ライフサイエンスコーパス: C-C chemokine

1 ls are a rich source of eosinophil-selective C-C chemokines.

2 nd decrease in the production of a number of C-C chemokines.

3 y on the discrete target cell selectivity of C-C chemokines.

4 xodus-2 also had unusual characteristics for C-C chemokines.

5 n vivo chemoattractant activity of different C-C chemokines.

6 alternative macrophage activation-associated C-C chemokine (AMAC) 1, or dendritic cell-derived C-C ch

7 Up-regulation of the three C-C chemokines and down-modulation of cell surface CCR5

8 othelial cells (PMC) to release C-X-C and/or C-C chemokines and express adhesion molecules that initi

9 the mammalian enzyme, fungal DppIVA cleaved C-C chemokines and GM-CSF.

10 cells from normal and HIV-1+ donors produce C-C chemokines and other unidentified factors that can i

11 The data suggest that a dual mechanism of C-C chemokines and specific Abs may engage and down-modu

12 showed distinct differences in expression of C-C chemokines and their receptors between children with

13 We hypothesized that IL-2 alters cytokine, C-C chemokine, and adhesion molecule expression in assoc

14 ot rendered susceptible by neutralization of C-C chemokines, and addition of C-C chemokines did not c

15 matory protein-1alpha (MIP-1alpha) and other C-C chemokines, and that addition of anti-CD28 gives ver

16 C-C chemokines are a structurally defined family of chem

17 These data indicate that multiple C-C chemokines are involved in the recruitment of partic

18 The C-C chemokines are major mediators of chemotaxis of mono

19 RS is overproduction of eosinophil-promoting C-C chemokines by sinus epithelium, perhaps driven in pa

20 Previous studies have suggested that the C-C chemokine C10 is involved in the chronic stages of h

21 Unlike other C-C chemokines, C10 levels in the peritoneal wash were i

22 hemokine (AMAC) 1, or dendritic cell-derived C-C chemokine (DCCK) 1).

23 alization of C-C chemokines, and addition of C-C chemokines did not consistently suppress endogenous

24 haracterized by elevated IgE, Th2 cytokines, C-C chemokines, eosinophilic inflammation, and persisten

25 The C-C chemokine eotaxin is a potent chemoattractant for eo

26 on in response to i.p. administration of the C-C chemokine, eotaxin, was studied in vivo.

27 We show that the C-C chemokines, eotaxin and RANTES (regulated upon activ

28 Up-regulation of C-C chemokine expression characterizes allergic inflamma

29 that Th1 and Th2 cytokines may regulate the C-C chemokine expression in PMCs and thus play a biologi

30 dy, we examined the effect of MIP-1 gamma, a C-C chemokine family member, on receptor activator of NF

31 the present study, we present data that the C-C chemokine family members may be a factor influencing

32 ng site regulation of MCP-1, a member of the C-C chemokine family, in a rat model of volume-overload

33 RANTES, a member of the C-C chemokine family, is a potent chemoattractant for T

34 biological activities for this member of the C-C chemokine family.

35 Th2 cells may induce selective production of C-C chemokines from epithelium and indicate that glucoco

36 xamine lung tissue for expression of CXC and C-C chemokine genes and bronchoalveolar lavage (BAL) flu

37 to aerosolized OVA has been used to identify C-C chemokine genes expressed at stages of massive eosin

38 lted in increased expression of both CXC and C-C chemokines genes in lung tissues.

39 osinophil activation; however, mRNA for this C-C chemokine has been shown to be constitutively expres

40 Hemofiltrate C-C chemokine (HCC)-1 is a recently cloned C-C chemokine

41 The C-C chemokines human monocyte chemoattractant protein-1

42 nflammation with increases in Th2 cytokines, C-C chemokines, IgE production, and mucous cell metaplas

43 M challenge with increases in Th2 cytokines, C-C chemokines, IgE production, and mucous cell metaplas

44 Eotaxin is a C-C chemokine implicated in the recruitment of eosinophi

45 od mononuclear cells (CBMC) to secrete these C-C chemokines in comparison to adult blood mononuclear

46 The CCR5 Abs were complementary to the C-C chemokines in inhibiting HIV replication in vitro.

47 Binding assays using 125I-labeled C-C chemokines in mammalian cells indicated that CHEMR1

48 CD4-specific chemoattractant, and RANTES, a C-C chemokine, in response to GD-specific IgG (GD-IgG).

49 hocyte chemoattractant, IL-16, and RANTES, a C-C chemokine, in their fibroblasts.

