ライフサイエンスコーパス: C termini

1 rved alpha-helical domains at both the N and C termini.

2 trating intermolecular interactions at their C termini.

3 pha, beta, and gamma) with cytoplasmic N and C termini.

4 The coiled coil was unzipped from its N and C termini.

5 domains are widely separated at their N and C termini.

6 e of apoA-IV that was truncated at its N and C termini.

7 helical structure flanked by flexible N and C termini.

8 with H2AX through domains at both its N and C termini.

9 cids (basic motifs) are present in p17 N and C termini.

10 lices (TM1 and TM2), and extracellular N and C termini.

11 stabilized by interactions between the N and C termini.

12 a conserved Ras-like core and extended N and C termini.

13 st multiple FH epitopes located at the N and C termini.

14 n protein aggregates with solvent-accessible C termini.

15 S(E/D)V amino acid sequence located at their C termini.

16 ide segments of cytosolic proteins from N to C termini.

17 ) helix flanked by small, unstructured N and C termini.

18 tor-binding region (RBR) but differ in their C termini.

19 omain, which is often involved in binding to C termini.

20 cells, GEC1 and GABARAP were cleaved at the C termini.

21 e the same N terminus but to differ in their C termini.

22 ts contain coiled-coil domains (CCDs) in the C termini.

23 buted at the confluence of cytoplasmic N and C termini.

24 antiparallel beta-sheet with flexible N and C termini.

25 sible binding event involving both the N and C termini.

26 helical structure in LPS with extended N and C termini.

27 ued in DAT chimeras encoding both SERT N and C termini.

28 62-133) due to the intertwining of its N and C termini.

29 cted by transversal filaments by their N and C termini.

30 highly conserved Rab-binding domain at their C termini.

31 acts to basic sequence motifs near the N and C termini.

32 se fold with degraded kinase motifs at their C termini.

33 entrally to enable contact between the N and C termini.

34 ultiple stages from the N-termini toward the C-termini.

35 otubule, at least partly through the tubulin C-termini.

36 out of alignment by two residues toward the C-termini.

37 renyl and methyl groups at their free N- and C-termini.

38 ides containing an arginine residue at their C-termini.

39 al G domain flanked by more divergent N- and C-termini.

40 giving rise to P0 isoforms with alternative C-termini.

41 mNramp3 hydrophobic core and PmNramp1 N- and C-termini.

42 tains long-range contacts between the N- and C-termini.

43 arallel with one another with the associated C-termini.

44 charged domains (Pro-Arg-Gly) at both N- and C-termini.

45 x transmembrane domains and cytosolic N- and C-termini.

46 mpanied by FRET decreases between the N- and C-termini.

47 ion to unfolded sequences in the AurA N- and C-termini.

48 creasing lengths and functionalizable N- and C-termini.

49 through their third intracellular loops and C-termini.

50 oligomers dictated by features of the N- and C-termini.

51 c cytosol have four residues, EEVD, at their C-termini.

52 ic packing interactions with extended N- and C-termini.

53 cross-linked peptides via (18)O-labeling at C-termini; (2) determination of the putative partial seq

54 urthermore, when manipulated from the N- and C-termini, ACBP unfolds by populating a transition state

55 for DAT, because replacing the SERT N and/or C termini affected neither substrate nor inhibitor affin

56 ansmembrane domains with extracellular N and C termini and a large N-glycosylated, extracellular loop

57 sistent with Kir channel crystal structures: C termini and M2 domains are centrally located relative

58 be significantly shortened at both the N and C termini and still maintain its enzymatic activity.

59 ch is gated through interactions between Rpt C termini and the alpha pockets.

60 emoval of the intrinsically disordered N and C termini and the hook region of beta1a prevented oligom

61 In both viruses, the gp120 N/C termini and the inner domain beta-sandwich and layer 2

62 ction sites: site 1 (Loop43), site 2 (N- and C-termini and adjacent Glu36, Loop33), and site 3 (Loop9

63 have mapped proteolysis sites at the N- and C-termini and at a limited internal segment, while other

64 od, and tissues by removing cleavable N- and C-termini and by shielding components from metabolic enz

65 l and nonhelical conformations at the N- and C-termini and in the vicinity of the gamma-cleavage site

66 formations that transition to loops at their C-termini and more likely to be surface accessible withi

67 nter-domain communication between the N- and C-termini and recruitment to androgen-target genes.

