortus Lon shares > 60% amino acid identity wi

123 A Brucella abortus mutant lacking TcpB fails to reduce lev

124 ce to elicit systemic infections with either Brucella abortus or B. melitensis at various doses.

125 h DNP-keyhole limpet hemocyanin, heat-killed Brucella abortus, or infection with Nippostrongylus bras

126 We report the cloning and sequencing of the Brucella abortus oxyR homolog and provide evidence that

127 Heat-killed Brucella abortus promotes secretion of Th1-inducing cyto

128 the sequence encoding the 31-kDa immunogenic Brucella abortus protein (BCSP 31) were used.

129 A low-molecular-weight recombinant Brucella abortus protein reactive with antibodies from a

130 Brucella abortus RB51 and isolates from cattle, bison, a

131 Brucella abortus RB51 is a stable rough, attenuated muta

132 of similar mass isolated from strain 16M or Brucella abortus RB51.

133 ntation by MHC II and allows host control of Brucella abortus replication in IL-4-treated DCs and in

134 Brucella abortus reportedly produces the monocatechol si

135 ulin conjugated to type 1 T cell-independent Brucella abortus ring test Ag (BRT).

136 When producing TNF-alpha, Brucella abortus rough lipopolysaccharide (LPS) activate

137 Cattle vaccinated with Brucella abortus rough strain RB51 (SRB51) produced smal

138 analysis of sera from cattle vaccinated with Brucella abortus S19 exhibit an elevated serologic respo

139 774.A1 murine macrophages were infected with Brucella abortus S2308-derived rough mutant CA180.

140 Brucella abortus S2308-infected IRF-1-/- mice were dead

141 Brucella abortus SodC was monomeric and released by osmo

142 Cattle vaccinated with Brucella abortus strain RB51 (SRB51) or infected with st

143 Brucella abortus strain RB51 is a stable, rough, attenua

144 Brucella abortus strain RB51 is an attenuated rough stra

145 Our studies indicated that Brucella abortus strain RB51 vaccination of mice induced

146 system, PhyR and sigma(E1), are required for Brucella abortus stress survival in vitro and maintenanc

147 Here we show that the intracellular pathogen Brucella abortus survives and replicates preferentially

148 II TA cassette in the intracellular pathogen Brucella abortus that consists of the toxin gene, brnT,

149 Yersinia pestis, Francisella tularensis, and Brucella abortus), the last four of which are biothreat

150 Brucella abortus, the bacteria responsible for bovine br

151 In the intracellular pathogen Brucella abortus, the general stress response (GSR) sign

152 yllumazine synthase (lumazine synthase) from Brucella abortus, the infectious organism of the disease

153 s about the molecular mechanisms employed by Brucella abortus to combat host defenses or to persist a

154 ouse AI model was developed with heat-killed Brucella abortus treatment.

155 The Brucella abortus type IV secretion system (T4SS), encode

156 The Brucella abortus type IV secretion system (T4SS), encode

157 The bacterium Brucella abortus uses a type IV secretion system (VirB T

158 same AT-rich site is recognized by MucR from Brucella abortus using a similar mechanism involving con

159 The Brucella abortus virB locus contains 12 open reading fra

160 The Brucella abortus virB locus is required for establishing

161 The Brucella abortus virB operon, consisting of 11 genes, vi

162 The Brucella abortus virB operon, encoding a type IV secreti

163 -alum (OVA/alum) immunization by heat-killed Brucella abortus was not reversed by anti-IL-12 antibody

164 IL-6 production triggered by infection with Brucella abortus, which induces ER stress by injecting t

165 -term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and

166 as Salmonella enterica serovar Typhimurium, Brucella abortus, Yersinia enterocolitica, and Pseudomon