50 Three C-C chemokines inhibit human immunodeficiency virus (HIV

51 TCA3, a C-C chemokine, is produced by Ag-activated T cells and i

52 e of the monocyte chemotactic and activating C-C chemokine JE/monocyte chemotactic protein-1 has been

53 Among C-C chemokines known to chemoattract different leukocyte

54 cytokines with myelogenic potential such as C-C chemokine ligand (CCL)2, interleukin (IL)-6, and VEG

55 haracterize the homologues of human eotaxin (C-C chemokine ligand 11) and CCR3 from other species, su

56 taxis requires either of the cognate ligands C-C chemokine ligand 19 (CCL19) or CCL21.

57 ey identify the T-cell activation regulators C-C chemokine ligand 19 and C-C chemokine receptor 7 as

58 t obesity activates hepatocyte expression of C-C chemokine ligand 2 (CCL2/MCP-1) leading to hepatic r

59 igh) monocytes accrue in response to a brief C-C chemokine ligand 2 burst.

60 eus, presumably via a mechanism of decreased C-C chemokine ligand 2 levels in the cerebrospinal fluid

61 ate the role of the C-C chemokine receptor 6/C-C chemokine ligand 20 (CCR6/CCL20) chemokine axis in m

62 ion in many inflammatory chemokines, such as C-C chemokine ligand 5, CXC ligand 9 (CXCL9), and CXCL10

63 TNF-deficient mice had reduced expression of C-C chemokine ligand 5, CXCL9, and CXCL10 at early time

64 Protein levels of C-C chemokine ligand-2 (CCL-2)/monocyte chemotactic prot

65 but not TGF-beta2 or TGF-beta3, and elevated C-C chemokines macrophage chemoattractant protein-1, mac

66 e, macrophage inflammatory protein-2 and the C-C chemokines macrophage inflammatory protein-1alpha an

67 ivity by induction of the cysteine-cysteine (C-C) chemokine macrophage inflammatory protein 1beta (MI

68 evated immunohistochemical expression of the C-C chemokines, macrophage inflammatory protein-1 alpha

69 chemokine GRO alpha and the mononuclear cell C-C chemokines: macrophage inflammatory protein 1 alpha,

70 ar cells may be critical effector cells, and C-C chemokines may play important roles in the initiatio

71 Lung mRNA expression of the C-C chemokine MCP-1 was increased in OVA-indomethacin mi

72 These results suggest that the production of C-C chemokines (MCP-1 or MIP-1 alpha) during an immune r

73 this considerable sequence homology to other C-C chemokines, MCP-2 appears to have unique functional

74 1, but had only minor effects on the related C-C chemokines MIP-1 alpha and RANTES.

75 The C-C chemokines MIP-1alpha, MIP-1beta, and RANTES have be

76 Importantly, the C-C chemokines MIP-1alpha, MIP-1beta, and RANTES were re

77 To elucidate the role of C-C chemokines, MIP-1 alpha and MCP-1, we have used both

78 The C-C chemokine monocyte chemoattractant protein-1 (MCP-1)

79 phage inflammatory protein-2, as well as the C-C chemokines murine monocyte chemoattractant protein-1

80 at CHEMR1 may be a receptor for unidentified C-C chemokine or a low-affinity receptor for MIP-1alpha.

81 demonstrating that mesothelial cell-derived C-C chemokines play a biologically important role in the

82 Thus, although C-C chemokines play a broad role in influencing inflamma

83 C-C chemokines play an important role in recruitment of

84 We studied the regulation of C-C chemokine production by CD28 costimulatory signals b

85 uency of resistant cultures without reducing C-C chemokine production.