68 el beta-sheets, flanked by disordered N- and C-termini and Ser13 phosphorylation creates a network of

69 ly been ascribed to the receptor cytoplasmic C-termini and to AMPAR-associated auxiliary subunits, bo

70 st kinesins transport cargoes bound to their C-termini and use N-terminal motor domains to move along

71 Different lola isoforms, each having unique C-termini and zinc finger domains, may control different

72 FP or cyan fluorescent protein (CFP) at N or C termini, and all such constructs, including double-tag

73 e cleavage and covalent linkage of the N and C termini, and the cyclized pilin integrates into the in

74 tructural similarities between TssA1 and gp6 C-termini, and propose that TssA1 could be a baseplate c

75 were highly heterogeneous at both the N- and C-termini, and showed partial aspartate isomerization at

76 glycosylases from diverse sources, where the C termini are disordered and do not form comparable intr

77 The N and C termini are highly dynamic and are involved in the int

78 The peptide C termini are located close to the main fibril axis, whe

79 We also found that NIP4;1 and NIP4;2 C termini are phosphorylated by a pollen-specific CPK th

80 The N and C termini are unexpectedly close, providing clues for sp

81 ed form in which the positions of the N- and C-termini are exchanged with a surface loop.

82 bile, the core is highly structured, and the C-termini are flexible but restrained by their contact w

83 In contrast, the sequences of the C-termini are highly conserved, consistent with them enc

84 To examine how many C-termini are needed for SSB function, we engineered cov

85 portions of the apparently disordered N- and C-termini are unresolved.

86 on experiments show that that GCC185's N-and C-termini are within <40 nm of each other on the Golgi.

87 forms (EAAT2a and EAAT2b) that vary at their C termini as a consequence of alternative RNA splicing.

88 hemoselective capture step merging the N and C termini as a covalently linked O/S-ester intermediate

89 ypeptides that lack structurally constrained C termini, as proteolysis appears to occur independently

90 hese properties are not common to all formin C termini, as those of mDia1 and INF2 do not behave simi

91 e exception of a few residues near the N and C termini, as well as three hydrophilic residues within

92 by 2 autoinhibitory domains within its N and C termini, both of which were found to play critical rol

93 e domain only constructs, when tagged at the C termini but not at the N termini.

94 gamma isoforms are highly conserved at their C-termini but have unique N-terminal sequences, and we h

95 plains activity of PPAD against arginines at C-termini but not within peptides.

96 ecursor (pVI) that is cleaved at both N- and C-termini by AVP.

97 these peptides are protected at their N- and C-termini by macrocyclization.

98 igomerization of Ca(v)1.2 channels via their C termini can result in the amplification of Ca(2+) infl

99 more compact and rigid sites at their N and C termini compared with WT alpha-Syn that may facilitate

100 bodies at the cell surface and extracellular C termini comprised most or all of those present at the

101 OD4.2.2 structure, though with altered N and C termini conformations.

102 ectorially from hydrophilic N to hydrophobic C termini, consistent with our discovery of a regular ar

103 lical membrane domains and large cytoplasmic C-termini containing two cystathionine-beta-synthase dom

104 udy, we conducted mutational analysis of the C termini (containing the conserved Jas motif) of two JA

105 verexpression of SynGAP alpha1 versus alpha2 C-termini-containing proteins in hippocampal neurons has

106 ole the highly divergent intracellular N and C termini contribute to these processes.

107 proteins to test whether DAT and SERT N and C termini contribute to transporter substrate and inhibi

108 ysis in mammals suggested that expanded NF-M C termini correlated with larger-diameter axons.

109 electrostatic repulsion between the Kv3.1b N/C termini, created by its C-terminal splice domain, unma

110 ologous factors (FHFs, FGF11-14) bind to the C termini (CTs) of specific voltage-gated sodium channel

111 transmembrane segment (TMS) topology (N- and C-termini cytoplasmic) and preferential conservation of

112 PilA proteins with diverse and/or truncated C termini decreased native pilA transcription, suggestin

113 on of PheH(+) at various sites on the N- and C-termini depend on the type of theory and basis set use

114 meric building blocks, while flanking N- and C-termini direct the formation of larger sHSP oligomers.

