ライフサイエンスコーパス: Brugia

1 uated two real-time PCR assays for detecting Brugia DNA in human blood and compared the results of th

2 4 in the clearance of a primary infection of Brugia from the murine host.

3 gulation of the Th2 response associated with Brugia infection.

4 immunologically intact permissive models of Brugia infection.

5 ype that reacts strongly with the surface of Brugia L3.

6 on passive transfer, led to the clearance of Brugia malayi (Bm) microfilariae (mf) from infected jird

7 nce tag, from the distantly related parasite Brugia malayi (Bm-her-1).

8 nts generated from MF patients, filarial Ag (Brugia malayi adult Ag (BmA))-stimulated supernatants fr

9 basophils released histamine in response to Brugia malayi Ag (BmAg).

10 Brugian filariasis (caused by the nematodes Brugia malayi and B. timori) is an important cause of di

11 During our investigations into the course of Brugia malayi and Brugia pahangi infections in immunodef

12 Extracts of Brugia malayi and Onchocerca volvulus, which contain Wol

13 e (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein c

14 duals (n = 11) were stimulated in vitro with Brugia malayi antigen (BMA) or mycobacterial purified pr

15 association between ratios of polyclonal to Brugia malayi antigen (BmAg)-specific IgE (range, 14:1 t

16 (-/-) mice were first immunized with soluble Brugia malayi antigens and then inoculated intravenously

17 d secondary murine and human infections with Brugia malayi are characterized by substantial increases

18 s brenneri, using Pristionchus pacificus and Brugia malayi as outgroups, and identified numerous oper

19 chocerca volvulus, Wuchereria bancrofti, and Brugia malayi available, new drug targets have been iden

20 response to live, infective-stage larvae of Brugia malayi but not to microfilariae of this parasite.

21 uble extracts of the human filarial parasite Brugia malayi can induce potent inflammatory responses,

22 Infection with the parasitic helminth Brugia malayi can result in development of a severe asth

23 sponding genes in Caenorhabditis elegans and Brugia malayi contained a cysteine codon in place of TGA

24 la melanogaster, Caenorhabditis elegans, and Brugia malayi EST sequences.

25 behaviour towards host cues when exposed to Brugia malayi filarial parasites.

26 The filarial nematode gene Bmgmf for Brugia malayi glia maturation factor contains six predic

27 Brugia malayi GMF (BmGMF) is also related to a large fam

28 The human filarial parasite Brugia malayi harbors an endosymbiotic bacterium Wolbach

29 e heme; however, the human filarial parasite Brugia malayi has acquired a bacterial gene encoding fer

30 sponse to the infective-stage larvae (L3) of Brugia malayi has not been well-characterized in vivo (b

31 he genomic environment of a newly identified Brugia malayi Hox6-8 ortholog (Bm-ant-1) revealed that i

32 ilarial Ag (MfAg) from the filarial parasite Brugia malayi in the presence of APCs.

33 We have shown that live microfilariae of Brugia malayi induce caspase-dependent apoptosis in huma

34 luated the contributions of T and B cells in Brugia malayi infection by utilizing knockout mice on a

35 after treatment with diethylcarbamazine for Brugia malayi infection, and recorded the severity of an

36 uired for host protection in mouse models of Brugia malayi infection.

37 A cDNA clone isolated from a Brugia malayi infective-stage larva expression library e

38 Together, these results suggest that Brugia malayi mf employ mechanisms of metabolic modulati

39 Brugia malayi microfilariae and adults were exposed in v

40 Blood-borne Brugia malayi microfilariae survived for significantly l

41 tics and anti-Wolbachia efficacy in a murine Brugia malayi model of minocycline versus doxycycline.

42 We have isolated and sequenced a Brugia malayi nematode 3.4-kb genomic DNA fragment and i

43 del of alternative activation in which adult Brugia malayi nematodes are implanted surgically in the

44 termine, via preclinical infection models of Brugia malayi or Onchocerca ochengi that elevated exposu

45 ells (PEC) from mice transplanted with adult Brugia malayi parasites suppress the proliferation of ly

46 ympahtic filariasis is the nematode parasite Brugia malayi that requires a competent mosquito vector

47 cation of binding protein(s) of the helminth Brugia malayi to CaGC and the ability of binding complex

48 The resistance of the human parasite Brugia malayi to the antiparasitic activity of cyclospor

49 e, C. remanei, C. brenneri, C. japonica, and Brugia malayi using some of the best-performing gene-fin

50 a donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which pr

51 ge larvae (L3) or live microfilariae (Mf) of Brugia malayi, a causative agent of human lymphatic fila

52 has been isolated from the filarial nematode Brugia malayi, a causative agent of human lymphatic fila

53 of almost all the major mammalian stages of Brugia malayi, a causative agent of lymphatic filariasis

54 ertaken the first study of heme transport in Brugia malayi, a causative agent of lymphatic filariasis

55 ical to the MIFs from the parasitic nematode Brugia malayi, and 22-35% identical to mammalian MIFs.