86 The C-C chemokines RANTES, MIP-1 alpha and MIP-1 beta were r

87 but was associated with the activity of the C-C chemokines RANTES, MIP-1alpha, and MIP-1beta.

88 tion, and could be neutralized by removal of C-C chemokines (RANTES (regulated upon activation, norma

89 f PBM and AM increases the production of the C-C chemokine, RANTES.

90 The recently discovered C-C chemokines, RANTES (regulated on activation, normal

91 The three C-C chemokines, RANTES, macrophage-inflammatory protein-

92 t protein (MCP) 1 are mediated by binding to C-C chemokine receptor (CCR) 2.

93 Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signa

94 The frequency of homozygous C-C chemokine receptor (CCR) 5- Delta 32 was higher in E

95 l major histocompatibility complex class II, C-C chemokine receptor (CCR) type 1, CCR2, CX3C chemokin

96 f chemokine (C-C motif) ligand (CCL)2, CCL4, C-C chemokine receptor (CCR)1, and CCR5, which are invol

97 s revealed that HCC-1 specifically activated C-C chemokine receptor (CCR)1, but not closely related r

98 8(-) T cells were activated CD69(+)CD45RA(-) C-C chemokine receptor (CCR)7(-) effector memory and per

99 has been shown to increase the production of C-C chemokine receptor (CCR5)-binding chemokines under c

100 The C-C chemokine receptor (CCR7) G protein-coupled receptor

101 C-C chemokine receptor 1 (CCR1) is a chemokine receptor

102 study addressed the role of their receptor, C-C chemokine receptor 1 (CCR1), in this model.

103 NAME-treated mice expressed higher levels of C-C chemokine receptor 2 (CCR2) and CCR3 mRNA and contai

104 ated with single nucleotide polymorphisms of C-C chemokine receptor 2 (CCR2) gene.

105 C-C chemokine receptor 2 (CCR2) is considered the major

106 tic steatosis in obese mice deficient in the C-C chemokine receptor 2 (CCR2) that regulates myeloid c

107 Changes in MCP-1, C-C chemokine receptor 2 (CCR2), procollagen I and III,

108 generate mice with a targeted disruption of C-C chemokine receptor 2 (CCR2), the receptor for MCP-1.

109 ote inflammation, it remains unclear whether C-C chemokine receptor 2 (CCR2)- and Ly6C-expressing inf

110 C-C chemokine receptor 5 (CCR5)-Delta 32 and C-C chemokine receptor 2 (CCR2)-64I (relative hazard = 0

111 We investigated the role of C-C chemokine receptor 2 (CCR2)-dependent cell recruitme

112 elosuppressive chemokine, specifically binds C-C chemokine receptor 2 (CCR2).

113 inducible nitric oxide synthase (iNOS), and C-C chemokine receptor 2 (CCR2).

114 high) monocytes express heightened levels of C-C chemokine receptor 2 on their surface, avidly infilt

115 or monocyte chemoattractant protein (MCP)-1, C-C chemokine receptor 2(CCR2), interleukin (IL)-1beta,

116 Compared with MMR- and C-C chemokine receptor 2-deficient mice, significantly h

117 the human thrombin receptor (PAR-1) and the C-C chemokine receptor 2B.

118 The beta-chemokine receptor C-C chemokine receptor 3 (CCR3) provides a mechanism for

119 etreatment of eosinophils with an mAb to the C-C chemokine receptor 3 (CCR3).

120 We found that HIV-1 coat proteins that used C-C chemokine receptor 3 or C-X-C chemokine receptor 4 a

121 odifications of the chemokine RANTES bind to C-C chemokine receptor 5 (CCR5) and block human immunode

122 We have shown that mice that express the C-C chemokine receptor 5 (CCR5) have enhanced local tumo

123 his study, we demonstrate a crucial role for C-C chemokine receptor 5 (CCR5) in the accelerated recru

124 s used a B16-F10 melanoma model to show that C-C chemokine receptor 5 (CCR5) knockout (CCR5(-/-)) mic

125 , we evaluated whether the disruption of the C-C chemokine receptor 5 (CCR5) locus in pigtailed macaq