115 eracting with the U-turn domains or with the C-termini domains.

116 One mouse truncated all C termini downstream of Oprm1 exon 3 (mE3M mice), while

117 tical in their N termini but unique in their C termini due to a -1 ribosomal frameshift during transl

118 een ssDNA binding sites, indicating that the C termini exert an inhibitory effect on ssDNA binding.

119 ed by a three-residue break with both N- and C-termini exposed to the cytoplasm.

120 n intramembrane protein where both the N and C termini face the cytoplasm.

121 f two PABPs on a poly(A) streak in which the C-termini face toward or away from each other).

122 ntrinsic function of both proteins, requires C termini facing the cytoplasmic leaflet of the plasma m

123 two equally active isoforms with alternative C-termini, Fes1L and Fes1S.

124 We conclude that the N- and C- termini function unexpectedly in negatively regulatin

125 in which the V1, V2, and V3 loops and N and C termini have been truncated) have indicated that a hal

126 AP, alpha1 and alpha2, which differ in their C-termini, have opposing effects on synaptic strength.

127 ved for subclasses having homologous F(ab')2 C termini (IgG1/3/4).

128 alpha-helices, (ii) extensions to the N and C termini, (iii) amino acid replacements in surface resi

129 nerated 3 mutant mouse models with truncated C termini in 2 different mouse strains, C57BL/6J (B6) an

130 eolysis to investigate the role of the N and C termini in ATP hydrolysis and auto-inhibition of the y

131 We deleted the noncatalytic N and C termini in both GSK-3 isoforms and generated point mut

132 a lipid bilayer, implicating both the N and C termini in membrane binding.

133 these mice revealed divergent roles for the C termini in morphine-induced behaviors, highlighting th

134 The unanchored ubiquitin C termini in the aggregates are generated in situ by agg

135 hin the cytoplasmic membrane, with the N and C termini in the cytoplasm and periplasm, respectively.

136 termini of the ssSPTs in the cytosol, their C termini in the lumen, and showed that they contain a s

137 by determining the orientation of the N- and C-termini in the amyloidogenic protein alpha-synuclein.

138 n response along the line joining the N- and C-termini) increased upon SBM binding from approximately

139 Rpt C termini insert individually into the alpha ring pocket

140 This N/C-termini interaction is a biomarker assay for the undes

141 to the human 43-mer inhibitory tract (N and C termini, mAbinhibit, and mAb4C11) and the neoepitope g

142 -electron microscopy, we show that the GroEL C-termini make physical contact with the PepQ folding in

143 acidic motifs located in the membrane-distal C termini may represent the first linear motifs which re

144 t stable proteoforms with undocumented N- or C-termini, meaning these proteoforms are stable function

145 /IAA and ARF proteins share highly conserved C-termini mediating homotypic and heterotypic interactio

146 To understand how the distinct C termini might affect transporter trafficking and surfa

147 large movement between two positions in the C termini of a dimeric cotransporter.

148 administration of an antibody targeting the C termini of Abeta40 and Abeta42.

149 The N and C termini of adjacent BAFF or APRIL monomers are spatial

150 onstrate that CryAB interacts with the N and C termini of Ago2, not the catalytic site defined by the

151 Thus, proteolytic modifications of the N and C termini of alpha2AP constitute major regulatory mechan

152 This novel interface involves the C termini of alpha3 and alpha5 helices.

153 Although the C termini of ARF and Aux/IAA proteins facilitate their h

154 Thus, the hydrophobic regions in the C termini of BH3-only members associated in distinct way

155 tion structures of the ANK repeat-containing C termini of both kidney-type glutaminase (KGA) and GLS2

156 The noncore C termini of both RAG1 and RAG2 are also required for AT

157 Here we show that both N and C termini of BRCA1 are required for its centrosomal loca

158 ibitor-induced dimers but suggested that the C termini of domain IV of the two monomers were in close

159 cisely determined the locations of the N and C termini of DRC3 and the C terminus of DRC4 within the

160 its N terminus interacts with both the N and C termini of E2F1.