56 cells were exposed to microfilariae (mf) of Brugia malayi, and their phenotypic and functional chara

57 enomes to that of another filarial parasite, Brugia malayi, and to those of several other nematodes,

58 rgillus nidulans, Schizosaccharomyces pombe, Brugia malayi, Caenorhabditis elegans, Trypanosoma cruzi

59 bitor of NO synthase abrogated resistance to Brugia malayi, one of the causative agents of human lymp

60 nsoni ova, larvae from the filarial helminth Brugia malayi, or CFA.

61 IL4Ralpha(-/-) mice elicited by the nematode Brugia malayi, or via intraperitoneal thioglycollate inj

62 ocheilonema viteae, Onchocerca volvulus, and Brugia malayi, strongly supporting the concept that the

63 pod Drosophila melanogaster and the nematode Brugia malayi, together with the partial genome sequenci

64 e infective-stage larvae or microfilariae of Brugia malayi, we found significant impairment of both T

65 our research on the human nematode parasite Brugia malayi, which causes elephantiasis.

66 t the filarial nematodes responsible for LF (Brugia malayi, Wuchereria bancrofti) or onchocerciasis (

67 interactions between the infective stage of Brugia malayi--one of the extracellular parasites respon

68 immune responses were assayed in a group of Brugia malayi-infected rhesus monkeys.

69 of a metalloprotease from the filarial worm Brugia malayi.

70 ss in the important human parasitic nematode Brugia malayi.

71 ainst the Wolbachia-dependent model filaria, Brugia malayi.

72 e tropical parasites Onchocerca volvulus and Brugia malayi.

73 r chronic exposure to the nematode parasite, Brugia malayi.

74 quisition in the parasitic filarial nematode Brugia malayi.

75 en developed for the human filarial parasite Brugia malayi.

76 a nematode model with the filarial parasite, Brugia malayi.

77 parasitic nematodes Wuchereria bancrofti and Brugia malayi.

78 gy to identify candidate vaccine antigens of Brugia malayi.

79 C. elegans and the human-parasitic nematode Brugia malayi.

80 rial nematodes, including Brugia pahangi and Brugia malayi.

81 nematode parasites Wuchereria bancrofti and Brugia malayi.

82 ability to combat infection by the nematode Brugia malayi.

83 interleukin-4 (IL-4) in host defense against Brugia malayi.

84 nematode parasites Wuchereria bancrofti and Brugia malayi.

85 in two nematodes; Caenorhabditis elegans and Brugia malayi.

86 ed with intracorneal binding complex or live Brugia microfilariae.

87 occur in many filarial nematodes, including Brugia pahangi and Brugia malayi.

88 Apoptosis of human monocytes with Brugia pahangi antigen (BpA) was demonstrated by scoring

89 ctivity against Acanthocheilonema viteae and Brugia pahangi in jirds.

90 Intraperitoneal (i.p.) infections with Brugia pahangi in Mongolian gerbils, or jirds (Meriones

91 gations into the course of Brugia malayi and Brugia pahangi infections in immunodeficient mouse model

92 limination following primary intraperitoneal Brugia pahangi infections in mice.

93 lymphocytes in antifilarial immunity, using Brugia pahangi infections in the murine peritoneal cavit

94 cleared a challenge infection with infective Brugia pahangi L3 in an accelerated manner, whereas coho

95 es aimed to define early tissue migration of Brugia pahangi L3 in the gerbil (Meriones unguiculatus)

96 ifferent cell types following infection with Brugia pahangi.

97 hsp83 was cloned from the filarial nematode Brugia pahangi.

98 solated from the filarial parasitic nematode Brugia pahangi.

99 PCR assay is a sensitive means of detecting Brugia parasite DNA in human blood.

100 a abortus-killed S19 was inoculated into the Brugia-permissive gerbil host to induce gamma interferon

101 of transmission of Wuchereria bancrofti and Brugia spp. through the application of annual mass drug

102 aused by the insect-borne filarial nematodes Brugia, Wuchereria and Loa.

103 22 million years ago (Myr ago) involving the Brugia/Wuchereria lineage and >20-17 Myr ago involving t