126 to CD4 followed by engagement of either the C-C chemokine receptor 5 (CCR5) or C-X-C chemokine recep

127 The C-C chemokine receptor 5 (CCR5) plays a crucial role in

128 C-C chemokine receptor 5 (CCR5), a member of G-protein-c

129 We tested this hypothesis for C-C chemokine receptor 5 (CCR5), a molecule involved in

130 k of a protective genotype, consisted of: 1) C-C chemokine receptor 5 (CCR5)-Delta 32 and C-C chemoki

131 ites in a G protein-coupled receptor (GPCR), C-C chemokine receptor 5 (CCR5).

132 viral load and could be traced to a single, C-C chemokine receptor 5-tropic founder virus with short

133 ntal autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogen

134 of IL17A, IL17F, retinoid-orphan-receptor C, C-C chemokine receptor 6, and the IL23 receptor.

135 his study was to investigate the role of the C-C chemokine receptor 6/C-C chemokine ligand 20 (CCR6/C

136 We hypothesized that chemokine receptors C-C chemokine receptor 7 (CCR7) and C-X-C chemokine rece

137 cells carry out immune functions, using the C-C chemokine receptor 7 (CCR7) and its cognate ligands,

138 ulates CXCR5 but not Bcl6, and downregulates C-C chemokine receptor 7 (CCR7) expression in T cells in

139 C-C chemokine receptor 7 (CCR7) facilitates entry of T c

140 (+) adipose tissue immune cells that express C-C chemokine receptor 7 (CCR7) in mice and humans, and

141 ation regulators C-C chemokine ligand 19 and C-C chemokine receptor 7 as potential mediators of immun

142 Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIVmac239 envelo

143 The C-C chemokine receptor CCR5 in humans and rhesus macaque

144 The C-C chemokine receptor CCR5 serves an important function

145 C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokine receptor type 1 (CCR1), which are the rece

146 Upstream to Fyn, MCP1 stimulated C-C chemokine receptor type 2 (CCR2) and Gi/o and inhibi

147 C-C chemokine receptor type 2 (CCR2) and its ligands (CC

148 A comparison of the MCP-1/C-C chemokine receptor type 2 (CCR2) chemokine system be

149 ptic burned patients with a special focus on C-C chemokine receptor type 2 (CCR2) expressions on clas

150 C-C chemokine receptor type 2 (CCR2) is expressed by act

151 d whether CCX140-B, a selective inhibitor of C-C chemokine receptor type 2 (CCR2), could further redu

152 nstants of C-C motif chemokine 7 (CCL7) with C-C chemokine receptor type 2 (CCR2), monosulfated CCR2,

153 The generated MDSC were expressed C-C chemokine receptor type 2 (CCR2), which was enhanced

154 A C-C chemokine receptor type 2 (CCR2)-positive macrophage

155 lating factor 1 receptor blockade diminished C-C chemokine receptor type 2 [CCR2(neg) (Ly6C(lo))] mon

156 d macrophage-1 receptor, Sialil-Lewis X, and C-C chemokine receptor type 2 expression in monocytes.

157 , especially within the hemoglobin delta and C-C chemokine receptor type 2 genes, respectively, causi

158 The C-C chemokine receptor type 2 protein (CCR2) functions i

159 fingolimod (FTY720)-sensitive manner and use C-C chemokine receptor type 2 to accumulate in inflamed

160 ilencing of the monocyte-recruiting receptor C-C chemokine receptor type 2 with short-interfering RNA

161 d IL-13 receptor alpha1 and donor eosinophil C-C chemokine receptor type 3 (CCR3) and interleukin 1 r

162 for this activation, and the combination of C-C chemokine receptor type 4 (CCR4) chemokine receptors

163 r studies demonstrated that ORM1 can bind to C-C chemokine receptor type 5 (CCR5) on muscle cells and

164 ficantly higher prechallenge levels of CD4(+)C-C chemokine receptor type 5 (CCR5)(+)HLA-DR(+) T cells

165 Individuals homozygous for the C-C chemokine receptor type 5 gene with 32-bp deletions

166 tems targeting the human hemoglobin beta and C-C chemokine receptor type 5 genes have substantial off

167 chemokine (C-C motif) ligand 5 that binds to C-C chemokine receptor type 5 on BCCs and BCCs secrete c

168 While frequencies of foreskin C-C chemokine receptor type 5(+) (CCR5(+)) T cells, T re

169 udied zinc finger nucleases (ZFNs) targeting C-C chemokine receptor type 5.