161 rrestins and specific phosphoresidues in the C termini of each receptor are crucial for determining t

162 ion resides in short acidic regions near the C termini of each subunit.

163 vered by yeast two-hybrid screening that the C termini of ENaC alpha and beta subunits bind filamin A

164 we affirm this prediction, showing that the C termini of epitope-tagged, full-length human, rabbit,

165 These results illustrate that the C termini of formins are highly diverse in their interac

166 ies against linear epitopes within the N and C termini of gD2.

167 ing protein that interacts directly with the C termini of glutamate receptors 2/3 (GluA2/3) via its P

168 is constitutively bound to IQ domains of the C termini of human Kv7 (hKv7, KCNQ) channels to mediate

169 ICP27 interacts require that both the N and C termini of ICP27 are intact.

170 raction requires sequences in both the N and C termini of ICP27.

171 at are predicted to modify the intracellular C termini of IL-15Ralpha, and another N-terminal exon "E

172 ation away from the cell surface, moving the C termini of IL-7Ralpha and gamma(c) from a distance of

173 The region at the C termini of integrin beta(1) and beta(3) tails recogniz

174 istance to the known separation of the N and C termini of MBP than FRET.

175 drial matrix, suggesting that both the N and C termini of MCU face the matrix.

176 -dependent conformational variation near the C termini of molecules within PrP(Sc) multimers.

177 The C termini of none of the three non-HbYX motif Rpt subuni

178 iple glutamate residues from side chains and C termini of paclitaxel-stabilized microtubules.

179 f complexes with Fab fragments bound to N or C termini of PDE6gamma revealed that PDE6gamma stretches

180 main of the active-zone protein RIM with the C termini of presynaptic N- and P/Q-type Ca(2+) channels

181 Covalently joining the N and C termini of proteins to obtain circular polypeptides, a

182 toxin 2 (Stx2A1) interact with the conserved C termini of ribosomal-stalk P-proteins to remove a spec

183 high affinity interaction between the N and C termini of S. mutans P1 creates a non-adherent phenoty

184 , sorting motifs have been identified in the C termini of several GPCRs that facilitate correct traff

185 al transcriptional activation domains in the C termini of several tail module subunits of Saccharomyc

186 e demonstrate the nonequivalent roles of the C termini of six AAA subunits (Rpt1-Rpt6) of PA700 in 26

187 of nNOS binds with very low affinity to the C termini of target proteins, and a necessary simultaneo

188 Molecular models of the N and C termini of the channel were generated using the I-TASS

189 y or through the interface between the N and C termini of the channel.

190 ive modification of numerous residues in the C termini of the D1 and D2 proteins on the donor side of

191 ally modulated by small regions in the N and C termini of the Gle2 binding domain sequence, suggestin

192 nces between individual residues at the N or C termini of the L5 loop.

193 We find that the nucleoporin Nup62 and the C termini of the nephronophthisis (NPHP) proteins NPHP4

194 f Mcl-1 deletion mutants from both the N and C termini of the protein, including one that contained a

195 cular organization and location of the N and C termini of the transient receptor potential vanilloid

196 looking down onto the cell surface with the C termini of the two chains separated by 110 A and the d

197 e system, we identified regions in the N and C termini of the V protein that inhibit viral RNA synthe

198 These observations suggest that the N and C termini of the Vik1 MHD form a discrete folding motif

199 ed to structural rearrangements of the N and C termini of their motor domain upon nucleotide binding.

200 While the C termini of these orthologs are not conserved in amino

201 and the synthetic peptides representing the C termini of these proteins were in the 1- to 40-muM ran

202 Organelle targeting signals reside in the C termini of these proteins.

203 enzymatic removal of the negatively charged C termini of tubulin.

204 on with epitopes carrying mutations near the C termini of TW10 and a second HLA-B*57-restricted epito

205 Dimeric Grb2 binds to the C termini of two FGFR2 molecules.

206 ents TRAV6, TRAV16, and TRBD1; 2) both N and C termini of Valpha and Vbeta TCR junctions frequently e

207 The C termini of various cellular proteins insert within the

208 Antibodies specific for the N or C termini of xlProminin-1 labeled the open rims of lamel

209 tifs (ERret) are incorporated into the N- or C- termini of Shaker monomers or within sodium channels

210 roduced cysteine residue pairs to the N- and C- termini of the cpRFP scaffold, and subsequently optim

211 e Galphao interacts with both the N- and the C- termini of TRPM1, Gbetagamma interacts only with the

212 Recombinant C-termini of ADAMTS10 and ADAMTS6, both of which induce

213 Separate analyses of domains near the N- and C-termini of agrin, laminin, and collagen IV in mouse an

214 The C-termini of all isoforms localize to the active zone.

215 near interactions play a role in capping the C-termini of alpha-helices and 310-helices.

216 domain-containing proteins that bind to the C-termini of AMPA-R GluA2 and GluA3 subunits.

217 wo L-terminase protomers projecting from the C-termini of an S-terminase ring.

218 with mass spectrometry show that the N- and C-termini of AtHsp18.5 are highly accessible and lack st

219 of Rpn11 dimerizes with that of Rpn8 and the C-termini of both subunits form long helices, which are

220 s selected from phage libraries to the N- or C-termini of core streptavidin and used them to setup ph

221 Antisera against the intracellular, C-termini of divalent metal transporter (Dmt1) and Heph

222 The C-termini of E2 [amino acids (aa) 890-1053] and MEK2 (aa

223 ich results in a scissor-like closing of the C-termini of each protomer.

224 the 'alpha3/alpha5' interface, in which the C-termini of helices alpha3 and alpha5 are in close prox

225 emonstrate following proteolysis that N- and C-termini of IP3 R1 remain associated, presumably throug

226 o bind to negatively charged residues at the C-termini of P-proteins.

227 ons of mRNA sequences that correspond to the C-termini of protein domains, suggesting ribosome protec

228 hesin, but flanking sequences at both N- and C-termini of SpyCatcher were disordered.

229 ion distances of neighboring residues at the C-termini of the alpha1 and alpha2 helices are consisten

230 rmed through interactions of residues at the C-termini of the four chains.

231 The C-termini of the Gtgamma- and Gtalpha-subunits (GalphaCT

232 ult in multiple peaks for the exposed N- and C-termini of the peptide and in inhomogeneous line-broad

233 The most mobile positions are at the N- and C-termini of the peptide.

234 linkers, leading to outward movements of the C-termini of the pore-lining M3 helices and opening of t

235 t interactions involving the L3 loop, N- and C-termini of the RRM domain are collectively important f

236 immunodominant antigenic sites in the N- and C-termini of the RSV-G protein, that were boosted >10-fo

237 hosphatase BL (PDZ2) interacts and binds the C-termini of the tumour suppressor protein APC and of th

238 , describing a possible mechanism of how the C-termini of these homologous Hsp70 variants can differe

239 r attaching isotopic tags to both the N- and C-termini of tryptic peptides, and second, a search engi

240 Most of these modifications occur on the C-termini of tubulin and may directly affect the binding

241 ized to investigate the effects of different C termini on the process of biomineralization.

242 bent TIA-1 shape, which organizes the N- and C-termini on the same side of the protein, are discussed

243 formation of intermolecular hydrogen bonds: C-termini or internal linear motifs of proteins bind as

244 embrane domains (TMDs), with both the N- and C-termini orientated toward the lumen of the ER.

245 -helical region within the membrane-proximal C termini play an important role.

246 Within the highly diverged N- and C-termini, posttranslational modifications are scattered

247 osylated because of the fact that the mutant C termini project extracellularly.

248 eas in 3'-terminal exons that encode protein C-termini, protein-level selection is significantly stro

249 cterized by a beta-turn structure near their C termini rather than the alpha-helical structure common

250 kely attributed to the changes in the N- and C-termini rather than in the RNA-binding region.

251 d 11 and 19 amino acid residues at the N and C termini, respectively, exhibited no significant change

252 3- and 10-amino-acid extensions at the N and C termini, respectively.

253 e lacking 104 and 65 residues from its N and C termini, respectively.