170 ation and expression of the migration marker C-C chemokine receptor type 7 (CCR7) in PGN-stimulated c

171 ode-homing molecules CD62 ligand (CD62L) and C-C chemokine receptor type 7 (CCR7), which are expresse

172 olling (CD14dimCD16(+)) monocytes, and their C-C chemokine receptor type-2 (CCR2) expression were qua

173 The C-C chemokine receptor, CCR2, has been identified as the

174 One C-C chemokine receptor, CCR2, has been identified that m

175 chemotaxis is mediated primarily through the C-C chemokine receptor, CCR3.

176 We have cloned a novel murine C-C chemokine receptor, designated mouse CCR2 (mCCR2), f

177 The C-C chemokine receptor-1 (CKR-1), the MCP-1 receptor-A (

178 (Ccl-2; also known as MCP-1) or its cognate C-C chemokine receptor-2 (Ccr-2) develop cardinal featur

179 1alpha) receptor gene Scya3r and two related C-C chemokine receptor-like genes reside.

180 used ApoE-/-OPN-/- mice expressed less CD68, C-C-chemokine receptor 2, and VCAM-1.

181 HIV-1 strains use C-C-chemokine receptor 5, CCR5, as a coreceptor for host

182 RA) joint, we investigated the expression of C-C chemokine receptors (CCR) 1-6 and C-X-C receptor 3 (

183 Fibronectin, C-C chemokine receptors (CCRs)2 and 7, and oxidative str

184 The pathways by which the C-C chemokine receptors activate phospholipase C (PLC) w

185 icant functional differences between the two C-C chemokine receptors and suggest a two-step mechanism

186 In experiments using cells transfected with C-C chemokine receptors, 125I-MCP-2 bound to human embry

187 but not to Galpha16, suggesting some of the C-C chemokine receptors, unlike the C-X-C chemokine rece

188 ones that encode two closely related, murine C-C chemokine receptors.

189 , interferon-gamma, [IFN-gamma], and IL-12), C-C chemokines (regulated upon activation, normal T cell

190 emotactic protein (MCP)-2 is a member of the C-C chemokine subfamily, which shares more than 60% sequ

191 nctional properties in comparison with other C-C chemokines such as MCP-1 and MCP-3.

192 Levels of C-C chemokines such as monocyte chemoattractant protein-

193 characterization of a novel murine and human C-C chemokine termed Exodus-2 for its similarity to Exod

194 e C-C chemokine (HCC)-1 is a recently cloned C-C chemokine that is structurally similar to macrophage

195 hemoattractant protein-1 is one of the major C-C chemokines that has been implicated in liver injury.

196 hat MCP-2 may share the receptors with these C-C chemokines, the actual functional receptors for MCP-

197 ocyte chemoattractant protein-1 (MCP-1) is a C-C chemokine thought to play a major role in recruiting

198 In this study, the ability of several C-C chemokines to induce transendothelial migration (TEM

199 tural basis for pleiotropic signaling of the C-C chemokine type 5 (CCR5) G protein-coupled receptor (

200 llograft RNA expression of several C-X-C and C-C chemokines was tested during rejection of full thick

201 ase in eotaxin, a potent eosinophil-specific C-C chemokine, was also observed during fibroblast-mast

202 When the two C-C chemokines were individually co-incubated with Con-A

203 n and cloning of a cDNA that encodes a mouse C-C chemokine with 68% amino acid identity to guinea pig

204 inflammatory protein 1alpha (MIP-1alpha), a C-C chemokine with monocyte chemoattractant capability,

205 ctic protein-4 (MCP-4) is a newly identified C-C chemokine with potent eosinophil chemoattractant pro