254 iotin acceptor domain attached to its N- and C- termini, respectively.

255 otease-resistant and has cysteine-rich N and C termini responsible for polymerization.

256 Importantly, removal of the C termini results in slower overall folding, reducing th

257 arginine(R)-phenylalanine(F) motif at their C-termini (RFamide peptides).

258 ormed between apposing cysteines ligates two C termini, serving as the structural basis of channel se

259 o as to juxtapose the amino (N) and carboxy (C) termini; several of these designed structures have be

260 ed motifs in their N-termini, and that their C-termini share a previously unnoticed structural simila

261 Substitution mutations in the N or C termini showed that the leucine-rich region (LRR) in t

262 nternal PrP fragments, cleaved at both N and C termini, similar to those found in PrP-CAA and GSS bra

263 played by oligomerization, disordered N and C termini, subunit exchange, and variable dimer interfac

264 pelling experimental evidence that DAT N and C termini synergistically contribute to substrate and in

265 g and immunolocalization of two dual, N- and C-termini-tagged APP constructs: CFP-APP-YFP [containing

266 Unfortunately, the structures of the N and C termini that are important for lipid binding were not

267 ferences primarily at the cytosolic N and/or C termini that are likely to impart on the transporters

268 t main transition states placed at the N and C termini that dictate the direction in which unfolding

269 four- to two-helix packing transition at the C-termini that send opposing signals in bacterial chemor

270 ifference between the two peptides is at the C-termini, the N-terminal segment plays a key role in th

271 II-III loop (residue 626) and both the N and C termini; the I-II loop (residue 406) showed weak FRET

272 oteins with subsequent ligation of the N and C termini to form a continuous peptide backbone.

273 Lys motifs were moved from the extreme N and C termini to the interior next to the cleavage site sequ

274 ) and polycystin-2 (PC2), interact via their C-termini to form a receptor-ion channel complex whose f

275 vable Fmoc or acetylated N-termini via their C-termini to produce active peptide SPR sensors that wer

276 intermediate Ti-1, which exposes the N- and C-termini to the cytoplasm, did not require an intact Ta

277 ASIC subunits contain intracellular N and C termini, two transmembrane domains that constitute the

278 used two full-sized IgG antibodies via their C termini using sortase transpeptidation and click chemi

279 degradation demonstrated that both the N and C termini were correct for each isoform.

280 The N and C termini were intrinsically disordered in both the full

281 chimeras showed that the intracellular N and C termini were involved in geldanamycin sensitivity.

282 ansmembrane domains 2 and 3, plus the N- and C-termini were found on the cytosolic side of the ER.

283 9 as well as the distance between the N- and C-termini were monitored to estimate the strength and or

284 -specific linkage of proteins via their N or C termini, when a remaining free terminus is required fo

285 epitopes, and gradually separate toward the C termini, where they associate with the membrane.

286 n endo conformation oriented toward the 3SCC C-termini, whereas the cysteines are predisposed for tri

287 -binding motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a univ

288 possesses multiple CaMBDs at cytosolic N and C termini, which is reminiscent of animal CNGCs and unli

289 find that Nod1 and Gef2 interact through the C-termini, which is important for their localization.

290 unfolding is initiated from both the N- and C-termini, while three-state unfolding is initiated only

291 t-translationally modified to join the N and C termini with a peptide bond.

292 ic proteins, we have modified their N and/or C termini with a short peptide sequence that interacts w

293 s to one subunit of tetrameric HCN2 and HCN4 C termini with high affinity ( approximately 0.12 muM) a

294 o confirm the exact orientation of its N and C termini with respect to the plasma membrane to get clu

295 Interaction of Galphas or Galphaq C termini with the GPCR increases signaling potency, sug

296 We also found that swapping PLB N and C termini with those from SLN caused the resulting chime

297 ith the potential to interact at both N- and C-termini with adjacent membrane-bound divisome componen

298 ing pathway, where the exposure of ubiquitin C termini within protein aggregates enables HDAC6 recogn

299 ed forms of SSB that possess only one or two C-termini within a four-OB-fold "tetramer".

300 ligases, only differ by one residue at their C-termini; yet each has its specific E1 for the activati